Clinical trials: Heart Failure, Systolic
Heart Failure, Systolic, Iron Deficiency
Intravenous Iron in paTients With Heart failURe and Reduced Ejection fracTion (HFREF) pLus Iron dEficiency
Effects of ferric carboxymaltose single HD (1000 mg) infusion upon FGF23 in patients with isolated HFREF compared to patients with HFREF+CKD (all pts with iron deficiency).
- Trial name
- Iron Turtle (NCT03079518)
- Testing
- Ferric Carboxymaltose, blood withdrawal
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- RWTH Aachen University
Ischemic Heart Disease, Ischemic Cardiomyopathy
Atrial Appendage Micrograft Transplants to Assist Heart Repair After Cardiac Surgery
Ischemic heart disease (IHD) leads the global mortality statistics. Atherosclerotic plaques in coronary arteries hallmark IHD, drive hypoxia, and may rupture to result in myocardial infarction (MI) and death of contractile…
- Conditions
- Ischemic Heart Disease, Ischemic Cardiomyopathy, Heart Failure, Systolic, Heart Failure NYHA Class III
- Trial name
- AAMS2 (NCT05632432)
- Testing
- Epicardial AAMs-patch transplantation, RNA-stabilized whole blood sampling, Plasma sampling
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Hospital District of Helsinki and Uusimaa
Anemia, Cardiovascular Disease
An Exploratory Sub-study for the RED-HF™ (Reduction of Events With Darbepoetin Alfa in Heart Failure) Trial
The purpose of Study 20060172 was to measure echocardiographic parameters and biomarkers in a subgroup of study subjects enrolled in Study 20050222 (the RED-HF Trial).
- Conditions
- Anemia, Cardiovascular Disease, Congestive Heart Failure, Heart Failure
- Trial name
- NCT00534456
- Testing
- Darbepoetin alfa
- Volunteers
- 12 people
- Sponsor
- Amgen
Hidradenitis, Hidradenitis Suppurativa
HIDRAdenitis Suppurativa and HEART Disease
In a prospective observational cohort study (n = 250) the investigators aim to assess the correlation between cardiac biomarkers, advanced echocardiography and HS severity and determine whether these are prognostic markers of…
- Conditions
- Hidradenitis, Hidradenitis Suppurativa, Hidradenitis Suppurativa, Familial, Left Ventricular Dysfunction
- Trial name
- NCT05989945
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Herlev and Gentofte Hospital
Heart Failure, Systolic, Mechanical Circulatory Support
Cardiac Output in Heart Failure Patients With Mechanical Pumps
This study will be looking at how cardiovascular hemodynamics, including cardiac output and flow through a left ventricular assist device (LVADs), change in response to alterations in preload, afterload, and contractility, and…
- Conditions
- Heart Failure, Systolic, Mechanical Circulatory Support, Cardiovascular Hemodynamics
- Trial name
- NCT05195931
- Testing
- preload challenge, afterload challenge, contractility assessment
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Colorado, Denver
Modified Release Oral Formulation, Left Ventricular Systolic Dysfunction
COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure
The primary objectives of this study are (i) to select an oral modified release (MR) formulation and dose of omecamtiv mecarbil for chronic twice daily (BID) dosing in adults with heart failure and left ventricular systolic…
- Conditions
- Modified Release Oral Formulation, Left Ventricular Systolic Dysfunction, Chronic Heart Failure, History of Chronic Heart Failure
- Trial name
- COSMIC-HF (NCT01786512)
- Testing
- Omecamtiv Mecarbil Matrix F1 Formulation, Omecamtiv Mecarbil Matrix F2 Formulation, Omecamtiv Mecarbil Swellable Core Technology F2
- Where
- 101 sites in United States, Australia and 11 more
- Volunteers
- 544 people
- Sponsor
- Cytokinetics
Diastolic Heart Failure, Hypertensive Heart Disease
Physiological Effects of Grape Seed Extract in Diastolic Heart Failure
Diastolic heart failure (also known as "heart failure with normal ejection fraction" or "heart failure with preserved ejection fraction") occurs even though the heart muscle's pumping function is normal.
- Conditions
- Diastolic Heart Failure, Hypertensive Heart Disease, Heart Failure With Preserved Ejection Fraction, Hypertension
- Trial name
- GRAPEVINE-HF (NCT01185067)
- Testing
- grape seed extract (MegaNatural BP, Polyphenolics, Inc.)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Heart Failure, CT Angiography
Efficacy and Safety of Ivabradine to Reduce Heart Rate Prior to Coronary CT-angiography in Advanced Heart Failure: Comparison With β-Blocker
The aim of this study is to compare the effects of Ivabradine and metoprolol to reduce heart rate prior to coronary CT angiography in patients with advanced heart failure.
- Conditions
- Heart Failure, CT Angiography, Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy
- Trial name
- NCT03830957
- Testing
- Ivabradine, Metoprolol
- Where
- Iran
- Volunteers
- 200 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
Chronic Systolic Heart Failure
Evaluate the Effect of Injectable Neucardin on the Cardiac Function of Subjects With Chronic Systolic Heart Failure
A multi-center, randomized, double-blind, placebo-controlled phase III clinical trial to evaluate the effect of injectable Neucardin on the heart function in male patients with NT-proBNP ≤ 1700 pg/ml and female patients with…
- Trial name
- NCT04468529
- Testing
- Recombinant human Neuregulin for injection
- Where
- 29 sites in China
- Volunteers
- 154 people
- Sponsor
- Zensun Sci. & Tech. Co., Ltd.
Heart Failure and Reduced Ejection Fraction, Functional Mitral Regurgitation
Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance
This is a multi-center, prospective, observational study designed to evaluate the impact of LV myocardial fibrosis extent assessed by CMR on LV reverse remodeling and clinical outcomes post TEER.
- Trial name
- SMARTER-CMR (NCT07131631)
- Testing
- Cardiac MRI
- Where
- 6 sites in United States, Italy
- Volunteers
- 125 people
- Sponsor
- Minneapolis Heart Institute Foundation
Chronic Systolic Heart Failure, Paroxysmal VT
Cardiac MRI for Optimal Heart Failure Outcomes With CRT Upgrades
This study will investigate the use of cardiac MRI in patients with standard ICDs and pacemakers to inform how cardiac resynchronization therapy (CRT) can best be implemented in these patient and which patients are the best…
- Trial name
- NCT03504891
- Testing
- MRI prior to CRT Upgrade, MRI prior to de novo CRT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Heart Failure, Systolic
TRANSFORM Heart Failure with Reduced Ejection Fraction
The goal of the TRANSFORM-HFrEF trial will be to study the current guideline-directed medical therapy (GDMT) landscape for HFrEF and determine effective methods and models of increasing adherence to GDMT and improving Quality of…
- Trial name
- TRANSFORMHFrEF (NCT04872959)
- Testing
- HealthReveal
- Sponsor
- Massachusetts General Hospital
Heart Failure
The Effects of the Inspiratory Muscle Plus Aerobic Training Compare to Aerobic Training Alone in Heart Failure Patients.
This study aims to compare effects of inspiratory muscle training added by aerobic training to aerobic training alone in heart failure patients with inspiratory muscle weakness.
- Trial name
- NCT00634296
- Testing
- Inspiratory muscle added by aerobic to aerobic alone
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Heart Failure, Coronary Artery Disease
Dobutamine vs Adenosine CMR Study
This is a single centre, prospective diagnostic accuracy study to assess the comparative sensitivity of dobutamine versus adenosine for detection of severe non-infarct epicardial coronary artery stenosis in subjects with reduced…
- Conditions
- Heart Failure, Coronary Artery Disease, Cardiac MRI
- Trial name
- DISCORDANCE (NCT03661827)
- Testing
- Stress Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 69 people
- Sponsor
- University of Leicester
Heart Failure, Systolic
Optimising Pacemaker Therapy Using Multi-point Pacing (the OPT-MPP Study)
Recently, the introduction of quadripolar left ventricular leads (one with four pacing poles) has allowed the opportunity to pace the lateral (back) of the heart from several points at once using a single lead (multi-point pacing…
- Trial name
- OPT-MPP (NCT03220659)
- Testing
- Multi-point pacing, Standard settings
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- University of Leeds
Myocardial Infarction, Heart Failure, Systolic
VItamin D as a Novel Determinant of Injurious Cardiac Remodelling After acuTE Myocardial Infarction
To provide insight into why vitamin D levels at baseline predict an adverse outcome including hospitalisation, we will establish whether baseline vitamin D levels are an independent marker of LV remodelling in patients…
- Trial name
- VINDICATE-MI (NCT03086746)
- Where
- United Kingdom
- Volunteers
- 800 people
- Sponsor
- University of Leeds