Clinical trials: Heat Stroke
Venous Thromboembolism (VTE), Acute Myocardial Infarction With ST Segment Elevation
Heat Shock Protein 47 in Thrombosis
The goal of this observational study is to learn if the novel biomarker Heat shock protein 47 (HSP47) can be used as a prognostic marker for vascular disease in people with acute venous thromboembolism (VTE), myocardial…
- Conditions
- Venous Thromboembolism (VTE), Acute Myocardial Infarction With ST Segment Elevation, Stroke (in Patients With Atrial Fibrillation)
- Trial name
- NCT06731673
- Where
- 2 sites in Denmark, Germany
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Heat Stress, Physiological Stress
Efficacy of Electric Fans in Children During Heat Waves
Extreme heat exposure is an escalating global public health concern, with climate change driving increases in the frequency, duration, and intensity of heat events.
- Conditions
- Heat Stress, Physiological Stress, Child Development
- Trial name
- NCT07864103
- Testing
- Simulated exposure to indoor overheating without fans, Simulated exposure to indoor overheating with fans
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Hyperthermia, Thermoregulation
Enhancing Heat Resiliency in Older Adults During Indoor Overheating Via Heat Acclimation by Warm Water Immersion
As overheating in buildings is expected to increase as global warming continues, proactive measures to increase heat resiliency in heat-vulnerable older people are needed, especially for those without access to home cooling or…
- Conditions
- Hyperthermia, Thermoregulation, Aging, Heat Acclimation and Thermotolerance
- Trial name
- NCT06670365
- Testing
- Heat acclimation by warm-water immersion
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Heat Stress, Physiological Stress
Impact of Indoor Overheating on Physiological Strain in Children
Communities worldwide are experiencing increasing heat extremes that challenge the limits of human thermoregulation, particularly among vulnerable populations such as children.
- Conditions
- Heat Stress, Physiological Stress, Cognitive Change
- Trial name
- NCT07261202
- Testing
- Simulated exposure to indoor overheating
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Heat Stress Disorders, Heat Stroke
Heat Strain Prevention in Elderly Agricultural Workers
The study explores a multi-component heat strain prevention program for older agricultural workers in response to climate change. It assesses hydration, rest breaks, reflective clothing, and shade provision.
- Conditions
- Heat Stress Disorders, Heat Stroke, Heat Exhaustion, Heat Cramps
- Trial name
- NCT06192069
- Testing
- Sustainable Heat Strain Prevention Program for Agricultural Elderly Workers (SHiP-AEW)
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
Heat Stress, Physiological Stress
Influence of Indoor Humidity on Physiological Strain in Older Adults During a Simulated Heat Wave
Laboratory-based studies show that exposure to high humidity can worsen the effects of heat stress in young and older adults by impeding sweat evaporation - the main mechanism by which the human body cools itself.
- Trial name
- NCT06842953
- Testing
- Simulated indoor overheating
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Functional Neural Connectivity
Functional Neural Connectivity at Rest as a Diagnostic Tool for Intolerance to Heat
Functional neural connectivity at rest of 3 groups (heat tolerant, heat intolerant and healthy subjects) will be assessed using the anatomical and functional MRI scans and compared.
- Trial name
- fMRI (NCT02498158)
- Testing
- MRI scans
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Heat Stress, Physiological Stress
Physiological Strain in Young Adults During a Simulated Heat Wave
The likelihood of exposure to overheated indoor environments is increasing as climate change is exacerbating the frequency and severity of hot weather and extreme heat events.
- Trial name
- NCT06618352
- Testing
- Simulated indoor overheating exposure
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Heat Stress, Physiological Stress
Physiological Strain in Older Adults During a Simulated Heat Wave
A recent report showed that maintaining indoor temperature at or below 26°C safeguards older, heat vulnerable adults against potentially dangerous increases in thermal and cardiovascular strain during an extreme heat event (PMID…
- Trial name
- NCT06633302
- Testing
- Simulated multi-day heatwave exposure
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Heat Stroke
Study of Risk Factors for the Occurrence and Severity of Exertional Heatstroke in the Military Environment
Although the circumstances of onset and management of exertional heatstroke have been identified for several years, its pathophysiology remains imperfectly understood. Exertional heatstroke is the result of both extrinsic (i.e.
- Trial name
- EXPLO-CCE (NCT04593316)
- Testing
- Saliva collection, Questionnaires, Ingestible core temperature capsule intake
- Where
- 3 sites in France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Heat Stroke, Healthy
The Development Of A Novel Biomarker For Early Identification Of The Individual's State Of Tolerance To Heat
Today, the level of tolerance to heat is based on physiological strain indices, with no correlates to any relevant biomarker. We hypothesize that oxidative stress (OS) and the formation of reactive oxygen and nitrogen species…
- Trial name
- NCT01290159
- Testing
- heat tolerance test (HTT)
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Heat Stroke, Acute Kidney Injury
Use of Sodium Bicarbonate as Prophylaxis for Kidney Damage in Patients With Heatstroke
This study protocol aims to prevent the need for renal replacement therapy in patients with rhabdomyolysis secondary to heatstroke.
- Conditions
- Heat Stroke, Acute Kidney Injury, Acute Kidney Injury Due to Hypovolaemia
- Trial name
- NCT06622525
- Testing
- Sodium bicarbonate, No intervention
- Where
- Mexico
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Hospital General de Mexicali
Heat Stroke, Early Waking
Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke
Heat stroke is a clinical syndrome with high incidence and high fatality rate in summer. Patients with liver, kidney, and brain damage are prone to secondary MODS, and the prognosis is poor due to high medical costs.
- Conditions
- Heat Stroke, Early Waking, MODS, Proteinosis
- Trial name
- NCT05155358
- Testing
- Peripheral blood test
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Overheating
Thermoregulatory Reactions of Medical Workers Who Use Personal Protective Equipment From Biological Hazards
This research will provide data on thermal condition, functional status and working conditions of medical workers who use personal protective equipment from biological hazards.
- Trial name
- NCT05091515
- Testing
- Personal protective equipment from biological hazard
- Where
- Russia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Scientific Institution "Izmerov Research Institute of Occupational Health"
Heat Stroke, Heat Exhaustion
Chemical Ice Packs for Cooling Hyperthermic Patients
A common tool to cool people in the pre-hospital setting is the chemical ice pack. These are used by athletic trainers, EMS personnel, ER staff, and people in the prehosoital setting.
- Trial name
- NCT01694290
- Testing
- Chemical Cold Pack
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Stanford University
Exertional Heat Illness, Hydration Status
Comparing Risk of Heat Illness Based on Peak Core Temps During Preseason Football Camp Across 3 Different Age Levels
To collect field data in professional, collegiate, and high school football players to determine how they respond physiologically to the rigors of preseason training environment.
- Trial name
- NCT01954537
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Heat Stroke
Study of Thermoregulation in Exercise Heat Stroke in the Military Environment
The EXPLO-MITO study is an ancillary study from the main EXPLO-CCE study (NCT04593316; IDRCB: 2020-A01967-32). The Heat Tolerance Test (HTT) is a physiological exploration that has several advantages for use in research and…
- Trial name
- EXPLO-MITO (NCT05847465)
- Testing
- Bike stress test, Heat Tolerance Test, Heat nociception test
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Hyperthermia
Rapid Cool: Heat Stroke Treatment
Hot climates such as in Phoenix, AZ commonly have individuals experiencing heat stroke, a life-threatening medical emergency. The dangerously high body temperature can result in death if not treated immediately with rapid body…
- Trial name
- NCT07743619
- Testing
- Recirculated water, Phoenix protocol
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Heat Stroke
Development of an Active Heat Dissipation Device Based on Thermoelectric Cooling Technology: Aiming to Improve Endurance Sports Performance
This project investigates the effectiveness of pre-exercise active cooling using a temperature-controlled cooling vest in reducing heat-related physiological strain during endurance-type aerobic exercise in non-regularly trained…
- Trial name
- DAHDD-TCT (NCT07539714)
- Testing
- TEC Vest, No Pre-Cooling (Without Vest), Water Cooled Vest
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University
Ischemic Stroke, Acute
Molecular Network Characteristics of Phlegm-heat Syndrome in Ischemic Stroke Based on Multi-omics Integrated Analysis
The molecular characteristics of ischemic stroke with phlegm-heat syndrome and candidate biomarkers were identified based on multi-omics data.
- Trial name
- NCT05626296
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Dongzhimen Hospital, Beijing