Clinical trials: Heart Failure, Unspecified
Heart Failure
BAROSTIM NEO System in the Treatment of Heart Failure
The purpose of this portion of study NCT01471860 is to assess the long-term safety and efficacy of the BAROSTIM NEO System in Canadian study participants implanted with the device.
- Trial name
- NCT01471860
- Testing
- BAROSTIM NEO System, Medical Management
- Where
- 30 sites in Canada, France and 2 more
- Volunteers
- 94 people
- Sponsor
- CVRx, Inc.
Advanced Heart Failure
Post Market Surveillance of the HeartMate 3 Left Ventricular Assist System in Korea
The Korea HM3 PMS is a prospective, single arm, open-label, multi-center, post market surveillance is designed to evaluate clinical and functional outcomes with the HM3 LVAS as a treatment for advanced heart failure.
- Trial name
- NCT04915924
- Testing
- HeartMate 3™ left ventricular assist system (HM3 LVAS)
- Where
- 22 sites in South Korea
- Volunteers
- 358 people
- Sponsor
- Abbott Medical Devices
Heart Failure
An Automated Continual Water Removal System in Patients With Advanced Diuretic Resistant Heart Failure
This study will assess the functionality and tolerability of an automated continual water removal system in up to 8 patients with HF and diuretic resistance.
- Trial name
- ACWR-HF (NCT05140759)
- Testing
- automated continual water removal system
- Where
- 3 sites in Georgia, Israel and 1 more
- Volunteers
- 3 people
- Sponsor
- Paragate Medical LTD
CHF
Effects of Remote Monitoring of Patients With Heart Failure Based on Smartphone Application
CHF is a most wild-spread and prognostically poor outcome most of cardiovascular and other disease. Despite of significant progress in treatment of CHF for the last years, death from this pathology stayed very high, reaching 60%…
- Trial name
- ERICA-HF (NCT04591964)
- Testing
- mobile application "M-Cardio" based on android
- Where
- Kyrgyzstan
- Volunteers
- 300 people
- Sponsor
- National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
Heart Failure
A ComPrehensive, ObservationaL Registry of Heart FaiLure With Mid-range and Preserved EjectiON Fraction
About 50% of all patients suffering from HF exhibit a reduced ejection fraction (EF ≤ 40%), termed HFrEF. The others may be classified into HF with midrange EF (HFmrEF, EF = 40-50%) or preserved ejection fraction (HFpEF, EF ≥…
- Trial name
- APOLLON (NCT03026114)
- Testing
- No intervention is planned in our study.
- Where
- Turkey (Türkiye)
- Volunteers
- 1,065 people
- Sponsor
- Muğla Sıtkı Koçman University
Sleep Breathing Disorders in the Responders to Cardiac Resynchronisation Therapy (CRT)
Sleep Apnea, Arrhythmias and Cardiac Reverse Remodeling in Heart Failure Patients
Prospective, international, non-randomized, multicentre, clinical investigation (phase IV). The aim of the study is to investigate the correlation between HF, severe SBD, and AF in CRT-P patients at 6 months.
- Trial name
- SYNCHRO (NCT02870647)
- Testing
- Echocardiographic, polygraphy, electrocardiography measurements and sleep questionnaire
- Where
- 3 sites in Italy, Spain
- Sponsor
- LivaNova
HFpEF - Heart Failure With Preserved Ejection Fraction
Cardiopulmonary Exercise Testing-based High-intensity Interval Training For Improving Heart Failure With Preserved Ejection Fraction
Cardiovascular-Kidney-Metabolic (CKM) Syndrome is a continuous clinical disease spectrum integrating cardiovascular, renal, and metabolic disorders.
- Trial name
- CPHIT-HFpEF (NCT07693049)
- Testing
- High-intensity interval training
- Where
- 13 sites in China
- Volunteers
- 192 people
- Sponsor
- Peking University Third Hospital
Heart Failure, Acidosis, Lactic
Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery
The objective of this study is to determine whether preoperative parenteral thiamin supplementation does prevent the intra and early postoperative increase of lactate and whether this effect is related to the extent of thiamine…
- Conditions
- Heart Failure, Acidosis, Lactic, Thiamine Deficiency
- Trial name
- NCT01524315
- Testing
- Vitamin B1-ratiopharm
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Laminopathy, Lamin A/C Gene Mutation
Subanalysis in Patients With CARDIoLAMinopathy Enrolled to REPORT-CCM Registry
Observational, retrospective registry with acute and chronic endpoints
- Conditions
- Laminopathy, Lamin A/C Gene Mutation, Heart Failure
- Trial name
- CARDILAM-CCM (NCT04904393)
- Testing
- Implant of the device for Cardiac Contractility Modulation (CCM) Therapy
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Monaldi Hospital
Acute Heart Failure
VExUS in Patients With Acute Heart Failure
The importance of assessing venous congestion in heart failure patients is widely acknowledged, but its study is hampered by the lack of a practical evaluation tool.
- Trial name
- NCT06397404
- Testing
- Venous excess ultrasound score (VExUS) protocol
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Heart Failure
Impact of Vericiguat on Hemodynamics of Heart Failure
Vericiguat is a new drug that was recently approved by the Food and Drug Administration for patients with heart failure. In a large randomized controlled trial, this drug was found to help patients with heart failure live longer…
- Trial name
- NCT05704478
- Testing
- Vericiguat
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Chronic Heart Failure
Evaluation of Longterm Outcome of New York Heart Association Class III Heart Failure Patients Receiving Telemonitoring Using a Pulmonary Artery Pressure Sensor System (CardioMEMS)
Invasive hemodynamic monitoring in advanced heart failure patients is a relative new option. In order to investigate the impact of remote telemonitoring of pulmonary artery pressures on mortality and morbidity in a routine…
- Trial name
- NCT03020043
- Where
- 2 sites in Germany
- Volunteers
- 500 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Heart Failure
Safety and Tolerability Study of AZD4831 in Patients With Heart Failure.
A randomized, double-blind, placebo-controlled, parallel group, multicentre study in patients with Heart Failure with preserved Ejection Fraction (HFpEF). The study will be conducted at approximately 15 sites in 5 countries.
- Trial name
- SATELLITE (NCT03756285)
- Testing
- AZD4831
- Where
- 13 sites in United States, Denmark and 3 more
- Volunteers
- 41 people
- Sponsor
- AstraZeneca
Heart Failure
Comparison of Cardiac Resynchronisation Therapy (CRT) Response Using High Frequency (HF) - ECG or Q-LV Guided Optimisation for Left Ventricular, Pacing Site.
The research aims to compare the response of Cardiac Resynchronisation Therapy (CRT) using HF ECG guided or the conventional method of Q-LV measurement guided optimisation for left ventricular, pacing site.
- Trial name
- NCT05829876
- Testing
- High Frequency ECG Mapping, Q-LV Measurement
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- University Hospital Birmingham
Heart Failure
The Effect of Nursing Care Decision Support System Designed for Fluid Volume Excess of Patients With Heart Failure on Clinical Outcomes of Patients and Home Self-Care Outcomes
This study aims to evaluate the effects of a nursing care decision support system designed to reduce fluid overload in patients with heart failure.
- Trial name
- HF-DSS-Nursing (NCT07067047)
- Testing
- Nursing Decision Support System
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Leyla Biçen
Dyspnea, Heart Failure Acute
Evaluation of the Effectiveness of the CardioStory Device in Distinguishing Heart Failure From Other Causes in Patients Presenting With Dyspnea
The CARDIOSTORY.TN study is a prospective observational study at Sahloul University Hospital (Sousse, Tunisia) evaluating the CardioStory device for distinguishing heart failure (HF) from other causes of acute dyspnea.
- Trial name
- CARDIOSTORY (NCT07147699)
- Testing
- cardiostory
- Sponsor
- Hôpital Universitaire Sahloul
Heart Failure, Atrial Fibrillation (AF)
Bachmann Bundle Pacing for Prevention of New-Onset Atrial Fibrillation in Patients With Heart Failure
This is a multi-center, prospective, single-blind, randomized controlled clinical trial to evaluate the efficacy and safety of Bachmann bundle pacing (BBP) in preventing new-onset atrial fibrillation (AF) in patients with chronic…
- Conditions
- Heart Failure, Atrial Fibrillation (AF), Cardiac Insufficiency
- Trial name
- NCT07547449
- Testing
- Bachmann Bundle Pacing, Right Atrial Appendage Pacing
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Advanced Refractory Left Ventricular Heart Failure
MOMENTUM 3 IDE Clinical Study Protocol
The objective of the study is to evaluate the safety and effectiveness of the HM3 LVAS by demonstrating non-inferiority to the HMII LVAS (HMII) when used for the treatment of advanced, refractory, left ventricular heart failure.
- Trial name
- HM3™ (NCT02224755)
- Testing
- HeartMate 3 LVAS, HeartMate II LVAS
- Where
- 69 sites in United States
- Volunteers
- 1,028 people
- Sponsor
- Abbott Medical Devices
Heart Failure, Diabetes
Safety and Effectiveness of SGLT-2 Inhibitors in Patients With Heart Failure and Diabetes
Patients with diabetes are at increased risk of developing heart failure (HF) which can lead to increased shortness of breath, reduced ability to exercise and in some cases premature death as the heart becomes less efficient at…
- Trial name
- REFORM (NCT02397421)
- Testing
- Dapagliflozin
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- University of Dundee
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