Clinical trials: Heart Infarction
Acute Myocardial Infarction, Heart Failure With Preserved Ejection Fraction
Predictors and Outcomes of In-hospital HFpEF in AMI Patients
This retrospective observation is to investigate the incidence,clinical outcomes and prognosis of hospitalized heart failure with preserved ejection fraction (HFpEF) in patients with acute myocardial infarction(AMI).
- Conditions
- Acute Myocardial Infarction, Heart Failure With Preserved Ejection Fraction, Predictor, Prognosis
- Trial name
- NCT03351179
- Testing
- clinical characteristics, previous history, laboratory bio-markers, echocardiographic measurements, angiographic findings,clinical outcomes
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xiangjun Yang
Acute Myocardial Infarction, Unstable Angina
Therapeutic Use of Contrast Ultrasound in Acute Coronary Artery Disease
Preclinical studies have demonstrated that high mechanical index (MI) impulses from a diagnostic ultrasound (DUS) transducer during an intravenous microbubble infusion (sonothrombolysis) can restore epicardial and microvascular…
- Trial name
- HUBBLE-I (NCT04732091)
- Testing
- Therapeutic ultrasound with 20 usec
- Where
- 2 sites in United States, Brazil
- Volunteers
- 540 people
- Sponsor
- University of Sao Paulo General Hospital
Myocardial Infarction, Myocardial Ischemia
Pain Perception is Attenuated in Patients With Painless Myocardial Infarction
To explore whether reduced systemic pain perception in response to painful stimuli and personality pain related variables characterizes silent MI patients.
- Trial name
- NCT00192790
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
Coronary Heart Disease
Effect of Nicorandil on Cardiac Sympathetic Nerve for the Patients of Acute ST Segment Elevation Myocardial Infarction
The investigators evaluate the effects of intracoronary and intravenous administration of nicorandil on cardiac sympathetic nerve activity and distribution in patients with acute myocardial infarction undergoing primary…
- Trial name
- NCT04826497
- Testing
- nicorandil
- Volunteers
- 80 people
- Sponsor
- Xuzhou Central Hospital
Hypertension, Acute Myocardial Infarction
PCI and Renal Denervation in Hypertensive Patients With Acute Coronary Syndromes
Research hypothesis: Is the treatment with renal denervation (RDN) early post ACS safe and effective and does it leads to improved cardiac function and attenuation of pathologic left ventricular remodelling? In a following study…
- Trial name
- COMBI-RDN (NCT02272920)
- Testing
- Renal denervation
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Sahlgrenska University Hospital
Atherosclerosis, Ischemia
Trial to Assess the Ocular Safety of Vorapaxar (SCH 530348) in Participants With Atherosclerosis (Study P05183)
This study is designed to evaluate the long-term ocular safety of SCH 530348 (vorapaxar) in participants with established atherosclerotic disease who are enrolled into the TRA 2°P - TIMI 50 Study (P04737) (NCT00526474).
- Conditions
- Atherosclerosis, Ischemia, Myocardial Infarction, Cerebrovascular Accident
- Trial name
- NCT00617123
- Testing
- Vorapaxar 2.5 mg
- Volunteers
- 258 people
- Sponsor
- Merck Sharp & Dohme LLC
Chest Pain, ST Elevation Myocardial Infarction
The Accuracy of the Mini RELF Device for the Diagnosis of an Acute Coronary Artery Occlusion.
Patient delay in seeking medical attendance for symptoms of acute ST elevation myocardial infarction (STEMI) is the major obstacle to reduce the current mortality from acute coronary syndromes.
- Trial name
- RELF IIa (NCT02983396)
- Testing
- Diagnostic accuracy of Mini Relf Device
- Where
- 3 sites in Belgium
- Volunteers
- 64 people
- Sponsor
- University Ghent
Type 2 Myocardial Infarction, Coronary Artery Disease
Coronary Angiography in Critically Ill Patients With Type II Myocardial Infarction
Study type: prospective cohort and randomized trial. Duration: estimated 2 years. Indications: Type II myocardial infarction in critically ill patients. Purpose: 1.
- Conditions
- Type 2 Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention, Critical Illness
- Trial name
- NCT04043091
- Testing
- percutaneous coronary intervention (stenting)
- Where
- Slovenia
- Sponsor
- University Medical Centre Ljubljana
ST Elevation Myocardial Infarction, Cardiovascular Diseases
RUral dispaRities in prehospitAL STEMI
Rural Americans are more likely to be unhealthy, older, living in poverty, uninsured, and medically underserved. The CDC has made achieving health equity and improving cardiovascular health for rural Americans one of their…
- Trial name
- NCT04381260
- Testing
- No intervention, Interview, Survey
- Where
- United States
- Volunteers
- 473 people
- Sponsor
- Wake Forest University Health Sciences
ST-segment Elevation Myocardial Infarction (STEMI)
Prolonged Clinical Follow-up of OPTIMA-5
The OPTIMA-5 trial is a prospective, multi-center, randomized, patient blinded, controlled trial comparing a single bolus of half-dose recombinant staphylokinase (r-SAK) with normal saline (NS) in patients with ST-segment…
- Trial name
- NCT05649696
- Testing
- Recombinant Staphylokinase, Normal Saline
- Where
- 8 sites in China
- Volunteers
- 210 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Type2 Diabetes, Antiplatelet Drugs
Type 2 Diabetes With Antiplatelet Drugs
Tabula Rasa HealthCare (TRHC), d/b/a CareKinesis, is the first national pharmacy that provides science-based medication risk identification and mitigation technologies and services.
- Conditions
- Type2 Diabetes, Antiplatelet Drugs, Myocardial Infarction, Heart Failure
- Trial name
- NCT05053828
- Testing
- Antiplatelet Drug
- Where
- United States
- Volunteers
- 173,464 people
- Sponsor
- Tabula Rasa HealthCare
Acute Myocardial Infarction, Pacing Therapy
Post-Myocardial Infarction Remodeling Prevention Therapy
The purpose of this study is to demonstrate the feasibility of pacing as a therapy to prevent adverse remodeling of the myocardium following an acute myocardial infarction (MI) in patients at highest risk for adverse myocardial…
- Conditions
- Acute Myocardial Infarction, Pacing Therapy, Cardiac Remodeling, Heart Failure
- Trial name
- PRomPT (NCT01213251)
- Testing
- Single Site Pacing, Dual Site Pacing
- Where
- 26 sites in United States, Denmark and 5 more
- Volunteers
- 129 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Acute Coronary Syndrome, Myocardial Infarction
Exploring the MEchanism of Plaque Rupture in Acute Coronary Syndrome Using Coronary CT Angiography and computationaL Fluid Dynamic
The EMERALD trial is a multinational, multicenter study. The patients presented with AMI/definite evidence of plaque rupture and had underwent coronary CT angiography from 1 month to 2 year prior to the event will be…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Plaque, Atherosclerotic, Rupture, Spontaneous
- Trial name
- EMERALD (NCT02374775)
- Where
- 2 sites in South Korea
- Volunteers
- 77 people
- Sponsor
- Seoul National University Hospital
Death, Stroke
Remote Ischemic Preconditioning in High Risk Cardiovascular Surgery Patients
Remote ischemic preconditioning (RIPC) occurs when a tissue (ex. heart) becomes less vulnerable to an ischemic insult if a remote tissue (ex. arm) has had previous exposure to a period of ischemia and reperfusion.
- Conditions
- Death, Stroke, Low Cardiac Output Syndrome, Myocardial Infarction
- Trial name
- NCT01328912
- Testing
- Remote ischemic preconditioning stimulus, control
- Where
- Canada
- Volunteers
- 429 people
- Sponsor
- Queen's University
Stroke, Ischemic Heart Disease
Door-to-door Survey of Cardiovascular Health, Stroke and Ischemic Heart Disease in Atahualpa
The aim of the Atahualpa project is to evaluate the cardiovascular (CVH) status of the inhabitants of a rural village of coastal Ecuador as well as to determine the prevalence and retrospective incidence of stroke and ischemic…
- Trial name
- TAP (NCT01627600)
- Where
- 2 sites in Ecuador
- Volunteers
- 642 people, healthy volunteers welcome
- Sponsor
- Hospital Clínica Kennedy
Acute Myocardial Infarction, Chest Pain
Evaluation of Serial Troponin and Cardiac Multimarkers at the Point of Care in the Emergency Department
This is a multi-center study to assess the diagnostic accuracy of the Troponin I assay in the Biosite Triage Cardio3 Panel at the point-of-care (POC) in adults presenting to the emergency department with possible acute myocardial…
- Conditions
- Acute Myocardial Infarction, Chest Pain, Acute Coronary Syndrome
- Trial name
- ESTIMATE (NCT00907231)
- Where
- 6 sites in United States
- Sponsor
- Abbott RDx Cardiometabolic
ST Elevation Myocardial Infarction
Aggressive hydraTion in Patients With ST -Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention to prevenT Contrast-Induced Nephropathy
To compare the efficacy of 2 different hydration strategies, hydration according to clinical guideline and adequate hydration, on contrast-induced nephropathy in patients with STEMI undergoing primary PCI to investigate the…
- Trial name
- ATTEMPT (NCT02067195)
- Testing
- Receiving hydration with a 1 mL/kg bolus of intravenous isotonic saline (0.9% sodium chloride), 3 mL/kg.hour bolus of intravenous isotonic saline (0.9% sodium chloride)
- Where
- China
- Volunteers
- 560 people
- Sponsor
- Guangdong Provincial People's Hospital
Myocardial Infarction, Coronary Artery Diseases
Physical and Chemical Study of Atherosclerosis Mechanisms
Study the mechanisms of atherosclerosis based on a comparative study of physical and chemical properties of lipid tissues at various localization with subsequent development of concept of treatment and prevention.
- Conditions
- Myocardial Infarction, Coronary Artery Diseases, Diabetes Mellitus, Type 2, Atherosclerosis of Femoral Artery
- Trial name
- PCSAM (NCT01700075)
- Testing
- Conventional treatment, Weight loss treatment
- Where
- Kazakhstan
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Nazarbayev University
Ischemic Heart Disease, Myocardial Infarction
Polyamine Treatment in Elderly Patients With Coronary Artery Disease
The present study is testing spermidine treatment in elderly patients with coronary artery disease. The study is a randomized, double-blind, placebo-controlled, two-armed, parallel-group, single centre, clinical study.
- Conditions
- Ischemic Heart Disease, Myocardial Infarction, Cardiovascular Diseases, Hypertensive Heart Disease
- Trial name
- PolyCAD (NCT06186102)
- Testing
- Spermidine
- Where
- Denmark
- Volunteers
- 187 people
- Sponsor
- University of Aarhus
ST Elevation Myocardial Infarction
A Prospective Evaluation of Clinical Impact of Physiology Versus Optical Coherence Tomography Guided PCI in STEMI Patients Without Undergoing Primary PCI
This study of physiologically functional FFR in STEMI patients without direct PCI treatment will provide unique data on plaque progression and risk factors.
- Trial name
- NCT04996277
- Testing
- angiography, Thrombus suction, Fibrinolytic therapy
- Volunteers
- 300 people
- Sponsor
- CCRF Inc., Beijing, China
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