Clinical trials: Heart Block
Coronary Artery Disease, Radial Artery Occlusion
A Study on the Application of Simple and Improved Radial Artery Compression Method After Transradial Coronary Intervention
The objective of this study was to evaluate the specific effect of a simple modified method of thick gauze (9cm*16cm*8mm) combined with a hemostatic device in the prevention of early radial artery occlusion and other related…
- Trial name
- NCT06787287
- Testing
- Modified compression method
- Where
- China
- Volunteers
- 1,624 people
- Sponsor
- Guozhe Sun
Severe Aortic Stenosis, Aortic Valve Stenosis
HLT transfemOral Replacement of aortIc Valve Via transcatherteriZatiON
The purpose of this study is to evaluate the safety and performance of the HLT System in patients with severe aortic stenosis who present at High Risk for aortic valve replacement surgery.
- Trial name
- HORIZON (NCT02157142)
- Testing
- HLT Transcatheter Aortic Valve System
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- HLT Inc.
Aortic Stenosis, Aortic Valve Stenosis
Angiotensin Receptor Blockers in Aortic Stenosis
This study is intended to investigate the effect of angiotensin receptor blockers (ARBs) on mild-to-moderate aortic stenosis.
- Trial name
- ARBAS (NCT04913870)
- Testing
- Angiotensin Receptor Blockers
- Where
- 2 sites in Canada, Denmark
- Volunteers
- 144 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Brachial Plexus Block, Horner Syndrome
The Effects of Horner's Syndrome Developing After Interscalene Brachial Plexus Block on Autonomic Nervous Activity
This study evaluates the effects of Horner's syndrome on cardiac autonomic nervous activity after interscalene brachial plexus block.
- Conditions
- Brachial Plexus Block, Horner Syndrome, Autonomic Imbalance
- Trial name
- NCT03514342
- Testing
- Interscalene brachial plexus block, 0.75% ropivacaine
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Daegu Catholic University Medical Center
Postoperative Pain, Acute Pain
M-TAPA Block for Analgesia After Open-Heart Surgery
Postoperative pain following open-heart surgery is primarily caused by median sternotomy, although additional contributors include costovertebral joint stress related to sternal retraction and the presence of chest wall and…
- Trial name
- NCT07232979
- Testing
- M TAPA block, Parasternal blocks, Local infiltration
- Volunteers
- 80 people
- Sponsor
- Bursa City Hospital
Heart Failure
Mechanically Optimizing Cardiac Preload in Heart Failure Patients
The purpose of the current study is to determine if partial balloon occlusion of the inferior vena cava can optimize cardiac pre-load and subsequently pulmonary pressures and cardiac output as a novel method to unload pulmonary…
- Trial name
- NCT04338503
- Testing
- Partial IVC occlusion
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cardioflow Technologies, LLC
Endomyocardial Fibrosis, Pulmonary Valve Stenosis
Right Ventricle Remodeling After Pulmonary Valve Replacement and Percutaneous Pulmonary Valve Insertion
This study investigates damage of the right cardiac chamber in adult patients with a congenital heart defect involving the pulmonary valve (the heart valve between the right cardiac chamber and the lungs).
- Conditions
- Endomyocardial Fibrosis, Pulmonary Valve Stenosis, Pulmonary Valve Insufficiency
- Trial name
- RV-REPAIR (NCT05090228)
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- UMC Utrecht
Aortic Valve Stenosis
Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)
Low-flow, low-gradient (LF-LG) aortic stenosis (AS) may occur with depressed (i.e. Classical LF; CLF) or preserved (i.e. Paradoxical LF; PLF) LV ejection fraction (LVEF) and both situations are amongst the most challenging…
- Trial name
- NCT01835028
- Testing
- Echocardiography, Computed tomography, Magnetic resonance imaging
- Where
- 11 sites in United States, Austria and 4 more
- Volunteers
- 320 people
- Sponsor
- Laval University
Pain, Postoperative, Heart Valve Diseases
Erector Spinae Plane Block for Minimal Invasive Cardiac Surgery (Heart-Port).
Minimally invasive cardiac surgery is performed through a right thoracotomy, the pain management of this surgery is of great importance.
- Trial name
- ESP (NCT04011501)
- Testing
- Continuous Erector spinae block
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Clinic of Barcelona
Hypertrophic Obstructive Cardiomyopathy
Transapical Beating-Heart Septal Myectomy in Patient With Hypertrophic Obstructive Cardiomyopathy: a Multi-Center Study
The primary purpose of this study is to evaluate the feasibility, the safety and the efficacy of the transapical beating-heart septal myectomy for the treatment of hypertrophic obstructive cardiomyopathy.
