Clinical trials: Helicobacter Pylori Resistance
Helicobacter Pylori Infection, Compliance, Patient
Comparison of Bismuth Containing Quadruple Therapy and Based Tailored Therapy for H. Pylori Infection
As the antibiotic resistance increases, the eradication rate of triple therapy is decreasing. Recent guideline recommend the use of bismuth-containing quadruple therapy in areas where clarithromycin resistance is greater than…
- Conditions
- Helicobacter Pylori Infection, Compliance, Patient, Drug Resistance, Antibiotics
- Trial name
- NCT03361267
- Testing
- Helicobacter pylori PCR test, CLO test
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Inha University Hospital
Helicobacter Pylori, Drug Resistance, Multiple
Susceptibility-guided Bismuth Quadruple Therapy for Multiple-resistant Helicobacter Pylori Strains
The goal of this clinical trial is to learn if the 14-day susceptibility-guided bismuth quadruple therapy works to treat multiple drug resistant Helicobacter pylori (H. pylori) in adults.
- Conditions
- Helicobacter Pylori, Drug Resistance, Multiple, Virulence Factor
- Trial name
- BSUS-1 (NCT06687473)
- Testing
- Bismuth-based susceptibility-guided treatment
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- National Cheng-Kung University Hospital
Helicobacter Pylori Infection
Rabeprazole Based Sequential-Concommitant Hybrid Therapies for H. Pylori Infections
This prospective controlled randomized open-label clinical trial is designed to determine the optimal eradication rate of rabeprazole based sequential-concommitant hybrid therapies for adults infected with Helicobacter pylori in…
- Trial name
- NCT01566643
- Testing
- RA5-RACM7, RA3-RACM7, RA7-RACM7
- Where
- Taiwan
- Volunteers
- 231 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Helicobacter Infection
Efficacy of High Dose Dual Therapy, Sequential Therapy and Triple Therapy in H. Pylori Eradication
Up to now, to our knowledge, there is few randomized, large scale study prospectively and simultaneously comparing the efficacy, adverse effects and patient adherence of these current recommended 1st-line or 2nd-line regimens for…
- Trial name
- NCT01163435
- Testing
- high dose dual therapy, sequential therapy, clarithromycin-based triple therapy
- Where
- Taiwan
- Volunteers
- 618 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Infection
The Efficacy of the 7 Days Tailored Therapy as 2nd Rescue Therapy for Eradication of H. Pylori Infection
As increasing the antibiotics resistance, the effectiveness of traditional Helicobacter pylori (H. pylori) therapies has been declined coincidentally. In this study, the investigators evaluated the efficacy of H.
- Trial name
- NCT02359331
- Testing
- H. pylori culture and antimicrobial susceptibility testing, 14 days empirical bismuth quadruple therapy (Proton pump inhibitor), Metronidazole
- Where
- South Korea
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Helicobacter Pylori Infection
Molecular Detection of Antibiotic Resistance and H Pylori Eradication
H pylori eradication failure with recommended triple therapy is mainly related to antibiotic resistance. However,IN VITRO culture of H pylori is uneasy and is not performed in routine practice.
- Trial name
- HELICOSTIC (NCT01168063)
- Testing
- Molecular detection of antibiotic resistance, standard triple therapy (PPI, amoxicillin, clarithromycin, metronidazole)
- Where
- France
- Volunteers
- 1,386 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Helicobacter Infections, Resistance Bacterial
Effectiveness of Rifabutin for Treatment of Helicobacter Pylori
The aim of this study is to determine the effectiveness of rifabutin triple therapy for the treatment of H. pylori infection in the Israeli population. Patients with or without a prior history of H.
- Conditions
- Helicobacter Infections, Resistance Bacterial, Gastritis H Pylori
- Trial name
- NCT04652284
- Testing
- Rifabutin, Amoxicillin, Esomeprazole
- Volunteers
- 300 people
- Sponsor
- Rabin Medical Center
Helicobacter Pylori Infection
Efficacy of Vonoprazan in Eradication of Resistant Strain of Helicobacter Pylori
The goal of this Randomized controlled trial is to assessment Efficacy of Vonoprazan versus Proton Pump Inhibitors in Combination with Antibiotics as a triple Therapy for Eradication of Clarithromycin Resistant Strain of…
- Trial name
- NCT06414707
- Testing
- Vonoprazan, Amoxicillin and Levofloxacin, Pantoprazole 40mg, Amoxicillin and Levofloxacin
- Where
- Egypt
- Volunteers
- 320 people
- Sponsor
- Ain Shams University
Helicobacter Pylori Resistance
Helicobacter Pylori Resistance
The main goal of the study was to characterize the morbidity, immunological, microbiolical and clinical phenotypes of patients with treated- resistance to Helicobacter pylori (HP) infection, and the effect of triple therapy…
- Trial name
- CRIHEP (NCT05019586)
- Testing
- levofloxacin, amoxicillin, clarithromycin
- Volunteers
- 185 people
- Sponsor
- University Hospital of North Norway
Helicobacter Pylori Infection
Susceptibility-Guided Sequential Therapy for Helicobacter Pylori Infection
The main objective of this trial is to assess whether a sequential therapy strategy based on molecular antibiotic susceptibility testing (including clarithromycin and fluoroquinolone) for H.
