Clinical trials: Helminth Infections
Malaria
Clinical Performance Evaluation of Fyodor Urine Malaria Test (UMT)
The purpose of this study is to evaluate the clinical performance of the one-step Fyodor Urine Malaria Test (UMT), to determine its accuracy (sensitivity and specificity) for the diagnosis of Plasmodium falciparum malaria in…
- Trial name
- NCT01921413
- Testing
- Urine Malaria Test
- Where
- Nigeria
- Volunteers
- 1,893 people, healthy volunteers welcome
- Sponsor
- Fyodor Biotechnologies Inc
Soil Transmitted Helminth (STH) Infections, Schistosomiasis Infection
Protocol for Integrating Mass Drug Administration Into Primary Health Care in Western Kenya
This study aims to determine whether distributing deworming drugs through routine healthcare services at the first point of contact in the health system is an effective way to prevent and treat worm infections in Western Kenya.
- Trial name
- NCT07507461
- Testing
- Primary Healthcare-Integrated Service Delivery, Standard Mass Drug Adminitsration service delivery
- Where
- Kenya
- Volunteers
- 1,229 people, healthy volunteers welcome
- Sponsor
- Amref Health Africa
Schistosomiasis, Anemia
Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal
SchistoVAN aims to study the role of schistosomiasis infection in the modulation of the immune response of children to childhood vaccine antigens, as well as the impact of this infection on their nutritional status and their…
- Conditions
- Schistosomiasis, Anemia, Underweight, Stunting
- Trial name
- SchistoVAN (NCT01553552)
- Where
- Senegal
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Biomedical Research Center EPLS
Fascioliasis
Parasitological Evaluation of Fascioliasis in Clinically Suspected Patients .
WHO considers foodborne trematodes as neglected tropical diseases. Fascioliasis is the most widely distributed trematode reported from over 81 countries around the world it imposes its highest burden in developing countries
- Trial name
- NCT03869788
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Helminthiasis
Urine Albendazole Levels for Coverage Assessment
This project will develop and assess the feasibility and acceptability of a urine-based assay to monitor adherence to Mass Drug Administration (MDA) campaigns within Soil-transmitted helminthiasis (STH) control programs…
- Trial name
- NCT04041427
- Testing
- Albendazole Pill, High fat content diet, Moderate fat content die
- Where
- Argentina
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Salta
E. Granulosus Cystic Hydatid d
Epi Cystic Hydatid Disease Peru
This is a study developed by researchers from the Universidad Peruana Cayetano Heredia, the Universidad Mayor de San Marcos and other local and foreign institutions.
- Trial name
- NCT00138346
- Where
- 2 sites in Peru
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Taenia Solium Infection
Taenia Solium Elimination Versus Control: What is the Best Way Forward for Sub-Saharan Africa?
Taenia solium taeniosis/cysticercosis is a neglected zoonotic parasitic disease complex with significant economic and public health impacts, occurring primarily in developing countries.
- Trial name
- CYSTISTOP (NCT02612896)
- Testing
- Mass drug administration, praziquantel 10mg/kg, Health education
- Where
- Zambia
- Volunteers
- 2,900 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Schistosoma Mansoni
A Randomised Trial of Artesunate-sulfamethoxypyrazine/Pyrimethamine Versus Praziquantel for the Treatment of S. Mansoni
The purpose of this study is to determine the comparative efficacy of artesunate plus sulfamethoxypyrazine-pyrimethamine versus Praziquantel in the treatment of school children infected with S.mansoni in western Kenya.
- Trial name
- NCT01054651
- Testing
- Artesunate+Sulfamethoxypyrazine/pyrimethamine, Praziquantel
- Where
- Kenya
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Kenya Medical Research Institute
Lymphatic Filariasis, Helminth Infection
Twice Yearly Treatment for the Control of LF
The Global Program for the Elimination of Lymphatic Filariasis (GPELF) has been in operation sing the year 2000, with the aim of eliminating the disease by the year 2020, following 5-6 rounds of effective annual Mass Drug…
- Trial name
- NCT03036059
- Testing
- 400 μg/kg Ivermectin + 400 mg Albendazole
- Where
- Ghana
- Volunteers
- 1,462 people, healthy volunteers welcome
- Sponsor
- Noguchi Memorial Institute for Medical Research
Filariasis
Safety, Tolerability and PK of Multiple-ascending Doses of Emodepside
The study evaluates safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of emodepside, after administration as a Liquid Service Formulation (LSF), over 10 days, in healthy male caucasian subjects.
- Trial name
- NCT03383614
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Drugs for Neglected Diseases
Helminthiasis
Assessment of Drug Efficacy of Local Albendazole
Infections with soil-transmitted helminthes (STH) occur throughout the developing world and remain a major public health problem in the poorest communities.
- Trial name
- NCT02420574
- Testing
- albendazole BENDEX, albendazole OVIS
- Volunteers
- 679 people, healthy volunteers welcome
- Sponsor
- University Ghent
Lymphatic Filariases
Prevalence Studies After Triple Drug Therapy for Lymphatic Filariasis
This study will assess the impact of 2-drug (DA) or 3-drug (IDA) regimens on lymphatic filariasis infection parameters in communities.
- Trial name
- NCT03352206
- Testing
- 2 drug dose - DA, 3 drug dose - IDA
- Where
- 5 sites in Fiji, Haiti and 3 more
- Volunteers
- 20,092 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Schistosomiasis, Helminthiasis
Schistosomiasis in Formal and Non-Formal Schools in Uganda: Implications for Control Programmes
Current efforts to control schistosomiasis and soil-transmitted helminthes infections focus on the school-age population, and school-based treatment delivery programs offer a major cost advantages because of the use of the…
- Conditions
- Schistosomiasis, Helminthiasis, Anaemia
- Trial name
- NCT00463593
- Where
- Uganda
- Volunteers
- 1,293 people, healthy volunteers welcome
- Sponsor
- DBL -Institute for Health Research and Development
Soil-Transmitted Helminths
Real World Evaluation of an Albendazole-Ivermectin Coformulation Safety and Effectiveness
An open-label, randomized by school, two-arm pragmatic trial, will be conducted involving two study sites in Sub-Saharan-Africa (SSA), Ghana and Kenya, to evaluate safety and effectiveness of the newly developed fixed dose…
- Trial name
- NCT06282315
- Testing
- Pre-screening Phase, Screenig Phase, Randomization
- Where
- 2 sites in Ghana, Kenya
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Insud Pharma
Tuberculosis
Trial to Investigate the Effect of Schistosoma Mansoni Infection on the Response to Vaccination With MVA85A in BCG-vaccinated African Adolescents
Mycobacterium tuberculosis (M. tb) is a pathogen with worldwide distribution which infects humans causing tuberculosis (TB), a transmissible disease resulting in very high mortality and morbidity; development of an effective…
- Trial name
- TB036 (NCT02178748)
- Testing
- MVA85A
- Where
- Uganda
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Schistosoma Haematobium
Performance of Tests for Schistosoma Haematobium Diagnosis
Urogenital schistosomiasis caused by infection with the blood fluke Schistosoma haematobium is a debilitating disease. The World Health Organization (WHO) has set the goal to eliminate schistosomiasis as a public health problem…
- Trial name
- SchistoBreak-D (NCT06808750)
- Testing
- S. haematobium egg detection by single urine filtration, S. haematobium egg detection by quintuple urine filtration, S. haematobium egg detection by artificial intelligence (AI) microscopy
- Where
- Tanzania
- Volunteers
- 801 people, healthy volunteers welcome
- Sponsor
- Stefanie Knopp
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity of the Na-APR-1 Hookworm Vaccine in Healthy Adults
Hookworms digest hemoglobin from erythrocytes for use as an energy source via a proteolytic cascade that begins with the aspartic protease, APR-1.
- Trial name
- NCT01717950
- Testing
- Na-APR-1 (M74)/Alhydrogel®, Gluco-Pyranosylphospho-Lipid A Aqueous Formulation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Trichuris Trichiura; Infection, Hookworm Infections
Efficacy and Safety of Emodepside in Adults Infected With Trichuris Trichiura and Hookworm
The rationale of the study is to provide evidence on the efficacy and safety of Emodepside in adults infected with Trichuris trichiura and hookworm.
- Trial name
- EMODEP_PEMBA (NCT05017194)
- Testing
- Emodepside
- Where
- Tanzania
- Volunteers
- 442 people, healthy volunteers welcome
- Sponsor
- Jennifer Keiser
Onchocerciasis, Loiasis
Development of a New Rapid Diagnostic Test to Support Onchocerciasis Elimination
Onchocerciasis, also known as river blindness, is one of the disease targeted for elimination by the World Health Organization (WHO) in the group of Neglected Tropical Diseases.
- Conditions
- Onchocerciasis, Loiasis, Mansonelliasis, Healthy Volunteers
- Trial name
- Obi1 (NCT06350851)
- Testing
- Biological samples collection (blood drawing + feces)
- Where
- Cameroon
- Volunteers
- 1,128 people, healthy volunteers welcome
- Sponsor
- Bioaster
Schistosomiasis, Schistosoma Mansoni
Single-sex Controlled Human Schistosomiasis Infection: Safety and Dose Finding
Groups of 3 or 7 volunteers will be exposed to a predetermined number of male Schistosoma mansoni cercariae until 10 volunteers are found infected.
- Trial name
- NCT02755324
- Testing
- male Schistosoma mansoni cercariae
- Where
- Netherlands
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Leiden University