Clinical trials: Helminthiasis
Tuberculosis
Trial to Investigate the Effect of Schistosoma Mansoni Infection on the Response to Vaccination With MVA85A in BCG-vaccinated African Adolescents
Mycobacterium tuberculosis (M. tb) is a pathogen with worldwide distribution which infects humans causing tuberculosis (TB), a transmissible disease resulting in very high mortality and morbidity; development of an effective…
- Trial name
- TB036 (NCT02178748)
- Testing
- MVA85A
- Where
- Uganda
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Intestinal Disease, Parasitic, Chronic Disease
Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland
The goal of the proposed study is to assess the prevalence of intestinal parasitic diseases in adults and children. These invasions are included to "dirty hand diseases" (per os invasions), therefore it applies mainly preschool…
- Trial name
- NCT03490435
- Testing
- Tests for diagnosis of intestinal parasitic diseases
- Where
- Poland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Nicolaus Copernicus University
Mansonella Perstans Infection, Mp Microfilaremia
Doxycycline to Treat Mansonella Perstans Infection in Patients With and Without Lymphatic Filariasis
This study will examine: 1) the safety and effectiveness of the drug doxycycline in reducing the number of Mansonella perstans (Mp) worms in the blood of infected patients, and 2) the effects of doxycycline followed by…
- Trial name
- NCT00340691
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Fascioliasis
Parasitological Evaluation of Fascioliasis in Clinically Suspected Patients .
WHO considers foodborne trematodes as neglected tropical diseases. Fascioliasis is the most widely distributed trematode reported from over 81 countries around the world it imposes its highest burden in developing countries
- Trial name
- NCT03869788
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
W. Bancrofti Filariasis
Research for Elim of Filariasis
Wuchereria bancrofti, is a mosquito-transmitted parasite that causes deforming lymphatic filariasis in the tropics. Improved treatment methods have led to new thinking that it should be possible to interrupt transmission and…
- Trial name
- NCT00145223
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Tuberculosis
Digital Health Promotion in Iringa, Tanzania
Increased health education has the potential to facilitate better use of health care services and to promote early treatment, thus it can strengthen the health care system, and ultimately reduce morbidity and mortality.
- Conditions
- HIV Infections, Tuberculosis, Cysticercosis, Tapeworm Pork
- Trial name
- NCT03808597
- Testing
- Digital health promotion intervention
- Where
- 6 sites in Tanzania
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Lymphatic Filariasis
Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali
Lymphatic filariasis is a public health problem in Mali. The existing data are not up to date and most of them are more than 15 years old.
- Trial name
- NCT02784743
- Testing
- ''albendazole'' and ''ivermectin''
- Volunteers
- 1,139 people, healthy volunteers welcome
- Sponsor
- Centre d'Appui à la lutte contre la Maladie
Onchocerciasis, Ocular, Loiasis
Clinical Trial Evaluating the Safety and Efficacy of Levamisole in Loa Loa Microfilaremic Patients
This study aims at evaluating the safety and efficacy of levamisole in patients with loiasis infection.
- Trial name
- EOLoa (NCT04049630)
- Testing
- LEV 1 mg/kg, LEV 1,5 mg/kg, LEV 2,5 mg/kg
- Where
- Republic of the Congo
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Programme National de Lutte contre l'Onchocercose, Republic of the Congo
Neurocysticercosis, Taeniosis
Investigation of Environmental Factors Associated With Transmission of T. Solium in Endemic Villages of Zambia
This study aims to determine the prevalence of taeniosis and (neuro)cysticercosis in two districts in the southern (Gwembe) and eastern province (Chipata) of Zambia.
- Trial name
- TEPIM (NCT03874689)
- Where
- Zambia
- Volunteers
- 2,921 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Filariasis
Exhaled NO Testing in Filariasis
This study is looking at the difference in exhaled nitric oxide levels in patients with and without laboratory evidence of filariasis.
- Trial name
- NCT01628497
- Where
- Guyana
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Schistosomiasis
Treatment of Female Genital Schistosomiasis (FGS) With Praziquantel: A Proof-of-Concept Study
Female genital schistosomiasis (FGS) is a frequent manifestation of the infection with Schistosoma haematobium or mansoni. FGS is probably the most neglected gynaecological condition in the tropics.
- Trial name
- NCT04115072
- Testing
- Praziquantel 600Mg Oral Tablet x 5, Praziquantel 600Mg Oral Tablet x 1
- Where
- Madagascar
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Regionshospital Nordjylland
Helminthiasis
Bioavailability and Safety of Two Oral Fixed Dose Preparations Containing 18 mg Ivermectin (IVM 18 MG TABLETS, LICONSA S.A., Spain) Versus Reference Dosing (Weight Based) Containing 6 mg Ivermectin (REVECTINA®, Abbott Laboratórios do Brasil Ltda, Brazil)
Evaluation of the bioavailability and safety of one oral preparation containing fixed dose 18 mg ivermectin (IVM 18 MG TABLETS, LICONSA S.A., Spain) or two oral preparations containing fixed dose 18 mg ivermectin (IVM 36 MG…
- Trial name
- NCT03173742
- Testing
- T1, T2, T3, T1,T3,T2, T2,T1,T3
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Insud Pharma
Soil-transmitted Helminth Infections
Validating Egg-based Diagnostics and Molecular Markers for the Spread of Anthelmintic Resistance
Soil-transmitted helminths (STHs) are a group of parasitic worms that infect millions of children in sub-tropical and tropical countries, resulting in malnutrition, growth stunting, intellectual retardation and cognitive…
- Trial name
- StarwormsWP1 (NCT03465488)
- Testing
- Albendazole Pill 400mg (GSK)
- Where
- 4 sites in Brazil, Ethiopia and 2 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Ghent
Schistosomiasis
Monitoring Schistosome Hybrids Under Under Praziquantel Pressure
The overall objective of this project is to examine and quantify the potential existence and impact on Praziquantel (PZQ) efficacy, of naturally occurring S. haematobium and S. bovis hybrid populations in northern Senegal.
- Trial name
- Sen_hybrids (NCT04635553)
- Testing
- Praziquantel 600 milligram
- Where
- Senegal
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
Helminthiasis, Tinea Capitis
Design and Clinical Evaluation of a School Meal With Deworming Properties
Intestinal parasites (IP) are among the world's neglected tropical diseases. Morbidity due to IPs is greatest in school-age children who typically have the highest burden of infection.
- Conditions
- Helminthiasis, Tinea Capitis, Anemia
- Trial name
- NCT02725255
- Testing
- Ujiplus, Albendazole, uji
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Kenya Medical Research Institute
Onchocerciasis, Loiasis
Evaluation of the Diagnosis Performances of DEC LTS-2 Skin Patch for Onchocerciasis in Central Africa
This study aims at evaluating the diagnosis performances of the LTS-2 DEC patch for onchocerciasis compared to the gold standard which are the skin snips.
- Conditions
- Onchocerciasis, Loiasis, Diagnoses Disease, Neglected Diseases
- Trial name
- EOLoa (NCT04035174)
- Testing
- LTS-2 DEC patch, Skin snips
- Where
- Cameroon
- Volunteers
- healthy volunteers welcome
- Sponsor
- Center for Research on Filariasis and Other Tropical Diseases, Cameroon
Healthy
Safety, Tolerability and PK of Single and Multiple Doses of Oxantel Pamoate Tablets
The goal of this clinical trial is to evaluate the safety, tolerability and pharmacokinetics of oxantel pamoate tablet after administration of a single and multiple dose in healthy male and female adult volunteers.
- Trial name
- HELP-OXA (NCT06606860)
- Testing
- Oxantel Pamoate
- Where
- Tanzania
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Taenia Solium Infection
Taenia Solium Elimination Versus Control: What is the Best Way Forward for Sub-Saharan Africa?
Taenia solium taeniosis/cysticercosis is a neglected zoonotic parasitic disease complex with significant economic and public health impacts, occurring primarily in developing countries.
- Trial name
- CYSTISTOP (NCT02612896)
- Testing
- Mass drug administration, praziquantel 10mg/kg, Health education
- Where
- Zambia
- Volunteers
- 2,900 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Hookworm Disease, Hookworm Infection
Study of Co-administered Na-APR-1 (M74) and Na-GST-1 in Gabonese Children
Double blind, randomized, controlled, dose-escalation Phase 1 clinical trial in hookworm-exposed children aged 6 to 10 years living in the area of Lambaréné, Gabon.
- Trial name
- NCT02839161
- Testing
- Na-GST-1/Alhydrogel, Na-APR-1 (M74)/Alhydrogel, Hepatitis B Vaccine
- Where
- Gabon
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Hookworm
Study to Test Whether Shoes Protect Children Against Hookworm Infection on Pemba Island, Zanzibar
Small association studies have hypothesised that shoes protect against hookworm infection. The purpose of this pragmatic study was determine, under field conditions, whether school-age children on Pemba Island, Zanzibar, would…
- Trial name
- SKIP (NCT01869127)
- Testing
- Shoes
- Where
- Tanzania
- Volunteers
- 1,056 people, healthy volunteers welcome
- Sponsor
- Bird, Christopher