Clinical trials: Heat-related Illness
Heat Stress Disorders
A Multi-Level Approach to Heat-Related Illness Prevention in Agricultural Workers
The project's primary aim is to evaluate the effectiveness of a multi-level heat prevention approach in reducing adverse heat health effects in outdoor agricultural workers The secondary aims are to: Test the effectiveness of an…
- Trial name
- NCT04234802
- Testing
- Heat Education and Awareness Tools
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cystic Fibrosis
Sweat Response, Sweat Composition and Thermoregulatory Response to Exercise in Heat in Adults With Cystic Fibrosis on Modulator Therapy.
Cystic fibrosis (CF) is a common inherited condition in the Caucasian population resulting in poor function and/or production of the CF transmembrane conductance regulator (CFTR) protein.
- Trial name
- Sweat-CF (NCT05896488)
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Portsmouth
Body Temperature Changes, Heat Stress
Working in the Heat at Simulated Altitude: Effects of Normobaric Hypoxia on Physiological Strain
Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers performing physically demanding work in hot environments.
- Conditions
- Body Temperature Changes, Heat Stress, Heat Exposure, Heat Fatigue
- Trial name
- NCT07664462
- Testing
- Simulated Occupational heat exposure under normoxic conditions, Simulated Occupational heat exposure under hypoxic conditions
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Ottawa
Heat Illness, Allergic Rhinitis
Over-the-Counter Antihistamines & Heat Stress
Allergic rhinitis (AR) currently affects ~25% of Canadians, and due to factors of climate change, this number is expected to increase over the coming decade.
- Conditions
- Heat Illness, Allergic Rhinitis, Heat Injury, Sudomotor Sympathetic Dysfunction
- Trial name
- NCT06217367
- Testing
- 50 mg Diphenhydramine, 10 mg Loratadine, 5 mg Desloratadine
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Lakehead University
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Niue
Ambient air temperatures in the Pacific have broken record highs in 2024. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate change.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06570993)
- Testing
- Cool roof
- Where
- Niue
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Hot Weather; Adverse Effect, Heat Effect
Beat the Heat Boston
The goal of this stepped wedge trial is to assess the practical effects of air conditioners on hot weather impacts among older adults.
- Conditions
- Hot Weather; Adverse Effect, Heat Effect, Heat Stress, Heat Stroke, Heat Exhaustion
- Trial name
- NCT06982339
- Testing
- Air Conditioner, Electricity subsidy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Harvard School of Public Health (HSPH)
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health
Ambient air temperatures in Asian, Latin American, African, and Pacific climate hotspots have broken record highs in 2024, driven by man-made climate change. Solutions are needed to reduce heat exposure in communities.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06579950)
- Testing
- Cool roof
- Where
- 5 sites in Burkina Faso, Fiji and 3 more
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Heat-related Illness, Chronic Disease
AI-Assisted Personalized Heat-Risk Alerts
This two-arm randomized controlled trial will evaluate whether an artificial intelligence-assisted personalized heat-risk alert system reduces heat-related illness symptom burden among adults with chronic conditions.
- Trial name
- HEAT-CARE (NCT07825831)
- Testing
- AI-Assisted Personalized Heat-Risk Alert System, Generic PMD Heat-Health Advisory
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- National University of Medical Sciences, Pakistan
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Tavua, Fiji
Ambient air temperatures in Fiji are increasing due to climate change. Solutions are needed to build heat resilience in communities and adapt.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- NCT07592117
- Testing
- Cool roof
- Where
- Fiji
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Heat Illness, Heat Stroke
Heat Emergency Awareness and Treatment (HEAT)
Investigators propose an intervention trial of a comprehensive education and treatment bundle designed to reduce morbidity and mortality associated with heat-related illness for low resource settings.
- Conditions
- Heat Illness, Heat Stroke, Heat Exhaustion, Heat Exposure
- Trial name
- HEAT (NCT03513315)
- Testing
- Implementation of Community-based Home Heat Bundle, Regular Community Healthcare provision
- Where
- 2 sites in Pakistan
- Volunteers
- 16,973 people
- Sponsor
- Johns Hopkins University
Cardiovascular Diseases, Respiratory Diseases
Study on Intervention Effect of Heat-related Health Risk Early Warning Digital Technology for School-age Children
This cluster randomized trial is conducted in Beijing primary schools to evaluate the efficacy of a WeChat mini-program-based high-temperature early warning intervention on the physical and cognitive health of school-age…
- Conditions
- Cardiovascular Diseases, Respiratory Diseases, Mental Health Disorders, Heat Illness
- Trial name
- NCT07643571
- Testing
- WeChat Mini-program Based Heat Health Risk Early Warning Intervention
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention, China
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Colima, Mexico
Ambient air temperatures in Mexico have broken record highs in 2024. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate change.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06834893)
- Testing
- Cool roof
- Where
- Mexico
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Skin Cancer, Heat Tolerance
Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient Individuals
The escalating environmental heat-stress associated with global warming is a societal challenge with large and potential harmful consequences for humans.
- Conditions
- Skin Cancer, Heat Tolerance, Heat-related Illness, Hyperthermia
- Trial name
- ICARUS (NCT07510061)
- Testing
- Controlled Heat and Ultraviolet Radiation Exposure Protocol
- Where
- 2 sites in Denmark, Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Thessaly