Clinical trials: Heart-Lung Transplantation
Heart Transplant
Non-Intubated Anesthesia for Adult Heart Transplantation
This prospective, multicenter, randomized controlled trial aims to evaluate whether non-intubated spontaneous ventilation anesthesia (NISVA) supported by a supraglottic airway can reduce cardiopulmonary complications and promote…
- Trial name
- NISVA-HTx (NCT07758894)
- Testing
- Non-Intubated Spontaneous Ventilation Anesthesia, Conventional Anesthesia, Standardized Perioperative Anesthetic and Analgesic Medication Regimen
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications
A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy
The purpose of this study is to determine the clinical benefit and characterize the safety profile of tabelecleucel for the treatment of Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV+ PTLD) in the…
- Conditions
- Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications, Lymphoproliferative Disorders, Allogeneic Hematopoietic Cell Transplant
- Trial name
- ALLELE (NCT03394365)
- Testing
- tabelecleucel
- Where
- 71 sites in United States, Australia and 7 more
- Volunteers
- 115 people
- Sponsor
- Pierre Fabre Medicament
Covid19
Comorbidities and Risk Score in COVID-19 Patients
Retrospective multi-center cohort study. Consecutive patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) up to October 2020 will be included.
- Trial name
- Comorbidities (NCT04670094)
- Where
- 5 sites in Italy
- Volunteers
- 4,555 people
- Sponsor
- University of Milano Bicocca
Cardiovascular Diseases+Liver Transplantation
Usefulness of Cardiopulmonary Exercise Testing for Cardiovascular Risk Estimation and Frailty Assessment in Liver Transplant Candidates
Patients undergoing liver transplantation (LT) have a high risk for cardiovascular disease (CVD). Frailty is a frequent condition among LT candidates.
- Trial name
- NCT04543825
- Testing
- Cardiopulmonary exercise testing
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- Andres Duarte-Rojo
Congenital Heart Disease, Heart Failure
The PAtients pResenTing With COngenital HeaRt DIseAse Register (ARTORIA-R)
Advances in surgical and medical care have led to improved outcomes in patients with congenital heart disease (CHD). As a consequence, the majority of patients nowadays survives to adulthood (adults with CHD, that is, adult CHD…
- Conditions
- Congenital Heart Disease, Heart Failure, Transplant; Complication, Failure, Arrythmia
- Trial name
- ARTORIA-R (NCT04848844)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Respiratory Distress Syndrome, Adult, Respiratory Insufficiency
Australia and New Zealand Adult Extracorporeal Membrane Oxygenation (ECMO) Audit 2005
Extracorporeal membrane oxygenation (ECMO) is a means of artificially performing the function of the human lung and/or heart outside the body.
- Conditions
- Respiratory Distress Syndrome, Adult, Respiratory Insufficiency, Shock, Cardiogenic
- Trial name
- NCT00157144
- Where
- Australia
- Sponsor
- Bayside Health
Cardiac Transplantation, Cardiopulmonary Bypass
Intraoperative Use of Extracorporeal Cytokine Adsorption During Orthotopic Heart Transplantation
There are several factors initiating cytokine storm and dysregulated systemic inflammatory response during cardiac transplantation.
- Trial name
- NCT03145441
- Testing
- CytoSorb®
- Where
- Hungary
- Volunteers
- 60 people
- Sponsor
- Semmelweis University
Endocrine System Diseases, Thyroid Diseases
Endocrine Changes and Their Correction in Heart and Lung Transplant Recipients and Donors
The aim of this study is to assess the impact of endocrine changes and their correction on survival and organ function in heart and lung transplant recipients.
- Conditions
- Endocrine System Diseases, Thyroid Diseases, Cortisol Deficiency, Diabetes Insipidus
- Trial name
- NCT04351945
- Testing
- Blood test
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Cardiovascular Risk Factor, Diabetes Mellitus, Type 1
Cardiopulmonary Testing for Potential Pancreas Transplant Candidates
Patients being assessed for Kidney Pancreas transplantation often have pre-existing co-morbid disease that contributes to structural cardiac and vascular disease.
- Conditions
- Cardiovascular Risk Factor, Diabetes Mellitus, Type 1, Pancreas Transplant; Complications
- Trial name
- NCT04312802
- Testing
- Cardiopulmonary exercise test (CPET)
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Oxford University Hospitals NHS Trust
COPD, Interstitial Pneumonia
Perioperative Risk Factors Related to the Prognosis of Lung Transplantation: A Retrospective Study
This study analyzes patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University from 2017 to 2024, focusing on anesthesia's impact on post-op results.
- Conditions
- COPD, Interstitial Pneumonia, Bronchiectasis, Respiratory Failure
- Trial name
- NCT06922916
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Zhejiang University
Congenital Abnormalities, Pulmonary Arterial Hypertension (PAH)
Safety and Effectiveness of a Virtual Pediatric Cardiac Rehabilitation Program or Telerehabilitation in Children With Heart Disease
Cardiac telerehabilitation is a much-needed pediatric therapy; however, a lack of randomized controlled trials has limited the development of and reimbursement for this valuable service.
- Conditions
- Congenital Abnormalities, Pulmonary Arterial Hypertension (PAH), Orthotopic Heart Transplant, Cardiac Rehabilitation
- Trial name
- NCT06819059
- Testing
- Pediatric Cardiac Telerehabilitation, Fitness Tracker Only
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Lung Transplant, Pulmonary Hypertension
Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension
The purpose of this study is to determine if transseptal extra-corporeal membrane oxygenation (ECMO) can bridge pulmonary hypertension- right heart failure (PH-RVF) patients to lung transplant safely.
- Trial name
- NCT06770023
- Testing
- Protek Solo Transseptal Cannula
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
Lung Transplantation, Heart-Lung Transplantation
Empowerment of Lung and Heart-lung Transplant Patients
Lung or combined heart-lung transplantation represents an established treatment strategy for patients with end-stage lung disease.
- Conditions
- Lung Transplantation, Heart-Lung Transplantation, "Rehabilitation", Psychotherapy
- Trial name
- NCT00808600
- Testing
- resource-activating behavioural training programme, Relaxation training, Intensified anaerobic exercise training
- Where
- Germany
- Volunteers
- 132 people
- Sponsor
- Hannover Medical School
Bone Density, Overweight
Nutritional Problems After Lung and Heart Transplantation
Part 1) Bone health after transplantation - possible influence of vitamin K Part 2) Fat metabolism and endocrine parameters - possible predictors for developement of overweight after transplantation
- Trial name
- NCT00826254
- Testing
- Vitamin K
- Where
- Norway
- Volunteers
- 94 people
- Sponsor
- Oslo University Hospital
Heart Transplantation
Haemoadsorption During Heart Transplantation
To investigate whether the use of haemoadsorption (HA) on cardiopulmonary bypass during heart transplantation (HTX) has an effect on circulating cytokine levels for the first 120 hours after HTX and induces a decreased…
- Trial name
- CytoSorbHTX (NCT05270902)
- Testing
- CytoSorb Adsorber
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Blood Recovery
Analysis of Red Blood Cell Integrity and Efficiency of Recovery Using a Novel Surgical Sponge-Blood Recovery Device (ProCell)
The purpose of this research study is to compare two methods of recovering blood from surgical sponges used during heart and lung surgeries.
- Trial name
- NCT05545930
- Testing
- Hand Wrung, ProCell Wrung
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University Hospitals Cleveland Medical Center
Congenital Heart Disease
TORCH-LATAM: A Regional Pathway to Improve Transplant Evaluation for Congenital Heart Disease
Congenital heart disease can progress to advanced cardiac or cardiopulmonary failure requiring heart, heart-lung, or, in selected congenital conditions, bilateral lung transplantation with cardiac repair.
- Trial name
- TORCH-LATAM (NCT07799272)
- Testing
- TORCH Integrated Transplant Access Pathway (TORCH-ITAP)
- Volunteers
- 600 people
- Sponsor
- CardioVision International Tech, S.A.S. de C.V.
Coronary Artery Disease
Comparison of Coronary CT Angiography With Conventional Coronary Angiography in Liver and Lung Transplant Candidates
The overall goal of this study is to determine if non-invasive imaging with state of the art CT coronary angiography can be used to screen for coronary artery disease in high risk patients prior to liver and lung transplantation.
- Trial name
- NCT00727051
- Where
- United States
- Sponsor
- University of California, San Francisco
Allogeneic Stem Cell Transplantation, Lung Allograft Transplantation
Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging
Background: Injury or diseases of the heart and lung can sometimes cause scar tissue (fibrosis) to build up in those organs. Current imaging scans can see this scar tissue once it has formed, but researchers want to find a way to…
- Conditions
- Allogeneic Stem Cell Transplantation, Lung Allograft Transplantation, Interstitial Lung Disease, Acute Lung Injury
- Trial name
- NCT07613099
- Testing
- [18F]FAPI-74, 18F-FAPI-74 PET/CT Imaging
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hepatitis C, Kidney Transplant; Complications
A Study to Evaluate Preemptive Therapy in Hepatitis C (HCV) Organ Transplant Recipients
This study is being done to determine the effectiveness of using a combination of two different drugs in preventing the transmission of HCV from a HCV positive donor to a HCV negative solid organ recipient.
- Conditions
- Hepatitis C, Kidney Transplant; Complications, Heart Transplant Infection
- Trial name
- NCT04508907
- Testing
- Mavyret
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic