Clinical trials: Heavy Drinking
Metabolic Disturbance, Alcohol; Harmful Use
Metabolic Effects of One-weak Heavy Drinking
Examination of the effect of one week's unhealthy lifestyle on glucose metabolism and liver parameters in a group of young, healthy males participating in Roskilde Festival 2016.
- Conditions
- Metabolic Disturbance, Alcohol; Harmful Use, Glucose Intolerance
- Trial name
- ROSMET (NCT04229550)
- Testing
- Festival participation
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Heavy Drinking and Sexual Risk Behavior
Alcohol and Sex Risk Intervention for MSM Supplement
Open pilot trial to test the feasibility and efficacy of a brief intervention with text messaging to reduce sexual risk behavior and heavy drinking among MSM
- Trial name
- NCT03522948
- Testing
- Brief intervention with text messaging to reduce sexual risk and heavy drinking among MSM
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Heavy Episodic Drinking, Problem Drinking
Greek Connections Study
The purpose of this study is to evaluate the feasibility and acceptability of an intervention aiming to reduce heavy episodic drinking and negative consequences from alcohol by increasing the availability of and engagement in…
- Conditions
- Heavy Episodic Drinking, Problem Drinking, College Student Drinking
- Trial name
- NCT07839026
- Testing
- Alcohol-free Social Activities Program
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- University of Washington
Heavy Drinking
Helpline Pilot Factorial Trial
The pilot factorial trial will (1) evaluate feasibility, acceptability, and fidelity of the intervention components (Aim 2.1), and (2) collect proof-of-concept data on the impact of the components on the proximal (motivation…
- Trial name
- NCT06591026
- Testing
- Standard Helpline (SH), Motivational Interviewing (MI), Coping Skills Training (CST)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The National Center on Addiction and Substance Abuse at Columbia University
Alcohol Use, Heavy Drinking
Brief Web-Based Alcohol Reduction Intervention for Undergraduates
Tertiary Health Research Intervention Via Email (THRIVE; Kypri et al., 2009), originally utilized with Australian students, is unique in that it contains efficacious components derived from motivational interviewing (e.g.…
- Conditions
- Alcohol Use, Heavy Drinking, Negative Consequences of Alcohol Use
- Trial name
- NCT01694082
- Testing
- THRIVE, Brief brochure and assessment control
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Yale University
Binge Drinking
Afferent Neurocardiac Signals, Cue Reactivity, and Cognitive Control
Conscious attempts to regulate alcohol use are often undermined by automatic attention and arousal processes activated by alcohol cues, as well as by diminished ability to inhibit in-the-moment behaviors.
- Trial name
- NCT05369169
- Testing
- Resonance breathing, Low demand cognitive task
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Alcohol Associated Liver Disease, Heavy Drinking Behavior
Safety, Tolerability, and Bioeffects of Alirocumab in Non-treatment Seeking Heavy Drinkers
Background: Drinking alcohol can lead to swelling and injury in the liver. Long-term heavy drinking may lead to liver disease. Researchers want to study the relationship between a drug called alirocumab, alcohol use, and liver…
- Trial name
- NCT04781322
- Testing
- Alirocumab
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
fMRI, Alcohol Drinking
Ghrelin for Alcohol Use in Non-Treatment-Seeking Heavy Drinkers
Background: Ghrelin is a hormone in the human body that is mostly produced by the stomach. It makes people feel hungry, and also is connected with the desire to drink alcohol.
- Conditions
- fMRI, Alcohol Drinking, Alcoholism
- Trial name
- NCT01779024
- Testing
- Ghrelin, fMRI, Alcohol
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Heavy Drinking
Dopamine Release in the Human Brain Following Alcohol Administration
The purpose of this study is to examine whether there is an increase in dopamine levels in the human striatum following an oral administration of alcohol, as has been evidenced in animal models.
