Clinical trials: Helping Behavior
Respiratory Failure, Hypoxemia
NIV-FOB, HFNC-FOB- Comparison of Methods
The aim of the study is to asses safety and indications and contraindications for performing bronchofiberocopy (FB) with respiratory support methods, i.e. non-invasive ventilation (NIV) and high flow nasal oxygen therapy (HFNO).
- Conditions
- Respiratory Failure, Hypoxemia, Hypoxemic Respiratory Failure
- Trial name
- NIRA (NCT05655026)
- Testing
- NIV, HFNO
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Medical University of Silesia
SVT, Vagal Bradycardia
Testing of a Valsalva Assist Device (VAD) in Healthy Volunteers Performing a Valsalva Manoeuvre
A prototype for a Valsalva Assist Device (VAD), which provides resistance to exhalation, has been developed and is ready for testing in healthy volunteers.
- Trial name
- NCT03298880
- Testing
- Supine VM VAD, Supine VAD manometer, Modified VM VAD
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Smoking Cessation
Post-Discharge Smoking Cessation Strategies: Helping HAND 4
This randomized controlled trial will compare the effectiveness of two models of post-discharge tobacco cessation treatment for adult smokers admitted to 3 U.S. hospitals.
- Trial name
- HH4 (NCT03603496)
- Testing
- Transitional Tobacco Care Management (TTCM), eReferral to State Tobacco Quitline (QL), Nicotine replacement therapy
- Where
- 3 sites in United States
- Volunteers
- 1,416 people
- Sponsor
- Massachusetts General Hospital
Head and Neck Neoplasms
Accuracy and Safety of Coplanar Template Assistance for Head and Neck Biopsies.
This is a prospective single-arm cohort study to evaluate the accuracy and safety of three-dimensional printing co-planer template(3D-PCT) for computed tomography (CT)-guided neck and head biopsy .
- Trial name
- NCT05396183
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
Heart Failure
Implantable Cardioverter Defibrillator (ICD) Function During Ventricular Assist Device (VAD) Implantation
The purpose of this research study is to test the function of a subjects implantable cardioverter defibrillator (ICD) function throughout the duration of their heart surgery.
- Trial name
- NCT01576562
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Virginia Commonwealth University
Stress, Psychological
Stress Free UCR: The Impact of 8 Weeks of Headspace on Stress in a Heterogeneous University Employee Cohort
The aim of this study is to test the effects of a digital meditation intervention in a sample of high stress UCR employees. We will randomize UCR employees to 8-weeks of either a digital mindfulness intervention (using the…
- Trial name
- NCT03695627
- Testing
- Meditation
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of California, Riverside
Infertility
Phase 3 Study to Evaluate the Efficacy and Safety of Pergoveris® in Assisted Reproductive Technology (ESPART)
This is a Phase 3, randomized, controlled, single-blind, multicenter, parallel-arm trial to assess the safety and efficacy of Pergoveris® (recombinant human follicle stimulating hormone [r-hFSH]/recombinant human luteinising…
- Trial name
- ESPART (NCT02047227)
- Testing
- Pergoveris®, GONAL-f®, Recombinant human chorionic gonadotrophin (r-hCG)
- Where
- Germany
- Volunteers
- 939 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Chronic Respiratory Failure
Assist Control Versus Pressure Support Modes for Domiciliary Noninvasive Ventilation in Chronic Respiratory Failure
Noninvasive ventilation is a therapeutic option in some patients with chronic respiratory failure. Patients usually ventilate during nightime with a domiciliary ventilator either in assist control or in pressure support mode.
- Trial name
- NCT00189527
- Testing
- respiratory settings
- Volunteers
- 100 people
- Sponsor
- Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
Mechanical Ventilation
Decreasing Trigger Sensitivity Could Assist PEEP to Further Improve Regional Ventilation Distribution
In mechanically ventilated patients during supine position, alveolar collapse usually distributes in dependent lung region.Decrease of flow trigger sensitivity might improve homogeneous of tidal volume distribution.
- Trial name
- NCT03241654
- Testing
- flow trigger
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Capital Medical University
Asthma, Asthma in Children
SMART@Home Feasibility Trial
The proposed research addresses the limitations or lack of a digital platform to provide remote care of medically complex patients. Previous attempts have had poor clinical validity and suffered lack of patient engagement.
- Trial name
- NCT06159127
- Testing
- SMART@Home
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Heart Failure, Heart-Assist Devices
Partial Left Ventricular Support in Advanced Heart Failure
Heart failure is a common condition, and the number of people with advanced disease continues to increase. We need new treatments that improve patients' symptoms and extend life.
