Clinical trials: Heart Defects
Congenital Heart Disease
A Comprehensive Registry Study of the Whole Life Cycle of Patients With CHD
This observational study aims to collect data on the prevalence, intervention, and prognosis of congenital heart disease (CHD) in Chinese patients across their entire lifecycle.
- Trial name
- NCT06611787
- Where
- China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
ERAS, Pediatric ALL
Pediatric Enhanced Recovery After Cardiac Surgery
Identify our institution's current perioperative management strategies for pediatric cardiac surgery patients. Identify predictive factors for receiving perioperative care following P-ERACS strategies.
- Conditions
- ERAS, Pediatric ALL, Congenital Heart Disease
- Trial name
- PERCS (NCT05665712)
- Testing
- enhanced recovery
- Where
- Canada
- Volunteers
- 483 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Long QT Syndrome
KCNQ1 Cascade Screening
The objectives of the protocol are to: (1) evaluate the uptake of cascade screening and preventative therapies after the implementation of a simplified screening process and (2) assess proband and family member perspectives about…
- Trial name
- NCT03783975
- Testing
- Simplified Cascade Screening
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Congenital Heart Diseases, Children
Physical Activity and Cognitive Development in Children
1. Compare physical activity and cognitive functions between children having cardiac surgery with an age-matched group of children undergoing non-cardiac surgery, as well as otherwise healthy siblings or best buddies (or age and…
- Trial name
- NCT02542683
- Testing
- structured physical activity program
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Columbia University
Congenital Heart Disease
Study on Clinical Prognosis, Risk Factors and Genetic Basis of Congenital Heart Disease
The objective of this study is to investigate the effect of parental peri-natal environmental risk factors and genetic factors on the development of Congenital Heart Disease (CHD).
- Trial name
- SCPRFGBCHD (NCT01669057)
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Turner Syndrome, Hypogonadism
Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism
Estrogen is necessary for feminization during puberty and to decrease bone resorption, the latter critical for the achievement of peak bone mass and normal bone health in the female.
- Conditions
- Turner Syndrome, Hypogonadism, Premature Ovarian Failure
- Trial name
- NCT00837616
- Testing
- 17 B estradiol orally, 17 B estradiol
- Where
- 3 sites in United States, Chile
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Congenital Heart Disease
The Relationship Between Brain MRI Phenotypes, Genes and Cognitive Outcome in CHD Adults
The main purpose of this proposal is to perform novel MRI analyses to determine the brain organizational changes associated with altered executive function and the modulating role of variants in neuroresilience and hypoxia…
- Trial name
- NCT05258981
- Testing
- MRI
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Pregnancy, Long QT Syndrome
Ventricular Repolarization During the Pregnancy-to-Postpartum Transition (QuTe)
Pregnancy and the postpartum period are accompanied by marked changes in heart rate, circulating hormones, and electrolyte balance that may influence ventricular repolarization.
- Trial name
- QuTe (NCT02931695)
- Testing
- Evaluation of QT interval duration, Circulating sex hormones levels sample
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- French Cardiology Society
Tetralogy of Fallot
Role of 3D Echocardiography Knowledge-based Reconstruction in ACHD
The main objective of this study is to evaluate the reproducibility and accuracy of TTE-3DKBR in assessing RV volume and EF compared to the reference method of CMR in a group of ACHD patients with known moderate or severe PR…
- Trial name
- NCT06282926
- Testing
- Echocardiography assessment
- Where
- United Kingdom
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Patent Foramen Ovale (PFO), High Altitude Pulmonary Edema
The Cardiovascular Effects of Patent Foramen Ovale in Hypoxia
Before birth, the foramen ovale is a normal opening in the heart that allows blood to flow from the mother to the baby. After birth, this opening usually closes.
- Trial name
- NCT07742540
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Heart Defect, Congenital, Executive Dysfunction
Executive Function Intervention for Children With Complex Congenital Heart Disease
Children with complex congenital heart disease (cCHD) nowadays survive thanks to medical advances into their teenage years and adulthood. However, many of them have difficulties with so-called executive functions.
- Trial name
- E-Fit Heart (NCT07692958)
- Testing
- E-Fit Intervention
- Where
- Switzerland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Bea Latal
Healthy, Congenital Heart Disease
A Study of Invasive Hemodynamic for MACHD Registry
This research study is being done to provide comparative data to the Mayo Clinic Adult Congenital Heart Disease Registry.
- Trial name
- NCT05849025
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Heart Defects, Congenital
NIRS Guidance Trail in Children's Heart Surgery
Heart surgery in young children involves some risks. This study looks at a new type of monitor that may reduce these risks. Near Infrared Reflectance Spectroscopy (NIRS) aims to measure if enough blood reaches vital organs in the…
- Trial name
- NIRS (NCT02157597)
- Testing
- NIRS based management, Control
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Congenital Heart Disease
A Comparison of Multidetector CT and TE in the Diagnosis of Congenital Cyanotic Heart Diseases
Multi-detector computed tomography angiography (MDCTA) provides high-resolution images of the heart and its vasculature, allowing for accurate anatomical assessment, detection of complex cardiac morphology,
- Trial name
- NCT06749548
- Testing
- Group 1
- Where
- Pakistan
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Superior University
Ductus Arteriosus, Patent
Ductus Arteriosus Closure and D-Dimer and Fibrinogen Levels
The aim of this study is to investigate whether there is a relationship between echocardiographic measurements regarding closure of PDA and serum D-Dimer and Fibrinogen levels in premature infants born before 32nd gestational…
- Trial name
- NCT04508036
- Testing
- Withdrawal of blood samples for D-Dimer, Withdrawal of blood samples for Fibrinogen, Echocardiographic Examination
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Congenital Heart Disease
The Application Value of STIC in the Diagnosis of Fetal Complex Congenital Heart Disease
The objective of this study is to use of STIC technology to assist the traditional echocardiography to diagnose the fetal congenital heart disease accurately and then to provide a basis for prenatal counseling.
- Trial name
- STIC (NCT02970071)
- Where
- China
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Congenital Heart Disease, Aortic Root Dilatation
Predictors of Aortic Root Dilatation in Tetralogy of Fallot Patients
To predict vulnerable patients for aortic root dilatation in TOF patients using CT as a reliable imaging modality, thus aiding early intervention, and identifying those who will require strict follow-up.
- Conditions
- Congenital Heart Disease, Aortic Root Dilatation, Tetralogy of Fallot
- Trial name
- NCT06081855
- Testing
- CT
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Assiut University
RASopathy, Costello Syndrome
Effect of RAS/MAPK Pathway Hyperactivation on Growth' and Bone' Profile of the RASopathies
Costello syndrome (CS) and cardio-facio cutaneous syndrome (CFCS) belongs to RASopathies, a group of multisystemic disorders caused by unregulated signalling through the RAS/MAPK pathway, an intracellular signalling pathway…
- Conditions
- RASopathy, Costello Syndrome, Noonan Syndrome, Cardio-Facio-Cutaneous Syndrome
- Trial name
- 3776 (NCT06331117)
- Testing
- Diagnostic test
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ductus Arteriosus, Patent
Analysis of the Impact of Patent Ductus Arteriosus on Brain Function in Preterm Neonates: Multimodal Approach Integrating EEG-NIRS, Ultrasound and Clinical Data
This project corresponds to the main field of research of the investigators's laboratory concerning analysis of cerebral electrometabolic and haemodynamic activity in neonates.
- Trial name
- NNP-MULTIMODAL (NCT02803671)
- Testing
- TFU-NIRS, NIRS, EEG
- Where
- France
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Congenital Heart Disease in Pregnancy
Association Between a Mother's Exposure to "Strep Throat" and Her Baby's Developing Heart Disease
The goal of this study is to find out if there is any association between a mother's exposure to bacteria that normally causes "strep throat" and her baby's developing heart disease/heart defect.
- Trial name
- NCT01603732
- Where
- 2 sites in United States
- Volunteers
- 397 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine