Clinical trials: Helicobacter
Helicobacter Pylori Infection, Gastritis
Comparison Between High-dose Amoxicillin Dual Therapy and Pylera Quadruple Therapy in the Treatment of Helicobacter Pylori Infection
Helicobacter pylori is a pathogenic bacteria transmitted from individual to individual, being scientifically recognized as an agent who causes persistent inflammatory activity on the gastric mucosa.
- Conditions
- Helicobacter Pylori Infection, Gastritis, Gastric Cancer
- Trial name
- NCT05100446
- Testing
- Amoxicillin - high dose dual therapy, Pylera, Esomeprazole 40mg
- Where
- Portugal
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Unidade Local de Saúde do Alto Ave, EPE
Helicobacter Pylori, Family
Family-based Screening and Treatment of Helicobacter Pylori：A Real World Study
The habit of family meals makes the infection rate of Helicobacter pylori high in China, which is also the main cause of reinfection of Helicobacter pylori.
- Trial name
- NCT04956679
- Testing
- carbon 13 breath test
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shandong University
HIV, Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
The Impact of Helicobacter Pylori Infection on Immune Regulation and Clinical Course in HIV Patients in Ghana
The main objective of the study is to investigate the impact of H. pylori infection on immune activation and clinical outcome in HIV patients. Other specific study objectives are: 1. To investigate the effects of H.
- Trial name
- HHECO (NCT01897909)
- Where
- Ghana
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Bernhard Nocht Institute for Tropical Medicine
Helicobacter
Efficacy of Probiotics in the Gut Microbiota and H Pylori Density
We aimed to assess the efficacy of Lactobacillus acidophilus and Lactobacillus rhamnosus in the reduction of bacterial load of H.
- Trial name
- NCT02725138
- Testing
- Probiotic
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Statistical Center, NTUHCTC
Helicobacter Pylori Infection
Helicobacter Pylori Infection Occurrence in Russia
This study is planned to reveal the occurrence rate of H.pylori infection in ambulatory settings' patients in Russia and to compare the occurrence rates in different years in treatment-naïve and previously treated subjects.
- Trial name
- NCT04892238
- Testing
- 13-C urea breath test
- Where
- 2 sites in Russia
- Volunteers
- 70,000 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Scientific Institution
Chronic Gastritis Caused by Helicobacter Pylori
Effect of Chicken Egg Antibody (IgY) on Patients With Chronic Gastritis
H. pylori positive patient volunteers that passed the selection criteria are recruited and divided into a test and a control group.
- Trial name
- NCT02721355
- Testing
- GastimunHP
- Where
- Vietnam
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Immunology Research Institute in Gifu
Inflammatory Bowel Diseases, Helicobacter Pylori Infection
The Relationship Between Helicobacter Pylori Infection and Inflammatory Bowel Diseases: A Real-life Observation
Numerous epidemiological studies have investigated the association between Helicobacter pylori (H. pylori) infection and inflammatory bowel disease (IBD) with various conflicting results.
- Trial name
- NCT04708405
- Testing
- Observation
- Where
- Egypt
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Helicobacter Pylori Infection
Quadruple vs Tailored Therapy in the Treatment of Helicobacter Pylori Infection
Non-bismuth quadruple therapies have been proposed as potential strategies in improving the efficacy of first-line treatments. The non-bismuth quadruple therapy in its concomitant variant consists of proton pump inhibitor…
- Trial name
- NCT04621487
- Testing
- Amoxicillin, Metronidazole, Clarithromycin
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Helicobacter Pylori Infection, Dyspepsia
Assessment and Management of Chronic Dyspepsia in Eastern Uganda
Chronic dyspepsia, or a sensation of indigestion, remains an underdiagnosed and often inappropriately managed cause of morbidity in countries with limited medical resources.
- Trial name
- NCT04525664
- Testing
- Clarithromycin 500mg, Amoxicillin 1000 MG, Omeprazole 40 MG
- Where
- United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Bile Reflux Gastritis, Gastric Cancer
Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Cross-sectional Study.
To explore the effects of bile reflux on gastric cancer and its precancerous lesions, so as to better prevent the occurrence and development of gastric cancer.
- Conditions
- Bile Reflux Gastritis, Gastric Cancer, Helicobacter Pylori Infection, Intestinal Metaplasia
- Trial name
- NCT03976739
- Where
- China
- Volunteers
- 1,162 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori Infection
Helicobacter Pylori Eradication Rates of Bismuth-containing Quadruple Therapy vs Modified Quadruple Therapy in Korea
South Korea has the highest incidence of gastric cancer worldwide and Helicobacter pylori infection is still prevalent. Clarithromycin-containing triple therapy is still the primary therapy approved by the Korean government.
