Clinical trials: Heavy Drinking
Heavy Drinking, Alcohol Dependence
Alcohol Disorder hOsPital Treatment Trial
The specific aims of this pragmatic randomized controlled trial are to compare initiating injectable extended release naltrexone (XR-NTX) or oral naltrexone (PO-NTX) at the time of discharge from a medical hospitalization for…
- Conditions
- Heavy Drinking, Alcohol Dependence, Alcohol Use Disorder
- Trial name
- ADOPT (NCT02478489)
- Testing
- Oral naltrexone (PO-NTX), Extended-release injectable naltrexone (XR-NTX)
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Boston University
Opioid Use Disorder, Alcohol Intoxication
Pain Sensitivity, Alcohol-Induced Analgesia, and Heavy Drinking in Individuals With Opioid Use Disorder
The goal of this clinical trial is to examine whether individuals with co-occurring opioid use disorder and alcohol use (OUD+ALC) experience heightened pain sensitivity, pain-related negative affect, and greater alcohol…
- Conditions
- Opioid Use Disorder, Alcohol Intoxication, Pain
- Trial name
- NCT07894276
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University
Tobacco Dependence, Alcohol Dependence
Effect of Varenicline on Reactivity to Smoking and Drinking Cues
Alcohol and nicotine dependence are often co-morbid, with 85% of alcoholics also smoking. However, very little research has been conducted into the nature of this co-occurrence.
- Trial name
- NCT00873535
- Testing
- Varenicline
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Heavy Drinking
Testing a Novel Instagram Intervention for Heavy Alcohol Use
This project aims to test the efficacy of an Instagram-based intervention for reducing heavy alcohol use. More specifically, the investigators will use a randomized controlled design to analyze differences in alcohol use and…
- Trial name
- NCT06420050
- Testing
- Instagram Intervention
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emily Grekin
Heavy Episodic Drinking
Understanding the Associations Between Romantic Relationship Conflict, Psychophysiological Responding and Alcohol Misuse Among Emerging Adults
Emerging Adults (EA) engage in heavy episodic drinking (HED) at a greater quantity and frequency than any other time in their lives, which may lead to significant short- and long-term consequences.
- Trial name
- NCT06976528
- Testing
- Alcohol administration
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- New York University
Reduction in Heavy Drinking in Patients With HIV
Reducing Heavy Drinking to Optimize HIV/AIDS Treatment and Prevention
This is a double-blind placebo-controlled study to evaluate the effect of Naltrexone (NTX) and counseling on highly active antiretroviral treatment (HAART) medication adherence in a cohort of HIV-infected patients who report…
- Trial name
- DAWN (NCT01227044)
- Testing
- Naltrexone
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Yale University
Alcohol Drinking, Chronic Pain
Alcohol Use and Chronic Pain Among Primary Care Patients
Chronic pain and unhealthy drinking are common co-occurring conditions among patients presenting to primary care. Given their impact on functioning and medical outcomes, there would be considerable benefit to developing an…
- Trial name
- NCT04958200
- Testing
- mhealth-pc for alcohol and pain, Treatment As Usual
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Boston University Charles River Campus
Alcohol Drinking, Alcohol Intoxication
Mindfulness-Based Intervention and Transcranial Direct Current Brain Stimulation to Reduce Heavy Drinking
Alcohol use disorder (AUD) impacts millions of Americans and is associated with significant behavioral, social, economic, medical, and neurobiological dysfunction, yet current behavioral treatments for AUD are only modestly…
- Conditions
- Alcohol Drinking, Alcohol Intoxication, Alcoholism
- Trial name
- MBItDCS (NCT02861807)
- Testing
- Brain stimulation with mindfulness-based relapse prevention
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of New Mexico
HIV, Heavy Drinking
Gabapentin to Reduce Alcohol and Improve Viral Load Suppression
GRAIL is a Randomized Controlled Trial (RCT) among 300 HIV-positive persons with heavy alcohol consumption (by NIAAA definition) who have had detectable HIV viral load (HVL) at least 6 months after their HIV diagnosis.
- Trial name
- GRAIL (NCT05443555)
- Testing
- Gabapentin
- Where
- Uganda
- Volunteers
- 220 people
- Sponsor
- Boston Medical Center
Alcohol-Related Disorders, Alcohol Use Disorders
Tailored Mobile Text Messaging to Reduce Problem Drinking
This study is designed to develop and test a tailored adaptive text messaging/short message service (SMS) intervention for individuals interested in stopping or reducing their alcohol consumption; and test and compare it to…
- Conditions
- Alcohol-Related Disorders, Alcohol Use Disorders, Alcohol Drinking, Alcoholism
- Trial name
- NCT01885312
- Testing
- Adaptive Tailored Intervention, Consequence-based Intervention, Tailored, not adaptive, based Intervention
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Heavy Drinking and Sexual Risk Behavior
Alcohol and Sex Risk mHealth-Enhanced Brief Intervention for BLMSM
Randomized controlled pilot trial to test the feasibility and efficacy of a brief intervention with app-based messaging to reduce sexual risk behavior and heavy drinking among Black/African American and Hispanic/Latino MSM.
- Trial name
- NCT04821427
- Testing
- Brief mhealth intervention + mobile messaging to reduce sexual risk behavior and heavy drinking
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Alcohol Use, Heavy Drinking
Brief Web-Based Alcohol Reduction Intervention for Undergraduates
Tertiary Health Research Intervention Via Email (THRIVE; Kypri et al., 2009), originally utilized with Australian students, is unique in that it contains efficacious components derived from motivational interviewing (e.g.…
- Conditions
- Alcohol Use, Heavy Drinking, Negative Consequences of Alcohol Use
- Trial name
- NCT01694082
- Testing
- THRIVE, Brief brochure and assessment control
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Consumption
Effect of Heavy Alcohol Consumption on Farnesoid X Receptor (FXR) Signaling
The main purpose of this study is to see whether heavy drinking will interfere with a specific pathway, called FXR signaling in the liver.
- Trial name
- NCT02654236
- Testing
- 10 mg Obeticholic Acid (OCA)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Suthat Liangpunsakul
Alcohol Use Disorder, Alcohol Dependence
Transcranial Magnetic Stimulation (TMS) Effects Using Magnetoencephalography (MEG) Study
Alcohol use disorder (AUD) is a complex chronic brain disease characterized by compulsive alcohol use, loss of control over drinking, and negative emotional states.
- Conditions
- Alcohol Use Disorder, Alcohol Dependence, Alcohol Consumption
- Trial name
- TMS (NCT06770556)
- Testing
- Active iTBS, 10 Hz TMS, 1 Hz TMS
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Alcoholism
Rapid Determination Of The Clinical Utility Of Perampanel For The Treatment Of Alcohol Dependence
The purpose of this study is to determine whether perampanel alters the response to alcohol for heavy drinkers. It is hypothesized that perampanel will reduce the rewarding and reinforcing properties of alcohol in the laboratory…
- Trial name
- NCT02120365
- Testing
- Perampanel
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- Virginia Commonwealth University
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Effect of Sublingual Formulation of Dexmedetomidine HCl (BXCL501) - Alcohol Interaction Study
The overall objective of the proposed study is to determine if Dexmedetomidine HCl (BXCL501) is safe for treatment of alcohol use disorder (AUD) with comorbid posttraumatic stress disorder (PTSD) and also shows potential signals…
- Trial name
- NCT04827056
- Testing
- Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 40µg, Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 80µg, Ethanol Infusion
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Alcohol Use Disorder
INIA Stress and Chronic Alcohol Interactions: Glucocorticoid Antagonists in Heavy Drinkers
In alcohol use disorder (AUD) and matched healthy control (HC) men and women, the proposed research examines the effects of MIFE, with demonstrated preclinical effects on drinking-related behaviors, compared with placebo on a…
- Trial name
- NCT02989662
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Heavy Drinking
Brief Academic Future Thinking Intervention for College Student Drinkers
The present study investigated the feasibility, acceptability, and initial utility of a brief academic goal-relevant episodic future thinking (A-EFT) task among heavy college drinkers.
- Trial name
- NCT04275739
- Testing
- Academic Episodic Future Thinking, Vivid Memory Task
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Memphis
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Effect of Sublingual Formulation of Dexmedetomidine Hydrochloride (HCl) (BXCL501) - Outpatient Study
The overall objective of the proposed study is to determine if Dexmedetomidine HCl (BXCL501) is safe for treatment of alcohol use disorder (AUD) with comorbid posttraumatic stress disorder (PTSD) in an outpatient setting and also…
- Trial name
- NCT06335407
- Testing
- Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 40µg, Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 80µg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Alcohol Use, Unspecified
Behavioral Economic Treatment to Enhance Rural (BETTER) Living
The purpose of this trial is to get feedback to help develop programs delivered by phone and text messages to improve wellness and health behaviors.
- Trial name
- NCT05235971
- Testing
- Episodic Future thinking, Volitional choice, Monitoring only
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Michigan