- Trial name
- NCT05957419
- Testing
- Transapical beating-heart septal myectomy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xiang Wei
Chronic Total Occlusion of Coronary Artery, Vascular Disease
XIENCE V® USA Dual Antiplatelet Therapy (DAPT) Cohort
XIENCE V USA is a prospective, multi-center, multi-cohort postapproval study. The objectives of this study are To evaluate XIENCE V EECSS continued safety and effectiveness during commercial use in real world settings, and To…
- Conditions
- Chronic Total Occlusion of Coronary Artery, Vascular Disease, Myocardial Ischemia, Coronary Artery Stenosis
- Trial name
- XVU-AV DAPT (NCT01106534)
- Testing
- clopidogrel + aspirin OR prasugrel + aspirin, XIENCE V Everolimus Eluting Coronary Stent System (XIENCE V EECSS)
- Where
- 144 sites in United States
- Volunteers
- 870 people
- Sponsor
- Abbott Medical Devices
TAVI(Transcatheter Aortic Valve Implantation), Remote Monitoring
Remote ECG Monitoring Post TAVI
The DRAGON TAVI study is a multicenter, prospective, open, randomised trial, which will enrol 250 patients, randomized 1:1 to the study group (continuous 30-day ECG monitoring with visits triggered by ECG findings) and standard…
- Conditions
- TAVI(Transcatheter Aortic Valve Implantation), Remote Monitoring, Arrythmia, Atrial Fibrillation (AF)
- Trial name
- DRAGON-TAVI (NCT07521800)
- Testing
- Remote ECG monitoring, Standard Care (in control arm)
- Where
- 4 sites in Italy, Poland
- Volunteers
- 250 people
- Sponsor
- Medical University of Silesia
Aortic Valve Stenosis, Transcatheter Aortic Valve Implantation
Near INfrared Spectroscopy in Aortic valvE ReplacemenT
Transcatheter aortic valve implantation (TAVI) is an alternative for patients, that are considered to be too sick for conventional aortic valve replacement.
- Conditions
- Aortic Valve Stenosis, Transcatheter Aortic Valve Implantation, Eligibility for Both Anaesthetic Methods
- Trial name
- INSERT (NCT01251328)
- Testing
- General anaesthesia, Sedation
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Cardiovascular Diseases, Coronary Disease
Angioplasty and Heart Stents to Treat Individuals With an Occluded Artery Following a Heart Attack
The purpose of this study is to evaluate arterial patency and left ventricular ejection fraction by examining angiographic data one year following a heart attack and treatment with late revascularization.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Infarction
- Trial name
- TOSCA-2 (NCT00025766)
- Testing
- PCI with stenting, Optimal Medical Therapy
- Where
- Canada
- Volunteers
- 380 people
- Sponsor
- University Health Network, Toronto
Bradycardia, Atrioventricular Block
Procedural Endpoint in Left Bundle Branch Area Pacing: Conduction System Capture Versus LV Septal Capture
This is a prospective, multicenter, randomized controlled trial designed to determine whether direct capture of the left ventricular conduction system must be achieved as the procedural endpoint of left bundle branch area pacing…
- Conditions
- Bradycardia, Atrioventricular Block, Sick Sinus Syndrome, Cardiac Pacing
- Trial name
- COMPARE-SYNC (NCT07804394)
- Testing
- LBBAP with mandatory left ventricular conduction system capture (LBBP or LFP), LBBAP with left ventricular septal capture as the accepted procedural endpoint (LVSP)
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Myocardial Infarction
BRIEF-PCI: Brief Infusion of Eptifibatide Following Percutaneous Coronary Intervention
This trial was designed to examine the efficacy of a brief versus a standard prolonged (18 hours) infusion of eptifibatide in preventing troponin I release following successful coronary stenting.
- Trial name
- NCT00111566
- Testing
- eptifibatide
- Where
- Canada
- Volunteers
- 624 people
- Sponsor
- Cardiology Research UBC
Anesthesia, Local, Analgesia
Analgesic Efficacy of Ultrasound Guided Bilateral Erector Spinae Plane Block in Pediatric.
This randomized, double-blinded, study aims to compare the efficacy of analgesia and any side effects of U/S guided bilateral Erector SpinaePlane block versus non-block t paediatric patients undergoing corrective cardiac…
- Trial name
- NCT04452656
- Testing
- bilateral erector spinae block
- Where
- Egypt
- Volunteers
- 98 people
- Sponsor
- Cairo University
Ischemic Heart Disease (IHD), Off-pump Coronary Artery Bypass
Efficacy of Multiple Nerve Blocks on the Recovery of Patients Undergoing Off Pump CABG Surgeries
In cardiac surgery patients , effective pain control is crucial to support early extubation, mobilization, and cognitive recovery, yet systemic opioids carry substantial risks such as respiratory depression, delirium, and delayed…
- Conditions
- Ischemic Heart Disease (IHD), Off-pump Coronary Artery Bypass, Regional Block for Pain Control
- Trial name
- NCT07794527
- Testing
- regional nerve block with local anesthesia
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Atrial Fibrillation
Effects of Topical Local Anesthesia of Pulmonary Vein Combined With Vagus Nerve Block on the Incidence of Atrial Fibrillation After Thoracic Surgery
This study intends to explore a new therapy to reduce the incidence of atrial fibrillation in thoracic patient who receive video-assisted thoracoscopic lobectomy .The results of the study are to assess the effects of this new…
- Trial name
- NCT03919786
- Testing
- topical local anesthesia of pulmonary vein combined with vagus nerve block
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Han Yuan
Congenital Disorders
Mild Valvar Pulmonary Stenosis
Mild valvar pulmonary stenosis can be detected in 1/10,000 live births. Historical data suggested that most of these patients do well.
- Trial name
- NCT00277927
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Children's Healthcare of Atlanta