Clinical trials: Heart Failure; With Decompensation
Heart Failure, Heart Failure Preserved Ejection Fraction
Exercise, Mediterranean Diet and Inflammation in Heart Failure
This randomized clinical trial will test whether a multimodal anti-inflammatory program added to standard treatment improves the prognosis of patients with heart failure who have recently been hospitalized or visited the…
- Conditions
- Heart Failure, Heart Failure Preserved Ejection Fraction, Heart Failure, Diastolic (HFpEF), Chronic Inflammation
- Trial name
- FLARE-HF (NCT07885514)
- Testing
- Structured exercise training program, Mediterranean diet counseling, Standard heart failure management
- Volunteers
- 214 people
- Sponsor
- Hospital Severo Ochoa
Heart Failure; With Decompensation
Remote Dielectric Sensing (ReDS) Assisted Diuresis in Acute Decompensated Heart Failure
This study evaluates the use of a wearable vest capable of non-invasively measuring lung fluid content in hospitalized patients with heart failure
- Trial name
- RADAR-HF (NCT03586336)
- Testing
- ReDS-Guided, Usual Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Acute Heart Failure (AHF)
Digoxin After Acute Heart Failure (DIG-DICA)
The DIG-DICA trial is a randomized, controlled, open-label, single-center study designed to evaluate whether adding low-dose digoxin to optimal medical therapy after an episode of acute decompensated heart failure improves…
- Trial name
- DIG-DICA (NCT07321509)
- Testing
- Usual Care, Digoxin
- Where
- Argentina
- Volunteers
- 120 people
- Sponsor
- Hospital General de Agudos "Dr. Cosme Argerich"
CHF, Congestive Heart Failure
Evaluation of Home-based Sensor System to Detect Health Decompensation in Elderly Patients With History of CHF
Sensorum Health (Sensorum) is conducting a pilot study to determine if Sensorum's proprietary passive sensor network can be used to identify signals of early health decompensation in subjects prior to a hospitalization for…
- Trial name
- NCT05865197
- Testing
- Data collection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sensorum Health Inc.
Heart Failure, Congestive, Heart Decompensation
A Study of Two Doses of Intravenous NATRECOR hBNP (Nesiritide) in Patients With Worsening Congestive Heart Failure Who Have Difficulty Breathing at Rest
The purpose of this study is to assess the safety and efficacy of two doses of intravenous NATRECOR® hBNP (a recombinant form of the natural human peptide normally secreted by the heart) versus placebo in the treatment of…
- Trial name
- NCT00288730
- Testing
- nesiritide
- Volunteers
- 127 people
- Sponsor
- Scios, Inc.
Cardiac Decompensation
Evaluate Heart Failure Patients With Specially Designed Patient Adherence and Monitoring Software on Standard Mobile Devices
This is planned as a feasibility study. The objective is to evaluate a specially designed patient adherence and monitoring software on standard mobile devices in remote monitoring of heart failure patients.
- Trial name
- REMOTE-HF-1 (NCT01430936)
- Where
- 5 sites in United States, India and 1 more
- Volunteers
- 51 people
- Sponsor
- Aventyn, Inc.
Heart Failure, Cardiac Failure
Social Prescribing to Improve Adherence and Outcomes in Women With Heart Failure
Background: Heart Failure (HF) is the second most common cause of hospitalizations for women in North America. Non-adherence to guideline-directed medical therapy (GDMT) is associated with 50% of all treatment failures and high…
- Conditions
- Heart Failure, Cardiac Failure, Heart Decompensation, Congestive Heart Failure(CHF)
- Trial name
- NCT06628973
- Testing
- Social prescribing
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Heart Decompensation, Acute
Study With Healthy Japanese and Non-Asian Participants With BMS-986231
The purpose of this Phase 1 study is to evaluate the safety, tolerability, PK, and pharmacodynamics (PD) of BMS-986231 in healthy Japanese and Non-Asian participants. There is no formal hypothesis to be statistically tested.
- Trial name
- NCT02932969
- Testing
- BMS-986231
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Heart Failure; With Decompensation, Cardiorenal Syndrome
The Aortix CRS Pilot Study
The Aortix CRS Pilot Study: An Evaluation of the Safety and Performance of the Aortix System for Intra-Aortic Mechanical Circulatory Support in Patients with Cardiorenal Syndrome
- Conditions
- Heart Failure; With Decompensation, Cardiorenal Syndrome, Cardio-Renal Syndrome, Heart Failure
- Trial name
- NCT04145635
- Testing
- Aortix System
- Where
- 19 sites in United States, Australia
- Volunteers
- 21 people
- Sponsor
- Procyrion
Heart Decompensation
A Study Testing the Effectiveness of Nesiritide in Patients With Acute Decompensated Heart Failure
The purpose of this study is to find out if nesiritide (a human B-type natriuretic peptide/hBNP) as compared to placebo, plus the usual treatment for acute decompensated heart failure, helps to improve breathing difficulties…
- Trial name
- NCT00475852
- Testing
- Nesiritide
- Where
- 328 sites in United States, Argentina and 26 more
- Volunteers
- 7,141 people
- Sponsor
- Scios, Inc.
Acute Heart Failure
Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure
Single center, prospective, randomized, non-blinded research study comparing intravenous vasodilator infusion vs. inotropic infusion in patients admitted to the hospital or in the emergency room at Montefiore Medical Center…
- Trial name
- PRIORITY-ADHF (NCT02767024)
- Testing
- Sodium nitroprusside, Dobutamine, Furosemide
- Where
- United States
- Sponsor
- Montefiore Medical Center
MASLD, Liver Cirrhosis, Alcoholic
Acquisition of Cardiac Function Parameters in MRI and Echocardiography in Patients With Ethyltoxic Liver Cirrhosis and Transjugular Intrahepatic Portosystemic Shunt (TIPSS) Placement
The aim of this clinical trial is to investigate the development of cardiac decompensation following transjugular intrahepatic portosystemic shunt (TIPSS) implantation in order to draw conclusions for future treatment methods or…
- Conditions
- MASLD, Liver Cirrhosis, Alcoholic, Cirrhosis of Liver, Heart Decompensation
- Trial name
- EVALUATION (NCT06814990)
- Testing
- Cardiac MRI, Blood samples, Echocardiography
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Stephanie Gräger
Heart Failure Acute, Telemonitoring
Continuous Remote ECG Monitoring to Predict 30-day Outcome After Hospital Discharge in Patients With Heart Failure : A Pilot Study Using a New Wearable Sensor
Heart failure (HF) is a growing global public health concern. Worldwide, the estimated prevalence of HF has increased to >64.3 million cases.
- Trial name
- TELE_HF (NCT07699874)
- Testing
- ECG Monitoting
- Where
- Tunisia
- Volunteers
- 50 people
- Sponsor
- University of Monastir
Acute Decompensated Heart Failure
Point Of Care With Serial NT-proBNP Measurement in Patients With Acute Decompensation of Heart Failure
The goal of this study is to explore whether the availability of serial NT-proBNP measurements together with safety parameters such as electrolytes and creatinine may influence treatment decision in patients with acute…
- Trial name
- NCT04471610
- Testing
- Serial measurements of NT-pro BNP, potassium, sodium, and creatinine every second business day
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- Prof. Dr. Jörg Leuppi
Heart Failure, Patient Empowerment
Remote Patient Monitoring for Patients With Heart Failure in France
The goal of this multicenter observational longitudinal cohort study is to evaluate the ability of a Remote Patient Monitoring (RPM) program to prevent cardiac decompensation by detecting weak signals of decompensation early in…
- Conditions
- Heart Failure, Patient Empowerment, Cardiac Failure
- Trial name
- TELESAT-HF (NCT06312501)
- Testing
- Satelia®Cardio, Conventional care
- Where
- France
- Volunteers
- 20,000 people
- Sponsor
- Satelia
Respiratory Failure, Respiratory Arrest
Postoperative Respiratory Abnormalities
The study aims to determine how historical cases of respiratory abnormalities are documented by clinicians in the electronic health records (EHR) of Memorial Hermann Healthcare System (MHHS) inpatient facilities.
- Conditions
- Respiratory Failure, Respiratory Arrest, Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- AI-ARF (NCT04079829)
- Testing
- Observational retrospective cohort to describe data validity; and Data reliability; and Completeness of the data
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Efficacy Care R&D Ltd
Congestive Heart Failure
Evaluation of Cardiac Compass With OptiVol in the Early Detection of Decompensation Events for Heart Failure
The purpose of the PRECEDE-HF study is to collect data to compare patients whose heart failure is managed using Cardiac Compass with OptiVol (which is a tool in the device that records information about the heart that doctors can…
- Trial name
- PRECEDE-HF (NCT00510198)
- Testing
- Cardiac Compass with OptiVol Fluid Status Monitoring, Standard of Care alone (clinical assessment)
- Where
- 33 sites in United States
- Volunteers
- 120 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure (HF)
A Study of Ivabradine in African-American/ Black Subjects With Heart Failure and Left Ventricular Systolic Dysfunction.
This study is a prospective, open-label, single-arm intervention study in African-American/Black subjects with heart failure and reduced ejection fraction (HFrEF).
- Trial name
- NCT03456856
- Testing
- Ivabradine
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Amgen
Heart Failure; With Decompensation
Biomarker Guided Discharge of Heart Failure Patients
This is a multi-centre, single blind, randomized study. Patients admitted to hospital with acute decompensated heart failure will be randomized to biomarker guided discharge algorithm vs usual care in a 2:1 ratio.
- Trial name
- RADAR (NCT03103932)
- Testing
- Biomarker guided discharge algorithm
- Where
- Canada
- Volunteers
- 750 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Acute Heart Failure, Cardiac Decompensation
Global rEgistry on decongestioN Therapy Using Less invasivE UltraFiltration
In patients with advanced volume overload, minimally invasive ultrafiltration treatment in the acute phase can have a positive effect on clinical outcome.
- Conditions
- Acute Heart Failure, Cardiac Decompensation, Volume Overload
- Trial name
- GENTLE-UF (NCT02769351)
- Testing
- periph. minimal invasive ultrafiltration
- Where
- 19 sites in Germany, Sweden and 1 more
- Volunteers
- 104 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH