Clinical trials: Helicobacter Infections
Helicobacter
Sequential Therapy Versus Quadruple Therapy in H. Pylori Eradication
The investigators aimed to 1. compare the eradication rates and long term re-infection rates of sequential therapy for 14 days versus bismuth quadruple therapy for 10 days in the first line and second line treatment 2.
- Trial name
- NCT03156855
- Testing
- 14-day sequential therapy, Bismuth quadruple therapy
- Where
- 7 sites in Taiwan
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection, Dyspepsia
Effect of H. Pylori Eradication on The Improvement of Gastrointestinal Symptoms
This study aims to evaluate the effect of Helicobacter pylori eradication on gastrointestinal symptoms in adult patients. H. pylori infection is a common cause of dyspepsia and other upper gastrointestinal complaints.
- Conditions
- Helicobacter Pylori Infection, Dyspepsia, Gastrointestinal Symptoms
- Trial name
- HPE-GI (NCT07272681)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amany Usama Ahmed Arafa
Describe Current Practices in Hpylori Diagnosis
Assessing Knowledge, Practices, Attitudes and Barriers of Puplic Population Regarding Helicobacter Pylori Infection in Upper Egypt: Cross- Sectional Study
Assess non medical population knowledge of H. pylori epidemiology, diagnostic methods, treatment guidelines, and complications. Evaluate attitudes toward the importance of testing, eradication, and antibiotic resistance concerns.
- Trial name
- Hpylori/KAP (NCT07043881)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Assiut University
Erosive Esophagitis, Heartburn
A Study to Evaluate Vonoprazan Concentrations in Breast Milk of Healthy Lactating Women Receiving Vonoprazan 20 mg Once Daily or Vonoprazan 20 mg Twice Daily
The primary objective is to determine the pharmacokinetics (PK) of vonoprazan in breast milk of healthy lactating women who have received vonoprazan administered once daily or vonoprazan 20 mg administered twice daily for 4…
- Conditions
- Erosive Esophagitis, Heartburn, Symptomatic Nonerosive Gasroesophageal Reflux Disease, Helicobacter Pylori Infection
- Trial name
- NCT06391177
- Testing
- Vonoprazan
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Phathom Pharmaceuticals, Inc.
Gastric Cancer, Gastric (Stomach) Cancer
Gastric Cancer Endoscopic Screening in an Intermediate-risk Country - ROGCAS, a Dual-centre Pilot Program
Endoscopic screening of gastric cancer combined with screening colonoscopy
- Conditions
- Gastric Cancer, Gastric (Stomach) Cancer, Atrophic Gastritis, Intestinal Metaplasia of Gastric Mucosa
- Trial name
- ROGCAS (NCT06316882)
- Testing
- Screening endoscopy
- Where
- Portugal
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- Unidade Local De Saúde Do Norte Alentejano
Helicobacter Pylori Infection
Helicobacter Pylori and Body Iron in Adults
This study is an etiologic trial to test the hypothesis that predicts that Helicobacter pylori eradication in asymptomatic/mildly dyspeptic adults will result in an increase in body iron.
- Trial name
- HEISA (NCT03146325)
- Testing
- BISMUTH TETRACYCLINE METRONIDAZOLE OMEPRAZOLE
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Helicobacter Pylori
Association of Oral Helicobacter Pylori Infection With Gastric Helicobacter Pylori Infection
The aim of this study was to investigate the association between oral Helicobacter pylori infection and gastric Helicobacter pylori infection.
- Trial name
- NCT05790512
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori Infection
Trimebutine on the Development of Adverse Events Related to the Helicobacter Pylori Eradication Medications
Adverse events related to the eradication medication is one of the reason of lower eradication success in the H. pylori treatment.
- Trial name
- NCT04403087
- Testing
- Trimebutine 100 MG
- Where
- South Korea
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Chuncheon Sacred Heart Hospital
Helicobacter Pylori Infection
The Role of Probiotics in the Eradication of Helicobacter Pylori
All patients will receive quadruple eradication therapy for 10 days with Omerazole 20mg x2, Amoxicilin 1g x2, Clarithromycin 500mg x2 and Metronidazole 500mg x2. The patients will be randomised into two groups.
- Trial name
- NCT04178187
- Testing
- Caps Lactolevure
- Where
- 5 sites in Greece
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Evangelismos Hospital
Helicobacter Pylori Infection
Evaluation of SQ109 Plus PPI in Urea Breath Test-Positive Volunteers
Helicobacter pylori infection of the gastric epithelium is the most common bacterial infection worldwide. Its global prevalence is estimated at 50%, though the burden falls disproportionately on the developing world, where the…
- Trial name
- NCT01252108
- Testing
- SQ109
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sequella, Inc.
Helicobacter Pylori Infection, Eradication
Furazolidone Quadruple Regimen Eradicate H. Pylori Infection
Research protocol: Experimental group: First line solution (furazolidone regimen): esomeprazole magnesium 20 mg +colloidal bismuth pectin 200mg+ amoxicillin 1000 mg + furazolidone 100 mg, twice daily, for 14 days.
- Trial name
- NCT06823791
- Testing
- Furazolidone, Clarithromycin
- Where
- China
- Volunteers
- 493 people, healthy volunteers welcome
- Sponsor
- Liaocheng People's Hospital
Effects Toxics
The Effect and Frequency of Helicobacter Pylori Infection in Primary Immune Thrombocytopenic Patients
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet count (i.e less than 100.000) . In ITP, platelet surface membrane proteins become antigenic for unknown reasons , leading to stimulation of the…
- Trial name
- NCT03163147
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Vonoprazan, Helicobacter Pylori Infection
A RCT of the Efficacy of Vonoprazan 20mg QD in the Treatment of Helicobacter Pylori Infection
The treatment of helicobacter pylori is very important. The routine treatment is quadruple therapy. In recent years, double therapy has appeared and the curative effect is fair.
- Conditions
- Vonoprazan, Helicobacter Pylori Infection, Proton Pump Inhibitor
- Trial name
- VATH-1 (NCT05590286)
- Testing
- Vonoprazan Tablets, Amoxicillin Capsules, Esomeprazole
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Hangzhou
Helicobacter Infections
Levofloxacin Versus Clarithromycin Triple Therapy in First-Line Treatment for Helicobacter Pylori Eradication
Clarithromycin-based triple therapy containing a proton-pump inhibitor (PPI) twice daily, amoxicillin 1g twice daily, and clarithromycin 500 mg twice daily for 7 days is one of the standard firs-line therapy for Helicobacter…
- Trial name
- NCT00816140
- Testing
- Cravit based triple therapy, Klaricid based triple therapy
- Where
- Taiwan
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Infections, Helicobacter
Helicobacter Pylori Prevalence in Southern Region of Romania
Observational study, voluntary participation, 12 months, studying Helicobacter pylori prevalence.
- Trial name
- HELIUM (NCT05874960)
- Where
- Romania
- Volunteers
- 708 people, healthy volunteers welcome
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Helicobacter Pylori Infection, Colorectal Cancer
European Implementation Study on Simultaneous Screening for Gastric and Colorectal Cancers
The EUGastScreen study is designed as a quality implementation study to explore gastric cancer screening strategies within organised cancer screening frameworks.
- Conditions
- Helicobacter Pylori Infection, Colorectal Cancer, Gastric Cancer
- Trial name
- EUGastScreen (NCT07873580)
- Testing
- Fecal sample acquisition for Helicobacter pylori stool antigen test, Upper endoscopy with biopsies, Colonoscopy with biopsies after bowel cleansing
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Healthy Participants, Non-anemic Children
Ferrous Fumarate and Ferric Pyrophosphate as Food Fortificants in Developing Countries
Iron fortification of foods is usually considered the most cost-effective approach to prevent iron deficiency. However, iron is the most difficult mineral to add to foods.
- Conditions
- Healthy Participants, Non-anemic Children, Helicobacter Pylori Infection
- Trial name
- NCT00867867
- Testing
- Ferrous fumarate, Ferric pyrophosphate
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Helicobacter Pylori Infection, Antibiotic Resistant Infection
Optimal Tailored Treatment for H. Pylori Infection
The efficacy of the current standard triple therapy is at an unacceptably low level. Resistance to antibiotics is suspected to be the major cause of the low efficacy of standard triple therapy.
- Trial name
- NCT04462133
- Testing
- Dual-priming oligonucleotide-based multiplex polymerase chain reaction (DPO-PCR)
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Incheon St.Mary's Hospital
Heliobacter Pylori Infection
Effect of Helicobacter Pylori on the Availability of Vitamin E and C
This study argues that H.pylori infection, by increasing the production of reactive oxygen species, increases the utilization of dietary antioxidants(Vit E and Vit C) that serve in quenching the free radicals, thus decreasing…
- Trial name
- NCT00303160
- Testing
- vitamin C & E supplements
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Helicobacter
Comparison of the Levofloxacin Sequential Therapy and Quadruple Therapy in Second Line Treatment for HP
Objectives: Eradication of H. pylori infection could reduce the occurence or recurrence of gastric cancer and peptic ulcer diseases.
- Trial name
- NCT03148366
- Testing
- Levofloxacin based sequential therapy, bismuth quadruple therapy for 10 days (BQ)
- Where
- 2 sites in Taiwan
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital