Clinical trials: Heat
Healthy Adults
Evaluation of RSB11-HI Postbiotic Supplementation for Supporting Weight Management, Metabolic Wellness, and Quality of Life in Healthy Adults
This randomized, double-blind, placebo-controlled clinical trial will evaluate the safety, tolerability, and efficacy of RSB11-HI, a heat-inactivated postbiotic, in healthy adults over an 8-week intervention period.
- Trial name
- NCT07788833
- Testing
- RSB11-HI Heat-Inactivated Postbiotic
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Able Biolabs, LLC
Pain, Acute Pain
The Role of NaV1.8 in Human Pain Models
This study aims to understand how NaV1.8, a specific type of sodium channel found in peripheral nerves, contributes to different types of pain in humans.
- Conditions
- Pain, Acute Pain, Healthy Volunteer Study
- Trial name
- NCT07511400
- Testing
- Suzetrigine, Lidocaine (drug), Control Solution
- Where
- Austria
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Heat Stress, Kidney Injury
Does Probiotic Supplementation Prevent Kidney Injury During Strenuous Physical Exercise?
Severe heat strain arising from intense physical work under climate conditions that does not allow sufficient heat dissipation may lead to heat stroke.
- Trial name
- NCT04985292
- Testing
- Probiotic, Lactobacillus
- Where
- Sweden
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Heat Stress, Temperature Change, Body
Identifying the Limits of Survivability in Heat-exposed Older Females
Climate change increases extreme heat events, elevating global heat-illness risk. Females have reduced heat loss capacity (~5%) compared to males, driven by differences in skin blood flow and sweating responses.
- Conditions
- Heat Stress, Temperature Change, Body, Aging, Thermoregulation
- Trial name
- NCT07032493
- Testing
- Humidity-Ramp Protocol, Above-inflection fixed-condition exposure (5%), Below-inflection fixed-condition exposure (5%)
- Where
- 2 sites in Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Heat Acclimation and Thermotolerance
Effect of Combined Exercise, Heat, and Quercetin Supplementation on Whole Body Stress Response
The purpose of this study is to determine whether dietary quercetin supplementation effects thermotolerance and heat acclimation in human subjects exposed to exercise/heat stress. Specific Aim I.
- Trial name
- NCT01168739
- Testing
- Quercetin
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Acute Exercise, Heat Exposure
The Influence of Capsaicin Gel During Exercise Within the Heat
The purpose of this study is to examine the human thermoregulatory impact of applying a commercially available capsaicin gel to the skin prior to moderate intensity walking under heated conditions.
- Trial name
- NCT05298202
- Testing
- Capsaicin, Control Gel, Exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Heathly Subjects, Primary Health Care
Assessing the Effectiveness of Heat Adaptation Digital Messages From Primary Care Providers to Their Patients on the Change in Behaviour for Heatwave-related Preparedness
Extreme heat events pose a significant health threat in Canada, as demonstrated by the 2021 heat wave that claimed over 600 lives in Western Canada. Most heat-related deaths occur indoors and are preventable.
- Conditions
- Heathly Subjects, Primary Health Care, Climate Change, Public Health
- Trial name
- HeatSmart (NCT07024628)
- Testing
- Heat adaptation digital messaging, Non-heat-related digital messaging
- Where
- Canada
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Hopital Montfort
Alzheimer's Disease
A Study to Evaluate the Effect of Heat Application on the Delivery Profile of Corplex™ Donepezil Transdermal Delivery System (TDS)
A study to assess the effect of heat application on the delivery profile of Corplex™ Donepezil Transdermal Delivery System (TDS)
- Trial name
- NCT03438604
- Testing
- Donepezil TDS
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Corium, Inc.
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Niue
Ambient air temperatures in the Pacific have broken record highs in 2024. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate change.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06570993)
- Testing
- Cool roof
- Where
- Niue
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Aging
Identification of Critical Thermal Environments for Aged Adults
This study evaluates critical environmental limits (temperature and humidity) above which older adults are unable to effectively thermoregulate.
