Clinical trials: Heat Stress Disorders
Low Birth Weight Baby, Small for Gestational Age (SGA)
Biological Impacts of Rising Temperatures on Maternal, Fetal, and Newborn Health: A Cohort Study (BIRTH Cohort)
The goal of this study is to learn how being exposed to high environmental temperatures during pregnancy affects the health of pregnant women and their babies.
- Conditions
- Low Birth Weight Baby, Small for Gestational Age (SGA), Preterm Birth, Pregnancy Complications
- Trial name
- BIRTH (NCT06957769)
- Testing
- heat stress
- Where
- 3 sites in Pakistan
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Gastrointestinal Cancer, Immunotherapy
Hyperthermia Combined With Immune Checkpoint Inhibitors in the Treatment of Advanced Gastrointestinal Malignancies With Liver Metastases
This study aims to explore the synergistic antitumor effects and safety of hyperthermia combined with immune checkpoint inhibitors (ICIs) in patients with advanced gastrointestinal malignancies with liver metastases.
- Conditions
- Gastrointestinal Cancer, Immunotherapy, Liver Metastasis
- Trial name
- NCT07118566
- Testing
- Hyperthermia, Immunotherapy
- Volunteers
- 40 people
- Sponsor
- China Medical University, China
Hyperthermia, Major Depressive Disorder
Peripheral Neuroimmune Mechanisms of Hyperthermia
The goal of this study is to examine how whole-body hyperthermia affects the thermoinflammatory profile, which includes the combined immune and heat shock response, in patients with depression and whether these changes correlate…
- Conditions
- Hyperthermia, Major Depressive Disorder, Inflammation
- Trial name
- NCT05366270
- Testing
- WBH
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Cigarette Smoking
The Effect of Smoking on Thermoregulation
To the best of our knowledge, a possible relation between smoking and heat injuries or heat intolerance was never scientifically examined, although such a relation is logical according to the observations that smoking has a…
- Trial name
- NCT01596556
- Testing
- Nicotine, cigarette smoking
- Where
- Israel
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Diabetes Mellitus, Type 2, Insulin Resistance
Heat Therapy in Patients With Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) is a significant burden worldwide. In addition to lifestyle intervention, heat therapy has been shown to be effective in improving glycemic control.
- Trial name
- HEATED (NCT05237219)
- Testing
- Passive heating, Thermoneutral
- Where
- Hungary
- Sponsor
- University of Pecs
Heat Stroke Exertional, Heat Illness
Treatment of Exertional Heatstroke witH icE wAter Soaked Towels
Exertional heat stroke (EHS) is the most serious form of heat-illness that can occur during sports and exercise. If not recognized and treated immediately mortality rate of EHS is high.
- Conditions
- Heat Stroke Exertional, Heat Illness, Heat Exhaustion
- Trial name
- THE HEAT (NCT05717777)
- Testing
- There is no intervention, only observational study
- Where
- Netherlands
- Volunteers
- 55 people
- Sponsor
- Erasmus Medical Center
Energy Metabolism
Lactate Profile and Fat Oxidation During Exercise
The goal of this clinical trial is to test whether changes in lactate kinetics during exercise (due to glycogen depletion or hyperthermia) alter the pattern of fat oxidation during a maximal incremental cycle ergometer test in…
- Trial name
- LacFat (NCT05703100)
- Testing
- Incremental exercise test, Incremental exercise test under hyperthermia, Incremental exercise test under glycogen depletion
- Where
- Spain
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Technical University of Madrid
Plantar Fascia, Hyperthermia
Analysis of Hyperthermia as an Adjunctive Treatment to Evidence-based Clinical Intervention in Subjects With Plantar Fasciitis: a Double-blind Randomized Clinical Trial
This project aims to analyze the use of hyperthermia within a treatment protocol for plantar fasciitis, as well as to determine the difference between two and three sessions per week.
- Trial name
- NCT07103226
- Testing
- Hyperthermia, Physical Exercise, Stretching
- Volunteers
- 64 people
- Sponsor
- University of Malaga
Climate Change Heat Stress
Assessment of Climate Change Related Heat Stress Among Workers in Upper Egypt : Impact of Intervention Program on Physiological Responses
Climate change has a significant impact on human health and productivity at work. According to the Intergovernmental Panel on Climate Change (IPCC) and the United Nations, climate change is one of the most significant global…
- Trial name
- NCT07538778
- Testing
- Heat Stress Awareness Program (HSAP), no traing
- Volunteers
- 84 people
- Sponsor
- Assiut University
Dysmenorrhea
A Randomized, Sham Device Controlled, Single Blinded Trial of Portable Transcutaneous Electrical Nerve Stimulation and Heat Therapy Machine in Women With Dysmenorrhea
The hypothesis is that a transcutaneous electrical nerve stimulation and heat therapy machine could reduce dysmenorrhea in women with primary or secondary dysmenorrhea.
- Trial name
- NCT01662934
- Testing
- I RUNE
- Where
- South Korea
- Volunteers
- 118 people
- Sponsor
- Seoul National University Hospital
Body Temperature Changes
Cooling Via Cryogenx Body Cooling Device
The aim of this project is to test the rate of cooling following exercise in the heat utilising the CRYOGENX Cryosuit device i) against passive cooling, and ii) to quantify the rate of cooling and compare this rate with…
- Trial name
- NCT06517147
- Testing
- Cryogenx cooling, Regular cooling
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Brunel University
Preparation of Internal Thoracic Artery
Low Thermal Electrosurgical Device for Atraumatic Internal Thoracic Artery Harvesting
Electrosurgery is fundamental to the precise, fast and bloodless preparation of internal thoracic artery grafts in cardiac surgery.
- Trial name
- NCT03510026
- Testing
- Low thermal device preparation
- Volunteers
- 20 people
- Sponsor
- Triemli Hospital
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health
Ambient air temperatures in Asian, Latin American, African, and Pacific climate hotspots have broken record highs in 2024, driven by man-made climate change. Solutions are needed to reduce heat exposure in communities.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06579950)
- Testing
- Cool roof
- Where
- 5 sites in Burkina Faso, Fiji and 3 more
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Cervical Intraepithelial Neoplasia
A Trial of Two Electrosurgical Conizations: Histopathological Analysis of Excision Margins
The purpose of this trial is to evaluate if Straight Wire Excision of the Transformation Zone (SWETZ) is superior to (Large Loop Excision of the Transformation Zone) LLETZ cone in reducing the incomplete excision of disease.
- Trial name
- NCT01929993
- Testing
- SWETZ, LLETZ cone
- Where
- Brazil
- Volunteers
- 164 people
- Sponsor
- Oswaldo Cruz Foundation
Heat Illness, Quality of Life
Structural Heat Adaptation and Education in Urban Setting
This study aims to understand whether simple, low-cost interventions, such as improved home cooling, practical advice, and minor home modifications, can help protect people's health and improve quality of life during periods of…
- Trial name
- SHAPES (NCT06991543)
- Testing
- Community education and awareness, and personal lifestyle and cooling behavior modification, Participatory local structural and environmental heat mitigation solutions
- Where
- Pakistan
- Volunteers
- 7,128 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Breast Reconstruction, Breast Cancer
Comparison of PEAK PlasmaBlade™ to Conventional Diathermy in Abdominal Based Free Flap Breast Reconstruction
Electrosurgery allows for dissection with simultaneous haemostasis. One of its disadvantages is that the heat production can cause injury to the surrounding tissue which may result in wound healing problems and an increased rate…
- Trial name
- NCT04350411
- Testing
- Conventional diathermy, PEAK PlasmaBlade™
- Where
- United Kingdom
- Volunteers
- 108 people
- Sponsor
- Anglia Ruskin University
Physiological Stress
Examination of Textile Solutions for Reducing Physiological Stress
Using protective or combat garments under heavy heat stress conditions, during rest or exertion, may hinder the body's ability to effectively exchange heat with the environment and thereby can lead to heat injuries.
- Trial name
- NCT02442947
- Testing
- clothing type, protective garments of Paul Boye Technologies
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Glioblastoma Multiforme
NanoTherm In Adjuvant Therapy of Glioblastoma Multiforme
Glioblastoma multiforme (GBM), the most common and malignant primary brain tumor in adults is classified as a World Health Organisation (WHO) grade 4. Surgical removal of the tumor is the primary method of treatment.
- Trial name
- ANCHIALE (NCT06271421)
- Testing
- NanoTherm therapy, Glioma Resection, radiotherapy according to Stupp protocol
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Poznan University of Medical Sciences
Hyperthermia, Burn Injury
IEEM- Work:Rest Cycles in Burn Survivors- Humidity
The purpose of this project is to identify the effects of a severe burn injuries in humans on core temperature responses during work:rest cycles while in a heated environment.
- Trial name
- NCT06966336
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Macromastia
PEAK PlasmaBlade 4.0 in Bilateral Breast Reduction
The objective of this clinical study is to evaluate the operative performance of the PEAK PlasmaBlade 4.0 during bilateral breast reduction; to monitor and record post-operative pain, adverse events and skin scarring following…
- Trial name
- PRECISE (NCT00986453)
- Testing
- PEAK PlasmaBlade, Traditional Electrosurgery with scalpel
- Where
- 7 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Medtronic Surgical Technologies