Clinical trials: Heat Stress Disorders
Tumors
Optimal Application Dose of Superficial Hyperthermia
Hyperthermia - a warming of the tumor at 42-43 ° C - in combination with radiation and / or chemotherapy is a proven method of treatment for malignant tumors.
- Trial name
- NCT00766233
- Testing
- Hyperthermal treatment
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- Universitätsmedizin Mannheim
Temperature Change, Body
The Validity of CORE Sensor in Heat Training for Male and Female Endurance Athletes
This study is investigating the efficacy of CORE™ devices in calculating core body temperature in athletes under varying environmental conditions.
- Trial name
- CORE (NCT05692947)
- Testing
- Core body temperature device
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Heat Acclimation and Thermotolerance
Chronic Exercise With Overdressing
The purpose of this study is to determine if five training sessions of exercise with overdressing can induce heat acclimation.
- Trial name
- Chronic-XO (NCT07099872)
- Testing
- Control, Overdressing
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Ankyloglossia, Tongue-tie
Healing Efficacy of Diode Laser in Lingual Frenectomy
This study aims to compare the wound healing efficacy and postoperative experiences between the 940 nm diode laser technique and the traditional electrosurgery method for treating ankyloglossia (tongue-tie) in children aged 3 to…
- Trial name
- NCT07557875
- Testing
- Lingual Frenectomy using 940nm Diode Laser, Lingual Frenectomy using High-frequency Electrosurgery
- Where
- 2 sites in Vietnam
- Volunteers
- 53 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Solid Neoplasms
Celsius TCS Hyperthermia System PMCF Trial
Based on the basic data of all patients foreseen for a local hyperthermia in the participating centers the failure rate (of the Celsius TCS Hyperthermia System) and the complication rate (injury to the patients) will be recorded.
- Trial name
- NCT02896049
- Testing
- Hyperthermia
- Sponsor
- Celsius42 GmbH
Ovarian Cyst
A Random Clinical Trial (RCT) of the Impact of Electrocoagulation on Ovarian Reserve
Laparoscopic ovarian cystectomy is widely used for the removal of benign ovarian cysts but damage to ovarian reserve caused by electrocoagulation has recently been questioned.
- Trial name
- NCT00746278
- Testing
- Laparoscopic ovarian cystectomy using bipolar, Laparoscopic ovarian cystectomy using ultrasonic scalpel, Laparoscopic ovarian cystectomy using suture
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Shandong Provincial Hospital
Colorectal Neoplasm, Liver Neoplasm
A Phase I Study of Isolated Hepatic Perfusion With Escalating Dose Melphalan Followed by Postoperative Hepatic Arterial Floxuridine and Leucovorin for Metastatic Unresectable Colorectal Cancers of the Liver
Patients with unresectable metastatic colorectal cancer confined to the liver will undergo a 1 hour hyperthermic isolated hepatic perfusion (IHP) with escalating dose melphalan.
- Conditions
- Colorectal Neoplasm, Liver Neoplasm, Neoplasm Metastasis
- Trial name
- NCT00001576
- Testing
- Melphalan, Floxuridine, Leucovorin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Cancer Institute (NCI)
Heat Tolerance
Heat Stress and Physiological Strain of Permeable vs. Impermeable CB Protective Garment
Current protective clothing of any kind, especially the nuclear-biological-chemical (NBC) protective garments, amplify thermal stress because of the inherent properties of the clothing material.
- Trial name
- NCT01221012
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Aging
Cooling Strategies for Older Adults in the Heat
The earth's climate is warming, and the number of heat waves has increased in recent years. At the same time, the number of adults over the age of 65 is growing.
- Trial name
- NCT06349616
- Testing
- Intermittent cold-water hand and forearm immersion, No intermittent cold-water hand and forearm immersion
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Penn State University
Heat Stress, Physiological Stress
Suitability of the 26 °C Indoor Temperature Upper Limit for Older Adults: Impacts of Clothing and Daily Activity
While an upper limit of 26°C has been shown to be protective for heat-vulnerable older occupants (DOI: 10.1289/EHP11651), this recommendation did not consider the added heat burden associated with increases in internal heat…
- Trial name
- NCT07189507
- Testing
- Simulated indoor temperature upper limit
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Depression, Mood Disorders
Cold and Heat Investigation to Lower Levels of Depression
This study will recruit 112 medically healthy adults (aged 18-65) currently experiencing depressive symptoms to be randomized to receive either a single Whole Body Hyperthermia (heat therapy) treatment or a Whole Body…
- Conditions
- Depression, Mood Disorders, Healthy (Controls)
- Trial name
- CHILL'D (NCT06263738)
- Testing
- Whole Body Hyperthermia, Cold Water Plunge
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Barry Sandler
Healthy, Heat Stress, Exertional
Impact of Heat on Dual Task Performance
This study looks at how people response performing single and dual tasks (cognitive and motor) prior to and after a rapid heat stress that increased core temperature to 39C.
- Trial name
- NCT07629414
- Testing
- heat stress
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Hearing Loss
Local Heat-Stress as a Mechanism of Hearing Preservation
This pilot study plans to determine whether or not local heat-stress as a mechanism can help to preserve hearing in adults treated with Cisplatin.
- Trial name
- NCT02872844
- Testing
- ICS AirCal3
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
High-risk Pregnancy
Leg Heating in Pregnant Women With Obesity
Obesity is a major risk factor for hypertensive disorders of pregnancy (HDP). The underlying mechanisms are largely unclear, but maternal vascular endothelial dysfunction is likely involved.
- Trial name
- NCT06932250
- Testing
- Leg heating
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Cutaneous Leishmaniasis
Feasibility of Integrating Thermotherapy for Treatment of Cutaneous Leishmaniasis in Primary Health Care Setup
This study will look at how feasible it is to use thermotherapy (TT) as a treatment for skin(cutaneous) leishmaniasis (CL) in health centers in the Sodo and South Sodo districts, Ethiopia.
- Trial name
- TTCL (NCT06746350)
- Testing
- Thermotherapy
- Where
- Ethiopia
- Volunteers
- 103 people
- Sponsor
- Armauer Hansen Research Institute, Ethiopia
Hyperthermia, Radiotherapy
Hyperthermia Combined With Neoadjuvant Radiochemotherapy for LARC
The purpose of this study is to determine whether adding deep hyperthermia to neoadjuvant concurrent radiochemotherapy could improve T-downstaging rate for locally advanced rectal cancer (LARC).
- Trial name
- PUTHRC-001 (NCT05070832)
- Testing
- Deep Hyperthermia
- Volunteers
- 142 people
- Sponsor
- Peking University Third Hospital
Resected Pancreatic Adenocarcinoma
Hyperthermia European Adjuvant Trial
Improvement of the clinical outcome in patients with resectable pancreatic carcinoma through an intensified adjuvant treatment with gemcitabine, cisplatin and regional deep hyperthermia as compared to standard chemotherapy.
- Trial name
- HEAT (NCT01077427)
- Testing
- Gemcitabine + Cisplatin + regional hyperthermia, Gemcitabine + Capecitabine
- Where
- Germany
- Volunteers
- 336 people
- Sponsor
- Klinikum der Universitaet Muenchen, Grosshadern
Obesity, Polycystic Ovary Syndrome
Heat Therapy and Cardiometabolic Health in Obese Women
Traditional medical treatments are often based on research done exclusively in males, and recent research efforts in the physiology community have highlighted critical sex differences in disease presentation and progression.
- Conditions
- Obesity, Polycystic Ovary Syndrome, Prehypertension, PreDiabetes
- Trial name
- CMH (NCT03644524)
- Testing
- Heat therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oregon
Aviation, Heat Stress
Changes in Aviators' Body Core Temperature Measurements at F-35
The many complaints that have been expressed by the US aircrew of the F-35 regarding the heat stress in the cockpit raised an obvious concern that, as a result of such heat levels, the aviators' core body temperature may increase…
- Trial name
- NCT03234270
- Testing
- Core temperature measurements
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Israeli Air Force Aeromedical Center
Heat Acclimation and Thermotolerance, Heat Effect
Exercise in Extreme Hot Weather Conditions
Background: Core body temperature increases in hot climates due to exercise workload, disrupting heat gain and loss of balance. The human thermoregulatory system regulates core body temperature through factors such as metabolic…
- Trial name
- EXHOTCON (NCT07307391)
- Testing
- hot wet high (HWH), hot dry high (HDH), Experimental: hot dry low (HWL)
- Where
- Spain
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Valladolid