Clinical trials: Heart Infarction
Aortic Stenosis, Cardiogenic Shock
Transcatheter AortiC Valve Implantation in aorTic stenosIs CardiogenIc Shock
The goal of this clinical trial is to learn if acute transcatheter aortic valve implantation (TAVI) is superior to standard treatment (stabilization in an intensive care unit and TAVI subsequently) to treat cardiogenic shock in…
- Trial name
- TACTICS (NCT06638268)
- Testing
- Acute TAVI, Stabilization and subacute TAVI
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Vascular Death, Myocardial Infarction
Vascular Events In Surgery patIents cOhort evaluatioN - Cardiac Surgery
Worldwide over 2 million adults (>30,000 Canadians) undergo heart surgery annually. Although heart surgery provides important survival benefits, it is associated with potential major complications such as death, stroke, and heart…
- Conditions
- Vascular Death, Myocardial Infarction, Stroke, Cardiac Surgery
- Trial name
- NCT01842568
- Where
- 24 sites in United States, Australia and 10 more
- Volunteers
- 15,989 people
- Sponsor
- Population Health Research Institute
Acute Myocardial Infarction
Safety Study of Allogeneic Mesenchymal Precursor Cell Infusion in Myocardial Infarction
This was a double-blind, randomized, placebo-controlled study that was designed to enroll a total of 225 participants with de novo anterior wall acute ST-segment elevation myocardial infarction (STEMI) due to a lesion of the left…
- Trial name
- AMICI (NCT01781390)
- Testing
- Mesenchymal Precursor Cells (MPC) 12.5 M, Mesenchymal Precursor Cells (MPC) 25 M
- Volunteers
- 106 people
- Sponsor
- Mesoblast, Inc.
Myocardial Infarction, Myocardial Ischemia
18F-fluorocholine PET-MR Imaging of Coronary Plaque Vulnerability
This study is designed as a prospective observational feasibility study. The investigators will study whether vulnerable plaques on OCT (fibrous cap ≤ 70 μm) show a locally increased uptake of 18F-choline on PET-MRI compared to…
- Conditions
- Myocardial Infarction, Myocardial Ischemia, Atherosclerosis, Coronary Artery Disease
- Trial name
- NCT03252990
- Testing
- PET-MRI, Optical Coherence Tomography
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Cardiovascular Diseases, Coronary Disease
Magnesium in Coronaries (MAGIC)
To determine whether early intravenous magnesium treatment of patients with suspected acute myocardial infarction reduces mortality.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00000610
- Testing
- magnesium
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Myocardial Injury
Perioperative Endothelial Dysfunction in Patients Undergoing Minor Abdominal Surgery
This study on minor surgery serves to explore whether a dose-response relationship exists between surgical stress and endothelial dysfunction in the early postoperative period.
- Trial name
- POETRYminor (NCT02690233)
- Testing
- Elective Surgery
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Zealand University Hospital
Cardiovascular Diseases, Coronary Disease
Individual Nurse-led Counselling Programme for Patients Early Discharged After Myocardial Infarction.
The European guidelines of cardiovascular disease prevention recommend treatment modalities, such as lifestyle changes in order to minimize the risk of further cardiac event after a myocardial infarction (MI).
- Conditions
- Cardiovascular Diseases, Coronary Disease, Myocardial Infarction
- Trial name
- NCT02640274
- Testing
- Nurse-led counselling programme, Usual care
- Where
- Norway
- Volunteers
- 71 people
- Sponsor
- Helse Nord-Trøndelag HF
Acute Myocardial Infarction, Acute Coronary Syndrome
Use of High Sensitivity Cardiac Troponin In Ruling Out Emergency Patients With Acute Myocardial Injury and Infarction
Examine the analytical and clinical performance of Atellica IM TnIH assay for the diagnosis and rule out of acute myocardial injury and myocardial infarction in patients presenting to the emergency department in whom serial cTnI…
- Trial name
- SAFETY (NCT04280926)
- Testing
- Cardiac Troponin Testing
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Fred Apple
Cardiogenic Shock, Acute Myocardial Infarction
Revascularization Strategy of Multivessel Disease for Patients with Acute Myocardial Infarction Complicated by Cardiogenic Shock Undergoing Veno-arterial Extracorporeal Membrane Oxygenator
This study is a prospective, open-label, two-arm, randomized multicenter trial to identify whether immediate multi-vessel PCI would be better in clinical outcomes compared with culprit lesion-only PCI for AMI and multi-vessel…
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, Multi Vessel Coronary Artery Disease, Extracorporeal Membrane Oxygenation
- Trial name
- RESCUE-SHOCK (NCT05527717)
- Testing
- Culprit lesion only PCI, Immediate multi-vessel PCI
- Where
- South Korea
- Volunteers
- 560 people
- Sponsor
- Samsung Medical Center
Atherosclerosis, Myocardial Ischemia
Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Particpants With Acute Coronary Syndrome (TRA•CER) (Study P04736)
The study is designed to determine whether vorapaxar, when added to the existing standard of care (eg, aspirin, clopidogrel) for preventing heart attack and stroke in patients with acute coronary syndrome, will yield additional…
- Conditions
- Atherosclerosis, Myocardial Ischemia, Myocardial Infarction
- Trial name
- NCT00527943
- Testing
- Vorapaxar
- Volunteers
- 12,944 people
- Sponsor
- Merck Sharp & Dohme LLC
ST Segment Elevation Myocardial Infarction
China STEMI-PCI Program
1. Registration 2. Performing in three stages 3. Major aim: Much more and standard reperfusion therapy in STEMI patients
- Trial name
- NCT01716884
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Peking University First Hospital
Stable Angina, Unstable Angina
Clinical Performance of CRE8 Drug Eluting Stent in All Comer Population
The aim of this study is to evaluate safety and efficacy performances of CRE8 Drug Eluting Stent, in patients comparable to the everyday's clinical practice population, with a specific focus on diabetics, that will be part of a…
- Conditions
- Stable Angina, Unstable Angina, Acute Myocardial Infarction
- Trial name
- PARTICIPATE (NCT01556126)
- Testing
- Amphilimus Eluting Stent (CRE8)
- Where
- 23 sites in Austria, Belgium and 4 more
- Volunteers
- 1,191 people
- Sponsor
- CID - Carbostent & Implantable Devices
Myocardial Infarction
TREatment With Beta-blockers After myOcardial Infarction withOut Reduced Ejection fracTion"
REBOOT clinical trial will study whether long-term maintenance beta-blockers therapy results in a clinical benefit after heart attack without reduced left ventricular function.
- Trial name
- NCT03596385
- Testing
- Beta blocker
- Where
- 111 sites in Italy, Spain
- Volunteers
- 8,505 people
- Sponsor
- Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Acute Myocardial Infarction, Coronary Artery Disease
Air Verses Oxygen In myocarDial Infarction Study
Aim The AVOID (Air Verses Oxygen In myocardial infarction) trial is designed to determine if the withholding of routine oxygen therapy in patients with acute heart attack leads to reduced heart damage compared to the current…
- Trial name
- AVOID (NCT01272713)
- Testing
- Oxygen therapy, No oxygen therapy
- Where
- 10 sites in Australia
- Volunteers
- 638 people
- Sponsor
- Bayside Health
Acute Myocardial Infarction, Disorder; Heart, Functional, Postoperative, Cardiac Surgery
High-sensitivity Troponin T in Acute Myocardial Infarction After Cardiac Valvular Surgery
A measurable degree of heart muscle tissue injury is expected in patients undergoing heart valvular surgery. The level of this injury can be measured by cardiac biomarkers in blood samples.
- Conditions
- Acute Myocardial Infarction, Disorder; Heart, Functional, Postoperative, Cardiac Surgery, Myocardial Infarction, Heart Valve Diseases
- Trial name
- NCT02518282
- Testing
- Serum levels of high-sensitivity troponin T, Twelve-lead ECGs, Transthoracic echocardiography (TTE)
- Where
- Spain
- Volunteers
- 800 people
- Sponsor
- University of Valladolid
Acute Myocardial Infarction, Revascularization
Long Term Predictors of Acute Myocardial Infarction in Patients With Coronary Revascularization
Worldwide, Ischemic heart disease is the single most common fatal disease. One of the most common causes of acute myocardial infarction is represented by obesity.
- Trial name
- NCT06546228
- Testing
- No intervention. Only observational.
- Where
- Italy
- Volunteers
- 652 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Cardiovascular Diseases
Bioabsorbable Scaffold vs Drug-coated Balloon for Coronary de Novo Lesions in STEMI: Prospective Observational Trial
a prospective, single center, observational clinical trail. Aim to to compare the efficacy and safety of the Bioabsorbable scaffold (BRS) Neovas BRS and Drug-coating balloon (DCB) in the treatment of STEMI patients with coronary…
- Trial name
- NeovasvsDCB (NCT04565561)
- Testing
- Neovas BRS or DCB
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shenzhen People's Hospital
Venous Thromboembolism (VTE), Acute Myocardial Infarction With ST Segment Elevation
Heat Shock Protein 47 in Thrombosis
The goal of this observational study is to learn if the novel biomarker Heat shock protein 47 (HSP47) can be used as a prognostic marker for vascular disease in people with acute venous thromboembolism (VTE), myocardial…
- Conditions
- Venous Thromboembolism (VTE), Acute Myocardial Infarction With ST Segment Elevation, Stroke (in Patients With Atrial Fibrillation)
- Trial name
- NCT06731673
- Where
- 2 sites in Denmark, Germany
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Myocardial Infarction
Beta Blocker Interruption After Uncomplicated Myocardial Infarction
ABYSS is a national, multicenter, randomised, open label trial using the PROBE study design, that will evaluate the non-inferiority of the interruption of ΒB therapy after an uncomplicated MI after six months or more of follow-up…
- Trial name
- AβYSS (NCT03498066)
- Testing
- Beta-blockers withdrawal, Continuation of the Betablockers (βB) treatment
- Where
- France
- Volunteers
- 3,700 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myocardial Infarction, Chronic Obstructive Pulmonary Disease
Survival After First Myocardial Infarction in Patients With and Without Chronic Obstructive Pulmonary Disease
An estimated three million people are affected by chronic obstructive pulmonary disease (COPD) in the UK, giving it a prevalence of 1.5% of the population in 2007/08.
- Trial name
- NCT01335672
- Where
- United Kingdom
- Volunteers
- 2,100,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
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