Clinical trials: Heat Stress
Heat Stress, Physiological Stress
Suitability of a 26 °C Indoor Environment for Mitigating Heat Strain in Young Adults
While an indoor upper temperature limit of 26 °C has been shown to protect heat-vulnerable older adults (DOI: 10.1289/EHP11651), this guideline has not been verified in young, habitually active adults.
- Conditions
- Heat Stress, Physiological Stress, Cognitive Change
- Trial name
- NCT07267598
- Testing
- Simulated indoor temperature upper limit
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Ottawa
Pre-hypertension
Heat & Aerobic Training (HEAT) Study
This study is intended for inactive, middle-aged adults with untreated pre-hypertension who live in the Urbana-Champaign area, who are interested in a comprehensive program designed to enhance physical activity \& reduce blood…
- Trial name
- HEAT (NCT02546726)
- Testing
- Heat & Aerobic Training (HEAT), Exercise Only
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Illinois at Urbana-Champaign
Neoplasms Pancreatic
Percutaneous Immunostimulating Interstitial Laser Thermotherapy in Pancreatic Cancer
Thermotherapy is a technology aiming at destroying tissue, for example tumor tissue. Immunostimulating Interstitial Laser Thermotherapy (imILT) is a specific form of thermotherapy, which, in addition to destroying tumor tissue…
- Trial name
- NCT03187587
- Testing
- imILT, Standard chemotherapy treatment
- Where
- Portugal
- Volunteers
- 8 people
- Sponsor
- Clinical Laserthermia Systems AB
Body Temperature Changes
Cooling Via Cryogenx Body Cooling Device
The aim of this project is to test the rate of cooling following exercise in the heat utilising the CRYOGENX Cryosuit device i) against passive cooling, and ii) to quantify the rate of cooling and compare this rate with…
- Trial name
- NCT06517147
- Testing
- Cryogenx cooling, Regular cooling
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Brunel University
Borderline and Locally Advanced Pancreatic Cancer
A Prospective Study of Concurrent Hyperthermia, Chemotherapy and Radiotherapy in Borderline and Locally Advanced Pancreatic Cancer (PANHEAT)
The project proposes a prospective multicenter study to evaluate the incorporation of deep regional hyperthermia into the standard of care neoadjuvant chemotherapy (mFOLFIRINOX/NABPACLITAXEL) followed by radiotherapy in…
- Trial name
- PANHEAT (NCT07839676)
- Testing
- Hyperthermia plus neoadjuvant chemotherapy/radiotherapy Arm Description: Hyperthermia plus neoadjuvant chemotherapy (mFOLFIRINOX/nab Paclitaxel) followed by a) surgically resectable: Hyp
- Where
- 2 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Fernando Pessoa Canarias University
Hot Weather; Adverse Effect, Kidney Dysfunction
Renal Considerations in the Heat Stress Recommendations
An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is unknown, but may be related to kidney dysfunction caused by increases in body…
- Conditions
- Hot Weather; Adverse Effect, Kidney Dysfunction, Kidney Injury, Hyperthermia
- Trial name
- Aim1 (NCT04767347)
- Testing
- 23.0°C WBGT - Fixed Work Rate, 25.5°C WBGT - Fixed Work Rate, 27.5°C WBGT - Fixed Work Rate
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Indiana University
Labour Pain, Cold Therapy
Effect of Intermittent Heat and Cold Therapy on Comfort During Labor
Summary of the Study Childbirth is one of the most significant and complex experiences in any mother's life. According to a study, labour pain ranges from mild to severe and is felt throughout the body, particularly in the lower…
- Conditions
- Labour Pain, Cold Therapy, Heat Therapy
- Trial name
- NCT06214585
- Testing
- Intermittent heat and cold versus heat-only therapy, Heat- only Therapy
- Where
- Nepal
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Tribhuvan University, Nepal
Thermoregulation
Physiological Responses to Heat Stress During High-risk Events
Exertional heat stroke (EHS) affects ~500 Military Personnel and over 100 Soldiers every year, and it is believed that these numbers are underreported.
- Trial name
- NCT06907225
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Osteoarthritis, Knee
The Effect of Cryotherapy in Pain Control, Function and Quality of Life in Individuals With Knee Osteoarthritis
The purpose of this study is to verify the effect of cryotherapy in pain control, function and quality of life in individuals with knee osteoarthritis.
- Trial name
- NCT02725047
- Testing
- Cryotherapy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Universidade Federal de Sao Carlos
Body Temperature Changes
Cooling Vest May Reduce Heat Stress During Surgery
The investigators will propose a randomized cross-over trial using a uniform and strongly balanced 4-period design in which will include four operations for each surgeon.
- Trial name
- NCT04511208
- Testing
- Cooling Vest, Without cooling vest
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Tonsil Disease, Tonsillitis
Intracapsular Tonsillectomy in Adults
Comparing the classical extracapsular tonsillectomy (TE) performed with electrosurgery to intracapsular approaches (SIPT) by coblation or microdebrider. The patient group is adults with recurrent or chronic tonsillitis
- Conditions
- Tonsil Disease, Tonsillitis, Tonsillitis Acute, Tonsillitis Chronic
- Trial name
- NCT03654742
- Testing
- tonsillectomy
- Where
- Finland
- Volunteers
- 167 people
- Sponsor
- Turku University Hospital
Heat Stress, Aging
Aging, Beta Blockers, and Thermoregulatory Responses
This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.
- Trial name
- NCT06582680
- Testing
- Ambient Heat
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Advanced Metastastic Malignant Melanoma, Refractory to First-Line Chemotherapy Irresectable Progressive Soft Tissue Metastases
Efficacy of Chemotherapy Combined With Regional Hypothermia in Advanced Malignant Melanoma Patients With Progressive Soft Tissue Metastases
The incidence of malignant melanoma continues to rise throughout the world. Approximately 12 in 100,000 Germans are diagnosed with malignant melanoma per year.
- Trial name
- NCT00264056
- Testing
- hyperthermia
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Fachklinik Hornheide an der Universität Münster
Solid Tumor
Hyperthermia With Flexible Electrode-typed 2-MHz Device During Radiotherapy for Solid Tumors
The main purpose of this study is to evaluate immunogenic effect of hyperthermia applied with flexible electrode-typed 2-MHz device during radiotherapy for solid tumors.
- Trial name
- NCT05282784
- Testing
- Hyperthermia, Radiotherapy
- Volunteers
- 20 people
- Sponsor
- Yonsei Hyperthermia Study Group
Adrenocortical Carcinoma, Peritoneal Carcinomatosis
Surgery and Heated Chemotherapy for Adrenocortical Carcinoma
Background: Adrenocortical carcinoma (ACC) is a rare tumor of the adrenal gland. Few people who develop this disease live more than 5 years after being diagnosed.
- Trial name
- NCT01833832
- Testing
- Cisplatin, Cytoreductive surgery, sodium thiosulfate
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
Heat Stress
Heat Stress Exposure Among Low-Income Residents in Bangladesh and Evaluation of Indoor Interventions
The goal of this clinical trial is to learn if infrastructure and equipment installed to cool homes reduce adverse health outcomes.
- Trial name
- NCT06979258
- Testing
- Cooling intervention
- Where
- Bangladesh
- Volunteers
- 1,539 people
- Sponsor
- University of California, Berkeley
Heat Stress, Physiological Stress
Suitability of the 26 °C Indoor Temperature Upper Limit for Older Adults: Impacts of Clothing and Daily Activity
While an upper limit of 26°C has been shown to be protective for heat-vulnerable older occupants (DOI: 10.1289/EHP11651), this recommendation did not consider the added heat burden associated with increases in internal heat…
- Trial name
- NCT07189507
- Testing
- Simulated indoor temperature upper limit
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Fluid Retention, Sodium Retention
The Effect of AMP Human Sodium Bicarbonate Lotion on Dehydrated Heat Stress
The primary purpose of the proposed study is to evaluate the effects of a topical sodium bicarbonate lotion (PR Lotion, AMP Human, Park City, UT) on measures of hydration status and fluid balance in humans when exposed to the…
- Conditions
- Fluid Retention, Sodium Retention, Heat Stress, Dehydration (Physiology)
- Trial name
- AMP2 (NCT05092854)
- Testing
- PR Lotion - AMP Human Performance, AminoVital - Rapid Recovery
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Hyperthermia, Fatigue; Heat
Work Design Interventions for Heat Resilience
The goal of this project is to compare different ways to schedule a workday to see if older workers should follow a specific work protocol to reduce strain on the heart and muscles.
- Conditions
- Hyperthermia, Fatigue; Heat, Work-Related Condition
- Trial name
- NCT06599788
- Testing
- Standard work pace, Reduced-pace work, Increased-pace work
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Hyperthermia, Major Depressive Disorder
Peripheral Neuroimmune Mechanisms of Hyperthermia
The goal of this study is to examine how whole-body hyperthermia affects the thermoinflammatory profile, which includes the combined immune and heat shock response, in patients with depression and whether these changes correlate…
- Conditions
- Hyperthermia, Major Depressive Disorder, Inflammation
- Trial name
- NCT05366270
- Testing
- WBH
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital