RecoveryPrehotempNCT07559344
Effects of Hot Baths Prior or After a Damaging Protocol on Muscle Function and HSP70 Expression
A study testing Immersion, NIRS and isokinetic dynamometer in people with Recovery and Mechanical Stress, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.
Trial summary
Muscle lengthening contractions lead to physiological responses such as strength loss, soreness, immune cell infiltration, and CK production, along with elevated heat shock proteins (HSPs), which protect and regenerate cells. Read more about this study
- Who is it for?
- Ages 19 to 25 years, men only
- Conditions the study is for
- Recovery, Mechanical Stress, Heat Stress
- What is being tested?
- Immersion, NIRS and isokinetic dynamometer
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 96 participants
- Where
- 1 siteFrance
- Study dates
- 16 Feb 2026to Feb 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 19 to 25 years
- Men only
- No healthy volunteers
- Adult
Who may be able to join
- Sex: Healthy, athletic men practicing track and field (10 to 12 hours/week)
- Age: 19 to 25 years old
- Social security coverage
- Signed informed consent
Who cannot join
- Age over 26 years
- Low level of physical activity (less than 8 hours per week)
- Recent sprain (type 1, 2, or 3) or ligament rupture in the lower limb (within the last 8 months)
- Exposure to an altitude of 2500m within 15 days prior to the protocol
- Presence of arterial hypotension:
- Systolic blood pressure below 90 mmHg
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- Diastolic blood pressure below 60 mmHg
- A drop in systolic blood pressure greater than 20 mmHg upon moving from a lying to a standing position.
- A drop in diastolic blood pressure greater than 10 mmHg upon moving from a lying to a standing position.
- Presence of dizziness, lightheadedness, or blurred vision upon moving from a lying to a standing position.
- Participant under guardianship/conservatorship or deprived of liberty.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
CHRU Amiens
Amiens, 80054
Yannis Hamidou, MD, 33+3 22 66 82 48, Hamidou.yannis@chu-amiens.fr
About this study
Muscle lengthening contractions lead to physiological responses such as strength loss, soreness, immune cell infiltration, and CK production, along with elevated heat shock proteins (HSPs), which protect and regenerate cells. Passive heating before or after exercise can aid in recovery by restoring strength and reducing soreness, requiring a core temperature of over 38.5°C for 20 minutes to be effective. Studies show that combined mechanical and thermal stress induces a cumulative HSP response, enhancing cellular protection. Thermal stress alone peaks at 16- 24 hours, whereas mechanical stress shows a biphasic response, with peaks at 3-6 hours and around 39 hours. Thus, combining heat with exercise could optimize HSP production, improving recovery by increasing and accelerating the HSP response. However, more research is needed to determine the best timing for thermal stress in human applications, especially in sports and therapy contexts.
This study aimed to compare the effects of hot-water immersion administered before versus after muscle-lengthening exercise on muscle function and HSP70 expression in healthy young athletes.
- Conditions
- Recovery, Mechanical Stress, Heat Stress, HSP70, Cumulative Response, Hot-water Immersion
- Being tested
- Immersion, NIRS, isokinetic dynamometer, pressure algometer, Hokanson armband
- Keywords
- Recovery, mechanical stress, heat stress, HSP70, cumulative response, hot-water immersion
- Medical subject headings
- Heat Stress Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ImmersionOther
Immersion lasted 40 minutes with the goal of reaching a core temperature of 38.5°C in the heat-stress groups
NIRSOther
NIRS
isokinetic dynamometerOther
isokinetic dynamometer
pressure algometerOther
pressure algometer
Hokanson armbandOther
Hokanson armband
| Study group | Role | What they receive |
|---|---|---|
| 41 pre-EIMD | Experimental | hot-water immersion at 41°C performed 24 hours before EIMD (pre-EIMD) Receives: Other: Immersion; Other: NIRS; Other: isokinetic dynamometer; Other: pressure algometer; Other: Hokanson armband |
| 41 post-EIMD | Experimental | hot- water immersion at 41°C immediately after EIMD (post-EIMD) Receives: Other: Immersion; Other: NIRS; Other: isokinetic dynamometer; Other: pressure algometer; Other: Hokanson armband |
| 36°C post- EIMD | Sham comparator | sham immersion at 36°C post- EIMD Receives: Other: Immersion; Other: NIRS; Other: isokinetic dynamometer; Other: pressure algometer; Other: Hokanson armband |
What is being measured
The primary outcome is the main question the study is designed to answer.
