Clinical trials: Heart Failure, Reduced Ejection Fraction
Heart Failure With Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy
Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study
Prospective, randomized, open-label, international, multi-center clinical study to evaluate the safety and efficacy of the AccuCinch Ventricular Restoration System in patients with heart failure and reduced ejection fraction…
- Trial name
- NCT04331769
- Testing
- AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy
- Where
- 122 sites in United States, Belarus and 8 more
- Volunteers
- 400 people
- Sponsor
- Ancora Heart, Inc.
Heart Failure, Systolic Heart Failure
Medical Arm of the Interagency Registry for Mechanically Assisted Circulatory Support
Medamacs is a prospective, observational study of ambulatory patients with advanced heart failure. The study enrolls patients who have not yet received a Left Ventricular Assist Device (LVAD) but who receive their care at a…
- Trial name
- Medamacs (NCT01932294)
- Where
- 11 sites in United States
- Volunteers
- 171 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Systolic Heart Failure, Peripheral Chemoreceptor Hypersensitivity
Bilateral Surgical Resection of Carotid Bodies in Patients With Systolic Heart Failure
The primary aim of the study is to determine safety, tolerability and feasibility of bilateral carotid body resection in patients with systolic heart failure and peripheral chemoreceptor hypersensitivity.
- Trial name
- NCT01782677
- Testing
- Bilateral Surgical Resection of Carotid Bodies
- Where
- Poland
- Volunteers
- 5 people
- Sponsor
- Noblewell
Heart Failure, Heart Failure With Reduced Ejection Fraction
Renal-based Optimization of QUADruple Therapy in Patients With Heart Failure With Reduced Ejection Fraction.
The goal of this clinical trial is to evaluate guideline-directed medical therapy (GDMT) up-titration in patients with heart failure with reduced ejection fraction.The main question it aims to answer is the improvement in…
- Trial name
- ReQUAD-HF (NCT06273280)
- Testing
- SOC, Protocolized up-titration
- Where
- Belgium
- Volunteers
- 345 people
- Sponsor
- Ziekenhuis Oost-Limburg
Heart Failure, Systolic, Heart Failure With Preserved Ejection Fraction
Virtual Visits to Optimize Research Trial Offerings to HF Patients
This pilot study seeks to understand if distance health technology with virtual visits hold the key to improving access for patients who wish to partake in clinical trials clearing barriers to enrollment.
- Trial name
- Optimize-HF (NCT04064541)
- Testing
- Virtual Visit
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- The Cleveland Clinic
Atrial Fibrillation (AF), Heart Failure and Reduced Ejection Fraction
Wearable Device-Assisted Remote Management to Improve Prognosis in Patients With Acute Heart Failure Complicated by Atrial Fibrillation: WARM-HF Trial (Stage 2)
With the advancement of wearable technology, continuous non-invasive monitoring of vital signs, arrhythmia burden, and physical status has become increasingly feasible.
- Trial name
- NCT07687862
- Testing
- wearable device based remote management (GDMT titration for HF, rhythm control and anticoagulation management for AF)
- Volunteers
- 818 people
- Sponsor
- Beijing Anzhen Hospital
Heart Failure With Reduced Ejection Fraction
Exploration of Clonal Hematopoiesis of Indeterminate Potential in Non-ischemic Heart Failure With Reduced Ejection Fraction
Clonal hematopoiesis of indeterminate potential (CHIP) refers to a phenomenon in which blood cells with somatic mutation circulate in the peripheral blood due to abnormal proliferation and differentiation of mutant hematopoietic…
- Trial name
- NCT05981144
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation (AF)
Optimal PharmacoTherapy and Invasive Management of Atrial Fibrillation in Patients With Heart Failure
Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardiovascular epidemics, individually impairing quality of life and cardiac performance, as well as increasing the risk of hospitalisation and mortality.
- Trial name
- OPTIMal AF-HF (NCT07238452)
- Testing
- Pulmonary Vein Isolation, Pharmacological Rate Control
- Volunteers
- 1,050 people
- Sponsor
- University of British Columbia
Aortic Stenosis, Mitral Regurgitation
Evaluating Infrasonic Hemodynography
This comparative diagnostic accuracy study will determine the accuracy of a noninvasive wearable infrasonic sensor to detect the mechanical, electrical, and hemodynamic function of the cardiovascular system.
- Conditions
- Aortic Stenosis, Mitral Regurgitation, Pulmonary Hypertension, Heart Failure, Systolic
- Trial name
- NCT04636892
- Testing
- MindMics earbud
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Scripps Health
Heart Failure With Reduced Ejection Fraction, HIV Infections
Heart Failure Polypill at a Safety Net Hospital
A novel four-drug regimen for heart failure with reduced ejection fraction (HFrEF) extends patients' life expectancy by an average of 6 years compared to traditional therapies, in addition to improving quality of life.
- Trial name
- NCT06029712
- Testing
- Heart failure polypill, Control Rx
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of California, San Francisco
Heart Failure
Effect of Elamipretide on Left Ventricular Function in Subjects With Stable Heart Failure With Reduced Ejection Fraction
This was a randomized, double-blinded, placebo-controlled, multiple-dose study in subjects with stable heart failure (HF) with reduced ejection fraction (HFrEF).
- Trial name
- NCT02788747
- Testing
- 4 mg elamipretide, 40 mg elamipretide
- Where
- 15 sites in Italy, Netherlands and 1 more
- Volunteers
- 71 people
- Sponsor
- Stealth BioTherapeutics Inc.
Chronic Heart Failure With Reduced Ejection Fraction
Exercise Capacity Study of LCZ696 vs. Enalapril in Patients With Chronic Heart Failure and Reduced Ejection Fraction.
The purpose of the study was to determine the effect of LCZ696 vs. enalapril on improvement of exercise capacity in patients with chronic heart failure with reduced ejection fraction.
- Trial name
- NCT02768298
- Testing
- LCZ696, Enalapril
- Where
- 34 sites in Germany
- Volunteers
- 201 people
- Sponsor
- Novartis Pharmaceuticals
Transthyretin Amyloid Cardiomyopathy, Heart Failure
Clinical Comparison of Patients With Transthyretin Cardiac Amyloidosis and Patients With Heart Failure With Reduced Ejection Fraction
Clinical comparison of patients with transthyretin cardiac amyloidosis and patients with heart failure with reduced ejection fraction
- Trial name
- NCT05896904
- Testing
- Echocardiography
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Aarhus University Hospital Skejby
Heart Failure With Reduced Ejection Fraction
The Effect of Combined Upper and Lower Extremity Endurance Training in Patients With ICD
It was aimed to examine whether the arm endurance exercise training is effective in addition to the lower cycling training program in order to alleviate the negative functional results in heart failure patients with ICD.
- Trial name
- ICD (NCT04803968)
- Testing
- bicycle ergometer and arm ergometer exercise, bicycle ergometer exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Hitit University
Heart Failure, Systolic
Pharmacodynamic Effects of Sacubitril/Valsartan on Natriuretic Peptides, Angiotensin and Neprilysin
The study measure multiple neurohormones in patients with heart failure being treated with Sacubitril/Valsartan in increasing doses over an 8 week period.
- Trial name
- NCT03553303
- Testing
- Sacubitril / Valsartan Oral Tablet
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Heart Failure, Reduced Ejection Fraction, Vitamin B12 Deficiency
Heart Failure With Reduced Ejection Fraction: Adjuvant Therapy With Neurostimulation and Chlorella Pyrenoidosa (HD-tDCS)
Reduced ejection fraction heart failure (HFrEF) is a complex and multifactorial condition. It is characterized by a decrease in the ability of the left ventricle to eject blood effectively during systole, resulting in an ejection…
- Trial name
- HD-tDCS (NCT06528366)
- Testing
- Chlorella pyrenoidosa, High Definition Transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 28 people
- Sponsor
- Federal University of Paraíba
His Bundle Pacing, Heart Failure, Systolic
His-bundle Pacing vs. Right Ventricular Apical Pacing in Patients With Reduced Ejection Fraction
The study compares standard right ventricle apical pacing with so called His-bundle pacing, for patients with slightly or moderately reduced ejection fraction and atrioventricular block requiring pacemaker therapy.
- Trial name
- HIS-PrEF (NCT04529577)
- Testing
- His-bundle pacing
- Where
- 3 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Heart Failure With Preserved Ejection Fraction, Heart Failure With Mildly Reduced Ejection Fraction
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
This trial will examine if maridebart cafraglutide as an adjunct to standard of care will lead to a reduction in heart failure (HF) events such as HF hospitalizations and urgent HF visits, cardiovascular (CV) deaths and…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Heart Failure With Mildly Reduced Ejection Fraction, Obesity
- Trial name
- MARITIME-HF (NCT07037459)
- Testing
- Maridebart cafraglutide
- Where
- 686 sites in United States, Argentina and 33 more
- Volunteers
- 5,056 people
- Sponsor
- Amgen
Atrial Fibrillation, Heart Failure
A Village Doctor-led Telehealth Supported Improvement of Outcomes of AF Patients With Heart Failure Due to Reduced or Preserved Ejection Fraction: The MIRACLE-AF 2 Heart Failure Management Trial (MIRACLE AF-HF)
The primary objective is to determine whether a telemedicine-supported, village doctor-led integrated management model, AF-HF comorbidity ABC pathway and enhanced patient education, improves clinical outcomes compared with usual…
- Trial name
- NCT07492524
- Testing
- Village-Doctor Led Integrated Care, Usual Care
- Where
- 3 sites in China
- Volunteers
- 942 people
- Sponsor
- Jiangsu Taizhou People's Hospital
Heart Failure With Reduced Ejection Fraction (HFrEF)
Atrial Shunt for the Treatment of Heart Failure With Reduced Ejection Fraction
To evaluate the safety and effectiveness of the Atrial Shunt for the treatment of heart failure with reduced ejection fraction (HFrEF)
- Trial name
- PAST-HFrEF (NCT07820410)
- Testing
- D-shant Atrial Shunt, Guideline-Directed Medical Therapy (GDMT) for heart failure with reduced ejection fraction
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Beijing Anzhen Hospital