Clinical trials: Heart Infarction
Stable Angina, Non ST Segment Elevation Myocardial Infarction
INsTantenous wavE-Free Ratio-guided PCI Versus Fractional Flow REserve-Guided PCI in rouTine Clinical Practice, Prospective, Multicenter Registry
The current study sought to evaluate the clinical relevance of iFR-guided strategy in real world clinical practice using unrestricted study population from stable angina to acute coronary syndrome including acute ST-segment…
- Conditions
- Stable Angina, Non ST Segment Elevation Myocardial Infarction, ST-segment Elevation Myocardial Infarction, Silent Myocardial Ischemia
- Trial name
- INTERPRET (NCT03338309)
- Testing
- Instantaneous wave-free ratio measurement
- Where
- 4 sites in South Korea
- Volunteers
- 1,200 people
- Sponsor
- Samsung Medical Center
Myocardial Infarction
Examination of the Impact of CalmiGo's Stress Management Device on Vascular Heath and Cardiovascular Disease Risk.
The primary purpose of this study is to determine if there are significant differences with respect to baseline between those randomized to CGo and standard-of-care versus standard-of-care alone after completing 12-weeks of…
- Trial name
- CalmiGo (NCT04521699)
- Testing
- CalmioGO Stress management device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Cardiovascular Diseases, Coronary Disease
Multicenter Investigation of Limitation of Infarct Size (MILIS)
To assess the ability of two separate therapeutic interventions, propranolol and hyaluronidase, to limit the ultimate size of an acute myocardial infarction.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00000493
- Testing
- propranolol, hyaluronidase
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Myocardial Infarction
Effect of an Adult EDUcation Program on CArdiovascular ouTcomEs in Post-myocardial-infarction Patients
A non-MD-led adult education program consisting in 10 one-hour sessions designed to provide information and motivation will be offered to patients who have recently been hospitalized for acute myocardial infarction (STEMI and…
- Trial name
- EDUCATE (NCT04007887)
- Testing
- Adult education program
- Where
- Greece
- Volunteers
- 320 people
- Sponsor
- National and Kapodistrian University of Athens
ST Elevation (STEMI) Myocardial Infarction
Impact of Persistent Microvascular Obstruction by Cardiac Magnetic Resonance on Prognosis for ST-segment Elevation Myocardial Infarction
The aims of the study were to evaluate the predictive value of persistent microvascular obstruction (MVO) by cardiac magnetic resonance for main adverse cardiac events in ST-segment elevation myocardial infarction patients.
- Trial name
- IMCOME (NCT06759532)
- Where
- China
- Volunteers
- 344 people
- Sponsor
- Chinese PLA General Hospital
Non ST Elevation Myocardial Infarction (NSTEMI), Frailty
FINE75+: 5 Year Follow up
In the FINE 75+ study, 307 Non ST Elevation Myocardial Infarction (NSTEMI) patients, 75 years old or older, were included between September 2009 and June 2010.
- Trial name
- FINE75+5 (NCT02910687)
- Testing
- This is an observational study
- Where
- Sweden
- Volunteers
- 307 people
- Sponsor
- Linkoeping University
Type 2 Diabetes Mellitus Myocardial Infarction
Ertugliflozin's Effect on Heart Function in Diabetic Patients After Myocardial Infarction
This prospective, randomized, open-label, blinded endpoint (PROBE) trial evaluates the efficacy of early ertugliflozin initiation (10 mg daily) compared to standard care alone on cardiac function in 476 adult patients with type 2…
- Trial name
- NCT07621380
- Testing
- Ertugliflozin 10 mg, Standard AMI Care
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Shanghai Zhongshan Hospital
STEMI
Prognostic Value of Lactate Levels in Patients With STEMI Undergoing Primary PCI
To assess the prognostic value of systemic arterial lactate levels in patients with ST segment elevation myocardial infarction undergoing primary PCI and correlate with the results of primary PCI and 30 days MACE follow up.
- Trial name
- NCT05503329
- Testing
- arterial lactate level
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Ahmed Maher Teaching Hospital
Ventricular Arrhythmia, Cardiomyopathies
ElectroPhySiological Characterization Of the Arrhythmia Substrate for Sudden Cardiac Death PrEdiction
EP-SCOPE is a prospective, multicentric, non-randomized pilot study that aims to estimate the risk of life-threatening ventricular arrhythmia through use of advanced electrophysiological studies in patients with ischemic or…
- Conditions
- Ventricular Arrhythmia, Cardiomyopathies, Left Ventricular Ejection Fraction Less Then or Equal to 50percent
- Trial name
- EP-SCOPE (NCT07020702)
- Testing
- Implantation of an ICD
- Where
- 3 sites in France
- Volunteers
- 210 people
- Sponsor
- University Hospital, Bordeaux
STEMI - ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention
Non Culprit Functional Evaluation With 3D Angio QFR in STEMI PCI Procedure
Reliability of 3D angio QFR functional evaluation of all non culprit lesions >50% in STEMI patients during first acute procedure
- Conditions
- STEMI - ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention, Coronary Artery Disease
- Trial name
- NCT02998853
- Testing
- QFR measurement by dedicated workstation on xrays angio selected runs
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliera Sant'Anna e San Sebastiano
Coronary Artery Disease
Tirofiban in Stenting for Long Coronary Lesion
Periprocedural myonecrosis or infarction are associated with short, intermediate, and long term adverse outcomes. Previous study indicated 12.6% of patients suffered a peri-procedural CK-MB rise by overlapping use of drug-eluting…
- Trial name
- PETITION (NCT01498003)
- Testing
- tirofiban, normal saline solution
- Where
- China
- Volunteers
- 748 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
STEMI, Acute Myocardial Infarction
Resistance STEMI Study
In acute myocardial infarction, early restoration of blood flow to the jeopardized myocardium is of paramount importance to limit infarct size and to improve long term outcome.
- Trial name
- NCT03439150
- Testing
- Absolute flow and resistance measurement
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Acute Myocardial Infarction
Ticagrelor for PCI Post Thrombolysis
Ticagrelor is a first line therapy along with aspirin for patients undergoing primary PCI for STEMI. However, many patients are still treated with fibrinolytic therapy and the safety and efficacy of Ticagrelor has not been…
- Trial name
- SETFAST (NCT01930591)
- Testing
- Ticagrelor, Clopidogrel
- Where
- 5 sites in Canada
- Volunteers
- 140 people
- Sponsor
- Unity Health Toronto
Myocardial Infarction, Comorbidity
Web-Enhanced Guideline Implementation for Post MI CBOC Patients
To assist busy primary care clinicians in VA Community Based Outpatient Clinics (CBOCs) in managing complex patients by providing a single, interactive, and personalized source of information regarding applicable guidelines for…
- Trial name
- VA MI Plus (NCT00126750)
- Testing
- VA MI Plus Interactive
- Where
- 41 sites in United States, Puerto Rico
- Volunteers
- 847 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
ST-elevation Myocardial Infarction
Cooling in Myocardial Infarction
The primary goal in the treatment of acute myocardial infarction is to reperfuse the ischemic myocardium to reduce infarct size.
- Trial name
- STATIM (NCT01777750)
- Testing
- EMCOOLS flex pad; Philips Innercool RTx
- Where
- Austria
- Volunteers
- 120 people
- Sponsor
- Medical University of Vienna
Silent Cerebral Infarct, Biomarkers / Blood
Biomarkers as Prognostic Factors of Silent, Cerebral Infarctions in Patients Undergoing High-thromboembolic-risk Transcatheter Interventions
Background: The transcatheter interventions with high thromboembolic risk, as transcatheter carotid angioplasty or transcatheter ablation of cardiac arrhythmias are associated with asymptomatic strokes- silent strokes.
- Conditions
- Silent Cerebral Infarct, Biomarkers / Blood, Cardiac Ablation, Cognitive Impairment
- Trial name
- PRINCESS (NCT07844850)
- Testing
- High-thromboembolic-risk transcatheter interventions
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Acute Cardiogenic Shock
Transient Circulatory Support in Cardiogenic Shock
The purpose of this multicenter prospective study is to determine if the decision of transient circulatory support (TCS) in cardiogenic shock is relevant.
- Trial name
- ALLOASSIST (NCT03528291)
- Where
- France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Montpellier
Myocardial Infarction
Differential Expression and Analysis of Peripheral Plasma Exosome miRNA in Patients With Myocardial Infarction
The aim of this study is to determine the miRNA expression profile in peripheral blood exosomes of patients with myocardial infarction and to investigate its relationship with myocardial infarction.
- Trial name
- NCT04127591
- Testing
- exosome
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Coronary Disease, Coronary Arteriosclerosis
Effects of a Healthy Nordic Diet on Atherosclerosis in Patients with Coronary Heart Disease
Diet can play a key role in atherosclerosis and coronary heart disease (CHD), but little interventional data exists, and the mediators of possible anti-atherosclerotic effects of diet are unclear.
- Conditions
- Coronary Disease, Coronary Arteriosclerosis, Myocardial Infarction, Chronic Coronary Syndrome
- Trial name
- NORDHEART (NCT06701968)
- Testing
- Healthy Nordic Diet, Usual Care
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Uppsala University
ST-elevation Myocardial Infarction
Effect of Conditioning on Myocardial Damage in STEMI
The LIPSIA-Conditioning trial is an investigater initiated, randomized, single-center study that will assess the effect of different intrahospital conditioning protocols on myocardial damage assessed by MRI in patients with acute…
- Trial name
- LIPSIA-COND (NCT02158468)
- Testing
- Combined intrahospital pre- and postconditioning, Postconditioning
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- University of Leipzig