Clinical trials: Heat Effect
Heat Exposure, Exercise Performance
Effects of Creatine and Heat Exposure on Exercise Performance and Body Water Distribution
The goal of this clinical trial is to learn whether creatine supplementation changes how the body adapts to repeated exercise in the heat in healthy recreationally active adults and varsity athletes.
- Conditions
- Heat Exposure, Exercise Performance, Hydration, Body Fluid Compartments
- Trial name
- NCT07593014
- Testing
- Creatine Monohydrate
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Windsor
Heat Exposure, Exercise Training
Postexercise Hot-Water Immersion on Exercise Performance in Hypoxia
The purpose of this study is to determine the effect of 5 days post-exercise hot water immersion on exercise performance at simulated altitude.
- Trial name
- NCT06672614
- Testing
- Post-Exercise Hot Water Immersion, Control Group
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nipissing University
Hot Weather; Adverse Effect, Kidney Dysfunction
Renal Considerations in the Heat Stress Recommendations
An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is unknown, but may be related to kidney dysfunction caused by increases in body…
- Conditions
- Hot Weather; Adverse Effect, Kidney Dysfunction, Kidney Injury, Hyperthermia
- Trial name
- Aim1 (NCT04767347)
- Testing
- 23.0°C WBGT - Fixed Work Rate, 25.5°C WBGT - Fixed Work Rate, 27.5°C WBGT - Fixed Work Rate
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Indiana University
Temperature Monitoring, Cardiac Surgical Procedures
Comparison of the Accuracy and Precision of a Zero Heat Flux Thermometer (SpotOn) Versus Pulmonary Artery Temperature.
In this study, we aim to compare the core temperature measured with two noninvasive ZHF thermometers and a urinary bladder thermometer against a gold standard blood temperature measured in the pulmonary artery in patients…
- Trial name
- NCT05737147
- Testing
- Zero Heat Flux Thermometer
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Melanoma
A Phase II Study of Isolated Hepatic Perfusion (IHP) in Patients With Ocular Melanoma
Ocular melanoma, or cancer of the eye, is a rare form of cancer that can spread to the liver. A tumor in the liver, because of its size or location, sometimes cannot be removed with surgery.
- Trial name
- NCT00062933
- Testing
- Laparotomy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
Osteoarthritis, Knee
The Effect of Cryotherapy in Pain Control, Function and Quality of Life in Individuals With Knee Osteoarthritis
The purpose of this study is to verify the effect of cryotherapy in pain control, function and quality of life in individuals with knee osteoarthritis.
- Trial name
- NCT02725047
- Testing
- Cryotherapy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Universidade Federal de Sao Carlos
Fistula-In-Ano, Anal Fistula
Treatment of Anal Fistula With Lasercoagulation
The purpose of this study is to determine whether treatment with laser coagulation is an effective and safe treatment option for patients with anal fistula
- Trial name
- NCT03017898
- Testing
- Laser Coagulation
- Where
- Sweden
- Volunteers
- 52 people
- Sponsor
- Region Skane
Cancer Pancreas
Concurrent Hyperthermia and Chemoradiotherapy in LAPC: Phase II Study
This is a phase II randomized study of concurrent chemoradiotherapy and local hyperthermia (study group) versus chemoradiotherapy alone (control group) following neoadjuvant chemotherapy in locally advanced pancreatic cancer.
- Trial name
- HEATPAC (NCT02439593)
- Testing
- Chemoradiotherapy (CTRT), Thermochemoradiotherapy (CTRTHT)
- Where
- Switzerland
- Volunteers
- 78 people
- Sponsor
- Kantonsspital Aarau
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Niue
Ambient air temperatures in the Pacific have broken record highs in 2024. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate change.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06570993)
- Testing
- Cool roof
- Where
- Niue
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Acute Lung Injury, Pneumonia
Gases Humidification During Noninvasive Ventilation : Heat and Moisture Exchanger or Heated Humidifier ?
To humidify gases during non invasive ventilation, both to heated humidifier (HH) and heat and moisture exchanger (HME) are routinely used.
- Conditions
- Acute Lung Injury, Pneumonia, Chronic Obstructive Pulmonary Disease, Acute Heart Failure
- Trial name
- NCT00221819
- Testing
- heated humidifier (device), Heat and moisture exchanger (device)
- Where
- France
- Sponsor
- University Hospital, Bordeaux
Heat Acclimation and Thermotolerance
Chronic Exercise With Overdressing
The purpose of this study is to determine if five training sessions of exercise with overdressing can induce heat acclimation.
- Trial name
- Chronic-XO (NCT07099872)
- Testing
- Control, Overdressing
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Pancreatic Ductal Adenocarcinoma (mPDAC), Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)
A Study Comparing Whole-Body Heat Treatment Plus Systemic Therapy to Systemic Therapy Alone, for Advanced Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis and limited treatment options following failure of first-line therapy.
- Trial name
- MATTERS-2 (NCT07711067)
- Testing
- Whole-body hyperthermia, Standard-of-Care Systemic therapy
- Where
- 4 sites in Belgium, Spain
- Volunteers
- 95 people
- Sponsor
- ElmediX
Heat Stress, Physiological Stress
Suitability of the 26 °C Indoor Temperature Upper Limit for Older Adults: Impacts of Clothing and Daily Activity
While an upper limit of 26°C has been shown to be protective for heat-vulnerable older occupants (DOI: 10.1289/EHP11651), this recommendation did not consider the added heat burden associated with increases in internal heat…
- Trial name
- NCT07189507
- Testing
- Simulated indoor temperature upper limit
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Body Temperature Regulation
Physiological and Molecular Influences of Astaxanthin Supplementation on Heat Strain in Humans
Exposure to heat stress can compromise the physiological and cognitive function and be life threatening, particularly in a military setting.
- Trial name
- Astaxanthin (NCT02088242)
- Testing
- Astaxanthin
- Where
- Israel
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Pain, Chronic
Apply the PD Model of Peripheral Oxytocin Action to a Multimodal Stimulus
This is a study of participants that will receive an intravenous (IV) infusion of oxytocin (naturally occurring hormone that is made in the brain). In this study healthy volunteers are recruited.
- Trial name
- NCT04433741
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Sleep Apnea
Measuring Breathing Airflow Using a Heat Sensitive Camera (ThermFlow)
ThermPaed is a Sheffield Children's Hospital research collaborative which investigated the clinical diagnostic capabilities of high resolution thermal imaging (HRTI) in paediatrics.
- Trial name
- ThermFlow (NCT05972161)
- Testing
- Thermal Imaging camera
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Vaginitis Bacterial, Inflammation, Ear
Effect of Lactobacillus Johnsonii or White Pomegranate Extract on the Vaginal Health
The goal of this clinical trial is to explore the effect of Lactobacillus johnsonii and white pomegranate extract on female bacterial status, it aims to answer are: Evaluate Lactobacillus johnsonii TCI250 probiotics or white…
- Trial name
- NCT06069531
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Chung Shan Medical University
Acute Rhinitis, Acute Pharyngitis
Efficacy and Safety of Jinhua Qinggan Granules (JHQG) for the Use of Acute Upper Respiratory Infection
The goal of this clinical trial is to learn if drug Jinhua Qinggan Granules (JHQG) works to treat acute upper respiratory tract infection in adults. It will also learn about the safety of drug JHQG.
- Conditions
- Acute Rhinitis, Acute Pharyngitis, Acute Tonsillitis, Acute Sinusitis
- Trial name
- (JHQG-AURI) (NCT07720583)
- Testing
- Jinhua Qinggan Granules
- Where
- Pakistan
- Volunteers
- 546 people
- Sponsor
- University of Karachi
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health
Ambient air temperatures in Asian, Latin American, African, and Pacific climate hotspots have broken record highs in 2024, driven by man-made climate change. Solutions are needed to reduce heat exposure in communities.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06579950)
- Testing
- Cool roof
- Where
- 5 sites in Burkina Faso, Fiji and 3 more
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
HIV Infections
Feasibility and Pilot Efficacy of Flash-heated Breast Milk to Reduce Maternal-to-Child-Transmission of HIV in Tanzania
This study will investigate the feasibility of HIV positive mothers in Tanzania to correctly use the Flash-heat method to pasteurize their breast milk and for how long they are able to do so.
- Trial name
- Flash-heat (NCT00523510)
- Testing
- Infant feeding counseling that includes Flash-heat
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of California, Davis