Clinical trials: Heart Infarction
Myocardial Infarction
Postconditioning in ST-elevation Myocardial Infarction
Study objectives: To assess the effects of postconditioning on infarct size in patients with ST-elevation infarction referred to PCI. Study design: Prospective, randomized, open-label study with blinded endpoint evaluation.
- Trial name
- POSTEMI (NCT00922675)
- Testing
- Postconditioning, Control intervention
- Where
- Norway
- Volunteers
- 272 people
- Sponsor
- Oslo University Hospital
Stroke, Myocardial Infarctions
Aspirin Resistance and Stroke Risk: Platelet Function Analysis in Patients With Ischemic Events
The purpose of this study is to determine if PFA results correlate with ischemic event outcomes as well as bleeding complications.
- Trial name
- NCT01586975
- Testing
- Clopidogrel, Aspirin 81 mg, Aspirin >300 mg
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Northwestern University
Coronary Artery Disease, Myocardial Infarction
Efficacy of the Integration of Digital Therapeutics and Home-based Cardiac Rehabilitation in High-Risk Post-PCI Patients
The DTx-HBCR trial will randomize 366 high-risk patients who undergo PCI at the West China Hospital of Sichuan University to either the 6-month DTx-guided HBCR group (intervention group) or the 6-months usual care group (control…
- Trial name
- NCT06542575
- Testing
- DTx-guided HBCR
- Where
- China
- Volunteers
- 366 people
- Sponsor
- West China Hospital
Diabetes, Myocardial Infarction
Look AHEAD: Action for Health in Diabetes
The Look AHEAD study is a multi-center, randomized clinical trial to examine the long-term effects of a lifestyle intervention designed to achieve and maintain weight loss.
- Conditions
- Diabetes, Myocardial Infarction, Stroke, Kidney Diseases
- Trial name
- LookAHEAD (NCT00017953)
- Testing
- Lifestyle Intervention, Diabetes Support and Education
- Where
- 18 sites in United States
- Volunteers
- 5,145 people
- Sponsor
- Wake Forest University Health Sciences
Acute Myocardial Infarction
Bivalirudin in Acute Myocardial Infarction
The purpose of the study is to evaluate the efficacy and safety of bivalirudin in AMI patients with DES. This is a prospective, randomized, single-blind, active drug controlled multicenter clinical research and the study would…
- Trial name
- NCT02897037
- Testing
- Bivalirudin, heparin
- Where
- China
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Acute Coronary Syndrome, Myocardial Infarction
Utilization of Diagnostic Ultrasound in the Detection and Therapy of Acute Coronary Syndromes
The study will see if mechanical impulses delivered by an echocardiographic probe during a continuous infusion of MRX 801 are capable of improving blood flow in smaller heart vessels in patients with acute coronary syndromes.
- Trial name
- NCT00955136
- Testing
- Use of intermittent high MI impulses during echocardiogram
- Sponsor
- University of Nebraska
Cardiovascular Diseases, Heart Diseases
Protein S and Myocardial Infarction
To test the hypothesis that low levels of free protein S, a natural anticoagulant protein in plasma, were associated with an increased incidence of myocardial infarction in middle aged men and women.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00005329
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
ST-elevation Myocardial Infarction
Early Treatment With Evolocumab in Patients With ST-elevation Myocardial Infarction
This is a prospective, multi-centre, open label, randomised study of Phase II that enrolls patients hospitalized with a diagnosis of ST-elevation myocardial infarction (STEMI), comparing Evolocumab versus Standard of Care.
- Trial name
- ExOTIC (NCT04303377)
- Testing
- Evolocumab
- Where
- Italy
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Cardiac Arrest, Cardiopulmonary Resuscitation
Evaluation of eCPR Survivors
A cardiac arrest event has severe impact on the patient´s health-related quality of life. Survival of cardiac arrest does not innately translate to favorable quality of life.
- Conditions
- Cardiac Arrest, Cardiopulmonary Resuscitation, Extracorporeal Membrane Oxygenation Complication, Myocardial Infarction
- Trial name
- NCT05339854
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Charite University, Berlin, Germany
Atrial Fibrillation, Ischemic Stroke
Direct Oral Anticoagulants in Patients With Atrial Fibrillation (DOACs vs Warfarin)
The purpose of this study is to assess safety and effectiveness of direct oral anticoagulants (DOACs) and warfarin for stroke prevention in patients with non-valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation, Ischemic Stroke, Systemic Embolization, Major Bleed
- Trial name
- NCT03596502
- Testing
- Direct oral anticoagulants (DOACs), Warfarin
- Where
- Canada
- Volunteers
- 402,764 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Acute Myocardial Infarction
Exploratory P2 Trial to Evaluate Efficacy and Safety of Clotinab® (Abciximab) in Acute MI Patients
Exploratory Phase II Clinical Trial to Evaluate the Efficacy and Safety of Clotinab® (Abciximab) in Acute Myocardial Infarction Patients: Multicenter, Randomized, Double-Blind, Placebo-controlled and Parallel Group Trial
- Trial name
- NCT03087539
- Testing
- Abciximab
- Where
- South Korea
- Volunteers
- 146 people
- Sponsor
- ISU Abxis Co., Ltd.
Chest Pain, Acute Coronary Syndrome
Effectiveness and Safety of a Clinical Assessment and 0h/1h Troponin Rule-Out Protocol
Chest pain is a common presenting complaint at the Emergency Department (ED). Many of these patients undergo lengthy assessments in the ED or are admitted which contributes to ED and hospital crowding as well as a substantial…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Myocardial Infarction, Unstable Angina
- Trial name
- ESC-TROP (NCT03421873)
- Testing
- 0h/1h hs-cTnT protocol
- Where
- 5 sites in Sweden
- Volunteers
- 16,000 people
- Sponsor
- Ulf Ekelund
Myocardial Infarction, Acute, Left Ventricular Thrombus
Direct Oral Anticoagulants for Prevention of lEft ventRIcular Thrombus After Anterior Acute Myocardial InFarction - APERITIF
APERITIF is a prospective randomized open-label, blinded end-point (PROBE) trial, nested in the ongoing the "FRENCHIE" registry, a French multicenter prospective observational study granted by "ANR-RHU Grand Emprunt", in which…
- Trial name
- APERITIF (NCT05077683)
- Testing
- Rivaroxaban 2.5 MG [Xarelto], DAPT strategy
- Where
- France
- Volunteers
- 560 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myocardial Infarction
Biomarkers and SNP-polymorphisms in Post-infarction Cardiac Remodeling
The purpose of this study is to explore the serum levels of pro- and anti-inflammatory biomarkers and angiogenic growth factors and SNP polymorphisms of the promoter regions of their genes as well as to determine their role in…
- Trial name
- NCT04296253
- Testing
- SNP polymorphisms of the promoter regions pro - and anti-inflammatory cytokines and angiogenic growth factor
- Where
- Russia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
To Investigate the Effect of CHIP on Renal Insufficiency in AMI Patients
Clonal Hematopoiesis on Prognosis in Patients With Myocardial Infarction
This is an observational study without intervention. It is planned to include 500 patients with AMI from October 2023 to July 2026.The study was divided into three parts.
- Trial name
- NCT06156319
- Testing
- No intervention
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yang Jing
ST Elevation Myocardial Infarction
Supplemental Oxygen in Catheterized Coronary Emergency Reperfusion
The aim of SOCCER is to evaluate the effects of treatment with supplemental O2 before and during acute balloon angioplasty (PCI) for patients with ST-elevation myocardial infarction (STEMI).
- Trial name
- SOCCER (NCT01423929)
- Testing
- Oxygen, Room air
- Where
- 3 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Region Skane
Myocardial Infarction, Ischemia
Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II
AliveCor (www.alivecor.com) has developed several electrocardiogram (ECG) devices that interface with iOS and Android smartphones and tablets via various Kardia apps.
- Conditions
- Myocardial Infarction, Ischemia, Myocardial Ischemia, Heart Diseases
- Trial name
- STLEUISII (NCT06271577)
- Testing
- AliveCor 12-lead ECG
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- AliveCor
Troponin, Critical Care
Prognostic Value of Elevated Troponins in Critical Illness Study: A Pilot Study
Troponins are sensitive and specific markers of cardiac injury. Critically ill patients frequently have elevated troponins. In this population, distinguishing patients with elevated troponins from those with myocardial infarction…
- Conditions
- Troponin, Critical Care, Myocardial Infarction
- Trial name
- PRO-TROPICS (NCT02285686)
- Volunteers
- 251 people
- Sponsor
- McMaster University
Myocardial Infarction, Percutaneous Coronary Intervention
Comparison of Titanium-Nitride-Oxide Coated Bio-Active-Stent (Optimax™) to the Drug (Everolimus) -Eluting Stent (Synergy™) in Acute Coronary Syndrome
The purpose of the prospective, randomized and a multicenter trial is to compare clinical outcome in patients presenting with ACS, treated with PCI using Optimax-BAS versus Synergy-EES.
- Conditions
- Myocardial Infarction, Percutaneous Coronary Intervention, Atherosclerosis
- Trial name
- TIDES-ACS (NCT02049229)
- Testing
- percutaneous coronary intervention
- Where
- 6 sites in Finland
- Volunteers
- 1,800 people
- Sponsor
- The Hospital District of Satakunta
Coronary Artery Disease, Coronary Stenosis
ILUMIEN IV: OPTIMAL Percutaneous Coronary Intervention (PCI)
The objective of this prospective, single-blind clinical investigation is to demonstrate the superiority of an Optical Coherence Tomography (OCT)-guided stent implantation strategy as compared to an angiography-guided stent…
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Atherosclerosis, STEMI
- Trial name
- NCT03507777
- Testing
- Coronary PCI guided by OCT, Coronary PCI guided by Angiography
- Where
- 90 sites in United States, Australia and 18 more
- Volunteers
- 2,487 people
- Sponsor
- Abbott Medical Devices
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