Clinical trials: Heart Infarction
Acute ST Segment Elevation Myocardial Infarction
ABSORB STEMI: the TROFI II Study
This is a Prospective, randomized (1:1), active control, single-blind, non-inferiority, European multicenter clinical trial. The primary objective of this study is to assess the neointimal healing score (as evaluated by…
- Trial name
- NCT01986803
- Testing
- Percutaneous Coronary Intervention
- Where
- 8 sites in Denmark, Netherlands and 2 more
- Volunteers
- 191 people
- Sponsor
- ECRI bv
Intracardiac Thrombus, STEMI
Anticoagulation Therapy in Non-device-related Intra-cardiac Thrombus
Left ventricular thrombus is found in 10 to 25% of patients with impaired left ventricular function following ST-segment elevation myocardial infarction and up to 20% in dilated cardiomyopathy in observational studies.
- Conditions
- Intracardiac Thrombus, STEMI, Heart Failure
- Trial name
- ARGONAUT (NCT05825573)
- Testing
- Vitamin K antagonist, Direct oral anticoagulant
- Where
- 35 sites in France, Reunion
- Volunteers
- 340 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Myocardial Infarction, Cardiovascular Diseases
Safety and Efficacy Study of KAI-9803 to Treat Subjects With ST Elevation Myocardial Infarction [Heart Attack]
The purpose of this study is to determine whether KAI-9803 is safe and effective in reducing infarct size in subjects with ST elevation myocardial infarction (heart attack) undergoing a percutaneous coronary intervention (PCI).
- Conditions
- Myocardial Infarction, Cardiovascular Diseases, Pathologic Processes
- Trial name
- PROTECTION AMI (NCT00785954)
- Testing
- KAI-9803
- Where
- 126 sites in United States, Australia and 16 more
- Volunteers
- 1,180 people
- Sponsor
- KAI Pharmaceuticals
Non-ST Elevation Myocardial Infarction, Frail Elderly Syndrome
the Invasive and Conservative Strategies in Elderly Frail Patients With Non-STEMI
The role of a routine invasive strategy in frail patients with non-ST-segment elevation acute myocardial infarction is currently uncertain. We hypothesize that a routine invasive strategy will improve outcomes.
- Trial name
- MOSCA-FRAIL (NCT03208153)
- Testing
- Invasive, Conservative
- Where
- Spain
- Volunteers
- 167 people
- Sponsor
- University of Valencia
Stable Angina, Unstable Angina
Prospective, Single-arm, Multicenter Study for Evaluation the Safety and Effectiveness of the ALEX Stent in a Real-world Setting of Percutaneous Coronary Interventions in Patients With Coronary Heart Disease
To evaluate the safety and effectiveness of the ALEX stent in a real-world setting of percutaneous coronary interventions in patients with coronary heart disease.
- Conditions
- Stable Angina, Unstable Angina, Myocardial Infarction
- Trial name
- ALEX OCT (NCT01637012)
- Testing
- Implantation
- Where
- 5 sites in Poland
- Volunteers
- 60 people
- Sponsor
- Balton Sp.zo.o.
Acute Myocardial Infarction
A Trial of a Home Based Walking Program as an Alternate Program for Non Attenders at Cardiac Rehabilitation
The purpose of this study is to investigate if a home-based walking program is an acceptable alternative for those who choose not to attend formal cardiac rehabilitation programs and if such a program has an effect on coronary…
- Trial name
- CRU-SHAL (NCT00219830)
- Testing
- home-based walking program
- Where
- United Kingdom
- Sponsor
- Queen's University, Belfast
Ventricular Arrythmia, Cardiogenic Shock
Recurrent Ventricular Arrythmias in ICU
Electrical storm (ES) is a life-threatening syndrome defined by the recurrence of ventricular arrythmias. ES is also represented by a wide spectrum of clinical situations ranging from recurrent monomorphic VT reduced by…
- Conditions
- Ventricular Arrythmia, Cardiogenic Shock, Electrical Storm
- Trial name
- ElectStorm (NCT07033065)
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
ST Elevation Acute Myocardial Infarction
Bioresorbable Vascular Scaffold in Patients With Myocardial Infarction
Evaluation of the feasibility and safety of Bioresorbable Vascular Scaffold (BVS) in patient treated with primary PCI (pPCI).
- Trial name
- NCT02151929
- Testing
- Bioresorbable vascular scaffold, Everolimus eluting stent
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- San Giuseppe Moscati Hospital
Acute Myocardial Infarction
Study to Assess the Safety and Cardiovascular Effects of Autologous Adipose-Derived Stromal Cells Implantation In Patients During the Acute Recovery Phase of ST-Elevation Myocardial Infarction
The intent of this clinical study is to answer the questions: 1) Is the proposed treatment safe? and 2) Is treatment effective in improving cardiac function and clinical outcomes?
- Trial name
- Acute MI (NCT01974128)
- Testing
- ASC isolation and implantation
- Where
- United States
- Sponsor
- Ageless Regenerative Institute
ST Segment Elevation Myocardial Infarction
Smartphone Twelve Lead Electrocardiogram Utility In ST-Elevation Myocardial Infarction
The primary objective of this study is to determine if the Smartphone electrocardiogram (ECG) is an acceptable replacement for a standard ECG in the identification of ST Elevation Myocardial Infarction (STEMI).
- Trial name
- ST LEUIS (NCT02498405)
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Intermountain Health Care, Inc.
Cardiogenic Shock, Endothelial Dysfunction
Adrecizumab in Cardiogenic Shock
Cardiogenic shock is a serious medical condition with high mortality and morbidity. This trial assesses safety, tolerability and efficacy of Adrecizumab on top of standard of care in patients with cardiogenic shock.
- Trial name
- ACCOST-HH (NCT03989531)
- Testing
- Adrecizumab
- Where
- 3 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Dr. med. Mahir Karakas
Ventricular Arrythmia, Infarction, Myocardial
A Novel Myocardial Impedance Mapping System for Ablation of Post-infarction Ventricular Arrhytmias in Humans
Precise identification of the infarct scar is essential for successful catheter ablation of ventricular arrhythmias in patients with chronic myocardial infarction.
- Trial name
- NCT04000412
- Testing
- CardioZ multifrequency impedance recording system
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Conservative Pharmacotherapy, Staged Percutaneous Coronary Intervention
Non-culprit Vessels for ST-Segment Elevation Myocardial Infarction
To compare the different effect of conservative pharmacotherapy and Staged Percutaneous Coronary Intervention (SPCI) on significant non-culprit lesions in patients with ST-segment elevation myocardial infarction (STEMI) at…
- Conditions
- Conservative Pharmacotherapy, Staged Percutaneous Coronary Intervention, Non-culprit Vessels, ST-Segment Elevation Myocardial Infarction
- Trial name
- CPVsSPCI (NCT02154919)
- Testing
- Percutaneous coronary intervention
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Acute Myocardial Infarction
Effect of Complementary Intracoronary Streptokinase Administration Immediately After Primary Percutaneous Coronary Intervention on Microvascular Perfusion and Late Term Infarct Size in Patients With Acute Myocardial Infarction
The investigators hypothesized that complementary intracoronary streptokinase administration to primary percutaneous intervention in patients with acute myocardial infarction may provide further improvement in myocardial…
- Trial name
- NCT00302419
- Testing
- intracoronary infusion,, primary percutaneous coronary angioplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people
- Sponsor
- Istanbul University
Myocardial Infarction
A Trial of Low-dose Adjunctive alTeplase During prIMary PCI
The purpose of this study is to determine the safety and efficacy of reduced doses (10 mg and 20 mg) of intra-coronary alteplase compared with placebo as an adjunct to PCI in reducing MVO and its consequences in high risk…
- Trial name
- T-TIME (NCT02257294)
- Testing
- Alteplase
- Where
- 11 sites in United Kingdom
- Volunteers
- 440 people
- Sponsor
- NHS Greater Glasgow and Clyde
Hypovolemic Shock, Cardiogenic Shock
Renal Resistive Index in Patients With Shock
This study consists of two substudies. The first substudy: 'Renal resistive index in critically ill patients with cardiogenic and septic shock' Design: cross-sectional observational Aim of this project is: 1.
- Conditions
- Hypovolemic Shock, Cardiogenic Shock, Septic Shock, Kidney Failure, Acute
- Trial name
- NCT02558166
- Where
- Netherlands
- Volunteers
- 92 people
- Sponsor
- Amsterdam UMC, location VUmc
Myocardial Infarction
Evaluation of a Strategy Guided by Imaging Versus Systematic Coronary Angiography in Elderly Patients With Ischemia
The WHO predicts that cardiovascular morbi-mortality will increase by 120-137% within 20 years due to the aging population. Myocardial infarction without ST segment elevation (NSTEMI) is the most common form of infarction.
- Trial name
- EVAOLD (NCT03289728)
- Testing
- Stress single photon emission CT (SPECT) or Stress ultrasound with dobutamine (DSE), Cornorary angioplasty
- Where
- 2 sites in France
- Volunteers
- 588 people
- Sponsor
- University Hospital, Grenoble
Myocardial Infarction
Innovative Stratification of Arrhythmic Risk (ISAR-Trial): Eldery
The objective of this study was to determine the prognostic utility of established risk predictors following acute ST elevation myocardial infarction in patients over 75 years of age.
- Trial name
- NCT00196300
- Where
- 2 sites in Germany
- Volunteers
- 500 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Angina, Unstable, Myocardial Infarction
Heart Function and Exercise Capacity in Patients With Hypertrophic Cardiomyopathy
This study will examine the relationship between certain measures of heart function and exercise capacity in patients with hypertrophic cardiomyopathy (HCM).
- Conditions
- Angina, Unstable, Myocardial Infarction, Ischemic Heart Disease
- Trial name
- NCT00354328
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypogonadism, Acute Myocardial Infarction: Rehabilitation Phase
Effect of Testosterone Replacement on Exercise Capacity in Hypogonadal Men After a Recent Myocardial Infarction
The purpose of this study is to determine the effects of testosterone replacement in hypogonadal men on exercise tolerance and cardiac rehabilitation after an acute myocardial infarction.
- Trial name
- NCT02803073
- Testing
- Testosterone, Normal Saline
- Where
- United States
- Sponsor
- Texas Tech University Health Sciences Center
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