- Trial name
- NCT01879670
- Testing
- CircuLite Synergy left ventricular assist device
- Where
- 2 sites in Belgium, United Kingdom
- Volunteers
- 2 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Basic Cardiac Life Support, Cardiopulmonary Resuscitation
The Effect of T-CPR on the Quality of CPR and AED Use
The purpose of the study is to examine the effect of telephone assistance and standardized basic life support courses on the quality of cardiopulmonary resuscitation (CPR) and the use of automated external defibrillator (AED).
- Trial name
- NCT03690102
- Testing
- T-CPR, ERC standardized BLS course
- Where
- Denmark
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Copenhagen Academy for Medical Education and Simulation
Female Genital Fistula, Urinary Incontinence
Fistula Reintegration Pilot
This is a pilot study to test the feasibility and acceptability of a multi-component facility-based intervention designed to be provided adjunct to genital fistula surgery incorporating: health education, psychosocial counseling…
- Trial name
- NCT04748653
- Testing
- Multi-component reintegration intervention
- Where
- Uganda
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Kidney Failure, Acute
Study to Evaluate the Safety and Efficacy of the Renal Assist Device in Patients With Acute Renal Failure
The purpose of this study is to evaluate the safety and efficacy of the RAD to determine whether the RAD is effective in reducing mortality in patients with Acute Renal Failure due to Acute Tubule Necrosis and to evaluate the…
- Trial name
- NCT00280072
- Testing
- Renal Assist Device
- Where
- 16 sites in United States
- Sponsor
- RenaMed Biologics
Breast Cancer Female
DEPO-Trigger Trial: GnRH Agonist DEPOt TRIGGER for Final Oocyte Maturation
For breast cancer patients who are candidates to receive chemotherapy, concurrent use of temporary ovarian suppression with gonadotropin-releasing hormone agonists (GnRHa) can be offered as ovarian protection.
- Trial name
- Depo-Trigger (NCT04616729)
- Testing
- Triptorelin 3.75 MG Injection, Transvaginal oocyte retrieval, Triptorelin Injection
- Where
- 2 sites in Belgium
- Volunteers
- 30 people
- Sponsor
- Universitair Ziekenhuis Brussel
Advanced Heart Failure
A Prospective, Multicenter,Single-arm Study of DuoCor 2 Ventricular Assist System for the Treatment of Advanced Biventricular Heart Failure
The objective of this clinical investigation is to evaluate the safety and efficacy of the DuoCor 2 Ventricular Assist System (DuoCor 2 VAS) in subjects with advanced biventricular heart failure requiring circulatory support.
- Trial name
- NCT07757451
- Testing
- DuoCor 2 Ventricular Assist System (DuoCor 2 VAS)
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Shenzhen Core Medical Technology CO.,LTD.
no Specific Condition Targeted
Assessment of the Benefit of the Mobility Assistance System (SAM) on Transfer Independence for a Reimbursement Request
This is a randomized, cross-over, multi-center, intention-to-treat, open-label study to assess the impact of the SAM Ergonom light (SAM) device on independence when transferring from the supine to the sitting position at the edge…
- Trial name
- SAM-24 (NCT06698653)
- Testing
- SAM device (experimental): a removable structure, fixed to the horizontal frame of the medical bed, equipped with a handle to assist the sitting-up process, Over bed pole hoist (control device)
- Where
- 3 sites in France
- Volunteers
- 54 people
- Sponsor
- WINNCARE
Angiodysplastic Bleeding
u-STOP LVAD Bleed: Utilization of Umbilical Cord Lining Stem Cells (ULSCs) To Prevent Left Ventricular Assist Device (LVAD) Associated Angiodysplastic Bleeding
This is a Phase I, single ascending dose, first in human, open-label, non-controlled, dose-escalation trial that will investigate intravenous infusions of Umbilical cord lining stem cells (UCLSCs) in Left Ventricular Assist…
- Trial name
- NCT04811261
- Testing
- Intravenous Infusion of UCLSCs
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Florida
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications
RATIONALE: A personalized Internet-based program may help improve fatigue, depression, and quality of life in long-term survivors of stem cell transplant.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT00799461
- Testing
- internet-based intervention, questionnaire administration, psychosocial assessment and care
- Where
- United States
- Volunteers
- 1,337 people
- Sponsor
- Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
Infertility, Ovulation Induction
SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women
Efficacy and safety studies in the past have suggested that a starting dose of 75 International Unit (IU) of SJ-0021, and an increase in the dose by 37.5 IU every 7 days, are safe for treatment of subjects with ovulatory…
- Trial name
- NCT01185782
- Testing
- Gonalef® (Follitropin alfa), Purified pituitary gonadotropin (Fertinorm-P®)
- Where
- Japan
- Volunteers
- 300 people
- Sponsor
- Merck KGaA, Darmstadt, Germany