Clinical trials: Heart Failure, Unspecified
Chronic Heart Failure, Heart Failure NYHA Class II
Severe Heart Failure and Homebased Rehabilitation - An Intersectoral Randomized Controlled Trial
The purpose of this study is to investigate the effect of an early, coordinated rehabilitation intervention for patients with severe heart failure in NYHA class III and IV with a ejection fraction of <40% of normal cardiac…
- Conditions
- Chronic Heart Failure, Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure NYHA Class IV
- Trial name
- NCT01669395
- Testing
- Early homebased rehabilitation after hospital admission, Usual care
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Fluid Retention Caused by Heart Failure
Phase II Clinical Study of HRS-9057 Injection in Patients With Heart Failure-induced Fluid Retention
Phase II clinical study of HRS-9057 injection in patients with heart failure-induced fluid retention
- Trial name
- NCT07318103
- Testing
- HRS-9057 injection set, 5% Glucose Injection or 0.9% sodium chloride injection
- Where
- China
- Volunteers
- 153 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Cardiovascular Diseases, Heart Diseases
Epidemiology of Depression and Heart Failure in Aging
To understand how depression leads to congestive heart failure (CHF) in older adults.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Heart Failure, Heart Failure, Congestive
- Trial name
- NCT00241761
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure, Renal Insufficiency
Tolerability and Safety of CARDIOMEMS™ Intracardiac Continuous Cardiac Hemodynamic Monitoring Device in Patients With Cardio Renal Syndrome With Severe Renal Impairment
Renal failure is present in 40% of heart failure patients, and is one of the main comorbidities of heart failure. Follow-up with pulmonary artery pressure (PAP) monitoring has shown a reduction in mortality and frequency of…
- Trial name
- CARDIOMEMS (NCT05428631)
- Testing
- Implantation of the CARDIOMEMS™ HF device
- Where
- 2 sites in France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Heart Failure
Vitamin D in Patients With Heart Failure
To investigate the prevalence of vitamin D deficiency in patients with Heart Failure. To investigate if vitamin D levels are correlated to the degree of Heart Failure.
- Trial name
- KarViD (NCT00501553)
- Where
- Denmark
- Volunteers
- 148 people
- Sponsor
- Hvidovre University Hospital
Aortic Valve Stenosis, Myocardial Fibrosis
Quantification of Myocardial Fibrosis in Aortic Stenosis
This study is a long term follow-up of patients that were included as part of a previous study (NCT03422770), where patients with aortic stenosis and healthy controls went through echocardiography, cardiac MRI, long-term…
- Trial name
- SAS-F-5 (NCT06571175)
- Testing
- High frame rate echocardiography, MRI, Blood test
- Where
- Norway
- Volunteers
- 79 people
- Sponsor
- Norwegian University of Science and Technology
Cerebral Hemorrhage, Head Injury
Biomarkers Correlation With Volemia
The purpose of this study is to determine whether the Biomarkers (pro adrenomedullin (MR proADM), pro arginin vasopressin (CT proAVP), pro atrial natriuretic peptid (MR proANP), Pro Endothelin) changes at Day 2, Day 5 and Day 7…
- Conditions
- Cerebral Hemorrhage, Head Injury, Non Traumatic Post Surgery, Poly Trauma Patients Without Heart Failure
- Trial name
- ENVOL (NCT01858675)
- Testing
- Biomarkers, red blood cells and plasma assessment
- Where
- France
- Volunteers
- 66 people
- Sponsor
- ThermoFisher Scientific Brahms Biomarkers France
Heart Failure
Complex Pathophysiological Background of Heart Failure Deterioration
Preventing heart failure (HF) deterioration is a great challenge for contemporary medicine. The progress course of HF is with increasing frequency of subsequent hospitalizations (approximately 30% of hospitalizations are the…
- Trial name
- NCT02355769
- Where
- Poland
- Volunteers
- 102 people
- Sponsor
- Military Institute od Medicine National Research Institute
Neoplasms, Heart Failure
Ivabradine to Prevent Anthracycline-induced Cardiotoxicity
Anthracyclines are associated with cardiotoxic effects. Previous studies suggest that enalapril, and or carvedilol, protect against cardiovascular effects of these drugs.
- Conditions
- Neoplasms, Heart Failure, Cardiotoxicity, Chemotherapy Effect
- Trial name
- IPAC (NCT03650205)
- Testing
- Ivabradine
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- University of Sao Paulo
Palliative Care, Heart Failure
Advanced Heart Care at Home
End-of-life (EOL) care for heart failure (HF) patients includes high healthcare utilization and costs, in part due to the lack of integration of optimal HF management and home-based palliative care.
- Conditions
- Palliative Care, Heart Failure, Health Care Utilization, Quality Improvement
- Trial name
- AHCAH (NCT03724695)
- Testing
- Clinician nudge or opt out approach for AHCAH liaison visit
- Where
- United States
- Volunteers
- 709 people
- Sponsor
- University of Pennsylvania
Heart Failure With Reduced Ejection Fraction (HFrEF), Ventricular Tachycardia (VT)
Metabolomic Profiling in Ischemic and Non-Ischemic Cardiomyopathy Patients With Ventricular Arrhythmias
This single-center prospective observational study aims to evaluate differences in metabolomic pathways between patients with ischemic and non-ischemic cardiomyopathy with reduced left ventricular ejection fraction and documented…
- Conditions
- Heart Failure With Reduced Ejection Fraction (HFrEF), Ventricular Tachycardia (VT), Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy
- Trial name
- MET-CMP (NCT07507539)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Muhammed Heja Geçit
Heart Failure
Model 4296 Left Ventricular (LV) Lead Study
This study is designed to show that a new lead, which paces the left bottom chamber (left ventricle) of the heart, is safe. Using a lead on the left side of the heart has been shown to potentially improve heart failure symptoms.
- Trial name
- 4296 (NCT00927251)
- Testing
- Pacing Lead (Model 4296 LV Lead)
- Where
- 16 sites in Austria, Finland and 6 more
- Volunteers
- 90 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Aortic Valve Stenosis
Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)
The objective of this study is to determine the safety and efficacy of transcatheter aortic valve replacement (TAVR) via a transfemoral approach in HF patients with moderate AS as compared with OHFT.
- Trial name
- NCT02661451
- Testing
- SAPIEN 3 THV, Optimal Heart Failure Therapy
- Where
- 51 sites in United States, Canada and 1 more
- Volunteers
- 178 people
- Sponsor
- Cardiovascular Research Foundation, New York
Heart Failure
Observation of Clinical Routine Care for Heart Failure Patients Implanted With BIOTRONIK CRT Devices
The registry is primarily designed to assess outcome, efficacy and residual safety aspects of CRT based on long-term data from an unselected, real-life clinical set-up.
- Trial name
- BIO|STREAM HF (NCT03366545)
- Testing
- Cardiac Resynchronization Therapy (CRT)
- Where
- 114 sites in Australia, Austria and 18 more
- Volunteers
- 3,030 people
- Sponsor
- Biotronik SE & Co. KG
Heart Failure
Optimal Programming to Improve Mechanical Indices, Symptoms and Exercise in Cardiac Resynchronization Therapy.
This international study is assessing if repeat adjustment of the timing between the three leads in a cardiac resynchronization therapy (CRT) defibrillator will increase the likelihood of benefit (symptoms and heart function)…
- Trial name
- OPTIMISE-CRT (NCT00489177)
- Testing
- A, B
- Where
- Canada
- Volunteers
- 461 people
- Sponsor
- University of Calgary
Heart Failure
NAtional TUnisian REgistry of Heart Failure
NATURE-HF is an observational, multicentric and longitudinal study of heart failure performed with 100 tunisian cardiologists.
- Trial name
- NATURE-HF (NCT03262675)
- Where
- Tunisia
- Volunteers
- 2,040 people
- Sponsor
- Dacima Consulting
Heart Failure, Mental Health
Improving Care and Mental Well-Being for Adults With Heart Failure
Heart failure is a high-risk, chronic condition that impacts patients' mental health. Approximately 50% of heart failure patients experience comorbid mental health conditions, such as stress, depression and anxiety, which affect…
- Conditions
- Heart Failure, Mental Health, Stress, Anxiety
- Trial name
- NCT07313657
- Testing
- Heart Failure and Mental Health Intervention (FRAME)
- Where
- 9 sites in Canada
- Volunteers
- 7,300 people
- Sponsor
- Bruyère Health Research Institute.
Diabete Mellitus, Kidney Disease
Clinical Information System Impact on Hospitalized Patients With Chronic Disease
This is a retrospective, observational study using routinely collected information collected by Alberta Health Services. The study will identify patients with chronic disease, defined by one or more of the following conditions…
- Conditions
- Diabete Mellitus, Kidney Disease, Heart Failure, Coronary Artery Disease
- Trial name
- NCT07609381
- Testing
- Clinical Information System (CIS) / Connect Care Implementation
- Where
- Canada
- Volunteers
- 124,240 people
- Sponsor
- University of Calgary
Essential Hypertension, Chronic Stable Angina
Study to Compare the Pharmacokinetic Characteristics and Safety of Dilatrend SR Capsule 32mg and Dilatrend Tablet 25mg
The purpose of this study is to compare the pharmacokinetic characteristics and safety of dilatrend SR capsule 32mg and Dilatrend tablet 25mg in healthy male subjects.
- Conditions
- Essential Hypertension, Chronic Stable Angina, Congestive Heart Failure
- Trial name
- NCT01819870
- Testing
- Dilatrend SR capsule 32mg, Dilatrend IR tablet 25mg
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Heart Failure With Preserved Ejection Fraction, Diabetes Mellitus, Type 2
Phenotypes and Outcomes of Heart Failure With Preserved Ejection Fraction in Patients With Hypertension and Diabetes
Our study is the first multicenter study in Vietnam on clinical phenotypes of heart failure with preserved ejection fraction (HFpEF) in patients with concurrent type 2 diabetes (T2DM) and hypertension (HTN).
- Conditions
- Heart Failure With Preserved Ejection Fraction, Diabetes Mellitus, Type 2, Hypertension
- Trial name
- NCT04835194
- Where
- 2 sites in Vietnam
- Volunteers
- 233 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
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