Clinical trials: Helminth Infections
Healthy, Helminthiasis
Comparison of Immune Response in Normal Volunteers and Patients With Helminth Infections
This study will compare the structure, chemical composition and other characteristics of skin and blood in people with and without parasitic infections. Cell samples will be taken from blisters produced by suction blistering.
- Trial name
- NCT00004996
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Helminthiasis
An Evaluation of a Novel Food Product in Adults Residing in an Area Endemic for Helminths
The prevalence of intestinal helminths is worldwide. This study will evaluate the tolerability of a novel food product consumed by adults residing in an area endemic for helminths.
- Trial name
- NCT01271049
- Testing
- Novel Food Product, Control Food Product
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
Intestinal Helminthiasis, Ascariasis
Impact of Repeated Anthelmintic Treatment on the Risk of Malaria in Kenyan School Children
Many school children in Kenya are infected with plasmodia and helminth species and are at risk of coinfection. It has been suggested that the immune response evoked by helminth infections may modify immune responses to plasmodia…
- Conditions
- Intestinal Helminthiasis, Ascariasis, Hookworm, Malaria
- Trial name
- NCT01658774
- Testing
- Albendazole, Vitamin C
- Where
- Kenya
- Volunteers
- 2,377 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Tenia Solium Infection
Single Ascending Dose Safety Study of Oxfendazole
This research is being done to learn about the safety in humans of a medicine that is already used in cows and pigs to treat worms. The medicine may be useful for people who have these or other worms.
- Trial name
- OXFEND-02 (NCT01584362)
- Testing
- oxfendazole
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Hookworm Infections
Efficacy of Na-GST-1/Alhydrogel Hookworm Vaccine Assessed by Controlled Challenge Infection
This study evaluates the efficacy, safety and immunogenicity of different formulations of the Na-GST-1 hookworm vaccine using a controlled human hookworm infection model in healthy, hookworm-naive adults.
- Trial name
- NCT03172975
- Testing
- Na-GST-1/Alhydrogel, Na-GST-1/Alhydrogel + CPG 10104, Na-GST-1/Alhydrogel + GLA-AF
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Diarrhoea, Soil-transmitted Helminth Infection
Cluster Randomised Trial of Improved Sanitation in Rural Orissa, India
The study is a cluster-randomized, controlled trial conducted among 100 villages (including approximately 3500 households and 20,000 people) in Puri district, State of Orissa, India.
- Conditions
- Diarrhoea, Soil-transmitted Helminth Infection, Nutritional Status
- Trial name
- NCT01214785
- Testing
- Provision of household latrines
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
COVID-19
The Effect of Helminth Infection Plus COVID-19 Infection on the Immune Response and Intestinal Microorganisms
This is a pilot, cross-sectional, sample collection study to characterize the immune response and intestinal microorganisms in people with and without COVID-19 antibodies and helminth infection.
- Trial name
- NCT04813328
- Where
- India
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Helminthiasis
Bioavailability and Safety of Two Oral Fixed Dose Preparations Containing 18 mg Ivermectin (IVM 18 MG TABLETS, LICONSA S.A., Spain) Versus Reference Dosing (Weight Based) Containing 6 mg Ivermectin (REVECTINA®, Abbott Laboratórios do Brasil Ltda, Brazil)
Evaluation of the bioavailability and safety of one oral preparation containing fixed dose 18 mg ivermectin (IVM 18 MG TABLETS, LICONSA S.A., Spain) or two oral preparations containing fixed dose 18 mg ivermectin (IVM 36 MG…
- Trial name
- NCT03173742
- Testing
- T1, T2, T3, T1,T3,T2, T2,T1,T3
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Insud Pharma
Soil-transmitted Helminth Infections
Validating Egg-based Diagnostics and Molecular Markers for the Spread of Anthelmintic Resistance
Soil-transmitted helminths (STHs) are a group of parasitic worms that infect millions of children in sub-tropical and tropical countries, resulting in malnutrition, growth stunting, intellectual retardation and cognitive…
- Trial name
- StarwormsWP1 (NCT03465488)
- Testing
- Albendazole Pill 400mg (GSK)
- Where
- 4 sites in Brazil, Ethiopia and 2 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Ghent
Lymphatic Filariasis
Research for Elimination of Lymphatic Filariasis (ICIDR)
The purpose of this study is to check blood samples for lymphatic filariasis to determine whether the recent Program to Eliminate Lymphatic Filariasis was successful in controlling lymphatic filariasis in areas of Egypt.
