Clinical trials: Heart Arrest, Out-Of-Hospital
Out-of-Hospital Cardiac Arrest
Induced Hypothermia in Cardiac Arrest Patients Rescued by Extracorporeal Cardiopulmonary Resuscitation.
Background： Cardiopulmonary resuscitation (CPR) with closed-chest cardiac massage has been shown that survival to discharge rate is poor.
- Trial name
- NCT00965016
- Testing
- hypothermia
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Min-Sheng General Hospital
Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA)
Measurement of Airway Opening Index During Out-of-hospital Cardiac Arrest: The Lazarus AOI Trial.
Out-of-hospital cardiac arrest (OHCA) is a leading cause of death worldwide. Despite constantly improving resuscitation techniques, the chances of survival remain limited.
- Conditions
- Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA), Resuscitated Sudden Cardiac Death
- Trial name
- Lazarus-AOI (NCT07438938)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Ghent
Out-of-hospital Cardiac Arrest
Digestive ENdoscopy afTeR Out-of-hospitAl Cardiac arresT
Post-cardiac arrest ischemia/reperfusion phenomenon led to organs injury and failure. Among the different organs, gastro-intestinal tract injury could contribute to post-cardiac arrest shock.
- Trial name
- ENTRACT (NCT02349074)
- Testing
- Digestive endoscopy
- Where
- 9 sites in Belgium, France
- Volunteers
- 221 people
- Sponsor
- Versailles Hospital
Cardiac Arrest
Basic Life Support Termination of Resuscitation Implementation Study
In Ontario, most people who experience a cardiac arrest at home (when their heart stops beating) only receive basic life support from Primary Care Paramedics (PCPs) and all are transported to the hospital.
- Trial name
- NCT00370461
- Where
- 7 sites in Canada
- Volunteers
- 350 people
- Sponsor
- Sunnybrook Health Sciences Centre
Out of Hospital Cardiac Arrest
Cardiac Catheterization in Cardiac Arrest
This is a pilot study that will lead to a large randomized control trial (RCT), to assess whether early versus late or no cardiac catheterization is associated with improved outcomes in out-of-hospital cardiac arrest (OHCA)…
- Trial name
- NCT02587494
- Testing
- Cardiac catheterization
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Out-Of-Hospital Cardiac Arrest
The HeartRunner Trial
The study will assess 30-day survival for cases where volunteer citizen responders ('heart runners') were activated through a smartphone app to retrieve an AED in case of suspected out-of-hospital cardiac arrest (OHCA) versus…
- Trial name
- NCT03835403
- Testing
- Activation of HeartRunners
- Where
- Denmark
- Volunteers
- 2,114 people
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Out-of-hospital Cardiac Arrest (OHCA)
Trial of Mobile External Defibrillator for Out-of-hospital Cardiac Arrest in Singapore.
The goal of this clinical trial is to learn the feasibility of equipping the volunteer community responders (VCR) with the mobile external automated defibrillators (mAEDs) for the management of adults experiencing out-of-hospital…
- Trial name
- NCT07042061
- Testing
- Mobile external automated defibrillator
- Volunteers
- 1,000 people
- Sponsor
- Singapore General Hospital
Post-Cardiac Arrest Syndrome, Post Cardiac Arrest Brain Injury
Cerebral Oximetry in Management of Post Cardiac Arrest
Resuscitation from a cardiac arrest is a common reason for admission to an intensive care unit (ICU). Because the brain is highly vulnerable to oxygen deprivation, severe brain damage often occurs during a cardiac arrest.
- Conditions
- Post-Cardiac Arrest Syndrome, Post Cardiac Arrest Brain Injury, Hypoxic-Ischemic Brain Injury
- Trial name
- COMPACT (NCT07829887)
- Testing
- Cerebral oximetry-guided treatment
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of Calgary
Cardiac Arrest, Morality
Call to Door Timing in Out-of-hospital Cardiac Arrest
The investigators aimed to investigate the effect of delayed hospitalization on the basis of the call time on the clinical outcomes of patients with OHCA patients using a nationwide OHCA registry.
- Trial name
- NCT05724914
- Where
- South Korea
- Volunteers
- 182,508 people
- Sponsor
- Yonsei University
Cardiac Arrest, Out-Of-Hospital
New Information and Communication Technologies (ICT´s) in Basic Life Support Training for Non-medical Students: Educational Trial
With the increase in life expectancy of the general population and advances in medicine, there is now a population with a higher amount of cardiovascular diseases that lead to an increased risk of sudden cardiac arrest.
- Trial name
- NCT04286204
- Testing
- Basic Life Support training based on ICTs, Classic Basic Life Support training
- Where
- Colombia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Cardiac Arrest, Out of Hospital Cardiac Arrest
Compression Only-CPR Versus Standard-CPR
Out-of-hospital cardiac arrest (OHCA) is one of the leading causes of mortality in the industrialized world. Bystander CPR before arrival of the Emergency Medical Service (EMS) is a positive predictor of survival.
