Clinical trials: Heart Failure, Unspecified
Congestive Heart Failure
Post Approval Registry of Corox OTW, Endocardial, Left Ventricular Steroid Lead, Bipolar
The objective of this study is to confirm the long-term safety and reliability of the Corox OTW BP left ventricular (LV) pacing lead.
- Trial name
- CELESTIAL (NCT00810264)
- Testing
- CRT Therapy - LV Lead Registry
- Where
- 86 sites in United States
- Volunteers
- 2,499 people
- Sponsor
- Biotronik, Inc.
Cardiotoxicity, Chemotherapeutic Toxicity
Prevention of Chemotherapy-induced Cardiotoxicity in High-risk Patients
In cancer patients, the increase of troponin I soon after chemotherapy is a strong predictor of left ventricular dysfunction and poor cardiologic outcome.
- Trial name
- NCT00292526
- Testing
- Enalapril
- Where
- Italy
- Volunteers
- 114 people
- Sponsor
- European Institute of Oncology
Healthy Participants
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Drug Effects of BMS-986308 in Healthy Participants
The purpose of this study is to evaluate the safety, tolerability, drug levels, and drug effects of BMS-986308 compared to placebo in healthy participants.
- Trial name
- NCT04763226
- Testing
- BMS-986308, Furosemide
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Cardiac Catheterization, Blood Pressure
Noninvasive Real-time Intracardiac Pressure Measurements Using Subharmonic Ultrasound
This study will use contrast echocardiography to assess the accuracy of a new non-invasive imaging method for subharmonic aided pressure estimation (SHAPE) compared to simultaneously acquired intra-cardiac pressures measured…
- Conditions
- Cardiac Catheterization, Blood Pressure, Heart Ventricles, Echocardiography
- Trial name
- NCT03245255
- Testing
- Sonazoid
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Thomas Jefferson University
Systolic Heart Failure, Sub-clinical Hypothyroidism
Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism
The purpose of this study is to determine whether levothyroxine supplementation is beneficial in patients with systolic heart failure and subclinical hypothyroidism on the functional class evaluated with a 6 minute walk test.
- Trial name
- NCT02316743
- Testing
- Levothyroxine supplementation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Université de Sherbrooke
Atrial Fibrillation (AF)
Electroporation Treatment for Early AF Management in Heart Failure With Preserved Ejection Fraction (HFpEF) Pilot Study
The proposed pilot study is a prospective, randomized, single-center feasibility study, enrolling 200 patients with symptomatic paroxysmal AF.
- Trial name
- E-TEAM (NCT07385417)
- Testing
- AF Ablation
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Cardioangiologisches Centrum Bethanien
Heart Failure, Heart Failure and Reduced Ejection Fraction
Biomarkers for Left Ventricular Reverse Remodeling in Heart Failure (REVERT-HF)
Heart failure is a serious condition where the heart cannot pump blood effectively. Some patients with severe heart failure (known as heart failure with reduced ejection fraction, or HFrEF) can experience significant improvement…
- Trial name
- REVERT-HF (NCT07701876)
- Where
- China
- Volunteers
- 1,740 people
- Sponsor
- Ruijin Hospital Luwan Branch
Heart Failure
A Study to Evaluate the Clinical Epidemiology of Patients With Heart Failure (HF) in India
This non-interventional, prospective, multi-centric, cross-sectional study is aimed to observe clinical practice in India in managing Heart Failure patients \& to check one year outcome in HF patients.
- Trial name
- NCT02047526
- Sponsor
- AstraZeneca
Heart Failure With Preserved Ejection Fraction
Leg Heat Therapy in Heart Failure With Preserved Ejection Fraction
The objective of this pilot study is to establish evidence to support the validity of HT in improving skeletal muscle function and physical capacity of patients with HFpEF.
- Trial name
- NCT06388226
- Testing
- Leg heat therapy
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Indiana University
Heart Failure
A Novel Automated & Comprehensive Approach for Ventricular Function Assessment in Heart Failure
Heart failure is a major health care burden. It can occur with either normal or reduced LV ejection fraction, depending on different degrees of ventricular remodelling.
- Trial name
- NCT02791126
- Testing
- Cardiovascular Magnetic Resonance, Echocardiogram
- Where
- Singapore
- Volunteers
- 78 people
- Sponsor
- National Heart Centre Singapore
Cardiogenic Shock, Acute Coronary Event
Pharmacological and Mechanical Support Approaches in the Management of Acute Heart Failure in the Regional Network Model for the Management of Cardiogenic Shock
The goal of this observational study is to understand and describe the epidemiology of cardiogenic shock in Emilia Romagna with a specific focus on outcome stratified by aetiologies, sex and age.