- Trial name
- NCT01638364
- Testing
- alcoholic beverage, non-alcoholic beverage
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Smoking Cessation, Alcohol Drinking
Varenicline Augmentation of Patch Outcomes in Heavy Drinkers' Smoking Cessation
The purpose of this study is to learn if the combination of a study drug and patch is more effective in helping heavy drinkers stop smoking than just the patch alone The study drug, varenicline, has been approved by the Food and…
- Trial name
- NCT02859142
- Testing
- Chantix, Behavioral Counseling Sessions, NicodermCQ
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Alcohol Consumption
Effect of Heavy Alcohol Consumption on Farnesoid X Receptor (FXR) Signaling
The main purpose of this study is to see whether heavy drinking will interfere with a specific pathway, called FXR signaling in the liver.
- Trial name
- NCT02654236
- Testing
- 10 mg Obeticholic Acid (OCA)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Suthat Liangpunsakul
Heavy Drinking
Motivating Recruitment and Efficacy in Normative Feedback Interventions
Excessive alcohol consumption among college students continues to be a serious public health concern associated with a wide range of negative consequences.
- Trial name
- NCT04639882
- Testing
- Personalized normative feedback
- Where
- United States
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- University of Houston
Alcohol; Use, Problem
Probiotics, Immune Function, and the Brain in Alcohol Consumers
This pilot project is a brief, open-label clinical trial of probiotics as an intervention in heavy drinkers. Heavy drinkers who do not yet show significant signs of liver disease may stand to benefit from probiotics, but no…
- Trial name
- NCT05232682
- Testing
- Seed DS-01 Daily Synbiotic
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Drinking, Alcohol; Harmful Use
Alcohol and Immune Response
This study investigates how alcohol affects the immune system and behavior in healthy adults. The study also will examine how an individual's typical drinking habits may affect the immune system's response to alcohol.
- Trial name
- NCT03483389
- Testing
- Alcohol, Ethyl
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Brown University
Sexual Violence, Drinking Heavy
Reducing Alcohol Involved Sexual Violence in Higher Education
This cluster-randomized controlled trial across 28+ college campuses focuses on undergraduate college students at elevated risk for sexual violence and hazardous drinking (i.e., students with prior history of sexual violence…
- Trial name
- RAISE (NCT05185440)
- Testing
- GIFTSS Training, Learning Collaborative, Provider Scripts
- Where
- United States
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Heavy Drinking
Interactive Alcohol Decision-Making Programs
This project aims to develop a maximally effective, computer-delivered brief intervention (CDBI) for reducing heavy alcohol use.
- Trial name
- NCT05398315
- Testing
- Empathic Statements/Reflections, Narrator Backstory, Male Narrator
- Where
- United States
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Binge Eating, Binge Drinking
Brief Binge Eating and Drinking Online Intervention
This pilot project targets both binge drinking and binge eating behavior in college students through a mobile-based online program that provides students with evidence-based intervention material designed to reduce the incidence…
- Trial name
- NCT06326099
- Testing
- Brief Online Binge Eating and Drinking Intervention
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Tobacco Dependence, Alcohol Dependence
Effect of Varenicline on Reactivity to Smoking and Drinking Cues
Alcohol and nicotine dependence are often co-morbid, with 85% of alcoholics also smoking. However, very little research has been conducted into the nature of this co-occurrence.
- Trial name
- NCT00873535
- Testing
- Varenicline
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Stress Disorders, Post-Traumatic, Drinking Heavy
Project QueST 2023: Queer Survivors of Trauma
This study aims to test the initial efficacy of tailored online writing interventions specifically designed for sexual minority women, transgender individuals, and/or nonbinary people to target the primary outcomes: posttraumatic…
- Trial name
- QueST2023 (NCT05569915)
- Testing
- Trauma Expressive Writing, Stigma Expressive Writing, Control
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Syracuse University
Alcohol Drinking
Alcohol Brief Counseling in Primary Care
This study evaluates the effectiveness of a brief intervention for the reduction of alcohol use among risky alcohol users in primary care delivered by paramedics.
- Trial name
- NCT02642757
- Testing
- AUDIT brief intervention, Pamphlet on alcohol use
- Where
- 5 sites in Chile
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile