Clinical trials: Heart Failure, Reduced Ejection Fraction
Heart Failure
Qishen Yiqi Dripping Pills in Treatment of Chronic Heart FailUre
This trial will evaluate the efficacy and safety of Qishen Yiqi Dripping Pills in treatment of Chronic Heart Failure with reduced ejection fraction resorted from Coronary Heart Disease (Syndrome of Qi Deficiency with Blood…
- Trial name
- NCT07687186
- Testing
- Qishen Yiqi Dripping Pills 2 bags
- Where
- 60 sites in China
- Volunteers
- 636 people
- Sponsor
- Tasly Pharmaceutical Group Co., Ltd
Type 2 Diabetes Mellitus, Heart Failure
ERtugliflozin triAl in DIabetes With Preserved or Reduced ejeCtion FrAcTion mEchanistic Evaluation in Heart Failure
This study aims to elucidate the mechanisms whereby the SGLT2i "ertugliflozin" modifies cardiorenal interactions that regulate fluid volume and neurohormonal activation in patients with type 2 diabetes and heart failure (T2D-HF).
- Trial name
- ERADICATE-HF (NCT03416270)
- Testing
- Ertugliflozin
- Where
- 3 sites in Canada, Netherlands
- Volunteers
- 34 people
- Sponsor
- University Health Network, Toronto
Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation, Persistent
Pulmonary Artery Pressure and Right Heart Evaluation for Patients Requiring Physiological Pacing Treatment
With the aging of society, the use of cardiac pacing in patients with irreversible bradycardia is increasingly widespread. As early as the 1950s, right ventricular pacing (RVP) began to be used in patients with atrioventricular…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation, Persistent, Sick Sinus Syndrome, Atrioventricular Block
- Trial name
- NCT05575557
- Testing
- Right heart catheterization
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai 10th People's Hospital
Heart Failure, Heart Failure With Reduced Ejection Fraction
Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System
The Yale HF Registry is a live EHR based registry that allows for retrospective and real-time monitoring of Heart Failure case across the Yale New Haven Health System.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction, Heart Failure NYHA Class IV
- Trial name
- Yale-HF (NCT04237701)
- Where
- United States
- Volunteers
- 40,000 people
- Sponsor
- Yale University
Heart Failure, Systolic
CardiAMP™ Cell Therapy for Heart Failure Trial
This is a prospective, multi-center, randomized, controlled, patient- and evaluator-blinded study comparing treatment with the CardiAMP cell therapy to a sham control treatment.
- Trial name
- NCT02438306
- Testing
- Autologous cell therapy
- Where
- 24 sites in United States, Canada
- Volunteers
- 125 people
- Sponsor
- BioCardia, Inc.
Heart Failure With Reduced Ejection Fraction
Respiratory Sinus Arrhythmia (RSA) Pacing Post-CABG Surgery in Patients With HFrEF
The goal of this clinical trial is to test a new type of pacemaker in heart failure patients following a heart bypass operation.
- Trial name
- RSA-PACE (NCT06359938)
- Testing
- Atrial pacing with respiratory sinus arrhythmia (RSA) variability, Monotonic right atrial overdrive pacing
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Ceryx Medical Ltd
Chronic Heart Failure With Reduced Ejection Fraction
A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)
The purpose of this study is to evaluate the efficacy and safety of vericiguat in participants with chronic heart failure with reduced ejection fraction (HFrEF), specifically those with symptomatic chronic HFrEF who have not had…
- Trial name
- VICTOR (NCT05093933)
- Testing
- Vericiguat
- Where
- 519 sites in United States, Argentina and 34 more
- Volunteers
- 6,106 people
- Sponsor
- Merck Sharp & Dohme LLC
Adults With Heart Failure, Mild Decrease in Ejection Fraction/Preserved Ejection Fraction, and Obesity
Study on the Efficacy and Safety of HRS-7535 in Patients With Mild Decrease in Ejection Fraction/Preserved Ejection Fraction Heart Failure and Obesity
This is a multicenter, randomized, double-blind, placebo-controlled, parallel design phase II clinical trial, including a screening period of up to 2 weeks, a 36-weeks' treatment period, and a 1-week safety follow-up visit period.
- Trial name
- NCT06820099
- Testing
- HRS-7535 tablet
- Where
- China
- Volunteers
- 225 people
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Heart Failure With Reduced Ejection Fraction
Factors Associated With Sub - Targeted Therapeutic Dose Of Renin - Angiotensin Blockage Among Chronic Heart Failure With Reduced Ejection Fraction Patients
Objective: To analyze factors associated with Thai heart failure with reduced ejection fraction patients who received sub-target doses of Angiotensin converting enzyme inhibitors (ACEIs), angiotensin receptor-neprilysin…
- Trial name
- NCT06382571
- Testing
- Renin-Angiotensin System Inhibitor
- Volunteers
- 396 people
- Sponsor
- Chulalongkorn University
Assessment of the RV Function in Patients With Heart Faliure
Right Ventricular Function in Heart Failure
Only a few studies evaluated the RV systolic function in the three categories of HF, regarding the importance of understanding changes in RV function on clinical presentation and outcome; it was essential to understand the…
- Trial name
- NCT03641599
- Testing
- echocardiography
- Volunteers
- 150 people
- Sponsor
- shaimaa Mostafa
Systolic Heart Failure
A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart Failure
Objective The objective is to compare the efficacy of spironolactone and eplerenone on clinical outcome in patients with heart failure and a reduced ejection fraction. Method The study is a crossover cluster randomized trial.
- Trial name
- CROWD-ASPECT (NCT03984591)
- Testing
- Eplerenone, Spironolactone
- Where
- Denmark
- Volunteers
- 7,200 people
- Sponsor
- Bispebjerg Hospital
Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF)
IRONICA: IRON Repletion In Heart Failure - A Comparison of Oral and IV Approaches
The goal of this clinical trial is to learn which iron treatment works better for adults with congestive heart failure and low iron levels: intravenous (IV) iron given through a vein or oral (PO) iron taken by mouth.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF), Iron Deficiency
- Trial name
- IRONICA (NCT07053475)
- Testing
- Ferric Carboxymaltose, Ferrous Sulfate
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Syed Hamza Mufarrih
Heart Failure, Heart Failure, Systolic
Renal Denervation in Patients With Heart Failure Secondary to Chagas Disease
It is a randomized prospective controlled study of transcatheter renal denervation in patients with systolic heart failure secondary to Chagas' disease.
- Conditions
- Heart Failure, Heart Failure, Systolic, Chagas Disease, Chagas Cardiomyopathy
- Trial name
- NCT02099903
- Testing
- transcatheter renal denervation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- InCor Heart Institute
Chronic Heart Failure With Reduced and Mildly Reduced Ejection Fraction (HFrEF and HFmrEF)
Polypharmacy, Safety, and Medication Adherence in Patients With Chronic Heart Failure With Reduced and Mildly Reduced Ejection Fraction
This prospective registry study (FARAON) aims to assess the prevalence, structure, safety profile, and dynamics of polypharmacy, as well as its association with medication adherence, quality of life, and clinical outcomes in…
- Trial name
- FARAON (NCT07640854)
- Where
- Russia
- Volunteers
- 130 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Inflammatory Arthritis, Rheumatoid Arthritis
The Relationship Between Inflammatory ARTritis and CArdiac DIseAse
The goal of this prospective cohort study is to investigate cardiac comorbidity in a random sample of approximately 1200 patients from a population of outpatients with rheumatoid arthritis and axial spondyloarthritis referred to…
- Conditions
- Inflammatory Arthritis, Rheumatoid Arthritis, Spondylitis, Ankylosing, Axial Spondyloarthritis
- Trial name
- ARTCADIA (NCT05647577)
- Where
- Denmark
- Volunteers
- 1,285 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Diet, Sodium-Restricted, Heart Failure, Systolic
Effect of Sodium Intake on Brain Natriuretic Peptide Levels in Patients With Heart Failure
The SODA-HF trial is a randomized, double-blind, controlled trial to evaluate the effect of moderate to severe sodium restriction on brain natriuretic peptide in patients with heart failure and reduced ejection fraction (less…
- Conditions
- Diet, Sodium-Restricted, Heart Failure, Systolic, Natriuretic Peptide, Brain, Clinical Trial
- Trial name
- SODA-HF (NCT03351283)
- Testing
- Severe sodium restriction, Moderate sodium restriction
- Where
- Mexico
- Volunteers
- 70 people
- Sponsor
- Instituto Mexicano del Seguro Social
Heart Failure
A Trial to Study Neladenoson Bialanate Over 20 Weeks in Patients With Chronic Heart Failure With Reduced Ejection Fraction
The objective of the study is to find the optimal dose of once daily oral neladenoson bialanate (BAY 1067197) when given in addition to standard therapy for heart failure with reduced ejection fraction (HFrEF).
- Trial name
- PANTHEON (NCT02992288)
- Testing
- Neladenoson bialanate (BAY1067197)
- Where
- 75 sites in United States, Belgium and 9 more
- Volunteers
- 427 people
- Sponsor
- Bayer
Heart Failure With Reduced Ejection Fraction
HF Patients With LVADs Being Treated With SGLT2i
The main purpose of this study is to observe outcomes of sodium-glucose co-transporter 2 inhibitors (SGLT2i) in heart failure (HF) patients with left ventricular assist devices (LVAD).
- Trial name
- NCT05278962
- Testing
- SGLT2i, No SGLT2i
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Chicago
Heart Failure, Health Behavior
The Effectiveness of Integrated Interactive Digital Health Application and Telemonitoring in Patients with Heart Failure and Reduced Ejection Fraction
Patient Source: Patients discharged from the cardiology ward with heart failure. Intervention Group: Prior to discharge, patients will be provided with and instructed on how to use the "Intelligent Interactive Personal Management…
- Trial name
- NCT06583473
- Testing
- Interactive digital health application
- Volunteers
- 100 people
- Sponsor
- Hsiao Fu-Chih
Heart Failure With Reduced Ejection Fraction
A Study Investigating the Impact of IMT With CR On Exercise Responses In HF
The purpose of this study is to compare the impact of inspiratory muscle training (IMT) combined with cardiac rehabilitation (CR) on cardiovascular function in patients with heart failure.
- Trial name
- NCT07086131
- Testing
- Powerbreathe
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Mayo Clinic