Clinical trials: Heart Failure with Reduced Ejection Fraction HFrEF
Heart Failure
Effect of Pre-Hospital ARNI Therapy on Short-Term Outcomes in HFrEF
This study looks at people with heart failure who are admitted to the hospital. The goal of the study is to understand whether taking a heart failure medicine called angiotensin receptor-neprilysin inhibitor (ARNI) before…
- Trial name
- NCT07347925
- Testing
- Prehospital ARNI use, No prehospital ARNI use
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Future University in Egypt
Heart Failure with Reduced Ejection Fraction
Left Bundle Branch Area Pacing Using Conventional Stylet-driven Pacemaker Leads for Cardiac Resynchronization Therapy
The aim of this study proposal is to compare the effectiveness of two distinct pacing modalities for cardiac resynchronization therapy.
- Trial name
- LeCaRT (NCT05365568)
- Testing
- Left Bundle Branch Area Pacing (LBBAP), Biventricular pacing (BiV)
- Where
- 11 sites in Belgium
- Volunteers
- 170 people
- Sponsor
- AZ Sint-Jan AV
Heart Failure With Reduced Ejection Fraction
Safety of HMA-CD20 in Patients With HFrEF
The study is a phase II single-centered, single group, prospective clinical trial to evaluate the safety of HMA-CD20 doses among stable patients with class III/IV according to the NYHA classification with HFrEF receiving standard…
- Trial name
- ICFEr-RITU2 (NCT03332888)
- Testing
- Rituximab
- Volunteers
- 10 people
- Sponsor
- Instituto de Cardiología y Medicina Vascular Hospital Zambrano-Hellion Tec Salud
Heart Failure, Heart Failure, Systolic
COmparing arNi and Ace For Improving Erectile Dysfunction in mEN With reduCed Ejection Fraction Heart Failure
The purpose of this study was to determine the effect of sacubitril/valsartan (LCZ696) vs. Enalapril on improvement in erectile function and ability in male patients with chronic heart failure with reduced ejection fraction and…
- Conditions
- Heart Failure, Heart Failure, Systolic, Erectile Dysfunction
- Trial name
- CONFIDENCE-HF (NCT03917459)
- Testing
- LCZ696, Enalapril
- Where
- 13 sites in Germany
- Volunteers
- 27 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure, Left Bundle-Branch Block
Mid-Q Response Study
The Mid-Q Response study is a prospective, multi-center, randomized controlled, interventional, single-blinded, post-market study.
- Conditions
- Heart Failure, Left Bundle-Branch Block, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure NYHA Class II
- Trial name
- NCT04180696
- Testing
- aCRT ON, aCRT OFF
- Where
- 61 sites in Brunei, China and 8 more
- Volunteers
- 177 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure With Reduced Ejection Fraction
VAgal Nerve Stimulation: safeGUARDing Heart Failure Patients
The purpose of the VANGUARD study is to demonstrate the safety of Vagal Nerve Stimulation for the treatment of congestive heart failure with reduced ejection fraction, and to report secondary measures of efficacy.
- Trial name
- VANGUARD (NCT02113033)
- Testing
- Equilia® Vagal Nerve Stimulation
- Where
- 6 sites in Belgium, France and 2 more
- Volunteers
- 15 people
- Sponsor
- LivaNova
Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation (AF)
Optimal PharmacoTherapy and Invasive Management of Atrial Fibrillation in Patients With Heart Failure
Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardiovascular epidemics, individually impairing quality of life and cardiac performance, as well as increasing the risk of hospitalisation and mortality.
- Trial name
- OPTIMal AF-HF (NCT07238452)
- Testing
- Pulmonary Vein Isolation, Pharmacological Rate Control
- Volunteers
- 1,050 people
- Sponsor
- University of British Columbia
Heart Failure With Reduced Ejection Fraction (HF-rEF)
The Effectiveness and Safety of Artificial Intelligence(AI)-Assisted Medical Treatment Decision Support System Compared to Conventional Care in HFrEF Patients
This clinical trial aims to find out if using an artificial intelligence (AI) decision support system can help doctors better manage medications for people with heart failure with reduced ejection fraction (HFrEF).
- Trial name
- NCT07380555
- Testing
- artificial intelligence (AI) decision support system
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Shanghai Zhongshan Hospital
Heart Failure With Reduced Ejection Fraction
Initiation of ARNi and SGLT2i in Patients With HFrEF
Heart failure (HF) is a condition in which the heart does not contract ("pump") or relax well, leading to insufficient perfusion of vital organs.
