Clinical trials: Heart Transplant Recipients
Heart Transplantation, Elevated Resting Heart Rate
An Interventional Study to Evaluate the Effect of Ivabradine on Exercise Capacity in Heart Transplant Recipients
The hypothesis is that the treatment with ivabradine will increase pVO2 after 16 weeks of treatment compared to baseline in the heart transplant recipient population with elevated resting HR.
- Trial name
- NCT03619187
- Testing
- Ivabradine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Amgen
Heart Transplant Recipients
Autonomic Cardiovascular Control After Heart Transplantation
The purpose of this prospective study is to investigate denervation (ie. surgical cutting of autonomic nerves) and re-innervation (ie. growth of autonomic nerves) in heart transplant recipients. More specifically, we focus on: 1.
- Trial name
- AccHeart (NCT01759966)
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Cardiac Transplant Failure, Cardiac Transplant Rejection
Utility of Donor-Derived Cell Free DNA in Association With Gene Expression Profiling
Plasma donor-derived cell-free DNA (dd-cfDNA) is measured as a % of the total plasma cfDNA in association with the measurement of AlloMap, a non-invasive gene expression test to aid in heart transplant management.
- Conditions
- Cardiac Transplant Failure, Cardiac Transplant Rejection, Heart Diseases
- Trial name
- D-OAR (NCT02178943)
- Where
- 28 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- CareDx
Periodontal Diseases, Heart Transplantation
Periodontal Status and Dental Behavior of Heart Trasplant Recipients and Healthy Controls
Forty heart transplant recipients and forty age and sex mathced systemically healthy patients were included. Periodontal examination was performed and a questionnaire was applied to record demographic data, systemic health and…
- Trial name
- NCT03809676
- Testing
- periodontal examination
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Baskent University
Transplantation, Heart-Lung, Chronic Lung Allograft Dysfunction
Evaluation of Electrical Impedance Tomography for the Diagnosis of Chronic Rejection in Lung Transplants Recipients
Electrical impedance tomography (EIT) is non-invasive and provides functional imaging of the lung and it could be a useful tool to diagnose chronic lung allograft dysfunction (CLAD) and specially Bronchiolitis Obliterans Syndrome…
- Conditions
- Transplantation, Heart-Lung, Chronic Lung Allograft Dysfunction, Bronchiolitis Obliterans Syndrome
- Trial name
- CLAD (NCT02863835)
- Testing
- EIT, Salbutamol nebulisation and with CPAP
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Heart Transplantation
Imminently Effect of Interval Training With High Intensity (HIT) After Heart Transplantation
High intensity Interval training (HIT) has repeatedly been documented to have superior positive effects on oxygen uptake and general physical health compared to continuous moderate exercise in healthy individuals and patients…
- Trial name
- NCT02602834
- Testing
- interval training, moderate exercise
- Where
- Norway
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Cardiac Transplant
Cytokine Profiling Post-Heart Transplant
Measurement of cytokine levels in post-cardiac transplant patients with unexplained graft dysfunction.
- Trial name
- NCT01643564
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Heart Transplant Recipients
The GRAFT Study: Evaluation of Graft Function, Rejection and Cardiac Allograft Vasculopathy in First Heart Transplant Recipients.
Objective: To assess the relationship between coronary allograft vasculopathy (CAV) and graft function, and to evaluate non-invasive methods for CAV diagnosis.
- Trial name
- NCT02077764
- Testing
- OCT and coronary angiography, Right heart cat., PET
- Where
- Denmark
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital Skejby
Cardiac Allograft Vasculopathy
Noninvasive Evaluation of Cardiac Allograft Vasculopathy
Abnormal peripheral endothelial function and alterations in circulating biomarkers that are associated with endothelial activation and inflammation correlate with angiographic evidence of cardiac allograft vasculopathy, defined…
- Trial name
- CAVII (NCT01305382)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Minnesota
Cardiac Transplant Failure, Cardiac Transplant Rejection
Outcomes AlloMap Registry: the Long-term Management and Outcomes of Heart Transplant Recipients With AlloMap Testing
The objective of this registry is to observe short and long term clinical outcomes in heart transplant recipients who receive regular AlloMap testing as part of allograft rejection surveillance.
- Conditions
- Cardiac Transplant Failure, Cardiac Transplant Rejection, Heart Diseases
- Trial name
- OAR (NCT01833195)
- Where
- 36 sites in United States
- Volunteers
- 2,444 people, healthy volunteers welcome
- Sponsor
- CareDx
Cardiac Transplant Rejection
A Pilot Study Evaluating the Potential of 18F Fluorodeoxyglucose PET-CT Imaging in Diagnosing Cardiac Rejection.
This pilot study aims to assess whether 18F-FDG PET CT imaging has the potential in diagnosing cardiac rejection. The investigators aim to recruit 20 heart transplant subjects within two groups of 10 subjects each.
- Trial name
- NCT06519240
- Testing
- 18F-Fluorodeoxyglucose Positron Emission Tomography-computed Tomography (18F-FDG PET CT)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Cardiac Output, Low, High Blood Pressure
Assessment of Volumetric Hemodynamic Parameters and Nutritional Status in Stable Renal Transplant Recipients
Changes in volumetric hemodynamic parameters and fluid overload (Cardiac Index,Stroke Volume, Thoracic Fluid Content, Systemic Vascular Resistance) were measured using a impedance cardiography (ICG) (CardioScreen 1000 …
- Trial name
- NCT02852941
- Testing
- CardioScreen 1000, Tanita 418- Bioelectrical impedance analysis
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw