Clinical trials: Helicobacter Infections
Helicobacter Pylori Infection
A Study About the Selection of Time for Retreatment of Helicobacter Pylori After Eradication Failure
The patients who accepted the quadruple eradication program of the helicobacter pylori but failed to eradicate helicobacter pylori will be assessed the most suitable re-eradication time of helicobacter pylori.
- Trial name
- NCT05493644
- Testing
- Remedial treatment within 3 months, Remedial treatment within 3 to 6 months, Remedial treatment within 6 to 12 months
- Volunteers
- 660 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection
Tegoprazan-containing Sequential for H. Pylori
As H. pylori eradication, the investigators prepared a randomized controlled clinical trial whether tegoprazan-containing 10-day sequential treatment was effective compared to conventional PPI-containing 10-day sequential…
- Trial name
- NCT06382493
- Testing
- Tegoprazan-containing sequential H. pylori eradication therapy, Esomeprazole-containing sequential H. pylori eradication therapy
- Where
- South Korea
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
HELICOBACTER PYLORI INFECTIONS
Feasibility and Performance of FFPE qPCR for Detection of Clarithromycin Resistance in Helicobacter Pylori
This prospective observational study aims to evaluate the feasibility and performance of real-time PCR (qPCR) performed on formalin-fixed, paraffin-embedded (FFPE) gastric biopsies to detect Helicobacter pylori infection and…
- Trial name
- HED-2T (NCT07821294)
- Testing
- q-PCR on FFPE gastric biopsies
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Clinique Bizet
Helicobacter Pylori Infection
Comparison of Two Treatment Regimens of Helicobacter Pylori Infection
The goal of this interventional study is to compare the efficacy of clarithromycin Vs levofloxacin based regimen in treatment of Helicobacter pylori infection in patients presenting to medical OPD who are tested positive for H…
- Trial name
- NCT07021729
- Testing
- Clarithromycin, Levofloxacin
- Volunteers
- 156 people
- Sponsor
- Rehman Medical Institute - RMI
HELICOBACTER PYLORI INFECTIONS
Tegoprazan Plus Amoxicillin BID vs TID Regimens for H. Pylori Eradication（Frequency Adjusted Same-dose Therapy for H. Pylori）
This study is designed to evaluate two different tegoprazan-based dual therapy regimens for the treatment of Helicobacter pylori (H. pylori) infection.
- Trial name
- FAST-HP (NCT07242443)
- Testing
- Tegoprazan 50 mg, Amoxicillin 1 g TID, Amoxicillin 1.5 g BID
- Where
- China
- Volunteers
- 240 people
- Sponsor
- First People's Hospital of Hangzhou
Hyperemesis Gravidarum
The Association of Helicobacter Pylori in the Pathogenesis of Hyperemesis Gravidarum in Pregnant Women
The purpose of this study to explore the association between Hyperemesis Gravidarum in pregnant women and Helicobacter pylori infection.
- Trial name
- AOHPIPOHGIPW (NCT02830321)
- Testing
- helicopacter pylori stool antigen test (CER TEST BIOTEC)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- rasha fawzy abd el kader
Helicobacter Pylori Infection
Probiotics in the Reduction of Adverse Effects and Dysbiosis of H. Pylori Eradication
The investigators aimed to assess the effect of probiotic supplementation with Vigiis 101-LAB during H. pylori eradication therapy with 14-day sequential therapy in the reduction of adverse effects and the restoration of the…
- Trial name
- NCT03722433
- Testing
- Vigiis 101-LAB and sequential therapy
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
HELICOBACTER PYLORI INFECTIONS, Gastrointestinal Disease
Evaluation of IgY Antibody Efficacy in Egg Yolk Against Helicobacter Pylori in Bacterial Elimination and Clinical Symptoms Improvement of Gastrointestinal Patients
1. Investigating its effectiveness in removing bacteria in invivo conditions 2. Investigating the effectiveness in improving the clinical symptoms of patients
- Trial name
- Hp IgY (NCT06973889)
- Testing
- Helicobacter pylori eradication therapy
- Where
- 2 sites in Iran
- Volunteers
- 60 people
- Sponsor
- Mashhad University of Medical Sciences
H.Pylori Infection
Safety and Efficacy of Triple and Quadruple Regimens as First Line Therapy for Management of Helicobacter Pylori Infection in Egyptians
Our study aimed to investigate the efficacy and safety of hybrid regimen as a first line therapy for H. pylori eradication compared to triple and quadruple regimens in attempt to overcome antibiotic resistance
- Trial name
- NCT06315478
- Testing
- Omeprazole 20 MG Oral Tablet, Amoxicillin 500Mg Tab, Clarithromycin 500Mg Tab
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Helwan University
Gram-Negative Bacterial Infections, Helicobacter Infections
Efficacy and Safety Study of Finafloxacin Used in Helicobacter Pylori Infected Patients
The primary objective of this study is to compare the H. pylori eradication rates with Finafloxacin in combination with Amoxicillin or Esomeprazole.
- Conditions
- Gram-Negative Bacterial Infections, Helicobacter Infections, Dyspepsia
- Trial name
- FLASH (NCT00723502)
- Testing
- Finafloxacin + Amoxicillin, Finafloxacin + Esomeprazole
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- MerLion Pharmaceuticals GmbH
Helicobacter Pylori Infection
The Effect of Lactobacillus Reuteri Probiotic as an Adjunct Treatment for Helicobacter Pylori Infection in Adults
This is a prospective, randomised, double-blind, placebo-controlled trial involving newly diagnosed Helicobacter pylori (H. pylori) patients.
- Trial name
- NCT05399862
- Testing
- Lactobacillus reuteri DSM 17648 probiotic
- Where
- Malaysia
- Volunteers
- 90 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Helicobacter Pylori Infection
A Study on Eradication Rate of Triple Therapy According to Treatment Period and CYP2C19 Polymorphisms in H.Pylori Patients
This study compared efficacy and safety of basic triple therapy according to treatment period. This study evaluated Effect of CYP2C19 genetic polymorphisms on the efficacy
- Trial name
- NCT03099876
- Testing
- treatment period
- Where
- 4 sites in South Korea
- Volunteers
- 320 people
- Sponsor
- Il-Yang Pharm. Co., Ltd.
Dyspepsia
UBT as a Diagnostic Tool for HP Prevalance
The prevalence of H. pylori infection in Pakistan is unknown and investigators want to assess it in dyspeptic patients utilizing UBT.
- Trial name
- NCT02570776
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- National Institute of Liver & GI Diseases, Pakistan
Peptic Ulcer Disease, HELICOBACTER PYLORI INFECTIONS
Predicting Peptic Complications Using H. Pylori Serology and Gastric Ultrasound
This observational study aims to evaluate whether combining a simple blood test (H. pylori serology) with a non-invasive abdominal ultrasound can accurately predict severe complications in patients with peptic ulcer disease…
- Conditions
- Peptic Ulcer Disease, HELICOBACTER PYLORI INFECTIONS, Helicobacter Pylori Infection, Peptic Ulcer
- Trial name
- NCT07458490
- Volunteers
- 230 people
- Sponsor
- Assiut University
Helicobacter Pylori Infection, Obesity, Morbid
THE EFFECT OF HELICOBACTER PYLORI ERADICATION THERAPY TO GASTRIC WALL THICKNESS BEFORE THE LAPAROSCOPIC SLEEVE GASTRECTOMY
Laparoscopic sleeve gastrectomy is one of the most popular bariatric surgery in the world. The most important complication about this surgery that the leakage from the stapler line because of the inconvenient stapler choice..The…
- Trial name
- NCT03757650
- Testing
- Bismuth Subsalicylate
- Where
- Turkey (Türkiye)
- Volunteers
- 3 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Helicobacter Pylori Infection
Fecal Molecular Susceptibility-guided Hp Rescue Therapy
The goal of this clinical trial is to evaluate the eradication efficacy and health economic benefits of individualized regimens guided by fecal molecular susceptibility testing with 7-day and 14-day courses in the rescue…
- Trial name
- NCT07405697
- Testing
- 7-day fecal molecular susceptibility-guided therapy, 14-day fecal molecular susceptibility-guided therapy
- Where
- 4 sites in China
- Volunteers
- 290 people
- Sponsor
- Shanghai Zhongshan Hospital
Helicobacter Pylori Infection
VA Dual Sequential Therapy
Sequential therapy for Hp was first introduced by Zullo et al. in 2000 and consists of two phases: the first phase involves proton pump inhibitors with one antibiotic, and the second phase involves proton pump inhibitors with two…
- Trial name
- JSHERO3 (NCT06929962)
- Testing
- Vonoprazan and Amoxicillin for the first 7 days, Vonoprazan and Amoxicillin for the first 5 days, Vonoprazan and Amoxicillin for the second 7 days
- Where
- China
- Volunteers
- 600 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Helicobacter Pylori
Effect of Oral Helicobacter Pylori Infection on the Efficacy of Gastroluminal Helicobacter Pylori Eradication Therapy
The aim of this study is to assess the effect of oral Helicobacter pylori infection on the efficacy of gastric Helicobacter pylori infection eradication.
- Trial name
- NCT05790525
- Testing
- Standard bismuth quadruple
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori Infection, Dysbiosis
The Efficacy of 10-day and 14-day Bismuth-based Quadruple Therapy in First-line H. Pylori Eradication
Helicobacter pylori (H. pylori) infection is the major cause of gastritis, peptic ulcer disease, and gastric cancer in adults. Bismuth-based quadruple therapy is recommended by a recent review to be the first-line treatment for…
- Conditions
- Helicobacter Pylori Infection, Dysbiosis, Probiotics
- Trial name
- Bsm10 (NCT04527055)
- Testing
- Bismuth Subcitrate 120 MG Oral Tablet, Lactobacillus acidophilus and Bifidobacterium lactis Bb12, Esomeprazole 40mg
- Where
- Taiwan
- Volunteers
- 312 people
- Sponsor
- National Cheng-Kung University Hospital
HELICOBACTER PYLORI INFECTIONS
Efficacy and Safety of 14-Day Vonoprazan-Based Dual Therapy Versus Quadruple Therapy for Helicobacter Pylori Eradication: A Multicentre, Non-Inferiority Randomized Controlled Trial
This study is a multicentre, non-inferiority randomized controlled trial to compare the efficacy and safety of 14-day vonoprazan-based dual therapy with versus quadruple therapy for the eradication of Helicobacter pylori.
- Trial name
- NCT07179159
- Testing
- 14-day vonoprazan-amoxicillin dual therapy, 14-day vonoprazan-amoxicillin-levofloxacin-bismuth quadruple therapy, 14-day vonoprazan-amoxicillin-clarithromycin-bismuth quadruple therapy
- Where
- 2 sites in China
- Volunteers
- 372 people
- Sponsor
- Yanqing Li