- Trial name
- INITIATE (NCT05989503)
- Testing
- Sacubitril-valsartan, SGLT2 inhibitor
- Where
- 5 sites in Portugal
- Volunteers
- 62 people
- Sponsor
- Universidade do Porto
Heart Failure and Reduced Ejection Fraction
Study of Effects of Sacubitril/Valsartan vs. Enalapril on Aortic Stiffness in Patients With Mild to Moderate HF With Reduced Ejection Fraction
To determine whether treatment with sacubitril/valsartan provides a superior effect on aortic characteristic impedance compared to enalapril in patients with heart failure and reduced ejection fraction (left ventricular ejection…
- Trial name
- EVALUATE-HF (NCT02874794)
- Testing
- LCZ696 (sacubitril/valsartan), Enalapril
- Where
- 81 sites in United States
- Volunteers
- 465 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure and Reduced Ejection Fraction, Heart Failure Chronic
RELIEVE-HFrEF TRIAL: REducing Lung congestIon Symptoms Using the v-wavE Shunt in adVancEd Heart Failure With Reduced EF
This study will evaluate the V-Wave Ventura Interatrial shunt. The Shunt is a small, hourglass-shaped device implanted in the dividing wall (septum) between the right and left atria (top chambers) of the heart placed during a…
- Conditions
- Heart Failure and Reduced Ejection Fraction, Heart Failure Chronic, Heart Failure New York Heart Association Class III, Heart Failure Congestive
- Trial name
- RELIEVE-HFrEF (NCT07696975)
- Testing
- Implantation of the V-Wave Interatrial shunt
- Volunteers
- 250 people
- Sponsor
- V-Wave Ltd
Heart Failure, Heart Failure With Reduced Ejection Fraction
LYmphangiogenesis FacTors in Heart Failure States
Heart failure often causes fluid to accumulate in the body, leading to congestion and swelling. However, some people who have had heart failure for a long time seem to have very little congestion or swelling, even when the heart…
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Normal Ejection Fraction
- Trial name
- LYFT-HF (NCT03141567)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Medical University of South Carolina
Heart Failure With Reduced Ejection Fraction
Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score
The purpose of this trial is to better understand how the beta-blocker metoprolol works in people with Heart Failure with Reduced Ejection Fraction (HFrEF) according to participants genetics.
- Trial name
- NCT07490067
- Testing
- Metoprolol Succinate, Beta-Blocker Polygenic Score, Illumina Infinium Global Diversity Array with Enhanced Pharmacogenomics (PGx)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Heart Failure with Reduced Ejection Fraction, Chronic Heart Failure
Efficacy of a Streamlined Heart Failure Optimization Protocol
The SHORT trial compares the current standard optimization protocol to a shortened protocol in a randomized control trial.
- Trial name
- SHORT (NCT05021419)
- Testing
- Streamlined protocol, Standard Protocol
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- The Queen Elizabeth Hospital King's Lynn NHS Foundation Trust
Heart Failure With Reduced Ejection Fraction, Ischemic Cardiomyopathy
Revascularization Versus Medical Treatment in Patients With Ischemic Left Ventricular Dysfunction
Randomized trial to compare clinical outcomes between revascularization versus medical treatment alone in patients with ischemic cardiomyopathy and left ventricular dysfunction.
- Trial name
- RESTORE-PCI (NCT05828719)
- Testing
- Percutaneous coronary intervention
- Where
- South Korea
- Volunteers
- 900 people
- Sponsor
- Samsung Medical Center
Congenital Heart Disease, Heart Failure
" Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fraction in ACHD "
The treatment of adult patients with congenital heart disease (ACHD) and heart failure (HF) represents a great challenge since, to date, there is no standardized guideline for this specific population.
- Conditions
- Congenital Heart Disease, Heart Failure, Heart Failure With Reduced Ejection Fraction
- Trial name
- NCT05580510
- Testing
- Sacubitril 49 MG / Valsartan 51 MG [Entresto] BID, Empagliflozin 10 MG OD
- Where
- Mexico
- Volunteers
- 160 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Heart Failure with Reduced Ejection Fraction, Heart Failure
Prediction of Heart-Failure with Machine Learning
In this monocentric observational study the research question is to what extent data collected via Apple Watch can predict the heart failure status of decompensated HF patients.
- Conditions
- Heart Failure with Reduced Ejection Fraction, Heart Failure, Heart Failure，Congestive, Heart Failure Acute
- Trial name
- PRE-HF-ML (NCT06819618)
- Testing
- Monitoring with Apple Watch
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- University Medical Center Goettingen
Heart Failure With Reduced Ejection Fraction
Efficacy and Safety of Lactoferrin in Heart Failure Patients
This study will be conducted to determine the efficacy and safety of lactoferrin versus oral iron versus lactoferrin plus oral iron as an add on therapy in reduced ejection fraction heart failure patients with iron deficiency.
- Trial name
- NCT06427200
- Testing
- oral Iron, Lactoferrin, lactoferrin and oral iron
- Volunteers
- 114 people
- Sponsor
- Cairo University
Chronic Heart Failure
Intestinal Microbiota Transplantation in Patients With Chronic Heart Failure
The purpose of this study is to determine whether people with CHF, who often have different gut bacteria from healthy, would benefit from replacing their gut bacteria with healthy donor bacteria (also known as Intestinal…
- Trial name
- IMT (NCT07490054)
- Testing
- MTP-101-C encapsulated Microbiota, Vancomycin, Neomycin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Melana Yuzefpolskaya, MD
Heart Failure With Reduced Ejection Fraction, Coronary Artery Disease
Hyperemic Efficacy of IV Adenosine in HFrEF
Little is known about the hyperemic efficacy of IV adenosine as well as safety in patients with heart failure with reduced ejection fraction (HFrEF) because they were excluded from the major FFR studies.
- Trial name
- HF-FFR (NCT03235700)
- Testing
- Maximal hyperemia with adenosine followed by nicorandil, Maximal hyperemia with nicorandil followed by adenosine
- Where
- South Korea
- Volunteers
- 125 people
- Sponsor
- Sejong General Hospital