HSP 70 concentration
HSP 70 concentration in third groups
Measured: 1 year
Secondary outcomes (2)
gastro-intestinal temperature
Measured: 1 year
muscle temperature
Measured: 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Apr 2026
- Study start16 Feb 2026
- Primary completionFeb 2027 (estimated)
- Study completionFeb 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for RecoveryStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire, AmiensThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 96 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire, Amiens
- Sponsor type
- University, hospital or other
- Collaborators
- CH CORBIE
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07559344
- Sponsor's protocol ID
- PI2025_843_0182
- Acronym
- Prehotemp
- Status last verified
- Apr 2026
- First submitted
- 7 Apr 2026
- Last updated
- 30 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Hot Baths Prior or After a Damaging Protocol on Muscle Function and HSP70 Expression
- ClinicalTrials.gov ID
- NCT07559344
- Acronym / sponsor ID
- Prehotemp / PI2025_843_0182
- Conditions
- Recovery, Mechanical Stress, Heat Stress, HSP70, Cumulative Response, Hot-water Immersion
- Keywords
- Recovery, mechanical stress, heat stress, HSP70, cumulative response, hot-water immersion
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 96 participants (estimated)
- Lead sponsor
- Centre Hospitalier Universitaire, AmiensUniversity, hospital or other
- Collaborators
- CH CORBIE
- Study start
- 16 Feb 2026 (actual)
- Primary completion
- Feb 2027 (estimated)
- Study completion
- Feb 2027 (estimated)
- First posted
- 30 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Muscle lengthening contractions lead to physiological responses such as strength loss, soreness, immune cell infiltration, and CK production, along with elevated heat shock proteins (HSPs), which protect and regenerate cells. Passive heating before or after exercise can aid in recovery by restoring strength and reducing soreness, requiring a core temperature of over 38.5°C for 20 minutes to be effective. Studies show that combined mechanical and thermal stress induces a cumulative HSP response, enhancing cellular protection. Thermal stress alone peaks at 16- 24 hours, whereas mechanical stress shows a biphasic response, with peaks at 3-6 hours and around 39 hours. Thus, combining heat with exercise could optimize HSP production, improving recovery by increasing and accelerating the HSP response. However, more research is needed to determine the best timing for thermal stress in human applications, especially in sports and therapy contexts.
This study aimed to compare the effects of hot-water immersion administered before versus after muscle-lengthening exercise on muscle function and HSP70 expression in healthy young athletes.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| 41 pre-EIMD | Experimental | Other: Immersion, Other: NIRS, Other: isokinetic dynamometer, Other: pressure algometer, Other: Hokanson armbandhot-water immersion at 41°C performed 24 hours before EIMD (pre-EIMD) |
| 41 post-EIMD | Experimental | Other: Immersion, Other: NIRS, Other: isokinetic dynamometer, Other: pressure algometer, Other: Hokanson armbandhot- water immersion at 41°C immediately after EIMD (post-EIMD) |
| 36°C post- EIMD | Sham comparator | Other: Immersion, Other: NIRS, Other: isokinetic dynamometer, Other: pressure algometer, Other: Hokanson armbandsham immersion at 36°C post- EIMD |
Who may qualify
- Ages
- 19 to 25 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Sex: Healthy, athletic men practicing track and field (10 to 12 hours/week)
- Age: 19 to 25 years old
- Social security coverage
- Signed informed consent
Key exclusion criteria (11 listed)
- Age over 26 years
- Low level of physical activity (less than 8 hours per week)
- Recent sprain (type 1, 2, or 3) or ligament rupture in the lower limb (within the last 8 months)
- Exposure to an altitude of 2500m within 15 days prior to the protocol
- Presence of arterial hypotension:
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ImmersionImmersion lasted 40 minutes with the goal of reaching a core temperature of 38.5°C in the heat-stress groups | Other | 36°C post- EIMD, 41 post-EIMD, 41 pre-EIMD |
| NIRSNIRS | Other | 36°C post- EIMD, 41 post-EIMD, 41 pre-EIMD |
| isokinetic dynamometerisokinetic dynamometer | Other | 36°C post- EIMD, 41 post-EIMD, 41 pre-EIMD |
| pressure algometerpressure algometer | Other | 36°C post- EIMD, 41 post-EIMD, 41 pre-EIMD |
| Hokanson armbandHokanson armband | Other | 36°C post- EIMD, 41 post-EIMD, 41 pre-EIMD |
Primary outcome
HSP 70 concentration
Time frame: 1 year
HSP 70 concentration in third groups
2 secondary outcomes
gastro-intestinal temperature
Time frame: 1 year
muscle temperature
Time frame: 1 year
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Apr 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Immersion, NIRS and isokinetic dynamometer in people with Recovery and Mechanical Stress, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 30 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Yannis Hamidou, MD (33+3 22 66 82 48, Hamidou.yannis@chu-amiens.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
HSP 70 concentration (time frame: 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Apr 2026; AzTrials last refreshed its copy on 2 Nov 2026.