Clinical trials: Heart Infarction
Myocardial Infarction
Efficacy of Early Administration of Clotinab in Acute Myocardial Infarction
The ADMIRAL (Platelet glycoprotein IIb/IIIa inhibition with coronary stenting for acute myocardial infarction) study demonstrated that early administration of abciximab in patients with ST elevation acute myocardial infarction…
- Trial name
- ECLAT-STEMI (NCT00841438)
- Testing
- Clotinab
- Where
- 31 sites in South Korea
- Volunteers
- 786 people
- Sponsor
- Yonsei University
Coronary Artery Bypass Graft Redo, Heart Valve Diseases
SONOlysis in Risk REduction of Symptomatic and Silent Brain infarCtions dUring Cardiac surgEry
The aim of the project is to demonstrate a fibrinolytic effect of sonothrombolysis (continual transcranial Doppler monitoring) using 2 MHz diagnostic probe on the reduction of risk of brain infarctions due to the activation of…
- Trial name
- SONORESCUE (NCT01591018)
- Testing
- sonolysis, cardiac surgery
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Ostrava
Coronary Artery Disease, Myocardial Infarction
Delayed Plaque Morphology in Patients With STEMI After Thrombus Aspiration During Primary PCI
The purpose of this study is to characterize the plaque morphology in patients with acute STEMI by OCT after aspiration thrombectomy.
- Trial name
- STEMI-OCT (NCT02384824)
- Testing
- Primary Percutaneous Intervention
- Volunteers
- 100 people
- Sponsor
- Jian'an Wang,MD,PhD
History of Myocardial Infarction
FDG an Myocardial Infarction: The PIAF Trial
In order to define distinct and reliable arterial 18Fluorodeoxyglucose (FDG) thresholds identifying patients at risk for cardiovascular events, patients with a history of myocardial infarction will be included in this…
- Trial name
- PIAF (NCT05138718)
- Testing
- 18F-FDG PET/CT
- Where
- United States
- Volunteers
- 2,041 people
- Sponsor
- International Atomic Energy Agency
Coronary Artery Disease, Myocardial Infarction
Comparison Between Moderate-high Interval Exercise and Moderate Continuous Exercise in an Advanced Cardiac Rehabilitation Program
The research will study the differences between interval training and continuous training among cardiac patients in a cardiac rehabilitation facility. The main objectives are: 1. Functional capacity measures (VO2 max). 2.
- Trial name
- NCT02162290
- Testing
- Interval exercise training, Continuous exercise training
- Where
- Israel
- Volunteers
- 84 people
- Sponsor
- Assaf-Harofeh Medical Center
Cardiovascular Disease
Heart Attack Prevention Programme for You (HAPPY) London
Diseases of the heart and blood vessels, such as heart attacks and strokes, are very common and can lead to severe disability or death.
- Trial name
- HAPPYLondon (NCT01911910)
- Testing
- Electronic coaching plus standard care
- Where
- United Kingdom
- Volunteers
- 402 people
- Sponsor
- Queen Mary University of London
Ventricular Thrombosis Mural Following Myocardial Infarction
LV Thrombus After Acute AMI: A Randomized Controlled Trial
Left Ventricular (LV) thrombus formation is witnessed in at least 10% of patients with ST segment elevation myocardial infarction (STEMI).
- Trial name
- NCT01556659
- Testing
- Absence of vitamin K antagonist
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Sweden Satellite Registry
This registry is a clinical post-market evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES).
- Trial name
- NCT01667003
- Where
- 8 sites in Sweden
- Volunteers
- 406 people
- Sponsor
- Biotronik ApS
Cardiogenic Shock
The Effect of Simultaneous Renal Replacement Therapy on Extracorporeal Membrane Oxygenation Support for Cardiogenic Shock Patients
Extracorporeal membrane oxygenation (ECMO) is a temporary mechanical circulatory support device for cardiogenic shock (CS) patients.
- Trial name
- NCT02870946
- Testing
- Simultaneous RRT, Standard care
- Where
- China
- Volunteers
- 262 people
- Sponsor
- Beijing Anzhen Hospital
Cardiogenic Shock
CorVad Myocardial Infarction Complicated with Cardiogenic Shock Trial
Cardiogenic shock a serious complication of a heart attack (myocardial infarction). Despite evaluation of several new treatments during the last decade, the mortality in patients with cardiogenic shock still exceeds 50%.
- Trial name
- Corvad AMICS (NCT06886113)
- Testing
- Conventional circulatory support, CorVad
- Where
- China
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Shenzhen Core Medical Technology CO.,LTD.
Platelet Aggregation During Acute Myocardial Infarction
DPP-4 Inhibitors and Acute Myocardial Infarction:Effects on Platelet Function
Cardiovascular events are the main cause of mortality in diabetic patients ,on the other hand,during an acute myocardial infarction(AMI),hyperglycemia increases mortality and is related to different pathophysiologic processes.
- Trial name
- NCT02377388
- Testing
- sitagliptin OR saxagliptin
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- University of Sao Paulo General Hospital
Myocardial Infarction, Cardiac Rehabilitation
Post Myocardial Infarction's Rehabilitation Guided by Heart Rate Variability
Cardiac rehabilitation reduces morbidity and mortality after myocardial infarction (MI) and improve the sympathovagal balance. The autonomic nervous system (ANS) can be explored by the variation of heart rate (HRV).
- Trial name
- HRV REEDUC (NCT03745742)
- Testing
- HRV measurement
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Myocardial Infarction (AMI)
Using Advanced CT Scans and Blood Markers to Better Understand Heart Damage and Recovery After a Heart Attack
Acute myocardial infarction with ST-segment elevation (STEMI) remains a leading cause of morbidity and mortality worldwide. Although advances in reperfusion therapy have reduced early mortality, many patients later develop…
- Trial name
- NCT07268391
- Testing
- Blood analysis, spectral CT scan and cardiac magnetic resonance imaging (CMR) study, Blood analysis and spectral CT study
- Where
- 4 sites in Spain
- Volunteers
- 95 people
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
Acute Myocardial Infarction (AMI)
Angiography Derived Index of Microcirculatory Resistance in Patients With Acute Myocardial Infarction
Coronary microcirculatory dysfunction has been known to be prevalent even after successful revascularization of acute myocardial infarction (AMI) patients, and has been shown to be associated with poor prognosis.
- Trial name
- NCT05696379
- Testing
- Angiography derived index of micro-circulatory resistance (Angio-IMR)
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cardiovascular Diseases, Coronary Disease
Clinical Course of Coronary Artery Disease Among Blacks
To determine the clinical course of coronary artery disease among Blacks receiving medical care for symptomatic heart diseases.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Myocardial Infarction, Heart Diseases
- Trial name
- NCT00005191
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Anterior ST-Segment Elevation Myocardial Infarction
A Research Study to Evaluate the Efficacy and Safety of SGC001 in Patients With Anterior Wall ST-Segment Elevation Myocardial Infarction
This is a multicenter, randomized, double-blind, placebo-controlled, single-dose, Phase II clinical study to evaluate the efficacy, safety, and pharmacokinetic (PK) characteristics of SGC001 injection administered in addition to…
- Trial name
- NCT07306182
- Testing
- SGC001 injection
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Beijing Sungen Biomedical Technology Co., Ltd
ST-elevation Myocardial Infarction (STEMI), Clonal Hematopoiesis of Indeterminate Potential (CHIP)
Clonal Hematopoiesis of Indeterminate Potential and Infarct Severity in ST-Elevation Myocardial Infarction
Clonal Hematopoiesis of Indeterminate Potential (CHIP) refers to the age-related expansion of hematopoietic stem cell clones carrying somatic mutations in leukemia-associated driver genes (e.g., DNMT3A, TET2, ASXL1) in the…
- Trial name
- CHIP in STEMI (NCT07615023)
- Testing
- Clonal hematopoiesis assessment and cardiac magnetic resonance imaging
- Where
- Austria
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Cardiovascular Disease
Comprehensive Rimonabant Evaluation Study of Cardiovascular ENDpoints and Outcomes
The primary objective is to show whether rimonabant reduces the risk of a heart attack (MI), stroke, or death from an MI or stroke in patients with abdominal obesity with other cardiovascular (CV) risk factors.
- Trial name
- CRESCENDO (NCT00263042)
- Testing
- Rimonabant
- Where
- 43 sites in United States, Argentina and 41 more
- Volunteers
- 18,695 people
- Sponsor
- Sanofi
Diabetes, STEMI
Sweetheart-Register: Risk Management of Diabetics with Acute Myocardial Infarction
The Sweetheart register (Risk management of Diabetics with acute myocardial infarction) documents both the prevalence of pathologic glucose metabolism in consecutive high-risk patients with STEMI and NSTEMI in daily hospital…
- Conditions
- Diabetes, STEMI, NSTEMI, Myocardial Infarction
- Trial name
- Sweetheart (NCT01197742)
- Where
- 2 sites in Germany
- Volunteers
- 2,772 people
- Sponsor
- Stiftung Institut fuer Herzinfarktforschung
STEMI - ST Elevation Myocardial Infarction
Pretreatment With Unfractionated Heparin for ST Elevation Myocardial Infarction
Rupture of a coronary artery plaque leads to thrombotic occlusion of the coronary artery and would present as ST segment elevation myocardial infarction.
- Trial name
- UFH-STEMI (NCT05247424)
- Testing
- Unfractionated heparin
- Where
- Slovenia
- Volunteers
- 600 people
- Sponsor
- University Medical Centre Ljubljana
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