- Trial name
- TANGO2 (NCT02401633)
- Testing
- CO-CPR, S-CPR
- Where
- Sweden
- Volunteers
- 1,250 people
- Sponsor
- Karolinska Institutet
Out of Hospital Cardiac Arrest
Initiation of Cooling by EMS to Promote Adoption of In-hospital Hypothermia in Cardiac Arrest Survivors
This is a large pragmatic, randomized controlled trial comparing pre-hospital initiation of therapeutic hypothermia by Emergency Medical Services (EMS) providers to conventional post-resuscitation care.
- Trial name
- NCT01528475
- Testing
- Pre-hospital cooling
- Where
- 3 sites in Canada
- Volunteers
- 585 people
- Sponsor
- Sunnybrook Health Sciences Centre
Out-Of-Hospital Cardiac Arrest, Accidental Hypothermia
Core Temperature in Patients With OHCA
A prospective observational study aiming to monitor core temperature via an esophageal probe in out of hospital cardiac arrest during transport and until arrival in hospital.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Accidental Hypothermia, Temperature Change, Body
- Trial name
- CT-OCHA (NCT04976712)
- Where
- Italy
- Volunteers
- 256 people
- Sponsor
- Azienda Sanitaria dell'Alto Adige
Out-Of-Hospital Cardiac Arrest
Selective Cerebral Hypothermia Trial - Under Extracorporeal Cardiopulmonary Resuscitation (SHOT-ECPR)
The study is designed as a pilot, open-label study to investigate the feasibility and safety of selective cerebral hypothermia in OHCA patients receiving ECPR.
- Trial name
- NCT03345706
- Testing
- Selective cerebral hypothermia, Regular hypothermia
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Pediatric Out-of-Hospital Cardiac Arrest
POHCA Resuscitation: Evaluation of IM Epinephrine
This is a pragmatic, two-arm, open-label, prospective stepped-wedge cluster quasi randomized control trial (SW-CRCT) looking to evaluate early intramuscular (IM) epinephrine in the management of pediatric out-of-hospital cardiac…
- Trial name
- PRIME (NCT05166343)
- Testing
- Epinephrine Injection
- Where
- Canada
- Volunteers
- 284 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Out of Hospital Cardiac Arrest, Extracorporeal Cardiopulmonary Resuscitation
Rapid Prehospital ACcess to ECPR in Prague
A prospective pilot feasibility study of prehospital ECPR in patients with refractory OHCA
- Trial name
- RACE (NCT06789978)
- Testing
- Extracorporeal cardiopulmonary resuscitation (ECPR)
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- General University Hospital, Prague
Out-of-Hospital Cardiac Arrest (Simulated)
Simulation and Feasibility Study of Drone-Delivered AED for Out-of-Hospital Cardiac Arrest
Background: Survival after out-of-hospital cardiac arrest (OHCA) depends heavily on early defibrillation. Reducing the time from cardiac arrest to defibrillation is a key factor in improving survival.
- Trial name
- NCT07508774
- Testing
- Drone-Based AED Delivery System, Standard Ground Ambulance Response Pathway Simulation
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ye Sheng
Death, Sudden, Cardiac, Out-Of-Hospital Cardiac Arrest
Pre-hospital ECMO in Advanced Resuscitation in Patients With Refractory Cardiac Arrest. ( SUB30 )
To establish whether a pre-hospital advanced physician/ paramedic cardiac arrest team that is ECMO capable can establish ECMO flow within 30 minutes of collapse.
- Conditions
- Death, Sudden, Cardiac, Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation, Cardiopulmonary Arrest With Successful Resuscitation
- Trial name
- SUB30 (NCT03700125)
- Testing
- ECMO resuscitation
- Where
- 2 sites in United Kingdom
- Volunteers
- 5 people
- Sponsor
- Barts & The London NHS Trust
Coping Skills
CPR Training in Students to Increase Bystander Intervention in Out-of-hospital Cardiac Arrest.
The overall aim of this thesis is to identify the factors that may affect 13 year old students' acquisition of CPR skills and their willingness to act.
- Trial name
- NCT03233490
- Testing
- web course, CPR training
- Volunteers
- 1,547 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Out-Of-Hospital Cardiac Arrest, In-hospital Cardiac Arrest
RIAC - Registro Italiano Arresti Cardiaci (Italian Registry of Cardiac Arrest)
RIAC - An Observational, Prospective, Multi-centre, Study of Epidemiology, Treatment, and Outcome of Cardiac Arrest in Italy.
- Trial name
- RIAC (NCT03220269)
- Testing
- Out-of-hospital cardiac arrest (OHCA), In-hospital cardiac arrest (IHCA)
- Where
- Italy
- Volunteers
- 8,000 people
- Sponsor
- Italian Resuscitation Council