- Trial name
- NCT00406627
- Where
- Egypt
- Volunteers
- 117,500 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Intestinal Diseases, Parasitic
Postpartum Deworming: Improving Breastfeeding and Optimizing Infant Growth
Women of reproductive age are considered a high-risk group for worm infections by the World Health Organization. Maternal infection and anemia contribute to infant malnutrition by affecting milk quality and quantity, and duration…
- Trial name
- NCT01748929
- Testing
- Albendazole
- Where
- Peru
- Volunteers
- 1,010 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Crohn Disease, Colitis, Ulcerative
Immune Modulation From Trichuris Trichiura
Mucosal immunology during helminth infection
- Conditions
- Crohn Disease, Colitis, Ulcerative, Intestinal Helminthiasis
- Trial name
- NCT02399683
- Testing
- Trichuris trichiura eggs
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Schistosomiasis in Children, Soil Transmitted Helminth (STH) Infections
Burden of Schistosomiasis and Soil-transmitted Helminth Infections in Schoolchildren in Banfora, Burkina Faso
A cross-sectional study will be conducted among 300 schoolchildren in the Banfora region, including 120 in urban and 180 in rural areas, to assess the prevalence of schistosomiasis and soil-transmitted helminth infections.
- Conditions
- Schistosomiasis in Children, Soil Transmitted Helminth (STH) Infections, Malaria Infection, Anaemia
- Trial name
- NTDs_SAC (NCT06973200)
- Testing
- Dihydroartemisin-piperaquine
- Where
- Burkina Faso
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Centre MURAZ/Institut National de Santé Publique
Crohn Disease, Ulcerative Colitis
Immune Modulation From Trichuris Suis
Mucosal immunology during helminth infection
- Conditions
- Crohn Disease, Ulcerative Colitis, Intestinal Helminthiasis
- Trial name
- NCT03079700
- Testing
- Trichuris suis eggs
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Schistosomiasis Mansoni, Schistosomiasis Haematobium
Anti-Schistosomiasis Sm14-vaccine in Senegal
Previous clinical trials have already demonstrated the safety of the candidate vaccine in adults as well as in children, in good health or infected with schistosomiasis.
- Conditions
- Schistosomiasis Mansoni, Schistosomiasis Haematobium, Vaccination; Infection
- Trial name
- NCT05658614
- Testing
- Sm14 recombinant vaccine+ GLA-SE adjuvant
- Where
- Senegal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
COPD Exacerbation Acute, Ascaris Lumbricoides Infection
Impact of A. Lumbricoides on Pulmonary Aspergillosis Development
The prevalence of ascariasis in COPD patients with and without concomitant pulmonary aspergillosis and in controls will be determined.
- Conditions
- COPD Exacerbation Acute, Ascaris Lumbricoides Infection, Chronic Pulmonary Aspergillosis
- Trial name
- NCT05783544
- Testing
- Interleukin-1B, Interleukin-4, Interleukin-6
- Where
- Uzbekistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
Hookworm Disease, Hookworm Infection
Study of Co-administered Na-APR-1 (M74) and Na-GST-1 in Gabonese Children
Double blind, randomized, controlled, dose-escalation Phase 1 clinical trial in hookworm-exposed children aged 6 to 10 years living in the area of Lambaréné, Gabon.
- Trial name
- NCT02839161
- Testing
- Na-GST-1/Alhydrogel, Na-APR-1 (M74)/Alhydrogel, Hepatitis B Vaccine
- Where
- Gabon
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Cysticercosis
EFECAB: Improving Pig Management to Prevent Epilepsy in Burkina Faso
This is a pre-post randomized community-based controlled trial aimed at estimating the effectiveness of an educational package developed using PRECEDE PROCEED to reduce the cumulative incidence of Taenia solium cysticercosis in…
- Trial name
- EFECAB (NCT03095339)
- Testing
- Educational package
- Where
- Burkina Faso
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Neurocysticercosis
Phase I Trial Evaluating the Safety and Pharmacokinetics of Oxfendazole
The objectives of the Phase I study are to evaluate the safety and tolerance of increasing single oral doses of oxfendazole in healthy volunteers.The secondary objectives assess the pharmacokinetic profile of oxfendazole and…
- Trial name
- NCT02234570
- Testing
- Oxfendazole
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lymphatic Filariasis
Eval 3-Drug Therapy Diethylcarbamize, Albendazole and Ivermectin That Could Accelerate LF Elimination Outside of Africa
This study will determine if a combination of 3 drugs used to treat the infection that cause lymphatic filariasis (LF) due to Wuchereria bancrofti infection are more effective in killing or sterilizing the adult worms compared to…
- Trial name
- NCT01975441
- Testing
- Diethylcarbamazine, Albendazole, Ivermectin
- Where
- Papua New Guinea
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center