Clinical trials: Heavy Drinking
Sexually Aggressive Behavior, Risky Sexual Behavior
Alcohol And Sexual Risk Behavior
The current study proposes to develop, refine, and conduct a preliminary randomized controlled trial (RCT) of an innovative prevention program that is the first to (a) simultaneously target heavy episodic drinking (HED), sexually…
- Conditions
- Sexually Aggressive Behavior, Risky Sexual Behavior, Heavy Episodic Drinking
- Trial name
- PNF (NCT04416711)
- Testing
- Personalized Feedback, Cognitive Skills Training, Services As Usual
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- Arizona State University
Alcohol Consumption, PrEP Uptake
Enhancing HIV Prevention and Reducing Alcohol Use Among People Receiving STI Care in Lilongwe, Malawi
Purpose: To evaluate short-term efficacy and implementation of Treat4All, an alcohol reduction evidence-based intervention, for decreasing heavy drinking and optimizing HIV outcomes (viral suppression among People with HIV (PWH)…
- Conditions
- Alcohol Consumption, PrEP Uptake, Recent Heavy Drinking, HIV Prevention
- Trial name
- Treat4All (NCT06668363)
- Testing
- Treat4All, Standard of care (control arm)
- Where
- Malawi
- Volunteers
- 130 people
- Sponsor
- University of North Carolina, Chapel Hill
Heavy Drinking, HIV
Topiramate to Reduce Heavy Drinking in HIV-Positive Heavy Drinkers
Heavy drinking (HD) is a risk factor for HIV transmission and is more common in HIV+ individuals than in the general population.
- Conditions
- Heavy Drinking, HIV, Alcohol Dependence
- Trial name
- NCT01764685
- Testing
- Topiramate, Medical Management
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Pennsylvania
Alcohol Abuse, Alcoholism
Consequences of At-risk Alcohol Consumption in ICU Patients
At-risk drinking is known to cause a high incidence of alcohol withdrawal syndrome which has a high impact on morbidity and mortality.
- Trial name
- NCT03565016
- Testing
- no interventional study
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Nantes University Hospital
Squamous Cell Carcinoma of the Head and Neck
Study of Olaparib With Radiation Therapy and Cetuximab in Advanced Head and Neck Cancer With Heavy Smoking History
This is a research study that plans to learn more about the safety and tolerability of an investigational drug called Olaparib, in combination with radiation therapy and cetuximab.
- Trial name
- NCT01758731
- Testing
- Olaparib, Cetuximab, Radiation Therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Colorado, Denver
Alcohol Use Disorder
Does Oxytocin Alter Tolerance to or Motivation for Alcohol
This pilot study is intended to demonstrate feasibility and acquire preliminary data. If successful, this data could support a future project studying the effect of oxytocin on tolerance and alcohol seeking in humans.
- Trial name
- NCT05312008
- Testing
- Intranasal oxytocin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Indiana University
Heavy Drinking
Perceived Alcohol Rewards and Risks Study
The identification of mechanisms that underlie how people reduce or eliminate alcohol use is a critical public health issue. Understanding these mechanisms can inform how to effectively intervene with problem drinkers.
- Trial name
- PARS (NCT04710095)
- Testing
- Brief Alcohol Intervention, Control Condition
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Heavy Drinking
Brief Academic Future Thinking Intervention for College Student Drinkers
The present study investigated the feasibility, acceptability, and initial utility of a brief academic goal-relevant episodic future thinking (A-EFT) task among heavy college drinkers.
- Trial name
- NCT04275739
- Testing
- Academic Episodic Future Thinking, Vivid Memory Task
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Memphis
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Effect of Sublingual Formulation of Dexmedetomidine Hydrochloride (HCl) (BXCL501) - Outpatient Study
The overall objective of the proposed study is to determine if Dexmedetomidine HCl (BXCL501) is safe for treatment of alcohol use disorder (AUD) with comorbid posttraumatic stress disorder (PTSD) in an outpatient setting and also…
- Trial name
- NCT06335407
- Testing
- Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 40µg, Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 80µg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Unhealthy Alcohol Use
Financial Incentives, Randomization With Stepped Treatment Trial
The investigators plan to determine the effectiveness of contingency management (CM) plus stepped care for unhealthy alcohol use in HIV-positive patients.
- Trial name
- FIRST (NCT03089320)
- Testing
- Contingency Management Counseling, Addiction Physician Management, Motivational Enhancement Therapy
- Where
- 7 sites in United States
- Volunteers
- 120 people
- Sponsor
- Yale University
Heavy Drinking
Targeted Extinction of Drug Cues During Sleep - Olfactory Cue Reactivity Task
The study aims to utilise olfactory stimulation in addition to the visual stimulation in cue reactivity tasks to enhance precision in measuring alcohol based cues in individuals diagnosed with heavy drinking.
- Trial name
- TEDDS_OCRT (NCT05189379)
- Testing
- Non-Alcoholic Odour, Alcoholic Odour, Non-Alcoholic Images
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Heavy Drinking
Testing a Novel Instagram Intervention for Heavy Alcohol Use
This project aims to test the efficacy of an Instagram-based intervention for reducing heavy alcohol use. More specifically, the investigators will use a randomized controlled design to analyze differences in alcohol use and…
- Trial name
- NCT06420050
- Testing
- Instagram Intervention
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emily Grekin
Smoking, Heavy Episodic Drinking
Smoking Tobacco and Drinking Study
This trial will test the efficacy of a 3-month intervention on Facebook targeting tobacco use and heavy episodic drinking against a 3-month Facebook intervention targeting tobacco use.
- Trial name
- STAND (NCT03163303)
- Testing
- Tobacco Status Project Intervention, Tobacco Status Project + Alcohol Intervention, nicotine patch
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Drinking, Alcohol
Multimodal Sleep Intervention Using Wearable Technology
This research study is examining three different components of a digital sleep intervention: web-based sleep health advice, sleep and alcohol smartphone diary self-monitoring, and personalized sleep and alcohol consumption…
- Trial name
- NCT03658954
- Testing
- Advice, Self-monitoring, Feedback
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Use Disorder
A Combined Neurofeedback-TMS Intervention for Alcohol Use Disorder
The goal of this clinical study is to test the effectiveness of a supplemental fMRI neurofeedback and/or TMS intervention in individuals seeking treatment for Alcohol Use Disorder.
- Trial name
- CNT (NCT05621538)
- Testing
- Realtime fMRI Neurofeedback - Active, TMS - Active
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Auburn University
Arsenic Poisoning
Strong Heart Water Study
Develop and evaluate the effectiveness of multi-level participatory interventions in reducing arsenic exposure among American Indian (AI) communities from North and South Dakota who participated in the Strong Heart Study (SHS).
- Trial name
- SHWS (NCT03725592)
- Testing
- Standard Treatment, Intensive Education
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Alcohol Drinking
Alcohol Brief Counseling in Primary Care
This study evaluates the effectiveness of a brief intervention for the reduction of alcohol use among risky alcohol users in primary care delivered by paramedics.
- Trial name
- NCT02642757
- Testing
- AUDIT brief intervention, Pamphlet on alcohol use
- Where
- 5 sites in Chile
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Alcohol-Related Disorders, Alcohol Use Disorders
Component Analysis for Motivational Interviewing
The purpose of this study is to investigate the critical components of motivational interviewing (MI), a psychotherapeutic intervention, in reducing heavy or problematic drinking.
- Conditions
- Alcohol-Related Disorders, Alcohol Use Disorders, Alcohol Drinking, Alcoholism
- Trial name
- NCT01642381
- Testing
- Full Motivational Interviewing ("FMI"), Spirit Only Motivational Interviewing ("SOMI")
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Northwell Health
Heavy Drinking
Increasing Effectiveness of an Alcohol Use Reduction Exercise Using Self-Talk Videos
The goal of the current study is to develop and test an innovative, low-burden method of post-intervention contact that is based on principles of motivational interviewing and the elicitation of change talk.
- Trial name
- NCT06593483
- Testing
- Motivational Interview with Self-Talk Video, Motivational Interviewing
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Wayne State University
Heavy Drinking
Study of Nitrate-Rich Juice on Cognitive Function in Heavy Alcohol Drinkers: a Two-Stage Adaptive Design Real-World Clinical Trial
It is known that alcohol consumption can lead to cognitive impairment and dysregulation of inflammatory responses. A preliminary randomized controlled trial conducted by our research team has suggested that nitrate may improve…
- Trial name
- NCT06777459
- Testing
- Nitrate-rich beetroot juice
- Volunteers
- 43 people
- Sponsor
- Peking University Sixth Hospital