- Trial name
- NCT06827314
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Advanced Heart Failure, CRT and/or ICD
Screening for Advanced Heart Failure Treatment (SEE-HF)
Advanced heart failure therapy (heart transplantation or LVAD) is underutilized and patients are underserved. The purpose of this prospective, observational study is to obtain multi-center data on the proportion of patients with…
- Trial name
- SEE-HF (NCT01626404)
- Where
- 7 sites in Denmark, France and 4 more
- Volunteers
- 99 people
- Sponsor
- Abbott Medical Devices
Heart Failure
HF Assessment With BNP in the Home: Part II
HABIT-II is a feasibility study aimed at home monitoring of patients with heart failure. B-type natriuretic peptide (BNP) has strong correlations to the severity of heart failure.
- Trial name
- HABIT-II (NCT02351063)
- Testing
- Changes of heart failure medications
- Where
- 13 sites in United States, Ireland and 4 more
- Volunteers
- 1 people
- Sponsor
- Alere San Diego
Chronic Heart Failure, Self-care
Construction and Application of a Self-Care Behavior Intervention Scheme for Chronic Heart Failure Patients Based on Interaction Model of Client Health Behavior
The purpose of this study, which will last for 3 months, is to investigate the effect of the intervention based on the interaction model of health behavior on patients' disease perception, heart failure self-care level, quality…
- Conditions
- Chronic Heart Failure, Self-care, Health Education
- Trial name
- NCT06759987
- Testing
- self-care behavior intervention
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhi-fen Feng
Heart Failure With Reduced Ejection Fraction, Endothelial Dysfunction
Endothelial Function in Mechanical Circulatory Support
The pathophysiology of HF is highly variable, with overlapping pathogenic mechanisms that complicates any attempt to create a simple and unified conceptual model.
- Conditions
- Heart Failure With Reduced Ejection Fraction, Endothelial Dysfunction, LVAD
- Trial name
- NCT04539093
- Testing
- Exposure of interest - Use of left ventricular assist device (LVAD)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Medical College of Wisconsin
Heart Failure
CALM Study: Cardiomems Assisted Lvad Management
This prospective, open label, randomized, single-center pilot clinical trial will determine if the rate of heart failure related (HFR) hospitalizations is less in LVAD patients whose PAP is monitored with the CardioMEMS device vs…
- Trial name
- CALM (NCT07096544)
- Testing
- CardioMEMS Device
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Baylor Research Institute
Heart Failure
Karolinska-Rennes (KaRen) Prospective Study of Exercise Stress Echocardiography in Heart Failure With Preserved Ejection Fraction
Background: Heart failure with preserved ejection fraction (HFPEF) is common but not well understood. Electrical dyssynchrony in systolic heart failure is harmful.
- Trial name
- KaRen (NCT00774709)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- French Cardiology Society
Ventricular Tachycardia, Ventricular Fibrillation
DAVID II (Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial II)
The DAVID II Clinical Study evaluates the hypothesis that, in patients needing an ICD but without overt indications for pacing, AAI pacing with maximal concomitant drug therapy will not increase the rate of the combined endpoint…
- Conditions
- Ventricular Tachycardia, Ventricular Fibrillation, Sudden Cardiac Death, Congestive Heart Failure
- Trial name
- DAVIDII (NCT00187187)
- Testing
- Implantable Defibrillator (ICD)
- Volunteers
- 600 people
- Sponsor
- Abbott Medical Devices
Diabetes (DM), Hypertension
Multimodal Cardiovascular Magnetic Resonance Imaging for Cardiometabolic Pre-HF and HFpEF
This is an observational study aiming to characterize the pathophysiological features and clinical significance of cardiometabolic early-stage heart failure using advanced multimodal cardiovascular magnetic resonance (CMR)…
- Conditions
- Diabetes (DM), Hypertension, Heart Failure, Obesity & Overweight
- Trial name
- NCT07336316
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Systolic Heart Failure, Ventricular Premature Complexes
Impact of Catheter Ablation of Ventricular Arrhythmias on Suboptimal Biventricular Pacing in Cardiac Resynchronization Therapy
Cardiac resynchronization therapy reduces mortality in patients with systolic heart failure and left bundle branch block. Reduced biventricular pacing can lead to therapy failure.
- Conditions
- Systolic Heart Failure, Ventricular Premature Complexes, Ventricular Tachycardia, Cardiac Resynchronization Therapy
- Trial name
- NCT04065893
- Testing
- Catheter ablation of ventricular arrhythmia, Intensified medical therapy
- Where
- Germany
- Volunteers
- 65 people
- Sponsor
- Universitätsklinikum Köln
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