- Trial name
- NCT04284397
- Testing
- Low dose ASA, Control
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Penn State University
Heat Illness, Quality of Life
Structural Heat Adaptation and Education in Urban Setting
This study aims to understand whether simple, low-cost interventions, such as improved home cooling, practical advice, and minor home modifications, can help protect people's health and improve quality of life during periods of…
- Trial name
- SHAPES (NCT06991543)
- Testing
- Community education and awareness, and personal lifestyle and cooling behavior modification, Participatory local structural and environmental heat mitigation solutions
- Where
- Pakistan
- Volunteers
- 7,128 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Effect of Superstarch on Soccer Performance
Superstarch and Physical/Cognitive Performance Following a Simulated Soccer Game
To assess the efficacy of a hydrothermally modified starch supplement (Superstarch made byGeneration UCAN) vs isoenergetic placebo (glucose) on exercise performance, execution of specific soccer skills, and on cognitive function…
- Trial name
- NCT02667340
- Testing
- Superstarch
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Western Ontario, Canada
Heat Stress, Aging
Aging, Beta Blockers, and Thermoregulatory Responses
This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.
- Trial name
- NCT06582680
- Testing
- Ambient Heat
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Hyperthermia
The Effects of Facial Cooling on Fencing Performance
Fencing competitions can last between nine and eleven hours, during which athletes wear layers of protective equipment that impair evaporative heat transfer and spend a large amount of time at exercise intensities > 85% maximum…
- Trial name
- NCT05302739
- Testing
- Facial cooling
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- St Mary's University College
Hypothermia
Evaluating Adult Patient Temperatures During Lower Spinal Surgery
The purpose of this study is to evaluate patients' temperatures after using one of two ventilator circuits (breathing systems): the ANAPOD™ Heat and Humidification System (ANAPOD™ system) or the standard ventilator circuit with a…
- Trial name
- NCT03050775
- Testing
- Heated Ventilator Circuit, Standard Ventilator Circuit
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Lower Extremity Varicose Veins, Radiofrequency Ablation
Pain During Heat Treatment for Lower Extremity Varicose Veins: Radiofrequency vs. Microwave
This study compares two common heat-based procedures for treating varicose veins in the legs: radiofrequency ablation (RFA) and microwave ablation (MWA).
- Conditions
- Lower Extremity Varicose Veins, Radiofrequency Ablation, Microwave Ablation, Pain Measurement
- Trial name
- NCT07907315
- Testing
- Radiofrequency ablation, Microwave Ablation
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Chunshui He
Heat Stress, Body Temperature Changes
Heat Stress in Wheelchair Sports
The aim of the study is to study the thermoregulatory responses under real life conditions, such as during wheelchair rugby and basketball matches.
- Trial name
- NCT03815708
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Aging
Heat, Microvascular Function and Aging
Vascular dysfunction is a common factor in many chronic debilitating diseases, contributing to morbidity and mortality. With the onset of chronic disease or exposure to stress, the vasculature displays an inability to adequately…
- Trial name
- NCT06633198
- Testing
- Passive Heating, L-NAME
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- William Hughes
Heat Stroke
Study of Thermoregulation in Exercise Heat Stroke in the Military Environment
The EXPLO-MITO study is an ancillary study from the main EXPLO-CCE study (NCT04593316; IDRCB: 2020-A01967-32). The Heat Tolerance Test (HTT) is a physiological exploration that has several advantages for use in research and…
- Trial name
- EXPLO-MITO (NCT05847465)
- Testing
- Bike stress test, Heat Tolerance Test, Heat nociception test
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Hypothermia
Study of Heat and Intravenous Fluids for Exogenous Rewarming
The purpose of this study is to compare two novel active rewarming techniques in mildly hypothermic people. Volunteers will undergo 3 cooling trials in a circulating bath at 14 degrees celsius and will then be rewarmed with…
- Trial name
- SHIVER (NCT02339103)
- Testing
- Warmed IV fluids, Warmed perfusion pads
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Stanford University