Clinical trials: Helminthiasis
Onchocerciasis
Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness
The purpose of this study is to determine whether rifampin and/or azithromycin are effective in the treatment of river blindness (onchocerciasis).
- Trial name
- NCT00127504
- Testing
- Rifampin, Azithromycin
- Where
- Guatemala
- Volunteers
- 80 people
- Sponsor
- Centers for Disease Control and Prevention
Spleen-Preserving Surgery, Echinococcus Granulosus Infection
Spleen Preserving Surgery for Splenic Hydatidosis: A Cohort Study on Short and Long-Term Outcomes
This retrospective cohort study examines the effectiveness of minimally invasive spleen-preserving surgeries compared to total splenectomy for treating primary splenic hydatidosis in Jordan.
- Conditions
- Spleen-Preserving Surgery, Echinococcus Granulosus Infection, Hydatid Disease, Minimally Invasive Surgery
- Trial name
- NCT06289816
- Testing
- Minimally Invasive Surgery
- Where
- Jordan
- Volunteers
- 18 people
- Sponsor
- Yarmouk University
Diseases of the Urinary System, Schistosomiasis Haematobia
Urinary Schistosomiasis Infection
The purpose of this study is to determine what causes some people to become sick, and others not, when they are infected with the parasite Schistosoma haematobium, also known as Bilharzia.
- Trial name
- NCT00138450
- Where
- Kenya
- Volunteers
- 4,400 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Soil Transmitted Helminths
Effectiveness and Cost-effectiveness of Integrated Model for Malaria and Helminth Control
Malaria remains a major health problem, especially among children living in sub-Saharan Africa where more than 90% of the disease and deaths occur.
- Conditions
- Malaria, Soil Transmitted Helminths, Schistosomiasis, Seasonal Malaria Chemoprevention
- Trial name
- MALHELMIN (NCT06182176)
- Testing
- Sulphadoxine-pyrimethamine and Amodiaquine
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Hydatid Cyst
Radical Versus Conservative Surgical Treatment of Liver Hydatid Cysts
The management of liver hydatid cysts (LHC) is controversial. Surgery remains the basic treatment, and can be divided into radical and conservative approaches.
- Trial name
- NCT04988958
- Testing
- hydatid cyst resection
- Volunteers
- 914 people
- Sponsor
- Université de Sousse
Malaria, Soil Transmitted Helminths
Feasibility and Safety of Combining Anti-malarial With Deworming Drugs in African Children
Malaria remains a major health problem, especially in sub-Saharan Africa where more than 90% of the disease and deaths occur in children.
- Conditions
- Malaria, Soil Transmitted Helminths, Schistosomiasis, Integrated Control
- Trial name
- MALHELMIN (NCT05354258)
- Testing
- Albendazole, Praziquantel, Amodiaquine
- Where
- Senegal
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Echinococcosis, Hepatic
Presentation of Protoscolexes and Acephalocysts in the Fibrous Capsule Area of the Liver With Echinococcosis
The objective of the study is to determine the presence of germinal elements of echinococcosis in the liver parenchyma next to and in the thickness of the fibrous capsule of hydatid cysts.
- Trial name
- PAFCLE (NCT06316154)
- Testing
- Echinococcectomy
- Where
- Uzbekistan
- Volunteers
- 100 people
- Sponsor
- Republican Specialized Scientific and Practical Medical Center of Surgery Named After V. Vakhidov
Schistosomiasis, Soil-Transmitted Helminthiasis
Using Community-Based Volunteers to Reach Non-Enrolled School Aged Children Through Community-Directed Treatment of Schistosomiasis in School-Aged Children in Rural Northern Ghana
Schistosomiasis and soil-transmitted helminhtiasis occur throughout the developing world and are most prevalent in the poorest communitites.
- Trial name
- NCT00463931
- Where
- Ghana
- Volunteers
- 916 people
- Sponsor
- DBL -Institute for Health Research and Development
Hematuria, Hydronephrosis
Influence of Transmission Season on Outcome of Treatment of Schistosoma Haematobium Infection in Mozambique
To assess the influence of seasonal variations in Schistosoma haematobium transmission on treatment outcome (morbidity and re-infection)
- Trial name
- NCT00231322
- Testing
- praziquantel
- Where
- Mozambique
- Volunteers
- 520 people
- Sponsor
- DBL -Institute for Health Research and Development
Lymphedema, Lymphatic Filariasis
A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali
Current lymphedema management protocols are based on the use of simple measures of hygiene (regular washing with soap and water, skin and nail care), use of topical antibiotics or antifungal agents, exercise and footwear.
