Clinical trials: Helicobacter
Helicobacter Pylori Infection, Chronic Gastritis
Study on The Efficacy and Safety of Vonoprazan-containing Berberine Triple Therapy in Helicobacter Pylori First-Line Eradication
The purpose of this study was to evaluate the efficacy and safety of the triple therapy of berberine hydrochloride, vonorasan and amoxicillin for the primary eradication of Helicobacter pylori.It is hypothesized that berberine…
- Trial name
- NCT06514274
- Testing
- Berberine, Vonoprazan, Amoxicillin
- Where
- China
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori Infection
Tailored Therapy for Helicobacter Pylori Rescue Treatment
With increasing antibiotic resistance and unsatisfactory results of empiric eradication regimens, tailored therapy may be the best choice to achieve high efficacy for rescue treatment.
- Trial name
- NCT03413020
- Testing
- esomeprazole, bismuth Potassium Citrate, amoxicillin
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Gastritis, Peptic Ulcer
H. Pylori Testing for Patients With Non-specific Upper Abdominal Pain in the Emergency Department
This pilot study aims to estimate the prevalence of Helicobacter pylori (H. pylori) colonization in patients presenting with non-specific abdominal pain (NSAP) in an urban academic emergency department (ED) located in Washington…
- Conditions
- Gastritis, Peptic Ulcer, Peptic Ulcer Perforation, Stomach Ulcer
- Trial name
- NCT01376414
- Testing
- Urea Breath Test (UBT) for H. pylori infection
- Where
- 2 sites in United States
- Volunteers
- 212 people
- Sponsor
- George Washington University
Helicobacter Pylori Infection, Helicobacter Pylori Eradication
Efficacy of Amoxicillin-Esomeprazole HDDT Compared to Levofloxacin Triple Therapy for H. Pylori Eradication: A RCT
The goal of this clinical trial is to compare the efficacy of two different therapeutic regimen for the treatment of Helicobacter pylori infected dyspeptic patients. The aim is - 1. To identify the percentage of H.
- Trial name
- NCT06088316
- Testing
- group A : Amoxicillin Esomeprazole HDDT, group-B : Levofloxacin triple therapy
- Where
- Bangladesh
- Volunteers
- 70 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
H Pylori Infection, H Pylori Gastritis
Helicobacter Pylori Screening and Treatment in the At-risk South Florida Community- AIM 1
H. pylori is an infection of the stomach that can cause chronic gastritis, gastric cancer and peptic ulcer disease. The goal of this study is to screen people for this infection and offer treatment for those who test positive for…
- Conditions
- H Pylori Infection, H Pylori Gastritis, Gastric Cancer
- Trial name
- NCT07224035
- Testing
- PYTEST® 14C-Urea Breath Test, VOQUEZNA® Triple Pak®
- Where
- United States
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- University of Miami
Positive Helicobacter Pylori Serology, Coronary Thrombosis
Effectiveness of the Eradication of Helicobacter Pylori and an Inhibitor of Pump With Proton Versus Control
Low dose of aspirin is the main cause of gastro-duodenal ulcer. The best prevention is not definite particularly in patients without history of ulcer and infected by H.
- Conditions
- Positive Helicobacter Pylori Serology, Coronary Thrombosis, Supra-aortic Artery Thrombosis
- Trial name
- Aspylori (NCT00713947)
- Testing
- during one week for the active treatments, Pantoprazole
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Helicobacter Pylori Infection
Comparing the Efficacy of Hybrid, High-dose Dual and Bismuth Quadruple Therapies
Both hybrid and high-dose dual therapies developed by the scholars from Taiwan can achieve a high eradication rate for clarithromycin-resistant strains, and have a great potential to replace bismuth quadruple therapy in the…
- Trial name
- NCT03779074
- Testing
- 10d bismuth quadruple therapy, 14d hybrid therapy, 14D high-dose dual therapy
- Where
- Taiwan
- Volunteers
- 918 people
- Sponsor
- Kaohsiung Veterans General Hospital.
HELICOBACTER PYLORI INFECTIONS, Osteoporosis
Preventive Effect of H.Pylori Eradication on Osteoporosis
In this study, the investigators observed the long-term incidence rate of osteoporosis in patients who received Helicobacter pylori eradication and examined differences by age and sex.
- Trial name
- NCT06818591
- Testing
- DEXA(Dual-Energy X-ray Absorptiometry)
- Where
- South Korea
- Volunteers
- 846 people
- Sponsor
- Seoul National University Bundang Hospital
Gastric Ulcer Associated With Helicobacter Pylori
Additive Effect of Endonase on Eradication Rate of First Line Therapy for Helicobacter Pylori
Endonase, a kind of protease, is known to cause both extensive degradation of mucins and a reduction in mucus viscosity. As part of the search for more effective forms of therapy against H.
- Trial name
- NCT01645761
- Testing
- Endonase
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Gastric (Stomach) Cancer, Helicobacter Infection
An Observational Study for Gastric Cancer in Carriers of High Risk Helicobacter Pylori
This study is intended to be a prospective observational cohort study. The incidence of gastric cancer and progression of gastric precancerous lesions will be compared between groups through prospective follow-up of a population…
- Trial name
- NCT06896370
- Testing
- observational study
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
Helicobacter Pylori Infection
Study the Effect of Probiotics Combined With Bismuth Quadruple Rescue Therapy on H Pylori Infective Patients
Retrospectivly follow-up the outpatients for H pylori eradication failures more than 2 times in the digestive department of Changhai hospital from 2015-2017,analyse the eradication rates and adverse effects of the therapy with…
- Trial name
- NCT03297242
- Volunteers
- 30 people
- Sponsor
- Changhai Hospital
Non-alcoholic Fatty Liver Disease
Helicobacter Pylori Eradication in Diabetic Subjects With Non-alcoholic Fatty Liver Disease
The aim of study was to evaluate the effect of helicobacter pylori eradication on liver fat content, liver function tests, lipid profile, homeostasis model assessment-IR (HOMA-IR) index, and anthropometric measurements (body mass…
- Trial name
- NCT01712711
- Testing
- H.pylori eradication
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Tehran University of Medical Sciences
Helicobacter Pylori Infection
Comparison of Hybrid and Bismuth Quadruple Therapies for Helicobacter Pylori Eradication
According the Maastricht IV consensus report publish in the Gut 2012, bismuth containing quadruple therapy was suggested to be the first choice for eradication therapy of Helicobacter pylori in the area with high clarithromycin…
- Trial name
- NCT02541864
- Testing
- Bismuth quadruple therapy, Hybrid therapy
- Volunteers
- 330 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Helicobacter Pylori Infection
Performances of a Fast Test for the Detection of Helicobacter Pylori Antigens in Child Stool
The diagnostic tests used to detect Helicobacter pylori (H. pylori) infection are either direct and invasive, as in culture, histology and the rapid urease test (RUT) or noninvasive, such as serology, the 13C-Urea breathe test or…
- Trial name
- DISPOSE (NCT03324763)
- Testing
- stool sampling
- Where
- France
- Volunteers
- 158 people
- Sponsor
- Lille Catholic University
Helicobacter Pylori Infection
Auto Fecal Microbial Transplant Post Helicobacter Pylori Antibiotic Therapy
Current guidelines mandate Helicobacter pylori (H. Pylori) eradication with 2-3 antibiotics for 14 days ,This may result in multiple side effects and in eradication of important bacterial species to human health, exposing humans…
- Trial name
- NCT05329636
- Testing
- Fecal Microbial Transplant (FMT), Auto Fecal Microbial Transplant (FMT) via enema
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Helicobacter Pylori Infection
Efficacy and Safety of 14-day Concomitant Therapy for Helicobacter Pylori Infection
The purpose of this study is to evaluate efficacy of a 14-day concomitant therapy for the third-line treatment of Helicobacter pylori infection, and whether it is safe while maintaining an ideal eradication rates.
- Trial name
- NCT03726099
- Testing
- esomeprazole, amoxicillin, furazolidone，tetracycline
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shandong University
Ulcer
H. Pylori Eradication on Healing of Iatrogenic Gastric Ulcer by Endoscopic Mucosal Resection
This study will evaluate the effect of Helicobacter pylori eradication therapy on the healing of iatrogenic gastric ulcer caused by endoscopic mucosal resection of gastric neoplastic lesions and is a multicenter, randomized…
- Trial name
- NCT00926809
- Testing
- Lansoprazole (proton pump inhibitor), amoxicillin, clarythromycin
- Where
- 6 sites in South Korea
- Volunteers
- 232 people
- Sponsor
- Korean College of Helicobacter and Upper Gastrointestinal Research
Ulcer, Blood Tests
Functional Food Product
Background/Objective: This study evaluated the effects of pomegranate peel powder (PPP)-enriched muffins containing 1.5 g or 2.5 g PPP on H.
- Conditions
- Ulcer, Blood Tests, Liver Function Tests
- Trial name
- NCT07789561
- Testing
- pomegranate peel powder 1.5 g, pomegranate peel powder 3 g, Whole wheat muffin
- Where
- Pakistan
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Lahore
H. Pylori Eradication Failure
Mixed Strain H. Pylori Infection in Patients Who Have Problems With Eradication of H. Pylori
The purpose of this study is to determine whether mixed H. pylori strain infection is the reason for eradication failure during treatment of H. pylori infection.
- Trial name
- NCT01164969
- Testing
- Antibiotics to which H. pylori can not develope resistance
- Where
- Slovenia
- Volunteers
- 10 people
- Sponsor
- University Medical Centre Ljubljana
GERD
Effect of Helicobacter Pylori Eradication on Gastroesophageal RefIux Disease (GERD)
Evaluate the effect of H.pylori eradication on Gastroesophageal-reflux disease and symptoms improvement
- Trial name
- NCT06457334
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University