Clinical trials: Helicobacter Pylori Eradication
Helicobacter Pylori Infection
Development of Treatment Algorithm for Eradication of Helicobacter Pylori Based on Antibiotic Susceptibility Test
Helicobacter pylori eradication (H. pylori) rates with clarithromycin-based triple therapy are declining, and an alternative strategy is needed urgently.
- Trial name
- NCT02759029
- Testing
- eradication of Helicobacter pylori
- Where
- South Korea
- Volunteers
- 123 people
- Sponsor
- Gangnam Severance Hospital
Helicobacter Pylori Infection
Triple Versus Quadruple Therapy for the Eradication of Helicobacter Pylori
The study aimed to compare the efficacy and safety of 7-day and 14-day vonoprazan-amoxicillin-tetracycline triple therapy with 14-day vonoprazan-amoxicillin-tetracycline-bismuth quadruple therapy for the eradication of…
- Trial name
- SHARE2401 (NCT06299605)
- Testing
- Vonoprazan-Amoxicillin-Tetracycline-Bismuth quadruple regimen for 14 days, Vonoprazan-Amoxicillin-Tetracycline triple regimen for 14 days, Vonoprazan-Amoxicillin-Tetracycline triple regimen for 7 days
- Where
- China
- Volunteers
- 375 people
- Sponsor
- Shandong University
Gastrointestinal Ulcer Haemorrhage, Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
Helicobacter Eradication Aspirin Trial
HEAT (Helicobacter Eradication Aspirin Trial) is a large simple double-blind placebo controlled outcomes study of Helicobacter pylori (H. pylori) eradication to prevent ulcer bleeding in aspirin users.
- Trial name
- HEAT (NCT01506986)
- Testing
- Lansoprazole 30mg, Clarithromycin 500mg, Metronidazole 400mg
- Where
- 6 sites in United Kingdom
- Volunteers
- 30,024 people
- Sponsor
- University of Nottingham
Helicobacter Pylori Infection
Comparing the Efficacy of 14-day Reverse Hybrid Therapy and 14-day Triple Therapy Plus Bismuth Therapy
Reverse hybrid therapy achieves a higher eradication rate than bismuth (triple therapy plus bismuth) remains unanswered
- Trial name
- NCT03321773
- Testing
- triple therapy plus bismuth therapy, reverse hybrid therapy
- Where
- Taiwan
- Volunteers
- 440 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Helicobacter Pylori Infection, Atrophic Gastritis
Effect of H. Pylori Eradication on the Reversibility of Atrophic Gastritis and Intestinal Metaplasia in Korean Patients
Helicobacter pylori (H. pylori) infection has been associated with a development of atrophic gastritis and intestinal metaplasia. H.
- Conditions
- Helicobacter Pylori Infection, Atrophic Gastritis, Intestinal Metaplasia
- Trial name
- NCT02691637
- Where
- South Korea
- Volunteers
- 1,450 people
- Sponsor
- Seoul National University Bundang Hospital
Helicobacter Pylori Infection
A Clinical Trial on the Efficacy of Gastric Probiotics in the Treatment of Helicobacter Pylori Infection
The purpose of this study is to assess the safety and efficacy of Lactobacillus plantarum, Bacillus coagulans and Lactobacillus plantarum + Bacillus coagulans for eradication of Helicobacter Pylori, as well as the efficacy of…
- Trial name
- NCT05483660
- Testing
- Lactobacillus plantarum, Bacillus coagulans, Lactobacillus plantarum + Bacillus coagulans
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Peptic Ulcer, Dyspepsia
HEP-FYN 12-Years Follow-up
Aims: 1. Evaluate the long-term effect of screening and eradication of Helicobacter Pylori on the prevalence of dyspepsia, and, as secondary outcomes, to assess the effect on dyspepsia related health-care consumption and quality…
- Conditions
- Peptic Ulcer, Dyspepsia, Reflux
- Trial name
- NCT02001727
- Testing
- 13C-Urea breath test for Helicobacter Pylori, Questionaire
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Helicobacter Pylori Infection, Helicobacter Pylori Eradication Antibiotic
The Impact of Helicobacter Pylori Eradication on the Vaginal Microecology Change
This clinical controlled study enrolled 73 H. pylori（Helicobacter Pylori ）-infected female participants, stratified into reproductive-age and menopausal cohorts, alongside 10 non-infected controls.
- Trial name
- NCT07408271
- Testing
- rabeprazole-based triple therapy plus bismuth H. pylori eradication therapy
- Where
- China
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Helicobacter Pylori Infection
Simplified Dual Regimen Guided by Fecal Clarithromycin Resistance Gene Detection for First-line H. Pylori Eradication
To investigate the efficacy, safety, and compliance of a simplified strategy using vonoprazan plus clarithromycin for first-line treatment in patients with Helicobacter pylori infection, among those infected with strains without…
- Trial name
- NCT07439445
- Testing
- Vonoprazan 20 mg twice daily + clarithromycin 500 mg twice daily for 14 days
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University First Hospital
HELICOBACTER PYLORI INFECTIONS
Real-World Study of Helicobacter Pylori Eradication Success and Its Determinants
This study aims to evaluate the real-world effectiveness of different treatment regimens used to eradicate Helicobacter pylori (H. pylori) infection in routine clinical practice. H.