- Trial name
- NCT05549115
- Testing
- clarithromycin-sensitive(first-line), clarithromycin-resistant(first-line), empirical therapy group first-line
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Liaocheng People's Hospital
H Pylori Infection Eradication, Antibiotics Therapeutic Strategies
Therapeutic Trial Comparing Triple Therapy Guided by the PCR Detection of Clarithromycin Resistance vs Empiric Concomitant Quadruple Therapy for Helicobacter Pylori Infection
The H pylori infection remains a public health problem. The eradication rate with the first line triple therapy (PPI-amoxicillin-clarithromycin) is insufficient (estimated at 70%) due to the frequency of resistance to…
- Conditions
- H Pylori Infection Eradication, Antibiotics Therapeutic Strategies, H Pylori Eradication
- Trial name
- Hepysé (NCT02576236)
- Testing
- Quadruple concomitant therapy treatment, Triple therapy guided by the result of the molecular resistance test
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Helicobacter Pylori 23S rRNA Clarithromycin Resistance Mutation, Helicobacter Pylori Infection
Empirical vs Tailored Therapy for H. Pylori Infection
We aimed to compare the efficacy of genotypic resistance-guided tailored therapy vs empirical therapy for eradication of Helicobacter pylori (H. pylori) infection in randomized controlled trials.
- Trial name
- NCT04006340
- Testing
- triple therapy, quadruple therapy, dual-priming oligonucleotide-based multiplex (DPO)-PCR test
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Seoul National University Hospital
HELICOBACTER PYLORI INFECTIONS, Metabolic Syndrome
H. Pylori Infection and Metabolic Syndrome: A Retrospective Cross-Sectional Study
This retrospective cross-sectional study evaluates the association between Helicobacter pylori infection and metabolic syndrome using health examination data from 5,218 adults at Nanjing First Hospital.
- Trial name
- NCT07651202
- Testing
- No intervention. This is an observational study.
- Where
- China
- Volunteers
- 5,218 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
H Pylori Infection
Genotypic Resistance Guided Therapy for Refractory H. Pylori Infection
The inviestigators aimed to compare the efficacy of genotypic resistance guided versus susceptibility testing guided therapy in the third line treatment for refractory H. pylori infection.
- Trial name
- NCT03555526
- Testing
- Esomeprazole 40mg, Amoxicillin, metronidazole
- Where
- Taiwan
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Probiotic, Gut Microbiota
The Effects of Yogurt on Gut Microbiome and Metabolism in H. Pylori.
Helicobacter pylori is a common pathogen causing upper gastrointestinal diseases including gastric ulcer and gastric cancer. Recent epidemiological findings have also shown that it is also related to colon cancer, metabolic…
- Conditions
- Probiotic, Gut Microbiota, Helicobacter Pylori Infection, Insulin Resistance
- Trial name
- NCT05374980
- Testing
- Yogurt
- Where
- Taiwan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
HELICOBACTER PYLORI INFECTIONS, Rescue Therapy for Helicobacter Pylori
Rescue Reatment of Helicobacter Pylori Based on Fecal Antimicrobial Resistance Gene Testing
Helicobacter pylori(H. pylori, Hp) is a major etiological agent in chronic gastritis, peptic ulcer disease, gastric cancer, and gastric MALT lymphoma.
- Trial name
- NCT07533422
- Testing
- Personalized treatment based on the results of fecal antimicrobial resistance gene testing, Conventional Quadruple Therapy
- Volunteers
- 531 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Helicobacter Pylori
The Study of the Antimicrobial Resistance of Helicobacter Pylori in Shandong Province
The antimicrobial resistance of helicobacter pylori in Shandong province was analyzed by helicobacter pylori antibiotic sensitivity test.And the map of antimicrobial resistance of helicobacter pylori was constructed to provide…
- Trial name
- NCT04029415
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection, Antibiotic Resistant Infection
Non-invasive Test-guided Tailored Therapy Versus Empiric Treatment for Helicobacter Pylori Infection.
The aim of our study will be to assess in an open-label, multicenter, randomized controlled trial whether a tailored therapy guided by a non-invasive antibiotic susceptibility test on stool samples achieves higher Helicobacter…
- Conditions
- Helicobacter Pylori Infection, Antibiotic Resistant Infection, Antibiotic Resistant Strain
- Trial name
- THD-HP (NCT04107194)
- Testing
- Pantoprazole 40mg, Amoxicillin 1000 MG, Clarithromycin 500mg
- Where
- Italy
- Volunteers
- 362 people
- Sponsor
- University of Bari
Epilepsy, Generalized, Helicobacter Pylori Infection
Helicobacter Pylori Eradication Therapy for Epileptic Children
Helicobacter pylori (H. pylori) infection is associated with several health problems. The role of H. pylori infection in epilepsy has been investigated in a few studies.
- Trial name
- NCT05297695
- Testing
- Triple therapy for H. pylori infection
- Where
- Egypt
- Volunteers
- 126 people
- Sponsor
- Sohag University
Helicobacter Pylori Infection
Efficacy of 10-day Concomitant Regimen Versus High Dose Dual Therapy in Anti-Helicobacter Pylori Rescue Therapy
Currently, a 10-day concomitant therapy has been reported to be equally effective and safe to the 10-day sequential therapy for 1st-line anti-Helicobacter pylori(H. pylori) therapy.
- Trial name
- NCT01265069
- Testing
- high dose dual therapy, concomitant therapy
- Where
- Taiwan
- Volunteers
- 204 people
- Sponsor
- National Taiwan University Hospital