Clinical trials: Heart Disease, Coronary
Heart Failure
Post- Approval Study on Patients Who Received a HeartWare HVAD® During IDE Trials
Patients will be approached to participate in this PAS after the HeartWare® Ventricular Assist System receives PMA approval for the indicated use as a bridge to cardiac transplantation.
- Trial name
- HW-PAS-03 (NCT01832610)
- Testing
- HeartWare® VAS
- Where
- 25 sites in United States
- Volunteers
- 101 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Disease
Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery
Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery
- Trial name
- Decade (NCT02004613)
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 798 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Congenital Heart Disease, Periventricular Leucomalacia
Randomized Trial of Maternal Progesterone Therapy
Neurodevelopmental disability is now recognized as the most common long-term complication after cardiac surgery in neonates. Research studies have shown that progesterone is critical to the development of the brain and in a…
- Conditions
- Congenital Heart Disease, Periventricular Leucomalacia, Brain Development, Cardiac Surgery
- Trial name
- NCT02133573
- Testing
- Progesterone, Vaginal lubricant
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Children's Hospital of Philadelphia
Atrial Fibrillation
Recording for Potential AF Drivers and Patient Specific Atrial Anatomy & Atrial Electrogram Maps
The 64 pole basket catheter used for the mapping procedure will be defined "atypical" sites which sustain atrial fibrillation. The ablation through the driver will lead to more rapid ablation of the atrial fibrillation.
- Trial name
- CONFIRM (NCT01581437)
- Testing
- 64 pole basket catheter
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Virginia Commonwealth University
Coronary Artery Disease
Tailoring P2Y12 Inhibiting Therapy in Patients Requiring Oral Anticoagulation After PCI
Clopidogrel is the P2Y12 inhibitor of choice in PCI patients requiring OAC. However, concerns have been raised based on the notion that a considerable number of patients may have inadequate response to clopidogrel.
- Trial name
- SWAP-AC-2 (NCT04483583)
- Testing
- Ticagrelor 60mg, Clopidogrel
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Florida
Recurrent Pericarditis
A Pilot Study of KPL-914 in Recurrent Pericarditis
The purpose of this study is to assess the preliminary efficacy and safety of KPL-914 treatment in participants with recurrent pericarditis.
- Trial name
- NCT03980522
- Testing
- KPL-914
- Where
- 14 sites in United States
- Volunteers
- 26 people
- Sponsor
- Kiniksa Pharmaceuticals (UK), Ltd.
Hepatitis C, Chronic, Heart Failure
Hepatitis C Virus(HCV) Heart and Lung Study
This is a multicenter study in Hepatitis C Virus (HCV) infected adult patients who also have advanced cardiac disease or advanced lung disease.
- Conditions
- Hepatitis C, Chronic, Heart Failure, Pulmonary Disease, Chronic Obstructive, Lung Diseases, Interstitial
- Trial name
- NCT02858180
- Testing
- Sofosbuvir/ledipasvir fixed dose combination(SOF/LDV FDC)
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Duke University
Aortic Valve Stenosis
Targeting Pulsatile Load to Increase Exercise Capacity and Quality of Life After Aortic Valve Replacement for Severe Aortic Stenosis (PULSE AS)
The current trial is designed to assess the safety and efficacy of sustained oral administration of inorganic nitrate in patients with severe aortic stenosis and to assess the mechanisms by which inorganic nitrate enhances oxygen…
- Trial name
- PULSE-AS (NCT03483051)
- Testing
- Potassium Nitrate, Potassium Chloride
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pennsylvania
Coronary Heart Disease
Testosterone and Myocardial Perfusion in Coronary Heart Disease (CHD)
Testosterone has traditionally been regarded as a risk factor for heart disease due to the fact that males have a higher incidence of this disease than women, at least until the menopause.
- Trial name
- NCT00239590
- Testing
- Testosterone undecanoate
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Imperial College London
Myocardial Infarction, Unstable Angina
Myocardial Ischemia and Transfusion Pilot
The purpose of this study is to evaluate two approaches to red blood cell transfusion in anemic patients with acute coronary syndrome.
- Conditions
- Myocardial Infarction, Unstable Angina, Coronary Artery Disease
- Trial name
- MINT Pilot (NCT01167582)
- Testing
- Red blood cell transfusion
- Where
- 7 sites in United States
- Volunteers
- 110 people
- Sponsor
- Rutgers, The State University of New Jersey
Breast Cancer
Acute Exercise Cardioprotection From Doxorubicin
In rodents, a single bout of exercise prior to injection of a chemotherapy agent used to treat breast cancer prevents or attenuates a number of markers of cardiac injury.
- Trial name
- NCT02006979
- Testing
- exercise
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of British Columbia
Coronary Artery Disease, Myocardial Infarction
Colchicine Cardiovascular Outcomes Trial (COLCOT)
The study evaluates whether long-term treatment with colchicine reduces rates of cardiovascular events in patients after myocardial infarction.
- Trial name
- COLCOT (NCT02551094)
- Testing
- colchicine
- Where
- Canada
- Volunteers
- 4,745 people
- Sponsor
- Montreal Heart Institute
Coronary Artery Bypass Graft Redo, Heart Valve Diseases
SONOlysis in Risk REduction of Symptomatic and Silent Brain infarCtions dUring Cardiac surgEry
The aim of the project is to demonstrate a fibrinolytic effect of sonothrombolysis (continual transcranial Doppler monitoring) using 2 MHz diagnostic probe on the reduction of risk of brain infarctions due to the activation of…
- Trial name
- SONORESCUE (NCT01591018)
- Testing
- sonolysis, cardiac surgery
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Ostrava
Congestive Heart Failure, Cardiac Resynchronization Therapy
TRIAGE-CRT Telemonitoring in Patients With CHF and Indication of CRT-D
This feasibility study will investigate the clinical benefit of the combined use of BIOTRONIK Home Monitoring (HM) and weight and blood pressure (BP) external telemonitoring (ETM) in the follow-up treatment of patients implanted…
- Trial name
- NCT00395642
- Testing
- Kronos LV-T, Lumax HF-T
- Where
- 12 sites in United States
- Volunteers
- 66 people
- Sponsor
- Biotronik, Inc.
Heart Failure
Right Ventricular (RV) Pacing in Early Post-operative Continuous Flow Left Ventricular Assist Device (LVAD)
Continuous right ventricular (RV) pacing demonstrates harm in patients with normal left ventricular (LV) function as well as in patients with cardiomyopathy and clinical heart failure.
- Trial name
- NCT01446796
- Testing
- Implantable Cardioverter-Defibrillator (subject's pre-existing ICD)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Duke University
Coronary Artery Disease
Evaluation of Coronary Artery Calcification Using Gated Stationary Chest Tomosynthesis
The purpose of this study is to propose a new method for evaluating coronary artery calcium scores (CACS) in individuals with coronary artery disease.
- Trial name
- NCT03169062
- Testing
- Gated Stationary Chest Tomosynthesis
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of North Carolina, Chapel Hill
Heart Failure, Congestive, Chronic Heart Failure
Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure
This study will examine the effect of antidepressant medication on rates of death and disease in depressed people with chronic heart failure.
- Conditions
- Heart Failure, Congestive, Chronic Heart Failure, Depression
- Trial name
- SADHART-CHF (NCT00078286)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 469 people
- Sponsor
- Duke University
Advanced Refractory Left Ventricular Heart Failure
HeartMate 3 CE Mark Study Long Term Follow-up
The purpose of this clinical investigation is to report the long term survival and incidence of adverse events in the patients who were implanted with HM3 in the CE Mark Study and continue to be ongoing with the HeartMate 3 LVAS…
- Trial name
- HM3 CE LTFU (NCT03022461)
- Testing
- Long term follow-up
- Where
- 8 sites in Australia, Austria and 4 more
- Volunteers
- 25 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation, Familial Atrial Fibrillation
Atrial Fibrillation Health Literacy and Information Technology Trial
Atrial fibrillation (AF) is a common, morbid condition with increasing prevalence. Poor health-related quality of life is common in AF.
- Conditions
- Atrial Fibrillation, Familial Atrial Fibrillation, Arrythmia, Cardiac, Heart Diseases
- Trial name
- AFibLITT (NCT04075994)
- Testing
- Relational Agent and heart rate and rhythm monitor, Usual Care
- Where
- United States
- Volunteers
- 243 people
- Sponsor
- University of Pittsburgh
Coronary Artery Disease
High Ticagrelor Loading Dose in STEMI
Ticagrelor is a reversible direct acting P2Y12 antagonist, which has shown to be superior to clopidogrel, in adjunct to aspirin, in preventing recurrent ischemic events.
- Trial name
- NCT01898442
- Testing
- Ticagrelor 180mg, Ticagrelor 270mg, Ticagrelor 360mg
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Florida
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