Clinical trials: Heart Failure (HF)
Heart Failure, Chronic Kidney Diseases
Creating A Cardiorenal Multidisciplinary Team for Management HF and CKD Patients
Several drugs have been labeled as guideline-directed-medical therapies (GDMT) to improve overall health outcomes and slow the progression of disease in patients with heart failure (HF).
- Trial name
- NCT05531214
- Testing
- Multidisciplinary Care Coordination Team
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- George Washington University
Heart Failure (HF)
A Study on the Correlation Between Cardiac-Cerebral Oxygenation Reserve and Cognitive Function Changes in Heart Failure Patients
At different stages of heart failure (HF), the cardiac and cerebral oxygen reserve exhibits varying degrees of decline due to chronic hypoxia and microvascular dysfunction caused by reduced cardiac output, leading to cognitive…
- Trial name
- NCT07485816
- Testing
- breathing training
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yan'an Affiliated Hospital of Kunming Medical University
CRT Non-Response, LBBB
Left Ventricular Myocardial Work for Predicting Response to CRT
This study aims to establish the normal reference values for left ventricular myocardial work in healthy Chinese adults and the influencing factors.
- Conditions
- CRT Non-Response, LBBB, HF - Heart Failure, Healthy Adult
- Trial name
- CARE-MW (NCT07319065)
- Testing
- Ultrasound machine
- Where
- 82 sites in China
- Volunteers
- 3,240 people, healthy volunteers welcome
- Sponsor
- First Hospital of China Medical University
Heart Failure
Assessment of Safety, Tolerability, Immunogenicity, and Pharmacokinetics of AZD3427
This first-time-in-human (FTIH) study will be conducted to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of single doses of AZD3427 in healthy volunteers and multiple doses of…
- Trial name
- NCT04630067
- Testing
- AZD3427
- Where
- 10 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Heart Failure
Ultra-sound Assisted Management of Heart Failure
The purpose of this study is to evaluate the impact of using hand carried ultrasound measurements of volume status in directing treatment of heart failure patients admitted with acute exacerbation.
- Trial name
- USA-HF (NCT04376424)
- Testing
- Hand Held Ultrasound
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Heart Failure; With Decompensation
Smart SCALEs With Bioimpedance Analysis for Treatment Guidance in Decompensated Heart Failure
In this trial the measurement of whole body water will be compared to the standard method of measuring the body weight as treatment guidance in patients with decompensated heart failure.
- Trial name
- SCALE HF (NCT03288701)
- Testing
- Seca medical Body Composition Analyser 515
- Where
- Switzerland
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Heart Failure
A Comparison of Magnetic Resonance Imaging in Persons With Heart Failure to Health, Aged Matched Controls
The purpose of this study is to examine the relation between the structural brain changes associated with heart failure, neurocognitive performance, and how these changes impact self-care behaviors.
- Trial name
- MIND-HF (NCT02572648)
- Testing
- Brain Imaging (Neuroimaging), Cognitive Function Assessment
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Emory University
Heart Failure, Heart Failure With Reduced Ejection Fraction
Electronic S3 Prediction of Hospital Readmissions for HF Exacerbation
The study objective is to measure the value of the third heart sound (S3) for the prediction of recurrent heart failure (HF). For the purpose of this study, a heart failure event will be defined as a hospitalization with a…
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT04112849
- Testing
- Measurement of S3 heart sound
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Heart Failure
Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF)
This study is trying to improve the hospital-to-home transition for people with heart failure who receive home care services. The study will test an intervention called I-TRANSFER-HF, which differs from usual care by combining…
- Trial name
- NCT06118983
- Testing
- I-TRANSFER-HF
- Where
- 2 sites in United States
- Volunteers
- 1,094 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Heart Failure
Home-based Cardiac Rehabilitation for People Living With Heart Failure and Their Caregivers- The DK:REACH-HF Pilot Study
Background: Participation in cardiac rehabilitation (CR) is a strong recommendation of clinical guidelines for the management of heart failure (HF) because it is demonstrated to be a clinically effective and cost-effective…
- Trial name
- NCT06573242
- Testing
- Home-based cardiac rehabilitation for people living with Heart Failure and their caregivers
- Where
- 2 sites in Denmark
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Herlev and Gentofte Hospital
Heart Failure, Heart Failure With Preserved Ejection Fraction
PACIFIC-PRESERVED : PhenomApping, ClassIFication, and Innovation for Cardiac Dysfunction - HF With PRESERVED LVEF Study
This is a prospective multicenter study to decipher phenotypic variability within patients with heart failure and preserved left ventricular ejection fraction (HFpEF).