- Trial name
- NCT03665428
- Testing
- PAMB treatment (modified quadruple therapy), PBMT treatment (bismuth-containing quadruple therapy)
- Where
- South Korea
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- Chuncheon Sacred Heart Hospital
Helicobacter Pylori Infection, Family History of Stomach Cancer
Comparison of 7-day PPI-based Standard Triple Therapy and 10-day Bismuth Quadruple Therapy for H. Pylori Eradication
In this randomized controlled trial, we investigate the effect of 10-day bismuth quadruple therapy in comparison with that of 7-day PPI-based standard triple as 1st line treatment for H. pylori.
- Trial name
- NCT02557932
- Testing
- Standard triple therapy, Bismuth quadruple therapy
- Where
- South Korea
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Helicobacter Pylori Infection
Dysplasia Detection and Helicobacter Pylori Eradication
The investigators in the present study, aimed to assess the efficacy of both White-Light Endoscopy with High Resolution Endoscopy-Narrow-band imaging in the diagnosis of Premalignant Gastric Conditions, before and after…
- Trial name
- NCT03917836
- Testing
- endoscopy and histology
- Where
- Italy
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Helicobacter Pylori
A Comparison of High-dose Dual Therapy and Half-dose Clarithromycin-containing Bismuth Quadruple Therapy for H.P Eradication in Elderly Patients
The purpose of this study is to assess and compare the effectiveness and safety of high-dose dual therapy and half-dose clarithromycin-containing bismuth quadruple therapy in elderly patients for eradicating H.pylori.
- Trial name
- NCT04101708
- Testing
- Lansoprazole, Amoxicillin, Lansoprazole, Amoxicillin,Clarithromycin and Bismuth subcitrate
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shandong University
Helicobacter Pylori Infection
Efficacy and Safety of InSan Bamboo Salt on Improvement of Helicobacter Pylori Infection
The investigators performed a 4-week, randomized, double-blind, placebo-controlled human trial to evaluate the efficacy and safety of InSan Bamboo Salt on improvement of Helicobacter pylori infection.
- Trial name
- NCT01735136
- Testing
- InSan Bamboo Salt
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Helicobacter Pylori Infection
ADDITION OF BISMUTH TO THE STANDARD TRIPLE THERAPY FOR HELICOBACTER PYLORI ERADICATION
H pylori is an important cause of chronic gastritis and other complications. There is a decline in eradication rate for H pylori owing to multiple factors including drug resistance.
- Trial name
- NCT03968302
- Testing
- ARM A Triple therapy for helicobacter pylori, ARM B Quadruple therapy for helicobacter pylori
- Where
- Pakistan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Ziauddin University
Helicobacter Pylori Infection
The Diagnostic Validity of the Urea Breath Test
1. To compare the diagnostic accuracy of the 13C-Urea breath test between using the citric acid as test meal and controlled group by endoscopic biopsy methods(histology, CLOtest and H. pylori culture). 2.
- Trial name
- NCT02359942
- Testing
- Citric acid
- Where
- South Korea
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Helicobacter Pylori Infection, Gastric Ulcer
A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA
Helicobacter pylori (H.pylori) is a major human pathogenic bacterium in gastric mucosa which is linked to the development of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer.
- Conditions
- Helicobacter Pylori Infection, Gastric Ulcer, Duodenal Ulcer, Stomach Cancer
- Trial name
- NCT03057171
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Helicobacter Pylori Infected Subjects, Helicobacter Pylori Naive Subjects
Phase 1a/b Study on Safety of IMX101 in H. Pylori-negative and H. Pylori-infected Healthy Volunteers
A Phase 1, multi-center, randomised, double-blind and adjuvant-controlled study to evaluate the safety, tolerability, and efficacy of IMX101 in H. pylori-negative and H. pylori-infected healthy volunteers.
- Trial name
- IMX-02 (NCT03270800)
- Testing
- CTA control, IMX101 vaccine
- Where
- 2 sites in Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- ImevaX
Helicobacter Pylori Eradication Rate
Modified Non-clarithromycin Triple Therapy in Eradicating Helicobacter Pylori
Helicobacter pylori (H. pylori) infects more than 50% of the population in the world(1), especially 47-66% in China.
- Trial name
- NCT02776371
- Testing
- Modified non-clarithromycin triple therapy, Sequential therapy
- Where
- China
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Shandong University