Clinical trials: Heart Transplant
Heart Failure, Transplant; Failure, Heart
Exercise-based Cardiac Rehabilitation Program on Hospitalized Heart Failure Patients Submitted to Cardiac Transplantation
Objective: To evaluate the effects of an early-based cardiac rehabilitation program on the functional capacity, inspiratory muscular strength and clinical outcomes in hospitalized heart failure patients before and after heart…
- Conditions
- Heart Failure, Transplant; Failure, Heart, Physical Activity
- Trial name
- NCT03506737
- Testing
- Conventional exercise protocol, Cycle ergometer exercise protocol
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
Coronary Artery Bypass Grafting, Medication Adherence
Quality Measurement and Improvement Study of Surgical Coronary Revascularization: Medication Adherence
The study is a randomized controlled trial, having a plan to recruit 1000 patients underwent coronary artery bypass grafting in 1 of 5 participating sites in 2015, and randomized to either the intervention group or control group…
- Conditions
- Coronary Artery Bypass Grafting, Medication Adherence, Mobile Applications
- Trial name
- MISSION-2 (NCT02432469)
- Testing
- APP intervention
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Disease
Comparison Between 2 Bilateral Internal Thoracic Artery Coronary Artery Bypass Grafting Configurations
Bilateral internal thoracic arteries (BITA) demonstrated superiority over other grafts to the left coronary system in terms of patency and survival benefit.
- Trial name
- NCT01666366
- Testing
- Coronary artery bypass grafting
- Where
- Belgium
- Volunteers
- 304 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Cardiac Transplantation, Chronic Renal Insufficiency
Efficacy Study of Everolimus on Renal Function in Heart Transplant Recipients With Established Chronic Renal Failure
After transplantation, renal impairment, incidence and progression of atherosclerosis lead to modification of immunosuppressive regimens, as switch, reduction or discontinuation of CNI and/or introduction of everolimus.
- Trial name
- COREV (NCT00716573)
- Testing
- everolimus
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Coronary Artery Bypass Graft, Cardiopulmonary Bypass
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MDCO-2010 in Patients Undergoing Elective Coronary Artery Bypass Graft Surgery
The purpose of this study is to demonstrate that periprocedural infusion of escalating doses of MDCO-2010 is safe and tolerated in patients undergoing elective CABG surgery, to characterize the single dose pharmacokinetics of…
- Trial name
- NCT01535222
- Testing
- MDCO-2010
- Volunteers
- 32 people
- Sponsor
- The Medicines Company
Cardiovascular Diseases
Effects of Lower Limb Resistance Band Exercises in Phase 1 Cardiac Rehabilitation
This study will be randomized controlled trial with non-probability purposive sampling. Study conducted among post CABG patients. Sample size will be 56, 28 in each group.
- Trial name
- NCT06319651
- Testing
- Lower Limb Resistance Band Exercises, Routine Phase 1 cardiac rehabilitation
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- Riphah International University
Blood Recovery
Analysis of Red Blood Cell Integrity and Efficiency of Recovery Using a Novel Surgical Sponge-Blood Recovery Device (ProCell): Delayed Impact
The purpose of this research study is to compare two methods of recovering blood from surgical sponges used during heart and lung surgeries.
- Trial name
- NCT05545956
- Testing
- Hand Wrung, ProCell Wrung
- Where
- United States
- Sponsor
- University Hospitals Cleveland Medical Center
CAD - Coronary Artery Disease, CABG
Comparative Analysis of Analgesic Approaches in the Early Period After CABG
The goal of this clinical trial is to study postoperative analgesia in patients undergoing CABG. And learn if tafalgin (tyrosyl-D-arginyl-phenylalanyl-glycine amid) treats pain not inferiory then morphine.
- Conditions
- CAD - Coronary Artery Disease, CABG, Analgesia Assessment
- Trial name
- CABG-PAIN (NCT07451522)
- Testing
- Tafalgin (tyrosyl-D-arginyl-phenylalanyl-glycine amide), Morphine (+)
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Primorsky Regional General Hospital #1
Anesthesia
Anesthesia and Lymphocytes Apoptosis
Most researches revealed that volatile anesthetic sevoflurane has a more marked cardioprotective effect against ischemia compared with intravenous agent propofol.However, propofol has been suggested to be more benefit for…
- Trial name
- OPCAB (NCT01461551)
- Testing
- Sevoflurane, Propofol, combine of sevoflurane and propofol
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Ruijin Hospital
Liver Transplantation, End-stage Liver Disease (ESLD)
Restrictive Fluid Management In Liver Transplantation (REFIL) - Pilot
Hypothesis: A Canadian multicentre clinical trial is feasible. Study Design: Multicenter internal pilot parallel arm randomized controlled trial.
- Trial name
- REFIL-1 (NCT05647733)
- Testing
- Low splanchnic blood volume restrictive fluid management strategy, Optimized cardiac output liberal fluid management strategy, Phlebotomy
- Where
- 4 sites in Canada
- Volunteers
- 138 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Gingival Recession, Lack of Keratinized Gingiva (Disorder)
Progenitor Potential of Mesenchymal Stem Cells in Palatal Tissue Harvested From Molar and Premolar Sites
The primary purpose of this protocol is to isolate, investigate and compare the regenerative and differentiation potential of mesenchymal stem cells (MSC's) in the gingival (gum) tissue harvested from two different locations from…
- Trial name
- NCT03570333
- Testing
- progenitor potential of Gingival Mesenchymal cells
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Coronary Artery Bypass Grafting
Tissue Oxygenation During Heart Surgery
The goal of this study is to determine if off-pump CABG surgery is associated with better cerebral tissue oxygenation when compared with on-pump CABG.
- Trial name
- NCT01347827
- Testing
- measurements of brain tissue oxygenation
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Coronary Artery Disease, Atrial Fibrillation
TEmporary Spinal CoRd StiMulatIon to PrevenNt Atrial FibrillaTION AFter Cardiac Surgery
To compare of atrial arrhythmia incidence in patients with coronary artery disease and atrial fibrillation history, undergoing either coronary artery bypass grafting plus temporary spinal cord stimulation or coronary artery…
- Trial name
- TerminationAF (NCT03539354)
- Testing
- Temporary spinal cord stimulation, Coronary artery bypass grafting, B-blockers
- Where
- 2 sites in Russia
- Volunteers
- 60 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Diabetes Mellitus
Comparison of Insulin Therapy in Treating Post-Transplant Diabetes
To determine if the use of insulin isophane results in improved control of blood sugars compared to the use of insulin glargine in new onset diabetes after kidney, lung, or heart transplantation (NODAT).
- Trial name
- NCT01963728
- Testing
- Insulin, Isophane, insulin glargine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Inova Health Care Services
Saphenous Vein Graft Disease, Myocardial Ischemia
The RETRIEVE Study: Use of the FiberNet® Embolic Protection System in Saphenous Vein Grafts
This is a multicenter, prospective study designed to demonstrate the performance and safety of the FiberNet Embolic Protection System when used as an adjunctive device during saphenous vein graft (SVG) intervention.
- Conditions
- Saphenous Vein Graft Disease, Myocardial Ischemia, Embolism
- Trial name
- RETRIEVE (NCT00453518)
- Testing
- FiberNet EPS used during SVG intervention.
- Where
- 6 sites in United States
- Volunteers
- 29 people
- Sponsor
- Lumen Biomedical
ECMO and Acute MI
Use of ECMO in Acute MI
ECMO offers an acceptable cardiopulmonary support in adults with similar hospital survival rates as other mechanical support. It is versatile and salvages some patients, who may otherwise die.
- Trial name
- NCT00425685
- Volunteers
- 60 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Heart Transplantation
Cell Therapy With Treg Cells Obtained From Thymic Tissue (thyTreg) to Prevent Rejection in Heart Transplant Children
The investigators developed a protocol to isolate Treg cells from thymic tissue (thyTreg) discarded in pediatric cardiac surgeries.
- Trial name
- THYTECH (NCT04924491)
- Testing
- Autologous thyTreg
- Where
- Spain
- Volunteers
- 11 people
- Sponsor
- Rafael Correa-Rocha
Coronary Artery Disease
Graft Patency After FFR-guided Versus Angio-guided CABG (GRAFFITI) Trial
This is prospective, randomized, multicenter, multinational, randomized (1:1) study. The aim of this study is to assess the importance of functional assessment of coronary artery disease prior to bypass surgery.
- Trial name
- GRAFFITI (NCT01810224)
- Testing
- Surgical revascularization
- Where
- 3 sites in Belgium, Czechia and 1 more
- Volunteers
- 206 people
- Sponsor
- Onze Lieve Vrouw Hospital
Coronary Artery Bypass Grafting, Open Heart Surgery
Assessment of Platelet Function in Patients Undergoing Open Heart Surgery
The purpose of this external evaluation is to assess the system functionality and analytical performance of the Saturn Investigational Instrument (next generation VerifyNow instrument) and associated cartridge currently under…
- Conditions
- Coronary Artery Bypass Grafting, Open Heart Surgery, Aortic Surgery or Redo Surgery, On-pump Double or Triple Valve Procedures
- Trial name
- Saturn (NCT05441358)
- Testing
- Open Heart Surgery
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- LifeBridge Health
Coronary Bypass Graft Failure/Occlusion
Fondaparinux to Prevent Thrombotic Complications and Graft Failure in Patients Undergoing Coronary Artery Bypass Graft Surgery: The Fonda CABG Study
(i) Main Research Question(s): What is the effect of fondaparinux on coronary graft patency, heart attack, stroke, and death in patients who have undergone coronary artery bypass grafting (CABG)? To reliably answer this question…
- Trial name
- Fonda CABG (NCT00474591)
- Testing
- Fondaparinux
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Hamilton Health Sciences Corporation