- Trial name
- NCT07374822
- Testing
- No Study-Assigned Intervention
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Run-hua Li
Gastroesophageal Reflux Disease
Symptom Assessment for Patients With Gastro-esophageal Reflux Disease Receiving Helicobacter Pylori Eradication
Background: Rebound acid hypersecretion and acid-related symptoms after discontinuation of proton-pump inhibitor has been reported in previous studies.
- Trial name
- NCT02934152
- Testing
- H pylori eradication, H pylori eradication timing
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- National Taiwan University Hospital
H. Pylori Eradication Therapy
Efficacy and Safety of JP-1366-based Triple Therapy in Helicobacter Pylori-positive Subjects
This study aims to evaluate the Efficacy and Safety of JP-1366-based Triple-Therapy in H. pylori-positive Subjects
- Trial name
- NCT07875933
- Volunteers
- 414 people
- Sponsor
- Onconic Therapeutics Inc.
Helicobacter Pylori Infection
Tegoprazan-Amoxicillin Dual Therapy vs. Bismuth Quadruple Therapy for H. Pylori Infection (TATH-1)
Standard eradication therapies using proton pump inhibitors (PPIs) require double doses to achieve sufficient acid suppression, yet failure rates remain high due to antibiotic resistance.
- Trial name
- TATH-1 (NCT05647278)
- Testing
- Tegoprazan 50 mg, tablets, orally, qd, Esomeprazole 20mg BID, Tegoprazan 50 mg, tablets, orally, bid
- Where
- China
- Volunteers
- 370 people
- Sponsor
- Zhang Xiaofeng,MD
HELICOBACTER PYLORI INFECTIONS
Efficacy and Safety of 14-Day Vonoprazan-Based Dual Therapy Versus Quadruple Therapy for Helicobacter Pylori Eradication: A Multicentre, Non-Inferiority Randomized Controlled Trial
This study is a multicentre, non-inferiority randomized controlled trial to compare the efficacy and safety of 14-day vonoprazan-based dual therapy with versus quadruple therapy for the eradication of Helicobacter pylori.
- Trial name
- NCT07179159
- Testing
- 14-day vonoprazan-amoxicillin dual therapy, 14-day vonoprazan-amoxicillin-levofloxacin-bismuth quadruple therapy, 14-day vonoprazan-amoxicillin-clarithromycin-bismuth quadruple therapy
- Where
- 2 sites in China
- Volunteers
- 372 people
- Sponsor
- Yanqing Li
Helicobacter Pylori Infected Patients, Thyroid Cancer Patients
The Effect of Radioactive Iodine Administration for Thyroid Diseases on H.Pylori Eradication
Because of the high iodine uptake in the stomach, radioactive iodine treatment for thyroid diseases (cancer or hyperthyroidism) or radioactive iodine administered for thyroid scan may be able to eradicate H.pylori infection from…
- Conditions
- Helicobacter Pylori Infected Patients, Thyroid Cancer Patients, Hyperthyroidism
- Trial name
- NCT00822289
- Volunteers
- 120 people
- Sponsor
- Rabin Medical Center
Helicobacter Pylori Infection
Comparing the Efficacy of Hybrid, High-dose Dual and Bismuth Quadruple Therapies
Both hybrid and high-dose dual therapies developed by the scholars from Taiwan can achieve a high eradication rate for clarithromycin-resistant strains, and have a great potential to replace bismuth quadruple therapy in the…
- Trial name
- NCT03779074
- Testing
- 10d bismuth quadruple therapy, 14d hybrid therapy, 14D high-dose dual therapy
- Where
- Taiwan
- Volunteers
- 918 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Helicobacter Pylori Infection, Compliance, Patient
Comparison of Bismuth Containing Quadruple Therapy and Based Tailored Therapy for H. Pylori Infection
As the antibiotic resistance increases, the eradication rate of triple therapy is decreasing. Recent guideline recommend the use of bismuth-containing quadruple therapy in areas where clarithromycin resistance is greater than…
- Conditions
- Helicobacter Pylori Infection, Compliance, Patient, Drug Resistance, Antibiotics
- Trial name
- NCT03361267
- Testing
- Helicobacter pylori PCR test, CLO test
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Inha University Hospital
Helicobacter Pylori, Gut Microbiota
Helicobacter Pylori Eradication Therapy in Portugal
Helicobacter pylori (H. pylori) infection remains a major public health problem, with an estimated prevalence of over 50% worldwide and 60-86% for Portugal. H.
- Conditions
- Helicobacter Pylori, Gut Microbiota, Immunology
- Trial name
- NCT05449028
- Testing
- H. pylori eradication scheme A, H. pylori eradication scheme B, H. pylori eradication scheme C
- Where
- Portugal
- Volunteers
- 230 people
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Functional Dyspepsia
Helicobacter Eradication Relief of Dyspeptic Symptoms
A double-blind clinical trial investigating if a sub-group of functional dyspeptic patients without any use of NSAID or gastric erosions could have a better evolution of their dyspeptic symptoms after Helicobacter eradication…
- Trial name
- HEROES-12 (NCT00404534)
- Testing
- Amoxicillin, Clarythromycin, Omeprazole for ten days
- Where
- Brazil
- Volunteers
- 407 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Helicobacter Pylori
The Associations Between the Gastric Mucosal Pathology and the Eradication Rate of H.Pylori :A Multicenter Study
Use the two-categorical variable , eradicate success or failure ,as a dependent variable, and analyze the influential factors by logistic regression.And then the statistically significant influencing factors like gastric mucosal…
- Trial name
- NCT04030715
- Testing
- bismuth-containing quadral therapy based on antibiotic susceptibility
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Shandong University