Clinical trials: Heart Disorder
Paroxysmal AF, Treatment Decisions
Comparative Efficacy of 100-, 200-, & 400-mg Amiodarone in Patients With Paroxysmal AF Depending on Plasma Concentration
Amiodarone is a highly effective drug for the treatment and prevention of arrhythmias. In the 1970s and 1980s, numerous experimental and clinical studies comprehensively examined the mechanisms of amiodarone's antiarrhythmic…
- Conditions
- Paroxysmal AF, Treatment Decisions, Therapeutic Drug Monitoring (TDM)
- Trial name
- AMIODETECT (NCT07487714)
- Testing
- Pharmacotherapy with amiodarone 200 mg per day, Treatment with Amiodarone at a dose 100 mg per day, Treatment with Amiodarone at a dose 400 mg per day
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Turner Syndrome
Cardiopulmonary Exercise Testing in Girls (8-18y) with Turner Sydrome.
The goal of this clinical trial is to have a beter insight in the exercise tolerance in girls with Turner Syndrome aged 8-18 years .
- Trial name
- NCT06780514
- Testing
- Cardiopulmonary exercise test
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Ghent
Functional Mitral Regurgitation, Heart Failure
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
The objective of this prospective, randomized, double- blinded (patient and assessors), sham-controlled clinical trial is to assess the safety and efficacy of the CMCS in treating heart failure with functional regurgitation (FMR).
- Conditions
- Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases
- Trial name
- NCT03142152
- Testing
- Carillon Mitral Contour System, Guideline Directed Heart Failure Medication
- Where
- 92 sites in United States, Canada and 6 more
- Volunteers
- 300 people
- Sponsor
- Cardiac Dimensions, Inc.
New Onset Atrial Fibrillation, Acute Myocardial Infarction
New-Onset Atrial Fibrillation Complicating Acute Myocardial Infarction in China
To investigate the prognostic impacts of the atrial fibrillation burden (AFb) in acute myocardial infarction (AMI) patients who developed paroxysmal new-onset atrial fibrillation (NOAF) during the index AMI hospitalization.
- Trial name
- NOAFCAMI-China (NCT05511649)
- Testing
- continuous electronic monitor
- Where
- 3 sites in China
- Volunteers
- 832 people
- Sponsor
- Shanghai 10th People's Hospital
Diabetes Mellitus Type 2, Hypercholesterolemia
Effect of Ezetimibe or Simvastatin or Both on Low Densitiy Lipoprotein -Subfractions in Patients With Type 2 Diabetes
It is of interest how ezetimibe alone or in combination with statin may influence atherogenic dense Low Density Lipoprotein (dLDL) in patients with type 2 diabetes mellitus.
- Trial name
- EZE (NCT01384058)
- Testing
- ezetimibe, simvastatin, Ezetimibe 10/Simvastatin 20
- Where
- 2 sites in Germany
- Volunteers
- 41 people
- Sponsor
- University Hospital Freiburg
Bradycardia
BlueSync Field Evaluation
The purpose of this field evaluation is to collect and evaluate information related to CareLink transmission compliance as well as patient perceived benefit of BlueSync™ and the health care provider perception of the value of…
- Trial name
- NCT03518658
- Testing
- Evaluation Group, Control Group (Historical)
- Where
- 20 sites in United States, France and 2 more
- Volunteers
- 257 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure
Evaluation of Breathing, Sleep and the Effects of Continuous Positive Airway Pressure During Wakefulness in Children With Heart Failure
Adult patients with heart failure (HF) have an increased work of breathing and are at increased risk for obstructive and/or central apnea during sleep.
- Trial name
- IC-E-PPC (NCT02414126)
- Testing
- Effect of CPAP on respiratory work and cardiac function indices during wakefulness, CPAP
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cirrhosis, Liver, Cirrhotic Cardiomyopathy
Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis
Point-of-care echocardiography is used to guide septic shock resuscitation in patients with severe sepsis in the intensive care unit (ICU), but without systematic evidence for efficacy in critically patients with Cirrhosis and…
- Conditions
- Cirrhosis, Liver, Cirrhotic Cardiomyopathy, Septic Shock
- Trial name
- ECLIPSE-I (NCT07286643)
- Testing
- POCUS, Fixed Resuscitation Strategy based on Target MAP
- Where
- India
- Volunteers
- 140 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute Myocardial Infarction (AMI), ST-Segment Elevation Myocardial Infarction(STEMI)
Non-stenting Treatment Strategy for Acute Myocardial Infarction With Non-severe Stenosis(EROSION IV)
This study is a prospective, multicenter, open-label, non-inferiority, randomized controlled trial. A total of 2,000 patients with STEMI (<24 hours or 7-14 days) or NSTEMI will be recruited from at least 20 centers in China.
- Conditions
- Acute Myocardial Infarction (AMI), ST-Segment Elevation Myocardial Infarction(STEMI), Non-ST-Segment Elevation Myocardial Infarction(NSTEMI)
- Trial name
- NCT07567625
- Testing
- Guideline-recommended standard medical therapy alone, DES implantation plus guideline-recommended standard medical therapy
- Where
- 48 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Harbin Medical University
Myocardial Infarction
The Pressure-controlled Intermittent Coronary Sinus Occlusion on VentrIcular PERformance Study
The PICSO ViPER study is a prospective single centre cohort study of the use of PICSO in patients presenting acute myocardial infarction and impaired function of the left ventricle and candidate to angioplasty the left anterior…
- Trial name
- PICSO-ViPER (NCT04032925)
- Testing
- PICSO
- Where
- United Kingdom
- Volunteers
- 2 people
- Sponsor
- Oxford University Hospitals NHS Trust
Rheumatoid Arthritis, Myocardial Inflammation
Effects of Abatacept on Myocarditis in Rheumatoid Arthritis
This study aims to evaluate the effects of abatacept, a CTLA4-Ig fusion protein that binds cluster of differentiation antigen 80 (CD80)/86 (B7-1/B7-2), on subclinical myocarditis in rheumatoid arthritis (RA) through its effect on…
- Trial name
- AMiRA (NCT03619876)
- Testing
- Abatacept, Adalimumab
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Columbia University
Coronary Artery Disease
Tele - Cardiac Rehabilitation - Providing Secondary Prevention and Supervised Exercise Without Boundaries of Time and Space - PILOT 1
We aim to enroll subjects eligible to cardiac rehabilitation that are defined as low-risk according to national guidelines. We plan to gradually reduce the number of institution based CR and increase the tele monitored exercise…
- Trial name
- NCT03228225
- Testing
- Tele Cardiac Rehabilitation
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Cardiovascular Diseases, Coronary Disease
High Density Lipoprotein Subspecies and Coronary Disease
To investigate the relative contributions of high density lipoprotein-C (HDL-C) subspecies to risk for coronary heart disease (CHD) in two distinct existing populations (samples from the VA-HIT study and the Framingham Offspring…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Coronary Arteriosclerosis, Heart Diseases
- Trial name
- NCT00005676
- Volunteers
- 2,700 people
- Sponsor
- Tufts University
Heart Disease, Atrial Fibrillation
Data Collection and Analysis of Patients Who Have Had an Electrophysiological Procedure
The purpose of the database is to complete outcomes research of electrophysiological procedures.
- Trial name
- NCT00825968
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Emile Daoud
Heart Failure
Cardiac MR (CMR) in Cardiac Resynchronization Therapy Non-responders
Cardiac MR (CMR) will be used to assess myocardial activation and hemodynamics in patients with CRT. Goals are to demonstrate that differences in Left ventricle (LV)- right ventricle (RV) pacing delays cause differences in…
- Trial name
- NCT01367691
- Testing
- CRT reprogramming (Medtronic CRT)
- Where
- Germany
- Volunteers
- 1 people
- Sponsor
- University Hospital, Bonn
Bradycardia
Evaluation of the Performances of the Sleep Disordered Breathing Monitoring Function in Pacemaker
The IBSY04 clinical investigation is an European, prospective, multi-centre, non-randomized, longitudinal study.
- Trial name
- DREAM (NCT01537718)
- Testing
- REPLY 200
- Where
- 5 sites in France, Spain
- Volunteers
- 40 people
- Sponsor
- LivaNova
Arrhythmia
Population Pharmacokinetics of Propafenone and Propranolol in Children Patients
The use of propafenone and propranolol in children during clinical treatment was depending mostly on experience. Besides, there was no recommended dose for children in drug instruction.
- Trial name
- NCT05463614
- Testing
- Propafenone and Propranolol
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shandong University
Coronary Artery Disease, Exercise Addiction
Interval Aerobic Training and Continious Training
This research is comparing the effects of interval and continuous training which are the two types of aerobic training on persons' life quality and exercise capacity on coronary artery disease patients.
- Trial name
- NCT06525233
- Testing
- Physiotherapy and rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Diabetes Mellitus, Type 2, Coronary Disease
A Study Comparing Standard Care for Diabetes to Case-managed Care for Diabetes in Patients With Coronary Artery Disease
The purpose of this study is to compare two ways to treat patients with Type 2 Diabetes, Standard Care or Case-Managed Care. In-Patient Standard Care is guided by the assigned cardiologist and Out-Patient Standard Care by the…
- Trial name
- NCT00248352
- Testing
- Consultation with Endocrinologist, Counseling from Dietician, Counseling from Diabetes Educator
- Where
- Canada
- Volunteers
- 169 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Aortic Valve Stenosis
Use of Cardiac-MRI to Predict Results for People With Severe Aortic Stenosis
Background: Aortic valve stenosis is a disease that makes a major heart valve get smaller. This reduces heart function and causes death.
- Trial name
- NCT01905852
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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