- Trial name
- NCT04189029
- Testing
- Extensive phenotyping
- Where
- France
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dyspnea, Heart Failure
Systolic Time Intervals a Prognostic Tool of Heart Failure in Emergency Departement (STI/AHF)
The performance of STIs and clinical scores alone and their combination to predict short term prognosis of acute decompensated heart failure.
- Trial name
- NCT03831204
- Testing
- biopac, prognostic scores
- Where
- Tunisia
- Volunteers
- 642 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Atrial Fibrillation (AF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)
An AI-ECG-Based Approach for Dynamic Assessment of Heart Failure Risk and Myocardial Recovery Following Atrial Fibrillation Ablation
Background Artificial intelligence-enabled electrocardiography (AI-ECG) has emerged as a promising digital biomarker for detecting latent myocardial dysfunction and predicting cardiovascular risk.
- Trial name
- NCT07708818
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital
Heart Failure
Assessment of Cardiac Functional Reserve in Heart Failure With Preserved Ejection Fraction (HF-PEF)
This study will compare the ability of the heart to increase its contractile performance during stress in patients with a history of heart failure without systolic dysfunction and in controls.
- Trial name
- DobStress (NCT00585806)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Heart Failure
MAgna GraecIa Evaluation of Comorbidities in Patients With Heart Failure STUDY
The MAGIC-HF STUDY project (MAgna GraecIa evaluation of Comorbidities in patients with Heart Failure STUDY), is an observational prevalence and incidence study focusing on the role that risk factors, various comorbidities, and…
- Trial name
- MAGIC-HF (NCT05915364)
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Chronic Kidney Diseases, Chronic Heart Failure
Iron Deficiency and FGF23 Regulation in CKD and HF
This study investigates the effects of intravenous (IV) iron sucrose therapy on blood levels of Fibroblast Growth Factor 23 (FGF23, a protein that regulates the amount of phosphate in the body) in iron deficiency anemia in…
- Conditions
- Chronic Kidney Diseases, Chronic Heart Failure, Iron Deficiency Anemia
- Trial name
- INDIGO (NCT03106298)
- Testing
- Iron Sucrose
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Heart Failure, Cardiac Resynchronization Therapy
Narrow QRS HF Patients Assessed by ECG Belt
The purpose of this study is to quantitate electrical dyssynchrony in heart failure (HF) patients with a narrow QRS complexes (≤ 130 ms) using the ECG Belt.
- Trial name
- NCT03367104
- Testing
- ECG Belt
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Allina Health System
Implementation Science, Heart Transplant
Seeking Objectivity in Allocation of Advanced Heart Failure (SOCIAL HF) Therapies Trial
The primary goal of this study is to assess real-world effectiveness and implementation of an evidence-based multi-component strategy to reduce disparities in the allocation rate of advanced heart failure therapies, heart…
- Conditions
- Implementation Science, Heart Transplant, Decision Making
- Trial name
- SOCIAL HF (NCT05390411)
- Testing
- SOCIAL HF
- Where
- United States
- Volunteers
- 1,463 people, healthy volunteers welcome
- Sponsor
- Indiana University
Diabetes (DM), Hypertension
Multimodal Cardiovascular Magnetic Resonance Imaging for Cardiometabolic Pre-HF and HFpEF
This is an observational study aiming to characterize the pathophysiological features and clinical significance of cardiometabolic early-stage heart failure using advanced multimodal cardiovascular magnetic resonance (CMR)…
- Conditions
- Diabetes (DM), Hypertension, Heart Failure, Obesity & Overweight
- Trial name
- NCT07336316
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Heart Failure
Right Ventricular Contractile Reserve in HF
Right ventricle dysfunction and pulmonary hypertension are related to a worse prognosis in patients with heart failure with reduced left ventricular ejection fraction (HFrEF) or with normal left ventricular ejection fraction…
- Trial name
- RISE-HF (NCT05797584)
- Testing
- Dobutamine, Passive leg raising
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano