Clinical trials: Heart Infarction
Acute ST Elevation Myocardial Infarction
Assessment of Lumen Expansion After Thrombus Extraction in Primary Percutaneous Coronary Intervention
To use IVUS to assess (1) culprit plaque morphology and thrombus burden in patients with ST-elevation myocardial infarction; (2) the efficacy of thrombus removal with an aspiration catheter in 40 patients during primary PCI.
- Trial name
- INVEST-MI (NCT01878487)
- Testing
- Thrombus aspiration (Intravascular Ultrasound catheter (Boston))
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Coronary Arterial Disease (CAD), Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)
Artificial Intelligence Based Timing, Infarct Size and Outcomes in Acute Coronary Occlusion Myocardial Infarction
The present study is practice-driven and merely observational and prospective. In clinical routine, patients who suffer from suspected ACS and do not show ST elevation in the ECG, different timing proposals in the guidelines and…
- Trial name
- ANOMI (NCT06910436)
- Testing
- Coronary Angiogram
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Azienda Ospedaliera di Bolzano
Myocardial Infarction (MI), Tobacco Use
Telegram Messenger Support for Smoking Cessation After Heart Attack
This randomized controlled trial will evaluate whether a 6-month behavioral intervention delivered via Telegram messenger increases smoking cessation rates in patients after myocardial infarction (MI).
- Conditions
- Myocardial Infarction (MI), Tobacco Use, Smoking Cessation
- Trial name
- TELEGRAM-MI (NCT07230249)
- Testing
- Telegram-based Smoking Cessation Support, Standard Care (in control arm)
- Where
- Russia
- Volunteers
- 142 people
- Sponsor
- ITMO University
Predictive Value of Admission Blood Glucose Level in Acute Myocardial Infarction
Predictive Value Of Admission Blood Glucose Level In Patients With Acute Myocardial Infarction
Coronary atherosclerosis is the leading cause of death worldwide. Diabetes mellitus is associated with increased prevalence of coronary artery disease Increased plasma glucose is a common feature in the acute phase of myocardial…
- Trial name
- NCT03164707
- Testing
- Blood Glucose Level
- Volunteers
- 100 people
- Sponsor
- Assiut University
Sleep Disorders, Sleep Apnea
Bedside Sleep Medicine
The investigators aimed to evaluated the role of bedside sleep medicine in an cardiology intensive care unit. The patients will be submitted to a overnight polysomnography.
- Conditions
- Sleep Disorders, Sleep Apnea, Acute Myocardial Infarction, Acute Decompensated Heart Failure
- Trial name
- NCT01924507
- Testing
- CPAP
- Where
- Brazil
- Volunteers
- 400 people
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Myocardial Infarction
Sevoflurane and Percutaneous Coronary Intervention by Stent
Increase in CK-MB after percutaneous coronary angioplasty more than 100% of baseline can represents a problem to the patients resulting in increase of morbidity and mortality.
- Trial name
- NCT02671084
- Testing
- sevoflurane
- Where
- Brazil
- Volunteers
- 701 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Myocardial Infarction, Acute Coronary Syndrome
Hydroxychloroquine for the Prevention of Cardiovascular Events in Myocardial Infarction Patients - a Safety Pilot Trial
This safety pilot study evaluates the effect of hydroxychloroquine on preventing recurrent cardiovascular events among myocardial infarction patients.
- Conditions
- Myocardial Infarction, Acute Coronary Syndrome, Inflammation, Hydroxychloroquine
- Trial name
- OXI (NCT02648464)
- Testing
- Hydroxychloroquine
- Where
- 6 sites in Finland
- Volunteers
- 125 people
- Sponsor
- Helsinki University Central Hospital
Myocardial Infarction
A Study of NP-011 in Healthy Volunteers
This is a Phase 1, randomised, double-blind, placebo-controlled, single ascending dose (SAD) and multiple ascending dose (MAD) study to evaluate the safety, tolerability, and pharmacokinetic of NP-011 in healthy volunteers.
- Trial name
- NCT05387499
- Testing
- NP-011 (Single Ascending Dose Phase), NP-011 (Multiple Ascending Dose Phase)
- Where
- Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Nexel Co., Ltd.
Myocardial Infarction, Myocardial Ischemia
Co-transplantation of Mesenchymal Stem Cell Derived Exosomes and Autologous Mitochondria for Patients Candidate for CABG Surgery
Heart failure (HF) and acute myocardial infarction that often follows are among the main causes of disability and death worldwide.
- Conditions
- Myocardial Infarction, Myocardial Ischemia, Myocardial Stunning
- Trial name
- NCT05669144
- Testing
- mitochondria and MSC-derived exosomes
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Tehran University of Medical Sciences
Myocardial Infarction, Drug-Coated Balloon
Prevail Drug Balloon Study
This is an investigator-initiated, prospective, single-centre, non-randomized, all-comers registry that evaluates the safety and efficacy of any Paclitaxel Drug-Coated Balloon (DCB) for the treatment of coronary de novo lesion…
- Trial name
- NCT05562089
- Testing
- A Paclitaxel Drug-Coated Balloon
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Coronary Artery Disease
Pre-hOspital Evaluation of Chest Pain Patients With sUspected Non ST-segment eLevation myocARdial Infarction Using the HEART-score With a Troponin Point-of-care Test
Overcrowding in the emergency department is an increasing problem in hospitals worldwide. Point-of-care Troponin (POC cTn) testing combined with a well investigated risk stratification tool (HEART-score) used in the ambulance may…
- Trial name
- POPular HEART (NCT04851418)
- Testing
- Possible NSTE-ACS
- Where
- 2 sites in Netherlands
- Volunteers
- 650 people
- Sponsor
- St. Antonius Hospital
In-stent Restenosis Lesion, Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
Sirolimus With corTicOsteroid TheraPy for Rapid rEcurrences of Coronary Unexplained In-stent Restenosis
This study aims to evaluate, through a multicenter, prospective, double-blind, randomized, placebo-controlled clinical trial, whether immunosuppressive therapy improves target lesion-related cardiovascular outcomes compared to…
- Trial name
- STOP-RECUR (NCT06981845)
- Testing
- Immunosuppressive therapy
- Volunteers
- 52 people
- Sponsor
- China National Center for Cardiovascular Diseases
Shock, Cardiogenic, Cardiac Tamponade
Validation of Epworth Richmond's Echocardiography Education Focused Year
The use of echocardiography in intensive care is a developing field. In expert hands echocardiography has proven its utility in diagnosing cardiac pathology, differentiating shock states and in haemodynamic monitoring.
- Conditions
- Shock, Cardiogenic, Cardiac Tamponade, Pulmonary Embolism, Hypovolemia
- Trial name
- VEREEFY (NCT02961439)
- Testing
- Epworth Richmond's Echocardiography Focused Year
- Where
- Australia
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Epworth Healthcare
ST Elevation (STEMI) Myocardial Infarction
Development and Validation of a Cardiac Magnetic Resonance-Based Multimodal Deep Learning Model for Long-Term Outcome Prediction in ST-Segment Elevation Myocardial Infarction
Objective: This study aims to develop and test a novel artificial intelligence-based prediction model. This model will integrate cardiac magnetic resonance imaging and clinical data to predict the long-term risk of major adverse…
- Trial name
- NCT07277400
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Qian geng
Acute Coronary Syndrome, Percutaneous Coronary Intervention
A Cohort of Patients Undergoing Percutaneous Coronary Intervention
To investigate the risk factors involved in the occurrence and prognosis of the patients with acute coronary syndrome, patients undergoing percutaneous coronary intervention will be recruited and followed up for at least 2 years.
- Conditions
- Acute Coronary Syndrome, Percutaneous Coronary Intervention, Myocardial Infarction, Unstable Angina
- Trial name
- APCIcohort (NCT05719545)
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Su Guohai
Coronary Artery Disease, Coronary Artery Disease With Myocardial Infarction
Comparing a New Technique of Combining Carbon-dioxide With Electrocautery With Usual Technique of Stand-alone Electrocautery for Taking Down Left Internal Mammary Artery for Coronary Artery Bypass(CABG)
The goal of this study is to compare the efficacy of a new harvesting technique for an arterial conduit(LIMA - Left Internal Mammary artery) in patients undergoing Coronary artery bypass grafting.
- Trial name
- CABG (NCT06155045)
- Testing
- Modified Carbo-dissection Technique, Conventional Arm
- Where
- India
- Volunteers
- 46 people
- Sponsor
- Government Medical College Kottayam
Acute Coronary Syndrome
TnThs Predicting Evolving Non-STEMI
BACKGROUND: We sought to determine the diagnostic value of the new TnThs assay for early detection of evolving non-STEMI in patients with acute coronary syndrome and a negative 4th generation cTnT result on admission.
- Trial name
- NCT00953251
- Where
- Germany
- Volunteers
- 115 people
- Sponsor
- Heidelberg University
Vascular Diseases, Cardiovascular Diseases
Changes in Myocardial Biomechanics and Early Short-term Doxycycline Therapy in Patients With Primary Anterior STEMI
The purpose of the study is to investigate the changes of myocardial biomechanics and efficacy of doxycycline in patients with primary anterior STEMI.
- Conditions
- Vascular Diseases, Cardiovascular Diseases, Acute Myocardial Infarction
- Trial name
- MASTARD (NCT02562651)
- Testing
- Doxycycline, Standard care for STEMI
- Where
- Russia
- Volunteers
- 45 people
- Sponsor
- Russian Academy of Medical Sciences
Post-Infarction Heart Rupture, Post-Infarction Ventricular Septal Defect
Mechanical Complications of Acute Myocardial Infarction
Although the incidence of post-AMI mechanical complications has decreased in the last decades, mortality in patients who develop these complications after AMI still remains very high.
- Conditions
- Post-Infarction Heart Rupture, Post-Infarction Ventricular Septal Defect, Post-Infarction Mitral Papillary Muscle Rupture
- Trial name
- CAUTION (NCT03848429)
- Testing
- Surgery for mechanical complications of acute myocardial infarction
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Maastricht University Medical Center
Percutaneous Coronary Intervention (PCI), Acute Myocardial Infarction
Aerobic Exercise-induced Effect on Endothelial Function in Patients With Ischaemic Heart Disease
Endothelial dysfunction is one of the aetiological factors in ischaemic heart disease (IHD). Aerobic exercise is effective in improving endothelial function, as measured by flow-mediated dilation (FMD), in patients with IHD.
- Conditions
- Percutaneous Coronary Intervention (PCI), Acute Myocardial Infarction, Angina (Stable), Unstable Angina Pectoris
- Trial name
- ENDO-R (NCT06788275)
- Testing
- Aerobic exercise (MIT), Aerobic exercise (Short HIIT), Aerobic exercise (Long HIIT)
- Where
- 2 sites in Spain
- Volunteers
- 132 people
- Sponsor
- Instituto de Investigación Sanitaria y Biomédica de Alicante
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