Clinical trials: Heart Failure, Reduced Ejection Fraction
Heart Failure
Evaluation of the Effects of Sauna Therapy on Congestion and Loop Diuretic Use in Patients With Heart Failure With Reduced or Moderately Reduced Ejection Fraction
This study aims to evaluate the effect of sauna therapy on congestion levels during cardiac rehabilitation in patients with heart failure who have an impaired or moderately impaired ejection fraction, compared to standard cardiac…
- Trial name
- SAUNA-HF RCT (NCT07468344)
- Testing
- Sauna
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Central Hospital, Nancy, France
Heart Failure, Worsening Heart Failure
Metabolic Changes in Heart Failure Patients Treated With Vericiguat
Heart failure is a condition in which the heart cannot pump blood as effectively as it should. It can cause symptoms such as shortness of breath, tiredness, and fluid retention.
- Conditions
- Heart Failure, Worsening Heart Failure, Heart Failure With Reduced Ejection Fraction
- Trial name
- VERI-MET (NCT07901270)
- Testing
- Vericiguat
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Salerno
Heart Failure With Reduced Ejection Fraction, Renal Insufficiency, Chronic
SGLT2 Inhibitors and Treatment of Heart Failure in Severe Renal Insufficiency
In the treatment of heart failure (HF), SGLT-2 inhibitor (SGLT-2i) can significantly improve the clinical outcome and quality of life related to HF.
- Trial name
- NCT05737186
- Testing
- SGLT-2 inhibitor
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Peking University People's Hospital
Heart Failure With Reduced Ejection Fraction
A Virtual Heart Failure Optimization Program for Guideline Directed Medical Therapy and Cardiac Rehabilitation
The goal of this study is to test the impact of a virtual heart failure optimization program on uptake of guideline directed medical therapy, participation in cardiac rehabilitation \& impact on echocardiographic parameters.
- Trial name
- NCT05689086
- Testing
- Virtual Heart Failure Optimization Program
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- Cambridge Cardiac Care Centre
Heart Failure With Reduced Ejection Fraction HFrEF
Effect of Carvedilol Rapid Up-Titration in Patients With Heart Failure With Reduced Ejection Fraction
Guidelines-directed medical therapy has improved dramatically outcomes in heart failure with reduced ejection fraction (HFrEF) patients.
- Trial name
- NCT05179070
- Testing
- Carvedilol
- Where
- Indonesia
- Volunteers
- 26 people
- Sponsor
- Universitas Sebelas Maret
Heart Failure With Reduced Ejection Fraction
Daily Ambulatory Remote Monitoring System For Post-Dischage Management Of ADHF
Background: Despite the advances in pharmacological management of heart failure (HF), the associated mortality and re-hospitalization for HF remain poor.
- Trial name
- DAVID-HF (NCT03072693)
- Testing
- Home-based remote heart failure management, Home-based physiological parameter recording only
- Where
- Hong Kong
- Volunteers
- 876 people
- Sponsor
- The University of Hong Kong
Heart Failure, Heart Failure With Reduced Ejection Fraction
CRTd Responders Optimization
Suboptimal optimization of atrio-ventricular (AV) and inter-ventricular (VV) timings could affect the clinical response of CRTd in T2DM patients.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Cardiac Death
- Trial name
- NCT04547244
- Testing
- echocardiographic optimization of CRTd
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Campania Luigi Vanvitelli
Heart Failure, Volume Overload
Assessment of ProEnkephalin to Detect Acute Kidney Injury (AKI)
Researchers are observing the values of proEnkephalin (PENK) via a blood draw in hospitalized patients that are volume overloaded requiring diuresis.
- Conditions
- Heart Failure, Volume Overload, Decompensated Heart Failure, Systolic Heart Failure
- Trial name
- NCT04019314
- Testing
- Blood Collection, Blood Volume Analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
Study of JK07 in Patients With Chronic Heart Failure
This is a Phase 2, randomized, double-blind, placebo-controlled, multiple dose study to assess the safety, tolerability, and efficacy of JK07 in participants aged 18-85 with heart failure.
- Trial name
- RENEU-HF (NCT06369298)
- Testing
- JK07
- Where
- 62 sites in United States, Canada and 2 more
- Volunteers
- 282 people
- Sponsor
- Salubris Biotherapeutics Inc
Heart Failure With Reduced Ejection Fraction
Evaluation of the HekaHeart Platform in Medication Management for Heart Failure Patients
This pilot study will test the feasibility of a novel digital health technology-enabled platform, HekaHeart, developed to facilitate comprehensive medical management, including medication initiation, titration, e-prescription…
- Trial name
- HekaHeart POC (NCT06433687)
- Testing
- HekaHeart platform medication management and remote monitoring
- Where
- 2 sites in United States
- Sponsor
- Yale University
Heart Failure
REDUCE LAP-HFREF TRIAL
The objective of this pilot study is to evaluate the safety and performance of implanting the IASD® System II in Heart Failure patients with reduced ejection fraction and elevated left sided filling pressures, who remain…
- Trial name
- NCT03093961
- Testing
- IASD implant
- Where
- 4 sites in United States, Australia and 1 more
- Volunteers
- 10 people
- Sponsor
- Corvia Medical
Coronary Artery Disease, Heart Failure Systolic
The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)
The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy (STICH3C) trial is a prospective, unblinded, international multi-center randomized trial of 754 subjects enrolled in approximately 45 centers comparing…
- Trial name
- NCT05427370
- Testing
- Revascularization by PCI, Revascularization by CABG
- Where
- 46 sites in United States, Austria and 14 more
- Volunteers
- 754 people
- Sponsor
- Sunnybrook Health Sciences Centre
Heart Failure With Reduced Ejection Fraction
Telemonitored Fast Track Medical Sequencing for Heart Failure With Reduced Ejection Fraction
Research hypothesis: Fast telemonitored medical sequencing in patients with heart failure with reduced ejection fraction (HFrEF) is safe and feasible.
- Trial name
- TELE-FASTER (NCT05637853)
- Testing
- GDMT
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Göteborg University
Heart Failure
The Re-Prosper HF Study
Heart failure with reduced ejection fraction (HFrEF) is a common cause for admission within the Veterans Affairs (VA) Health Care System.
- Trial name
- Re-Prosper HF (NCT04551222)
- Testing
- probenecid
- Where
- 5 sites in United States
- Volunteers
- 125 people
- Sponsor
- VA Office of Research and Development
Non-ischemic Dilated Cardiomyopathy, Heart Failure With Reduced Ejection Fraction
High Fat Diet for Cardiac Metabolic Reprogramming
Heart failure (HF) continues to be a leading cause of morbidity and mortality worldwide, despite advances in treatment. HF is often characterized by an altered metabolism in the heart, where glucose is favored over fatty acids as…
- Trial name
- HF4HF (NCT06747429)
- Testing
- High fat diet, Standard diet
- Where
- 5 sites in France, Italy and 2 more
- Volunteers
- 80 people
- Sponsor
- Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Heart Failure With Reduced Ejection Fraction, Thoracic Epidural Anesthesia
Thoracic Epidural Anesthesia Reduces Mortality and Rehospitalization for Patients With Heart Failure With Reduced Ejection Fraction
Despite significant scientific breakthrough in management, patients with heart failure with reduced ejection fraction (HFrEF) remain high morbidity and mortality, with a 5-year survival rate of 25% after hospitalization for…
- Trial name
- NCT06068166
- Testing
- TEA plus GDMT, GDMT
- Volunteers
- 1,840 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Atrial Fibrillation, Heart Failure
Cryoballoon Ablation Versus Medical Therapy in Patients With Heart Failure and Atrial Fibrillation
Rationale: Atrial fibrillation (AF) and heart failure (HF) can cause each other and sustain each other. Combined, the two diseases negatively influence each other's prognosis and lead to higher mortality.
- Conditions
- Atrial Fibrillation, Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure, Systolic
- Trial name
- RACE-8-HF (NCT04342832)
- Testing
- Cryoballoon ablation
- Where
- 2 sites in Netherlands
- Volunteers
- 64 people
- Sponsor
- Maastricht University
Cardiomyopathy Due to Drug, Heart Failure, Systolic
Prophylactic Lisinopril to Prevent Anthracycline Cardiomyopathy.
The intent of the study is to show the potential benefits of angiotensin converting enzyme inhibitors in preventing anthracycline induced cardiotoxicity.
- Trial name
- NCT03392740
- Testing
- Lisinopril
- Where
- United States
- Sponsor
- Ascension Health
Heart Failure
A Cohort Study to Compare the Hospitalization Between Naive Sacubitril/Valsartan and Naive ACEi/ARBs Heart Failure Patients With Reduced Ejection Fraction Using Secondary US Electronic Health Records Data
A non-interventional retrospective cohort study conducted to compare the naive sacubitril/valsartan Heart Failure with reduced Ejection Fraction (HFrEF) patient population to a matched naive ACEi/ARB HFrEF patient population.
- Trial name
- NCT05096143
- Testing
- Sacubitril/valsartan, ACEi/ARB
- Where
- United States
- Volunteers
- 42,269 people
- Sponsor
- Novartis Pharmaceuticals
Left Ventricular Dysfunction, Heart Failure, Systolic
Reprogramming to Prevent Progressive Pacemaker-induced Remodelling
The aim is to provide evidence of the long-term benefits of personalised pacemaker programming on heart function and battery longevity.
- Conditions
- Left Ventricular Dysfunction, Heart Failure, Systolic, Left Ventricular Failure, Pacemaker; Complication, Mechanical
- Trial name
- PPPR (NCT03627585)
- Testing
- Personalised programming
- Where
- 2 sites in United Kingdom
- Volunteers
- 91 people
- Sponsor
- University of Leeds