Clinical trials: Heat Stress Disorders
Aging, Hyperthermia
Heat Waves and the Elderly - Cooling Modalities
The purpose of this study is to assess how well cooling modalities work in reducing cardiovascular stress of the elderly to heat wave conditions
- Trial name
- NCT05484739
- Testing
- Water Spray, Fan, Water Spray and Fan
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Bladder Cancer, Hyperthermia
Use of Immediate Hyperthermic Intravesical Chemotherapy Following TURBT
This is a prospective single-arm pilot study investigating the safety and feasibility of giving hyperthermic intravesical chemotherapy immediately following transurethral resection of bladder tumour.
- Conditions
- Bladder Cancer, Hyperthermia, Chemotherapy Effect
- Trial name
- I-HIVEC (NCT03689478)
- Testing
- Hyperthermic intravesical chemotherapy
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Rectal Cancer, Locally Advanced Rectal Cancer
Preoperative Radiochemotherapy With Hyperthermia for Locally Advanced Rectal Cancer
The current trial is evaluating the impact of deep regional hyperthermia on the pathological complete response rate in locally advanced rectal cancer in the context of preoperative 5FU based radiochemotherapy.
- Conditions
- Rectal Cancer, Locally Advanced Rectal Cancer, Hyperthermia, Hyperthermic Radiochemotherapy
- Trial name
- HT01 (NCT02353858)
- Testing
- Deep regional hyperthermia, Radiotherapy, Chemotherapy (5-Fluorouracil)
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- University Hospital Tuebingen
Heat Stroke
Mechanism Study of G Protein-coupled Receptor 81 in Multiple Organ Dysfunction of Heat Stroke
Heat stroke is one of the common acute and critical conditions in the ICU, characterized by a high incidence and mortality rate, and there is still a lack of effective and precise treatment methods.
- Trial name
- NCT07346443
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Total Abdominal Hysterectomy
Are Sutures Required in Total Abdominal Hysterectomy? A Randomised Control Trial
The Hypothesis of this study is that performing total abdominal hysterectomy using the newer electrocoagulation forceps, specifically, the gyrus open seal forceps, curved, compared to the traditional clamp \& suture technique…
- Trial name
- NCT00484835
- Testing
- Performing abdominal hysterectomy using gyrus electrocoagulation forceps
- Where
- 3 sites in Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Southern Health
Sickle Cell Trait
Sickle Cell Trait in Football Players
This study will look at the five different types of sickle cell and their relation to self-reported ill health to determine whether or not one or two of the sickle cell haplotypes are correlated with worse health outcomes.
- Trial name
- NCT01891877
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Heathly Subjects, Primary Health Care
Assessing the Effectiveness of Heat Adaptation Digital Messages From Primary Care Providers to Their Patients on the Change in Behaviour for Heatwave-related Preparedness
Extreme heat events pose a significant health threat in Canada, as demonstrated by the 2021 heat wave that claimed over 600 lives in Western Canada. Most heat-related deaths occur indoors and are preventable.
- Conditions
- Heathly Subjects, Primary Health Care, Climate Change, Public Health
- Trial name
- HeatSmart (NCT07024628)
- Testing
- Heat adaptation digital messaging, Non-heat-related digital messaging
- Where
- Canada
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Hopital Montfort
Pancreatic Ductal Adenocarcinoma (mPDAC), Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)
A Study Comparing Whole-Body Heat Treatment Plus Systemic Therapy to Systemic Therapy Alone, for Advanced Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis and limited treatment options following failure of first-line therapy.
- Trial name
- MATTERS-2 (NCT07711067)
- Testing
- Whole-body hyperthermia, Standard-of-Care Systemic therapy
- Where
- 4 sites in Belgium, Spain
- Volunteers
- 95 people
- Sponsor
- ElmediX
Multiple Myeloma
A Study of Tanespimycin (KOS-953) in Patients With Relapsed-refractory Multiple Myeloma
This is a phase 2/3, open label trial for patients with relapsed-refractory multiple myeloma. Study agent is tanespimycin (KOS-953), at three different dose levels in combination with a fixed dose of bortezomib.
- Trial name
- TIME-2 (NCT00514371)
- Testing
- tanespimycin, Bortezomib
- Where
- 11 sites in United States
- Volunteers
- 22 people
- Sponsor
- Bristol-Myers Squibb
Elevated Blood Pressure
Post-exercise Hot Water Immersion to Improve Overnight Blood Pressure
The goal of this clinical trial is to test whether putting a participant's legs in a hot bath after exercise improves blood pressure in people with higher blood pressure. .
- Trial name
- ExHT (NCT06348225)
- Testing
- Exercise, Heat Therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Providence College
Physical Therapy Techniques
Heat Transfer by Three Types of Packs and Its Implication on the Flexibility of the Lower Back
The purpose of this study is to compare the effects generated by the application of three different packs on the flexibility of the lower back of sedentary students.
- Trial name
- NCT02391376
- Testing
- moist heat pack; ;, seed pack, gel pack
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universidad Católica del Maule
Heat Stroke, Early Waking
Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke
Heat stroke is a clinical syndrome with high incidence and high fatality rate in summer. Patients with liver, kidney, and brain damage are prone to secondary MODS, and the prognosis is poor due to high medical costs.
- Conditions
- Heat Stroke, Early Waking, MODS, Proteinosis
- Trial name
- NCT05155358
- Testing
- Peripheral blood test
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Hyperthermia, Heat; Weather
Protective Cooling Measures to Safeguard Elderly People From Dangerous Summer Heat
With the increasing incidence and severity of extreme heat events accompanying climate change, there is an urgent need for sustainable cooling strategies to protect heat-vulnerable older adults, who are at increased risk of…
- Conditions
- Hyperthermia, Heat; Weather, Aging, Type2 Diabetes
- Trial name
- NCT05274009
- Testing
- No cooling (control), Recommended cooling, Hybrid cooling
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Cerebral Palsy
A Comparative Study of the Effectiveness of Treatment of Contractures With Mechanically Applied Stretch and Heat.
This study is looking at new ways to stretch knee contractures in children with cerebral palsy using a specially designed splint.
- Trial name
- NCT00281359
- Testing
- With heat, No heat
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Hyperthermia, Colorectal Neoplasms
Impact of an Optimised Monitored Anesthesia on the Patients' Recovery After Cytoreduction Surgery Plus HIPEC
The objective of our PILOT study is to evaluate the impact of a controlled (monitored) randomized anesthesia during cytoreductive surgery with HIPEC to oxaliplatin in order to treat adenocarcinomas of colorectal origin.
- Conditions
- Hyperthermia, Colorectal Neoplasms, Oxaliplatin
- Trial name
- CHIPNOL (NCT04104334)
- Testing
- Remifentanil infusion, desflurane titration and fluid infusion will be guided by NOL index, BIS index and Flotrac EV1000 system respectively, Remifentanil infusion and desflurane titration will be guided by anesthesia usual practices
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Physical Inactivity, Vascular Dysfunction
Heat Therapy During Reduced Physical Activity
The purpose of this randomized controlled trial is to determine whether daily Finnish dry sauna therapy attenuates the adverse cardiovascular, muscular, and metabolic effects of seven days of experimentally reduced physical…
- Conditions
- Physical Inactivity, Vascular Dysfunction, Skeletal Muscle Atrophy
- Trial name
- HEAT-RPA (NCT07847424)
- Testing
- Sauna, Reduced Physical Activity
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham Young University
Personal Protective Equipment, Heat Stress
Testing of Personal Protective Equipment (PPE)
Pandemics and re-emerging diseases put pressure on the health care system to prepare for patient care and sample logistics requiring enhanced personnel protective equipment (PPE) for health care workers.
- Trial name
- PPE-Test (NCT03004690)
- Testing
- PPE Suit A, PPE Suit B
- Where
- Austria
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Knee Osteoarthritis
Deep Versus Superficial Heating in Patients With Knee Osteoarthritis
Heat therapy is frequently prescribed to patients with symptomatic knee osteoarthritis (OA). Deep hyperthermia via localized microwave diathermy is effective in several musculoskeletal painful conditions.
- Trial name
- NCT01343147
- Testing
- Microwave diathermy, Superficial hyperthermia
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Catholic University of the Sacred Heart
Hyperthermia
Cold Water Immersion Stirring in Hyperthermic Individuals
The best way to cool a very hot person is using cold water immersion, however, the optimization of this technique has not been established.
- Trial name
- NCT04613843
- Testing
- Water Stirring, No Water Stirring
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Range of Motion, Articular
Different Therapeutical Modalities Associated to Hamstring Flexibility Training
The purpose of this study is to compare the acute effect of the use of different thermal modalities associated to the training of passive flexibility of the hamstring muscles in the amplitude of motion of the knee extension.
- Trial name
- NCT03021850
- Testing
- Flexibility training with or without different thermal modalities
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre