Clinical trials: Heat Stress Disorders
Heat Illness
Community Health Adaptation & Resilience Mobilization (CHARM) HeatWise
Extreme heat events pose serious health risks, especially for communities with limited access to cooling, transportation, or social support.
- Trial name
- CHARM (NCT07500545)
- Testing
- CHARM HeatWise
- Where
- United States
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- Public Health Institute, California
Advanced Metastastic Malignant Melanoma, Refractory to First-Line Chemotherapy Irresectable Progressive Soft Tissue Metastases
Efficacy of Chemotherapy Combined With Regional Hypothermia in Advanced Malignant Melanoma Patients With Progressive Soft Tissue Metastases
The incidence of malignant melanoma continues to rise throughout the world. Approximately 12 in 100,000 Germans are diagnosed with malignant melanoma per year.
- Trial name
- NCT00264056
- Testing
- hyperthermia
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Fachklinik Hornheide an der Universität Münster
Thermoregulation, Cold Exposure
Effect of Pre-cooling on Whole-body Heat Loss During Exercise-heat Stress
Endurance exercise performance declines in hot environments as core body temperature increases. To enhance performance, body pre-cooling strategies, such as cold-water immersion have been employed to lower resting core…
- Conditions
- Thermoregulation, Cold Exposure, Heat Stress, Exercise
- Trial name
- NCT06670339
- Testing
- No Cooling, Pre-Cooling
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Heat Stress, Physiological Stress
Efficacy of Electric Fans in Children During Heat Waves
Extreme heat exposure is an escalating global public health concern, with climate change driving increases in the frequency, duration, and intensity of heat events.
- Conditions
- Heat Stress, Physiological Stress, Child Development
- Trial name
- NCT07864103
- Testing
- Simulated exposure to indoor overheating without fans, Simulated exposure to indoor overheating with fans
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Obesity, Gender
Work-Related Effects of Heat, Activity, and Fat in Middle Aged Men
Obesity is associated with many undesirable health effects and disease, and middle age is associated with increased risk for disease.
- Conditions
- Obesity, Gender, Problem of Aging
- Trial name
- NCT02532725
- Testing
- Cardiopulmonary Exercise Stress Test, Climatic-Controlled Cardiopulmonary Exercise Stress Test, Body Composition Evaluation
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Freeman-Sheldon Research Group, Inc.
Postmenopausal, Female
How Seasons Affect Kidney Health in Post-Menopausal Females
The investigators are assessing how seasonal changes affect kidney function biomarkers in post-menopausal women, an understudied group.
- Trial name
- NCT06866743
- Testing
- There will be no intervention.
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Florida State University
Native and Valve in Valve Aortic Valve Failure
Bioprosthetic or Native Aortic Scallop Intentional Laceration to Prevent Iatrogenic Coronary Artery Obstruction (BASILICA) Prospective Investigation
Background: TAVR is a common therapy for people with heart problems. It stands for transcatheter aortic valve replacement, TAVR can be a better option than surgery. But it isn t safe for everyone.
- Trial name
- BASILICA (NCT03381989)
- Testing
- ASHI_INTECC Astato XS 20 0.014 guidewire
- Where
- 4 sites in United States
- Volunteers
- 31 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sarcoma,Soft Tissue
Feasibility of Total Neoadjuvant Treatment With HYPErthermia in Patients With High-risk Extremity and Trunk Soft Tissue Sarcoma (TNT-HYPE)
Soft tissue sarcomas (STSs) are rare cancers with a 5-year survival rate of 60%, and there is no standard treatment for high-risk extremity and trunk STSs (eSTS).
- Trial name
- TNT-HYPE (NCT06835049)
- Testing
- Doxorubicin, Ifosfamide, Dacarbazine
- Where
- 8 sites in Switzerland
- Volunteers
- 24 people
- Sponsor
- Swiss Cancer Institute
Eco-anxiety, PTSD - Post Traumatic Stress Disorder
Assessing the Effects of Cool Roofs on Mental Health in Ahmedabad, India
Ambient air temperatures in India have broken record highs. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate change.
- Conditions
- Eco-anxiety, PTSD - Post Traumatic Stress Disorder, Resilience, Anxiety
- Trial name
- REFLECT (NCT07251218)
- Testing
- Cool roof
- Where
- India
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Hyperthermia
Military Alerting System for Monitoring Body Temperature During Active Cooling
BHSAI is developing a computational system that provides early alerts of a rise in core body temperature to help reduce the risk of heat injury in the field and during training.
- Trial name
- MAMBA (NCT04431596)
- Testing
- Forearm cooling, Mist-fan cooling
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Safety Study
Hyperthermia Safety Study Uses Temperature Management System to Gently Raise Participant's Body Temperature to a Fever-range Level in a Controlled Setting.
The Abreu BTT 700 Temperature Management System (TMS) is a device that gently raises the body temperature of the participant to a fever-range level in a controlled setting. There will be one study treatment session.
- Trial name
- BTT (NCT07564440)
- Testing
- Hyperthermia
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Marc Abreu
Cervical Cancer
Radiation Therapy or Chemoradiation, Interstitial Brachytherapy in Combination With Hyperthermia in Advanced Cervical Cancer
The combination of radiation therapy or chemoradiation with Interstitial brachytherapy for advanced cervical cancer (pN+, FIGO-Stage II B - IV A is standard of therapy.
- Trial name
- NCT03249519
- Testing
- Radiation, brachytherapy, Cisplatin
- Where
- Germany
- Volunteers
- 999 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Melanoma
A Phase II Study of Isolated Hepatic Perfusion (IHP) in Patients With Ocular Melanoma
Ocular melanoma, or cancer of the eye, is a rare form of cancer that can spread to the liver. A tumor in the liver, because of its size or location, sometimes cannot be removed with surgery.
- Trial name
- NCT00062933
- Testing
- Laparotomy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
Recovery, Mechanical Stress
Effects of Hot Baths Prior or After a Damaging Protocol on Muscle Function and HSP70 Expression
Muscle lengthening contractions lead to physiological responses such as strength loss, soreness, immune cell infiltration, and CK production, along with elevated heat shock proteins (HSPs), which protect and regenerate cells.
- Conditions
- Recovery, Mechanical Stress, Heat Stress, HSP70
- Trial name
- Prehotemp (NCT07559344)
- Testing
- Immersion, NIRS, isokinetic dynamometer
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Heat Stress, Heat
Study of Biomarkers of Heat Tolerance and Recovery During Ultra-endurance Exercise
Military personnel are called upon to serve in hot, dry or humid climates, which places great demands on their ability to tolerate heat. Induced heat stress can impair performance and lead to pathologies.
- Trial name
- PENTHERE (NCT05921864)
- Testing
- Passive heat exposure, Active heat exposure
- Where
- France
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Metastatic Solid Tumors, Stage 4 Cancer
The Sarah Nanotechnology System for Treatment of Advanced Metastatic Solid Tumors Using Hyperthermia.
This is a sequential, dose-escalation, non-randomized, prospective, early feasibility trial. The goal of this clinical trial is to gather information on the safety and the recommended dose of the Sarah Nanotechnology System.
- Trial name
- NCT07224464
- Testing
- The Sarah Nanotechnology System - intended to deliver thermal energy to malignant cells for the purpose of thermal destruction of these cells in patients with advanced metastatic solid tumors.
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- New Phase Ltd.
Hyperthermia
The Effectiveness of Emergency Room Protocols for Treating Hyperthermia
This study will help us as scientists and clinicians understand how effective commonly used cooling protocols in emergency departments are and which of the protocols is the most effective.
- Trial name
- EDCP (NCT07433036)
- Testing
- Passive cooling, Cooling packs, Ice sheets
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Colorado Springs
Environmental Exposure
Interventions to Decrease Heat Stress Among Latinx Farmworkers in Idaho
The goal of this study is to collaborate with farmworker, community organizations, and labor contractors/employers to develop workplace- and individual-level interventions, and evaluate the efficacy of those interventions in…
- Trial name
- NCT05807282
- Testing
- Interventions to Decrease Heat Stress among Latinx Farmworkers in Idaho
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boise State University
Stereotactic Body Radiation Therapy; PD-1 Inhibitor; Hyperthermia; NSCLC
SBRT Combined With PD-1 Inhibitor and Thoracic Hyperthermia for Advanced NSCLC
The aim of this trial is to investigate the primary efficacy of SBRT combined with PD-1 inhibitor and thoracic hyperthermia in patients with EGFR, ALK, and ROS1 negative stage IV NSCLC patients who progressed after first-line…
- Trial name
- NCT05520853
- Testing
- SBRT combined with PD-1 inhibitors and thoracic hyperthermia
- Where
- China
- Volunteers
- 63 people
- Sponsor
- First People's Hospital of Hangzhou
Risk of Heat Stress
Occupational Heat Stress on Workers' Productivity
Workplace heat exposure affects billions of people during their everyday work activities. Occupational heat stress impairs workers' health and capacity to perform manual labour.
- Trial name
- NCT04160728
- Testing
- Work/ rest scenario, Hydration scenario, Clothing scenario
- Where
- Greece
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Petros Dinas