- Conditions
- Lymphedema, Lymphatic Filariasis, Filariasis
- Trial name
- LeDoxy-Mali (NCT02927496)
- Testing
- Doxycycline
- Where
- Mali
- Volunteers
- 220 people
- Sponsor
- The Task Force for Global Health
Schistosomiasis
A Phase I Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel® With or Without GLA-AF for Intestinal Schistosomiasis in Healthy Adults
This is a Phase I, first-in-human study of a vaccine against S. mansoni infection.The study will recruit 72 healthy adult males and non-pregnant females from a single clinical center to test two formulations of Sm-TSP-2 vaccine…
- Trial name
- NCT02337855
- Testing
- Sm-TSP-2/Alhydrogel, Sm-TSP-2/Alhydrogel/GLA-AF
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hepatic Echinococcosis
5G Remote Robotic Surgery for Hepatic Echinococcosis in High-Altitude Region
Hepatic echinococcosis (HE) is a serious endemic parasitic disease in high-altitude regions like Xizang. Radical hepatectomy is the primary curative treatment, but expert resources are often concentrated in large medical centers.
- Trial name
- HAT (NCT07551063)
- Testing
- 5G-based Telerobotic Hepatectomy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- West China Hospital
Urinary Schistosomiasis, Schistosoma Haematobium
Efficacy of Bilhvax in Association With Praziquantel for Prevention of Clinical Recurrences of Schistosoma Haematobium
Objectives:To reduce the risk of S. haematobium pathology recurrences during the three years following vaccine administration and to control the safety of this therapeutic strategy in children exposed to urinary schistosomiasis.
- Trial name
- Bilhvax3 (NCT00870649)
- Testing
- Bilhvax vaccine (Sh28GST)
- Where
- Senegal
- Volunteers
- 250 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Lymphatic Filariases, Scabies
Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji
Lymphatic Filariasis (LF), scabies and soil transmitted helminths (STH) are common neglected tropical diseases affecting the people of Fiji.
- Conditions
- Lymphatic Filariases, Scabies, Impetigo, Soil Transmitted Helminths
- Trial name
- FIT (NCT03177993)
- Testing
- 3 drug dose - IDA, 3 drug dose - IDA with second dose of ivermectin, 2 drug dose - DA
- Where
- Fiji
- Volunteers
- 4,773 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
HIV Infection, Nematode Infection
Study of Patients With Strongyloides Stercoralis Infection
This study will explore faster and easier ways to detect infection with the intestinal parasite Strongyloides stercoralis and learn more about the conditions under which it causes serious disease.
- Conditions
- HIV Infection, Nematode Infection, Strongyloidiasis
- Trial name
- NCT00001245
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Loiasis
Post-treatment Effects of Ivermectin (IVM) or Diethylcarbamazine (DEC) in Loiasis
Background: Loa loa is a small worm that infects people in West and Central Africa. It is spread by the bite of a fly. Adult worms live under the skin and can cause swelling in the arms, legs, and face.
- Trial name
- NCT01593722
- Testing
- Diethylcarbamazine, Ivermectin
- Where
- Cameroon
- Volunteers
- 155 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Onchocerciasis
Study to Assess Adverse Events, Change in Disease Activity and How Oral ABBV-4083 Capsules When Given Alone or In Combination With Albendazole Capsules Moves in The Body of Adult Participants With Onchocerca Volvulus Infection
Onchocerciasis is a major public health problem in affected countries that causes disease-induced disability, and overall loss of economic productivity.
- Trial name
- NCT04913610
- Testing
- ABBV-4083, Albendazole
- Where
- 2 sites in Democratic Republic of the Congo
- Volunteers
- 153 people
- Sponsor
- AbbVie
Mansonelliasis, Pruritus
Epidemiology and Control of Mansonella Perstans Infection in Uganda
Mansonella perstans (M. perstans) infection is widespread in Uganda. Knowledge about the epidemiology of this infection, and of the morbidity it induces is poor, and no effective treatment is available.
- Conditions
- Mansonelliasis, Pruritus, Lymphoedema, Abdominal Pains
- Trial name
- NCT00215280
- Testing
- ivermectin and albendazole
- Where
- Uganda
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- DBL -Institute for Health Research and Development
Helminthiasis
Relative Efficacy of Two Regimens of Ante-helminthic Treatment
The most common soil transmitted helminthic infections(STHI) includes infection with Ascaris lumbricoides, Trichuris trichiura, and Hookworm.
- Trial name
- NCT00367627
- Testing
- Albendazole
- Where
- Bangladesh
- Volunteers
- 200 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Schistosomiasis
Schistosoma Haematobium Infections and Praziquantel
The purpose of this study is to evaluate the impact of praziquantel for the treatment of Schistosoma haematobium infection among schoolchildren in Al Salamania in Central Sudan.
- Trial name
- NCT01558336
- Testing
- praziquantel
- Where
- Sudan
- Volunteers
- 520 people
- Sponsor
- University of Khartoum