Clinical trials: Heart Infarction
ST-Elevation Myocardial Infarction
Colchicine's Efficacy in MI Patients: Comparing PCI and Non-Reperfusion Approaches
This study investigates the effect of Colchicine in preventing heart structure changes following ST-segment elevation myocardial infarction.
- Trial name
- NCT06426537
- Testing
- Colchicine 0.5 MG Oral Tablet
- Where
- Indonesia
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Brawijaya
Cardiogenic Shock, Myocardial Infarction
Quality of Care in Centers Providing Extracorporeal Membrane Oxygenation
Cardiac arrest centers are specialized in treating critically ill patients with severe cardiovascular diseases, such as cardiac arrest, cardiogenic shock or acute myocardial infarction.
- Conditions
- Cardiogenic Shock, Myocardial Infarction, Cardiac Arrest, Extracorporeal Circulation; Complications
- Trial name
- NCT05331001
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Ischemic Heart Failure, Ischemic Heart Disease
Study to Examine the Safety and Effectiveness of Implanted Skeletal Muscle Cells (Cells Removed From the Thigh Muscle) Into Scarred Areas of Heart Muscle After Heart Attack.
Study to examine the safety and effectiveness of implanted skeletal muscle cells (cells removed from the thigh muscle) into scarred areas of heart muscle after heart attack.
- Conditions
- Ischemic Heart Failure, Ischemic Heart Disease, Ischemic Cardiomyopathy
- Trial name
- NCT00102128
- Testing
- Cellular Therapy (Cultured Autologous Skeletal Myoblast Transplantation)
- Where
- 28 sites in Belgium, France and 4 more
- Sponsor
- Genzyme, a Sanofi Company
Heart Failure With Reduced Ejection Fraction, Ventricular Arrhythmia
Circulating RNA Markers of Ventricular Arrhythmias in Remotely Monitored Patients With Post-Infarction Heart Failure and Implanted Cardioverter-Defibrillators
This prospective observational study evaluates whether circulating small non-coding RNAs, particularly microRNAs, are associated with ventricular arrhythmias in patients with post-myocardial infarction heart failure who have an…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Ventricular Arrhythmia, Ischemic Cardiomyopathy
- Trial name
- NCT07795892
- Testing
- Circulating Small RNA Profiling
- Where
- Poland
- Volunteers
- 57 people
- Sponsor
- University of Rzeszow
Thrombosis, Myocardial Infarction
Differential EFfects of Dual antIplatelet and Dual aNtithrombotic thErapy on Hemostasis in Chronic Coronary Syndrome Patients
The investigators will be comparing the effects of two different drug treatment strategies, in patients with history of a heart attack, on different markers of bleeding and clotting risk.
- Trial name
- DEFINE CCS (NCT05116995)
- Testing
- Rivaroxaban, Ticagrelor
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Nova Scotia Health Authority
Cardiogenic Shock
French Observatory on the Management of Cardiogenic Shock 2
The aim of this observational study is to describe the baseline characteristics, management strategies, and early outcomes (during hospitalisation and at 30 days) of patients admitted to intensive care with cardiogenic shock…
- Trial name
- FRENSHOCK 2 (NCT07868757)
- Where
- 2 sites in France
- Volunteers
- 1,000 people
- Sponsor
- French Cardiology Society
Acute ST Segment Elevation Myocardial Infarction
Safety and Efficacy of Percutaneous Coronary Intervention Combined With Thrombolysis at Different Time
Patients with acute ST-segment elevation myocardial infarction and thrombolysis indications, will be given the recombinant human prourokinase for thrombolysis treatment, and in accordance with the guidelines, will be treated with…
- Trial name
- SEPCIT (NCT03137212)
- Testing
- thrombolysis and PCI of A type, thrombolysis and PCI of B type
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Hospital of Jilin University
Acute Myocardial Infarction
Association of Air Quality and Myocardial Infarction
Besides classical cardiovascular risk factors such as smoking, obesity, elevated cholesterol levels and diabetes there are also acute factors potentially triggering acute coronary events.
- Trial name
- NCT02880436
- Testing
- air pollution
- Where
- Austria
- Volunteers
- 12,000 people
- Sponsor
- Medical University of Graz
Myocardial Infarction
The Effect of Education and Telephone Follow-up Intervention Based on the Roy Adaptation Model
In this parallel randomized controlled trial (n = 33/group), the control group received routine care, while the intervention group received a telephone follow-up intervention, which consisted of a pre-discharge education program…
- Trial name
- NCT03771937
- Testing
- Education and telephone follow-up intervention
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Atherosclerotic Cardiovascular Disease
In Silico Study Assessing the Impact of Inclisiran on Major Adverse Cardiovascular Events in Patients With Established Cardiovascular Disease
Study CKJX839B1FR01 in an In silico trial to predict the efficacy of Inclisiran therapy on major adverse cardiovascular events (MACE) and cardiovascular (CV) death in virtual patients with atherosclerotic cardiovascular disease…
- Trial name
- SIRIUS (NCT05974345)
- Testing
- Inclisiran sodium, Ezetimibe, Evolocumab
- Where
- France
- Volunteers
- 204,691 people
- Sponsor
- Novartis Pharmaceuticals
Coronary Heart Disease
China PEACE-Prospective AMI Study
Coronary heart disease (CHD) and heart attacks pose a serious health risk to men and women, however little information is available about how evidence-based therapies are incorporated appropriately into routine clinical practice…
- Trial name
- NCT01624909
- Where
- China
- Volunteers
- 4,286 people
- Sponsor
- China National Center for Cardiovascular Diseases
Non ST Elevation Myocardial Infarction, Unstable Angina
Conservative Non-Invasive Versus Routine Invasive Management in Coronary Artery Bypass Surgery Patients with Non ST Elevation Elevation Acute Coronary Syndrome
Background: Most coronary artery bypass grafts (CABG) are diseased or blocked within 10 years of surgery meaning CABG survivors have an ever increasing risk of recurrent angina, heart attack and death.
- Trial name
- CABG-ACS (NCT01895751)
- Testing
- Invasive management
- Where
- 5 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- NHS National Waiting Times Centre Board
Cardiovascular Shock
Central Venous Pressure (CVP) Changes do Not Predict Preload Unresponsiveness
Passive leg raising (PLR) is routinely used to predict preload responsiveness in critically ill patients. However, real-time measurements of cardiac output are required to assess its effects.
- Trial name
- NCT03753672
- Testing
- preload responsiveness
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Hopital Antoine Beclere
Cerebral Infarction
Evaluation of Ambulatory ECG Telemetry for the Early Detection of Atrial Fibrillation During Hospital Assessment of Cerebral Infarction
The aim of the study is to show that an ambulatory ECG telemetry monitoring of some patients hospitalized for cerebral infarction increases the frequency of the diagnosis of atrial fibrillation, cause of their stroke, and…
- Trial name
- TELEMETRIE (NCT03992157)
- Testing
- ECG telemetry
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Hopital Foch
Myocardial Infarction
Moderate Alcohol Consumption and Heart Function in Patients With a Recent Myocardial Infarction
A total of 220 patients (110 per arm) who report moderate alcohol consumption between 1 and 28 standard units (1 standard unit = ~10 grams) per week in the 12 months prior to hospital admission will be planned for randomization…
- Trial name
- Moderate (NCT05920629)
- Testing
- Alcohol consumption
- Where
- 4 sites in Switzerland
- Volunteers
- 220 people
- Sponsor
- Baris Gencer
Coronary Artery Disease
Effects of Exercise Training on Endothelial Function, Inflammation, Arterial Stiffness and Autonomic Function in CAD
The main purposes of this study is to analyze, in a randomized controlled trial, the effects of an exercise-based cardiac rehabilitation program (i) on biomarkers of endothelial function, (ii) on biomarkers of inflammation, (iii)…
- Trial name
- NCT01432639
- Testing
- Exercise-based cardiac rehabilitation program
- Where
- Portugal
- Volunteers
- 96 people
- Sponsor
- Universidade do Porto
Atherosclerotic Cardiovascular Disease, Coronary Artery Disease
The Young Heart Study
The purpose of our project is to better understand the characteristics of the young patients with coronary artery disease presenting for cardiac catheterization at our institution and to put forth a program to optimize their risk…
- Trial name
- NCT04462159
- Testing
- Risk Reduction Program
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwell Health
STEMI, PCI
Intravascular Ultrasound guidaNce versuS angIoGrapHy Guidance in Patients With ST-segment Elevation Myocardial Infarction
STEMI represents the subtype of ACS with the worst prognosis, associated with high mortality and an elevated risk of complications. The use of IVI guidance holds the potential to reduce the incidence of MACE.
- Trial name
- INSIGHT-STEMI (NCT07616024)
- Testing
- Intravascular Ultrasound, Coronary angiography guidance
- Where
- China
- Volunteers
- 2,488 people
- Sponsor
- Shanghai Zhongshan Hospital
Cardiovascular Disease
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of AZD3366 in Healthy Subjects, Japanese and Chinese Subjects
Part A of this study is a Phase 1, First-in-human (FiH), randomized, single-blind, placebo controlled study to assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of AZD3366 following single…
- Trial name
- NCT04588727
- Testing
- AZD3366, Ticagrelor, acetylsalicylic acid (ASA)
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Acute Myocardial Infarction, Percutaneous Coronary Intervention
Effects of Different Vasodilators on Coronary No-reflow During primAry percuTaneous Coronary intErvention in Patients With Acute Myocardial Infarction
The purpose of this study is to evaluate the efficacy of three different vasodilators including diltiazem, verapamil and nitroglycerin for reversal of no-reflow/slow-flow during direct percutaneous coronary intervention for acute…
- Trial name
- EDUCATE-AMI (NCT00712894)
- Testing
- Diltiazem, Verapamil, Nitroglycerin
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Fudan University
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